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Keywords = flexor tendon repair

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12 pages, 1207 KB  
Case Report
Structured Multi-Modal Rehabilitation Program for FHL Tendinitis and Os Trigonum Excision: A Case Report
by Başar Öztürk and Beyza Başer Öztürk
J. Am. Podiatr. Med. Assoc. 2026, 116(3), 27; https://doi.org/10.3390/japma116030027 - 24 Apr 2026
Viewed by 393
Abstract
Flexor hallucis longus (FHL) tendon injuries, although rare, severely affect foot stability and mobility, particularly in individuals engaging in repetitive push-off actions. This case study examines a 27-year-old male who underwent surgical repair for FHL tendon rupture, followed by a structured, multi-modal rehabilitation [...] Read more.
Flexor hallucis longus (FHL) tendon injuries, although rare, severely affect foot stability and mobility, particularly in individuals engaging in repetitive push-off actions. This case study examines a 27-year-old male who underwent surgical repair for FHL tendon rupture, followed by a structured, multi-modal rehabilitation program integrating advanced therapeutic techniques. The 12-week program was divided into three distinct phases to ensure a structured and progressive recovery process. The Early Phase (Weeks 1–4) focused on pain and edema control through interventions such as massage, electrotherapy, kinesiotaping, and the use of peritendinous ultrasonography to monitor recovery progress. The Intermediate Phase (Weeks 5–8) aimed to enhance strength and flexibility by incorporating Proprioceptive Neuromuscular Facilitation (PNF), weight-bearing exercises, dynamic stretching, and the progressive integration of Graston massage techniques. Finally, the Advanced Phase (Weeks 9–12) prioritized functional recovery, utilizing balance training, load transfer exercises, agility drills, and Theragun applications to prepare the individual for a return to optimal physical performance. Significant improvements were observed, including pain reduction (VAS score reduced by X%), increased dorsiflexion flexibility (from X° to X°), and enhanced muscle strength (e.g., tibialis anterior strength increased by X%). Functional assessments, such as the Y Balance Test, revealed improved endurance and mobility. This case study highlights the benefits of integrating innovative techniques like Graston massage and Theragun within a structured, evidence-based rehabilitation program to optimize recovery post-FHL tendon surgery. Full article
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18 pages, 4911 KB  
Article
Multimodal Surgical Management of Stage 1a/1b PCFD (Stage II AAFD): Early Outcomes of a Standardized Four-in-One Procedure Protocol
by Yu Ting Chen, Cing Syue Lin, Shou En Cheng, Shang Ming Lin and Tsung Yu Lan
Diagnostics 2026, 16(8), 1124; https://doi.org/10.3390/diagnostics16081124 - 9 Apr 2026
Viewed by 531
Abstract
Background/Objectives: Progressive collapsing foot deformity (PCFD) is driven by multiplanar peritalar instability. This study evaluated the clinical and radiographic outcomes of a standardized four-component reconstruction protocol designed to facilitate immediate postoperative weight-bearing in Stage 1a/1b PCFD. Methods: This single-center retrospective study included 20 [...] Read more.
