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Article

1 Citations

2,692 Views

17 Pages

Glycosyl Mobile Radical Structures of Folic Acid Receptors Impact the Internalization of Functionalized Folate Amphiphilic Alternating Copolymer in Cancer Cells

Emilyn B. Aucoin,
Elizabeth Skapinker,
Abdulrahman M. Yaish,
Yunfan Li,
Haley L. Kombargi,
Daniel Jeyaraj,
Pankaj Garg,
Nicole Mendonza,
Cecile Malardier-Jugroot and
Myron R. Szewczuk

Receptors2024, 3(4), 457-473;https://doi.org/10.3390/receptors3040023

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21 October 2024

Folate receptor alpha (FRα) is a glycosylphosphatidylinositol (GPI) membrane-anchored protein containing three N-glycosylated residues at the N47, N139, and N179 termini. These glycosylation sites have been reported to be crucial for the recept...

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Article

20 Citations

5,007 Views

21 Pages

Functionalized Folic Acid-Conjugated Amphiphilic Alternating Copolymer Actively Targets 3D Multicellular Tumour Spheroids and Delivers the Hydrophobic Drug to the Inner Core

Xia Li,
Manpreet Sambi,
Alexandria DeCarlo,
Sergey V. Burov,
Roman Akasov,
Elena Markvicheva,
Cecile Malardier-Jugroot and
Myron R. Szewczuk

Nanomaterials2018, 8(8), 588;https://doi.org/10.3390/nano8080588

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2 August 2018

Engineering of a “smart” drug delivery system to specifically target tumour cells has been at the forefront of cancer research, having been engineered for safer, more efficient and effective use of chemotherapy for the treatment of cancer...

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