Advances in Cell and Tissue Engineering: Biomechanical Modeling and Mechanobiology
A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".
Deadline for manuscript submissions: 20 June 2025 | Viewed by 594
Special Issue Editors
Interests: biomechanical engineering; biomechanics; biomedical modeling; biomaterials; biomedical imaging; cell culture; immunoblotting; cell imaging; cell signaling; immunofluorescence
Special Issues, Collections and Topics in MDPI journals
2. Department and Bioengineering, Lehigh University, Bethlehem, PA 18015, USA
Interests: biomechanics; dynamic loading; modelling of cell motility; gait analysis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Understanding pathology and treating diseases require detailed observations and analyses of research targets at multiple scales, from nano to macro. Most diseases arise due to imbalances in cell and tissue homeostasis, which are affected by cell activity and differentiation. Cells can sense, respond, and adapt to mechanical stimuli, often differentiating between static and dynamic stimuli. Traditional mechanical processes applied to monolayers of cells, intact tissues, or engineered tissue structures can stimulate cell differentiation and promote metabolic changes. Cell differentiation and reproduction can promote tissue repair and regeneration, thereby impacting the treatment of tissues, organs, and systems within the body. Mechanobiological studies can help explain macroscopic pathogenesis from the microscopic level through cellular activities. These studies are further enhanced when coupled with advanced numerical analysis techniques, including but not limited to finite element analysis, computational fluid dynamics, multiphysics modeling, multi-scale modeling, agent-based modeling, network analyses, and artificial intelligence (AI)-based methodologies. The integration of these analytical tools with biomechanical and mechanobiological data can deepen our understanding and enable predictions of complex mechanobiological processes, which may lead to biomechanical or pharmacomechanical solutions to treat a wide variety of diseases.
This Special Issue aims to explore the potential of numerical and mechanical analyses in the biomedical field to accelerate the understanding of pathogenesis, accelerate drug development, and accelerate the development of novel disease treatments. We welcome numerical studies, experimental studies, and comprehensive reviews.
Dr. Scott Wood
Prof. Dr. Arkady Voloshin
Guest Editors
Manuscript Submission Information
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Keywords
- mechanobiological therapy
- mechanical analysis in biomedicine
- cell culture
- biomechanics
- cell differentiation
- mechanotransduction
- numerical techniques in biomedicine
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