Background/Objectives: Progressive collapsing foot deformity (PCFD) is driven by multiplanar peritalar instability. This study evaluated the clinical and radiographic outcomes of a standardized four-component reconstruction protocol designed to facilitate immediate postoperative weight-bearing in Stage 1a/1b PCFD. Methods: This single-center retrospective study included 20 patients treated between 2015 and 2023 with medializing calcaneal osteotomy, spring ligament repair, flexor digitorum longus (FDL) tendon transfer with internal brace augmentation, and subtalar arthroereisis. Clinical (VAS, AOFAS) and radiographic parameters (anteroposterior and lateral Meary angles, calcaneal pitch, and talonavicular coverage angle) were assessed longitudinally, with subgroup analysis comparing implant removal versus retention. Results: The protocol yielded significant overall improvements. Mean VAS decreased by 4.37 points (p < 0.001), and final AOFAS reached 84.7 ± 7.6 at the final follow-up. Although subtalar arthroereisis was removed in 45% of patients due to symptomatic irritation, subgroup analysis revealed no significant loss of radiographic correction (p > 0.05). Notably, a significant interaction effect was observed for VAS scores (p = 0.002) and AOFAS scores (p = 0.041), with the removal group demonstrating a pronounced functional recovery trajectory following explantation. No major complications occurred. Conclusions: A standardized four-in-one reconstruction provides reliable multiplanar correction in Stage 1a/1b PCFD. The maintenance of structural alignment despite a high implant removal rate supports the role of arthroereisis as a temporary but valuable adjunct for early mobilization. This strategy offers a reproducible framework for joint-preserving PCFD management. Full article
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10 pages, 752 KB  
Article
Flexor Tendon Repair Using a New Looped Six- and Eight-Strand Technique—A Biomechanical Analysis
by Lucas G. de Groot, Caroline A. Hundepool, Jaimy E. Koopman, Pierluigi Tos and Jelle M. Zuidam
J. Pers. Med. 2026, 16(3), 144; https://doi.org/10.3390/jpm16030144 - 3 Mar 2026
Viewed by 1046
Abstract
Background/Objectives: Tendon injuries are a common cause of emergency department presentation and impose a substantial socioeconomic burden. Despite advances in surgical techniques, rupture rates after primary repair remain at 3.1–11.7%. Contemporary repairs typically combine at least four core strands with epitenon sutures to [...] Read more.
Background/Objectives: Tendon injuries are a common cause of emergency department presentation and impose a substantial socioeconomic burden. Despite advances in surgical techniques, rupture rates after primary repair remain at 3.1–11.7%. Contemporary repairs typically combine at least four core strands with epitenon sutures to achieve sufficient tensile strength while limiting bulk. Increasing the number of core strands improves strength but may impair gliding and healing. Looped core sutures increase the effective strand number without additional knots or passes, potentially allowing omission of the epitenon suture and thus limiting repair complexity and bulk. The objective was to determine whether six- or eight-strand looped core suture techniques provide sufficient tensile strength to allow omission of an epitenon suture without excessive repair bulk, compared with a conventional four-strand Adelaide repair. Methods: One hundred and twenty human flexor digitorum profundus tendons were harvested from fresh-frozen anatomical specimens and allocated to six groups: Adelaide (four-strand) ± epitenon suture, six-strand ± epitenon suture, and eight-strand ± epitenon suture. Repairs were performed in zone II. The cross-sectional area (CSA) was measured before and after repair to quantify bulkiness. Tendons were tested to failure using axial tensile loading, and the failure mode was recorded. Results: The Adelaide with epitenon suture, six-strand with epitenon suture, and eight-strand with epitenon suture demonstrated significantly higher load to failure than the Adelaide without epitenon suture. The eight-strand without epitenon suture achieved a load to failure comparable to the Adelaide with epitenon suture, while also resulting in a smaller increase in CSA. The Adelaide with epitenon suture showed the greatest increase in CSA, while the six-strand without epitenon suture showed the smallest increase in CSA. Suture breakage was the predominant failure mode. Conclusions: An eight-strand looped core suture without epitenon suture provides comparable tensile strength to the conventional Adelaide repair with epitenon suture while minimizing repair bulk. The six-strand with epitenon suture demonstrated similar tensile strength to higher-strand techniques and may represent a mechanically adequate alternative with less tissue manipulation. These findings support a more individualized approach to flexor tendon repair, in which the choice of repair construct can be tailored to biomechanical demands and clinical context rather than applying a single uniform technique. Full article
(This article belongs to the Section Personalized Medical Care)
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17 pages, 2039 KB  
Article
Short-Term Effects of Broccoli-Derived Glucoraphanin on Recovery from Eccentric Muscle Damage: A Double-Blind Randomized Crossover Study
by Leonardo Cesanelli, Rono Thomas, Mantas Mickevičius, Audrius Sniečkus, Dalia Mickevičienė, Tomas Venckūnas, Arvydas Stasiulis and Sigitas Kamandulis
Nutrients 2026, 18(4), 710; https://doi.org/10.3390/nu18040710 - 23 Feb 2026
Cited by 1 | Viewed by 1107
Abstract
Background/Objectives: Broccoli-derived glucoraphanin (a sulforaphane precursor that activates Nrf2 defenses) may aid repair; however, its short-term effects in humans remain unknown. This study aimed to evaluate whether short-term supplementation with broccoli-derived glucoraphanin improves recovery from exercise-induced muscle damage. We hypothesized that short-term [...] Read more.
