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Article

6 Citations

3,635 Views

17 Pages

Structure–Activity Relationship of Synthetic Ginkgolic Acid Analogs for Treating Type 2 Diabetes by PTPN9 Inhibition

Jinsoo Kim,
Jinyoung Son,
Dohee Ahn,
Gibeom Nam,
Xiaodi Zhao,
Hyuna Park,
Woojoo Jeong and
Sang J. Chung

Int. J. Mol. Sci.2022, 23(7), 3927;https://doi.org/10.3390/ijms23073927

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1 April 2022

Ginkgolic acid (C13:0) (GA), isolated from Ginkgo biloba, is a potential therapeutic agent for type 2 diabetes. A series of GA analogs were designed and synthesized for the evaluation of their structure–activity relationship with respect to the...

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Article

2 Citations

3,267 Views

10 Pages

Ginkgolic Acid Derivatives from Ginkgo biloba Show Inhibitory Activity against Protein Tyrosine Phosphatases Associated with Insulin Resistance

Se Yun Jeong,
Kwang Ho Lee,
Jae Kwan Kim,
Dohee Ahn,
Hyemin Kim,
Sang J. Chung,
Sun-Young Yoon and
Ki Hyun Kim

Appl. Sci.2023, 13(24), 13220;https://doi.org/10.3390/app132413220

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13 December 2023

Ginkgo biloba L. (Ginkgoacea) contains an abundance of beneficial compounds and has demonstrated positive clinical effects in the management of metabolic syndrome. Recent studies have emphasized its efficacy against type 2 diabetes mellitus (T2DM), i...

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