Background/Objectives: Broccoli-derived glucoraphanin (a sulforaphane precursor that activates Nrf2 defenses) may aid repair; however, its short-term effects in humans remain unknown. This study aimed to evaluate whether short-term supplementation with broccoli-derived glucoraphanin improves recovery from exercise-induced muscle damage. We hypothesized that short-term supplementation with broccoli-derived glucoraphanin would attenuate exercise-induced muscle damage and accelerate recovery. Methods: In a randomized, double-blind, placebo-controlled crossover design, fifteen participants consumed either high-glucoraphanin broccoli powder (320 μg) or placebo for two weeks, followed by elbow flexor eccentric exercise. Strength, soreness, creatine kinase (CK), range of motion (ROM), arm girths, and ultrasound-assessed muscle and tendon morphology were measured at baseline, immediately post-exercise, and at 48 and 96 h post-exercise. Results: Significant main effects of time were observed for isometric and isokinetic torque (p < 0.05), CK (p < 0.05), soreness (p < 0.05), and structural swelling markers (p < 0.05), confirming exercise-induced muscle damage. However, there were no significant Time × Supplement interactions for any variable (p > 0.05), indicating that glucoraphanin did not influence recovery dynamics. Conclusions: These findings suggest that short-term high-dose broccoli supplementation reconstituted with hot water does not modulate recovery following eccentric muscle damage under the conditions tested, including the chosen preparation method and experimental context. Full article
(This article belongs to the Special Issue Nutrition Strategy and Resistance Training)
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7 pages, 902 KB  
Case Report
Successful Digital Replantation in a Resource-Limited Kenyan Hospital: A Case Report and Discussion
by Alfio Luca Costa, Luca Folini, Alvise Montanari and Franco Bassetto
Surgeries 2026, 7(1), 13; https://doi.org/10.3390/surgeries7010013 - 20 Jan 2026
Viewed by 693
Abstract
Replantation of an amputated finger is a complex microsurgical procedure that is rarely attempted in low-resource settings due to limited infrastructure and expertise. We report a case of complete amputation of a finger in rural Kenya that was successfully replanted during a humanitarian [...] Read more.
Replantation of an amputated finger is a complex microsurgical procedure that is rarely attempted in low-resource settings due to limited infrastructure and expertise. We report a case of complete amputation of a finger in rural Kenya that was successfully replanted during a humanitarian surgical mission. A 28-year-old man sustained a severe crush avulsion agricultural machine injury resulting in the amputation of all ten digits; only one digit was deemed suitable for replantation. The replantation was performed under loupe and microscope magnification by a visiting specialist team in collaboration with local staff. Intraoperatively, bony fixation with Kirschner wires, extensor and flexor digitorum profundus tendon repair, arterial and venous anastomoses, and neurorrhaphy of the digital nerve were achieved. Postoperatively, the finger survived with adequate perfusion. At one-month follow-up, the replanted finger was viable with progressing wound healing and early joint motion; further rehabilitation was arranged to maximize functional recovery. This case, which is, to our knowledge, one of the first documented digital replantations in East Africa, illustrates that successful microsurgical limb salvage is feasible in a non-specialized hospital setting. Our experience underscores that, with proper planning, training, and teamwork, advanced reconstructive procedures like finger replantation can be safely carried out even in resource-constrained hospitals, offering patients in low-income regions outcomes previously achievable only in high-resource centers. Full article
(This article belongs to the Section Hand Surgery and Research)
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37 pages, 11439 KB  
Article
Constitutive Modelling of Tendons as Fibre-Reinforced Soft Tissues with a Single Fibre Family: Stress-Relaxation Tests for Parameter Identification
by Vito Burgio, Martina Di Giacinti, Paola Antonaci and Cecilia Surace
Appl. Sci. 2026, 16(1), 447; https://doi.org/10.3390/app16010447 - 31 Dec 2025
Viewed by 420
Abstract
Background: Nowadays, flexor hand tendon repair represents a clinical need, and new suture patterns or devices are commonly tested on animal surrogates. Considering the literature, the most frequently adopted animal models for testing are the equivalent tendons taken from porcine specimens. The constitutive [...] Read more.
Background: Nowadays, flexor hand tendon repair represents a clinical need, and new suture patterns or devices are commonly tested on animal surrogates. Considering the literature, the most frequently adopted animal models for testing are the equivalent tendons taken from porcine specimens. The constitutive modelling of these tendons could open the way to the numerical testing of new repair techniques and the development of digital twins, reducing the use of animal models. Methods: Uniaxial tensile stress-relaxation tests at different strain levels during the loading and unloading phases on porcine tendons were performed. Constitutive formulations based on the assumptions of incompressible and nearly incompressible materials were evaluated. Results: The experimental data were evaluated considering the relaxation tests at different strain levels during both the loading and unloading phases. The experimental tests were used for the material parameter calibration of both models. Conclusions: The stress-relaxation tests conducted at different strain levels during the loading phase showed good agreement with previous findings reported in the literature. Both constitutive model formulations provided a reliable approximation for numerical simulations. Full article
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11 pages, 416 KB  
Article
Direct Flexor Tendon Repair More than 3 Months After Trauma: Clinical Outcomes of Four Consecutive Cases and Scoping Review on Time Limits
by Alessandro Crosio, Alice Clemente, Arturo Sebastiano Nozzolillo, Sara Dimartino, Simona Odella, Davide Ciclamini and Pierluigi Tos
J. Clin. Med. 2025, 14(16), 5796; https://doi.org/10.3390/jcm14165796 - 16 Aug 2025
Cited by 2 | Viewed by 4786
Abstract
Background/Objective: Traumatic injuries to the flexor tendons of the hand are frequently treated by hand surgeons. Late repair is not classically considered to be feasible due to the high risk of failure and functional complications. The present study aims to present the functional [...] Read more.
Background/Objective: Traumatic injuries to the flexor tendons of the hand are frequently treated by hand surgeons. Late repair is not classically considered to be feasible due to the high risk of failure and functional complications. The present study aims to present the functional results of primary flexor tendon repairs performed more than three months after trauma, along with evidence regarding the time limit for primary flexor tendon repair. Methods: The clinical outcomes of direct flexor tendon repairs in zones 1 and 2 of the long fingers or thumb are reported herein. A scoping review was undertaken using Medline and CINHAL to identify studies reporting the functional outcomes of flexor repair following trauma. Results: In this series, four patients were treated with direct M-Tang and epitendinous suture or pull-out reinsertion. Accessory procedures were required to perform a direct repair. The mean delay was 5.5 months, and the follow-up period was 24 months. The mean total active movement was 195°. Extension lags of 10° and 20° were registered at the proximal interphalangeal and distal interphalangeal joints, respectively. While a literature review showed that most cases treated with primary repair after three months resulted in functional complications, these procedures were performed around 40 years ago and no recent reports were found. Conclusions: In the small cohort of patients here reported it has been possible to repair flexor tendons in zones 1 and 2, and to reinsert a jersey finger, even three months after trauma. Accessory procedures were required. Accurate patient selection and counseling is mandatory before surgery to inform patients about alternatives. The literature review confirmed that no positive results have previously been reported in the literature on this topic. It is thought that modern materials and surgical techniques for flexor tendon repair should extend the edge for primary repair in selected patients, as compared to previous practices. Full article
(This article belongs to the Special Issue Hand Surgery: Latest Advances and Prospects)
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14 pages, 1860 KB  
Review
Optimizing Flexor Digitorum Profundus Tendon Repair: A Narrative Review
by Rishith R. Mereddy, Emily E. Zona, Camille J. LaLiberte and Aaron M. Dingle
J. Funct. Biomater. 2025, 16(3), 97; https://doi.org/10.3390/jfb16030097 - 11 Mar 2025
Cited by 2 | Viewed by 5018
Abstract
Zone II flexor digitorum profundus (FDP) tendon injuries are complex, and present significant challenges in hand surgery, due to the need to balance strength and flexibility during repair. Traditional suture techniques often lead to complications such as adhesions or tendon rupture, prompting the [...] Read more.
Zone II flexor digitorum profundus (FDP) tendon injuries are complex, and present significant challenges in hand surgery, due to the need to balance strength and flexibility during repair. Traditional suture techniques often lead to complications such as adhesions or tendon rupture, prompting the exploration of novel strategies to improve outcomes. This review investigates the use of flexor digitorum superficialis (FDS) tendon autografts to reinforce FDP repairs, alongside the integration of biomaterials to enhance mechanical strength without sacrificing FDS tissue. Key biomaterials, including collagen–polycaprolactone (PCL) composites, are evaluated for their biocompatibility, mechanical integrity, and controlled degradation properties. Collagen-PCL emerges as a leading candidate, offering the potential to reduce adhesions and promote tendon healing. Although nanomaterials such as nanofibers and nanoparticles show promise in preventing adhesions and supporting cellular proliferation, their application remains limited by manufacturing challenges. By combining advanced repair techniques with biomaterials like collagen-PCL, this approach aims to improve surgical outcomes and minimize complications. Future research will focus on validating these findings in biological models, assessing tendon healing through imaging, and comparing the cost-effectiveness of biomaterial-enhanced repairs with traditional methods. This review underscores the potential for biomaterial-based approaches to transform FDP tendon repair. Full article
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86 KB  
Article
Incidence of Wounds Associated with Posterior Midline Incision for Achilles Tendon Pathology in a Large Cohort at a Tertiary Care Center
by Michael J. Hurst, Hannah J. Hughes, Cody Blazek, Ryan J. Lerch, Patrick R. Burns and Jeffrey Manway
J. Am. Podiatr. Med. Assoc. 2024, 114(6), 22123; https://doi.org/10.7547/22-123 - 1 Nov 2024
Cited by 1 | Viewed by 102
Abstract
Background: We sought to determine the wound complications associated with a straight midline incision overlying the Achilles tendon. Data on sex, age, body mass index (BMI), surgery performed, date of surgery, and wound development were collected. Methods: We retrospectively collected data on 217 [...] Read more.
Background: We sought to determine the wound complications associated with a straight midline incision overlying the Achilles tendon. Data on sex, age, body mass index (BMI), surgery performed, date of surgery, and wound development were collected. Methods: We retrospectively collected data on 217 patients with a mean ± SD age of 46.16 ± 13.72 years and follow-up of 9.1 ± 12.42 months. The specific procedures performed with this incision included repair of ruptured Achilles tendon (n = 89), Haglund deformity correction (n = 75), and flexor hallucis longus tendon transfer (n = 63). Wound complication was defined as a delay in wound healing with necrosis of the incisional margins resulting in exposure of superficial or deep layers. Deep infection was defined as the need for intravenous antibiotics. Results: We reported 15 wound complications (6.91%): ten (4.6%) were superficial and five (2.3%) were deep. All five patients with deep wound complications required operative debridement, and four patients required intravenous antibiotics. The infection rate of the midline incisional approach was 1.83%. Superficial wound complications were treated with local care and oral antibiotics, as necessary. There were no significant differences between age (P = .5986; P < .05), BMI (P = .7968; P < .05), smoking history (P = .6356; P < .05), or length of follow-up (P = .8338; P < .05). The overall wound rate of 6.91% is comparable with other literature with larger cohorts. Conclusions: These results will help us better educate surgeons about the risk of wound development with the posterior midline Achilles tendon incision. Full article
10 pages, 6099 KB  
Case Report
Flexor Digitorum Longus Transfer in Chronic Plantar Plate Tears: Two Case Reports and Literature Review
by Antonio Córdoba-Fernández, Rocío Mateos-Carrasco, Antonio Jesús García-Gámez and Victoria Eugenia Córdoba-Jiménez
Reports 2024, 7(4), 87; https://doi.org/10.3390/reports7040087 - 29 Oct 2024
Viewed by 2922
Abstract
Background and Clinical Significance: The plantar plate (PP) tear of the second metatarsophalangeal joint (MTPJ) is a common cause of forefoot pain in clinical practice. The PP is the main stabilizing structure of the joint and, together with the collateral ligaments, is the [...] Read more.
Background and Clinical Significance: The plantar plate (PP) tear of the second metatarsophalangeal joint (MTPJ) is a common cause of forefoot pain in clinical practice. The PP is the main stabilizing structure of the joint and, together with the collateral ligaments, is the key to maintaining the stability of the MTPJ. Many surgical procedures have been described to repair PP tears. Currently, there is still controversy regarding which is the surgical superior option (direct versus indirect PP repair techniques). Transfer of the flexor digitorum longus tendon to the dorsum of the proximal phalanx is one of the surgical techniques described to treat PP tears associated with MTPJ instability. Case Presentation: We present two cases that developed instability of the second MTPJ secondary to chronic PP tear with symptoms resolved after transfer of the flexor digitorum longus (FDL). Conclusions: Currently, the literature review shows that the procedure seems to be the most consistent surgical option in chronic cases of PP tears. Full article
(This article belongs to the Section Surgery)
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12 pages, 1221 KB  
Article
Biomechanical Comparison of Three Modified Kessler Techniques for Flexor Tendon Repair: Implications in Surgical Practice and Early Active Mobilization
by Marlies Schellnegger, Alvin C. Lin, Judith C. J. Holzer-Geissler, Annika Haenel, Felix Pirrung, Andrzej Hecker, Lars P. Kamolz, Niels Hammer and Werner Girsch
J. Clin. Med. 2024, 13(19), 5766; https://doi.org/10.3390/jcm13195766 - 27 Sep 2024
Cited by 3 | Viewed by 9077
Abstract
Objective: Managing flexor tendon injuries surgically remains challenging due to the ongoing debate over the most effective suture technique and materials. An optimal repair must be technically feasible while providing enough strength to allow for early active mobilization during the post-operative phase. [...] Read more.
Objective: Managing flexor tendon injuries surgically remains challenging due to the ongoing debate over the most effective suture technique and materials. An optimal repair must be technically feasible while providing enough strength to allow for early active mobilization during the post-operative phase. This study aimed to assess the biomechanical properties of three modified Kessler repair techniques using two different suture materials: a conventional two-strand and a modified four-strand Kirchmayr–Kessler repair using 3-0 Prolene® (2s-KK-P and 4s-KK-P respectively), and a four-strand Kessler–Tsuge repair using 4-0 FiberLoop® (4s-KT-FL). Methods: Human flexor digitorum profundus (FDP) tendons were retrieved from Thiel-embalmed prosections. For each tendon, a full-thickness cross-sectional incision was created, and the ends were reattached using either a 2s-KK-P (n = 30), a 4s-KK-P (n = 30), or a 4s-KT-FL repair (n = 30). The repaired tendons were tested using either a quasi-static (n = 45) or cyclic testing protocol (n = 45). Maximum force (Fmax), 2 mm gap force (F2mm), and primary failure modes were recorded. Results: In both quasi-static and cyclic testing groups, tendons repaired using the 4s-KT-FL approach exhibited higher Fmax and F2mm values compared to the 2s-KK-P or 4s-KK-P repairs. Fmax was significantly higher with a 4s-KK-P versus 2s-KK-P repair, but there was no significant difference in F2mm. Suture pull-out was the main failure mode for the 4s-KT-FL repair, while suture breakage was the primary failure mode in 2s- and 4s-KK-P repairs. Conclusions: FDP tendons repaired using the 4s-KT-FL approach demonstrated superior biomechanical performance compared to 2s- and 4s-KK-P repairs, suggesting that the 4s-KT-FL tendon repair could potentially reduce the risk of gapping or re-rupture during early active mobilization. Full article
(This article belongs to the Section Orthopedics)
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27 pages, 2360 KB  
Systematic Review
Mesenchymal Stromal Cells for the Enhancement of Surgical Flexor Tendon Repair in Animal Models: A Systematic Review and Meta-Analysis
by Ilias Ektor Epanomeritakis, Andreas Eleftheriou, Anna Economou, Victor Lu and Wasim Khan
Bioengineering 2024, 11(7), 656; https://doi.org/10.3390/bioengineering11070656 - 27 Jun 2024
Cited by 4 | Viewed by 2512
Abstract
Flexor tendon lacerations are primarily treated by surgical repair. Limited intrinsic healing ability means the repair site can remain weak. Furthermore, adhesion formation may reduce range of motion post-operatively. Mesenchymal stromal cells (MSCs) have been trialled for repair and regeneration of multiple musculoskeletal [...] Read more.
Flexor tendon lacerations are primarily treated by surgical repair. Limited intrinsic healing ability means the repair site can remain weak. Furthermore, adhesion formation may reduce range of motion post-operatively. Mesenchymal stromal cells (MSCs) have been trialled for repair and regeneration of multiple musculoskeletal structures. Our goal was to determine the efficacy of MSCs in enhancing the biomechanical properties of surgically repaired flexor tendons. A PRISMA systematic review was conducted using four databases (PubMed, Ovid, Web of Science, and CINAHL) to identify studies using MSCs to augment surgical repair of flexor tendon injuries in animals compared to surgical repair alone. Nine studies were included, which investigated either bone marrow- or adipose-derived MSCs. Results of biomechanical testing were extracted and meta-analyses were performed regarding the maximum load, friction and properties relating to viscoelastic behaviour. There was no significant difference in maximum load at final follow-up. However, friction, a surrogate measure of adhesions, was significantly reduced following the application of MSCs (p = 0.04). Other properties showed variable results and dissipation of the therapeutic benefits of MSCs over time. In conclusion, MSCs reduce adhesion formation following tendon injury. This may result from their immunomodulatory function, dampening the inflammatory response. However, this may come at the cost of favourable healing which will restore the tendon’s viscoelastic properties. The short duration of some improvements may reflect MSCs’ limited survival or poor retention. Further investigation is needed to clarify the effect of MSC therapy and optimise its duration of action. Full article
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19 pages, 2588 KB  
Article
Examining the Potential of Vitamin C Supplementation in Tissue-Engineered Equine Superficial Digital Flexor Tendon Constructs
by Michael J. Mienaltowski, Mitchell Callahan, Nicole L. Gonzales and Angelique Wong
Int. J. Mol. Sci. 2023, 24(23), 17098; https://doi.org/10.3390/ijms242317098 - 4 Dec 2023
Cited by 2 | Viewed by 5988
Abstract
Because equine tendinopathies are slow to heal and often recur, therapeutic strategies are being considered that aid tendon repair. Given the success of utilizing vitamin C to promote tenogenesis in other species, we hypothesized that vitamin C supplementation would produce dose-dependent improvements in [...] Read more.
Because equine tendinopathies are slow to heal and often recur, therapeutic strategies are being considered that aid tendon repair. Given the success of utilizing vitamin C to promote tenogenesis in other species, we hypothesized that vitamin C supplementation would produce dose-dependent improvements in the tenogenic properties of tendon proper (TP) and peritenon (PERI) cells of the equine superficial digital flexor tendon (SDFT). Equine TP- and PERI-progenitor-cell-seeded fibrin three-dimensional constructs were supplemented with four concentrations of vitamin C. The gene expression profiles of the constructs were assessed with 3′-Tag-Seq and real-time quantitative polymerase chain reaction (RT-qPCR); collagen content and fibril ultrastructure were also analyzed. Moreover, cells were challenged with dexamethasone to determine the levels of cytoprotection afforded by vitamin C. Expression profiling demonstrated that vitamin C had an anti-inflammatory effect on TP and PERI cell constructs. Moreover, vitamin C supplementation mitigated the degenerative pathways seen in tendinopathy and increased collagen content in tendon constructs. When challenged with dexamethasone in two-dimensional culture, vitamin C had a cytoprotective effect for TP cells but not necessarily for PERI cells. Future studies will explore the effects of vitamin C on these cells during inflammation and within the tendon niche in vivo. Full article
(This article belongs to the Special Issue A Road Map to Tendon Regeneration)
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11 pages, 9682 KB  
Case Report
Surgical Repair of Luxation of the Superficial Digital Flexor Tendon in Dogs Using a Calcaneal Chondroplastic-like Technique—Three Cases
by Riccardo Botto, Sara Sassaroli, Luca Pennasilico and Angela Palumbo Piccionello
Animals 2023, 13(9), 1468; https://doi.org/10.3390/ani13091468 - 26 Apr 2023
Cited by 3 | Viewed by 7374
Abstract
The purpose of this report is to describe the technique and the clinical outcome of three dogs affected by superficial digital flexor (SDF) tendon luxation treated using a calcaneal chondroplastic-like technique. A German Pinscher with bilateral and lateral SDF tendon luxation, a Griffon [...] Read more.
The purpose of this report is to describe the technique and the clinical outcome of three dogs affected by superficial digital flexor (SDF) tendon luxation treated using a calcaneal chondroplastic-like technique. A German Pinscher with bilateral and lateral SDF tendon luxation, a Griffon Nivernais with medial SDF tendon luxation following self-mutilation of the IV toe, and an American Staffordshire Terrier with a lateral luxation and having undergone calcaneal chondroplasty and primary repair of the retinacular tissues. A fibrocartilage flap covering the calcaneal groove was elevated, the subchondral bone was removed from beneath it, and the flap was pressed back into the deepened sulcus, keeping its distal attachment as a hinge point. The SDF tendon was reduced, and its tracking along the deepened groove was ensured. Furthermore, the torn retinacular attachment was repaired. Clinical follow-ups at 4 and 8 weeks and 1 year apart showed no signs of lameness and no SDF tendon re-luxation. The calcaneal chondroplastic-like technique led to a satisfactory outcome with no complications. This technique is relatively straightforward, requires no implants, and is also successful without postoperative immobilization of the tarsal joint. Further cases are required to determine its benefits and its risks compared to conventional surgery. Full article
(This article belongs to the Section Veterinary Clinical Studies)
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7 pages, 1048 KB  
Article
A Missing Flexor Digitorum Brevis Tendon and Its Relationship to Sex and Ancestry: Evaluation in Hispanic Population
by Jailenne I. Quiñones-Rodriguez, Cristian Mantilla-Rosa, Félix Rodríguez, Catalina I. Villamil, Juan Fernández, Maryvi González-Solá, Cristhian Torres-Toro and Martin G. Rosario
Anatomia 2022, 1(2), 210-216; https://doi.org/10.3390/anatomia1020021 - 6 Dec 2022
Cited by 2 | Viewed by 6643
Abstract
Background: The flexor digitorum brevis tendon to the fifth digit is frequently absent, and this absence is typically an incidental discovery during dissection or surgical studies. This study aimed to assess the frequency of a missing flexor digitorum brevis tendon in a Hispanic [...] Read more.
Background: The flexor digitorum brevis tendon to the fifth digit is frequently absent, and this absence is typically an incidental discovery during dissection or surgical studies. This study aimed to assess the frequency of a missing flexor digitorum brevis tendon in a Hispanic population for the first time, the association between the absence of the flexor digitorum brevis tendon, variables such as sex and ethnicity, and the functional implications of an absent tendon. Methods: Our sample consists of 30 cadavers whose feet were dissected and examined for the presence or absence of the digiti minimi tendon. Results: We found no significant relationship between the presence or absence of the tendon to sex or ethnicity. However, due to a lack of significant effects on human ambulation from the absence of this tendon, and the ability of adjacent muscles to adapt to its absence, the absence of this tendon might become increasingly prevalent over time. Conclusions: Knowledge of the frequency of flexor digitorum brevis variations concerning the demographic characteristics of patients would be of clinical importance for tendon repair, tendon transfer to correct deformities such as claw toe or hammer toe, or soft tissue reconstruction in foot surgery. Full article
(This article belongs to the Special Issue State-of-the-Art Anatomical Research in the Mediterranean Region 2022)
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