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15 pages, 2879 KiB  
Article
Study on the Eye Movement Transfer Characteristics of Drivers Under Different Road Conditions
by Zhenxiang Hao, Jianping Hu, Xiaohui Sun, Jin Ran, Yuhang Zheng, Binhe Yang and Junyao Tang
Appl. Sci. 2025, 15(15), 8559; https://doi.org/10.3390/app15158559 (registering DOI) - 1 Aug 2025
Abstract
Given the severe global traffic safety challenges—including threats to human lives and socioeconomic impacts—this study analyzes visual behavior to promote sustainable transportation, improve road safety, and reduce resource waste and pollution caused by accidents. Four typical road sections, namely, turning, straight ahead, uphill, [...] Read more.
Given the severe global traffic safety challenges—including threats to human lives and socioeconomic impacts—this study analyzes visual behavior to promote sustainable transportation, improve road safety, and reduce resource waste and pollution caused by accidents. Four typical road sections, namely, turning, straight ahead, uphill, and downhill, were selected, and the eye movement data of 23 drivers in different driving stages were collected by aSee Glasses eye-tracking device to analyze the visual gaze characteristics of the drivers and their transfer patterns in each road section. Using Markov chain theory, the probability of staying at each gaze point and the transfer probability distribution between gaze points were investigated. The results of the study showed that drivers’ visual behaviors in different road sections showed significant differences: drivers in the turning section had the largest percentage of fixation on the near front, with a fixation duration and frequency of 29.99% and 28.80%, respectively; the straight ahead section, on the other hand, mainly focused on the right side of the road, with 31.57% of fixation duration and 19.45% of frequency of fixation; on the uphill section, drivers’ fixation duration on the left and right roads was more balanced, with 24.36% of fixation duration on the left side of the road and 25.51% on the right side of the road; drivers on the downhill section looked more frequently at the distance ahead, with a total fixation frequency of 23.20%, while paying higher attention to the right side of the road environment, with a fixation duration of 27.09%. In terms of visual fixation, the fixation shift in the turning road section was mainly concentrated between the near and distant parts of the road ahead and frequently turned to the left and right sides; the straight road section mainly showed a shift between the distant parts of the road ahead and the dashboard; the uphill road section was concentrated on the shift between the near parts of the road ahead and the two sides of the road, while the downhill road section mainly occurred between the distant parts of the road ahead and the rearview mirror. Although drivers’ fixations on the front of the road were most concentrated under the four road sections, with an overall fixation stability probability exceeding 67%, there were significant differences in fixation smoothness between different road sections. Through this study, this paper not only reveals the laws of drivers’ visual behavior under different driving environments but also provides theoretical support for behavior-based traffic safety improvement strategies. Full article
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17 pages, 3682 KiB  
Article
Comparative Analysis of Testicular Transcriptional and Translational Landscapes in Yak and Cattle–Yak: Implications for Hybrid Male Sterility
by Mengli Cao, Shaoke Guo, Ziqiang Ding, Liyan Hu, Lin Xiong, Qianyun Ge, Jie Pei and Xian Guo
Biomolecules 2025, 15(8), 1080; https://doi.org/10.3390/biom15081080 - 25 Jul 2025
Viewed by 270
Abstract
Cattle–yak, a hybrid of yak and cattle, exhibits significant heterosis but male infertility, hindering heterosis fixation. Although extensive research has been conducted on transcriptional mechanisms in the testes of cattle–yak, the understanding of their translational landscape remains limited. In this study, we characterized [...] Read more.
Cattle–yak, a hybrid of yak and cattle, exhibits significant heterosis but male infertility, hindering heterosis fixation. Although extensive research has been conducted on transcriptional mechanisms in the testes of cattle–yak, the understanding of their translational landscape remains limited. In this study, we characterized the translational landscape of yak and cattle–yak based on Ribo-seq technology integrated with RNA-seq data. The results revealed that gene expression was not fully concordant between transcriptional and translational levels, whereas cattle–yak testes exhibited a stronger correlation across these two regulatory layers. Notably, genes that were differentially expressed at the translational level only (MEIOB, MEI1, and SMC1B) were mainly involved in meiosis. A total of 4,236 genes with different translation efficiencies (TEs) were identified, and the TEs of most of the genes gradually decreased as the mRNA expression level increased. Further research revealed that genes with higher TE had a shorter coding sequence (CDS) length, lower GC content, and higher normalized minimum free energy in the testes of yaks, but this characteristic was not found in cattle–yaks. We also identified upstream open reading frames (uORFs) in yak and cattle–yak testes, and the sequence characteristics of translated uORFs and untranslated uORFs were markedly different. In addition, we identified several short polypeptides that may play potential roles in spermatogenesis. In summary, our study uncovers distinct translational dysregulations in cattle–yak testes, particularly affecting meiosis, which provides novel insights into the mechanisms of spermatogenesis and male infertility in hybrids. Full article
(This article belongs to the Section Molecular Biology)
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17 pages, 3355 KiB  
Article
Legume–Non-Legume Cover Crop Mixtures Enhance Soil Nutrient Availability and Physical Properties: A Meta-Analysis Across Chinese Agroecosystems
by Jiayu Ma, Baozhong Yin, Tian Gao, Kaixiao He, Xinqin Huang, Tiantong Jiang and Wenchao Zhen
Agronomy 2025, 15(8), 1756; https://doi.org/10.3390/agronomy15081756 - 22 Jul 2025
Viewed by 377
Abstract
Cover cropping has emerged as a pivotal sustainable agronomic practice aimed at enhancing soil health and sustaining crop productivity. To quantify its effects across diverse agroecosystems, we conducted a meta-analysis of 1877 paired observations from 114 studies (1980–2025) comparing cover cropping with bare [...] Read more.
Cover cropping has emerged as a pivotal sustainable agronomic practice aimed at enhancing soil health and sustaining crop productivity. To quantify its effects across diverse agroecosystems, we conducted a meta-analysis of 1877 paired observations from 114 studies (1980–2025) comparing cover cropping with bare fallow during fallow periods in major cereal systems across China. Cover cropping significantly reduced soil bulk density by 6.1% and increased key soil nutrients including total nitrogen (+13.1%), total phosphorus (+15.6%), hydrolysable nitrogen (+9.3%), available phosphorus (+11.1%), available potassium (+12.4%), soil organic matter (+11.7%), and microbial biomass carbon (+41.1%). Leguminous cover crops outperformed non-legumes in enhancing nitrogen availability, reflecting biological nitrogen fixation. Mixed-species cover crop mixtures showed superior benefits over monocultures, likely due to complementary effects on nutrient cycling and soil structure. Soil texture and initial soil organic carbon significantly moderated these outcomes. Furthermore, although overall soil pH remained stable, cover cropping exhibited a clear buffering effect, tending to regulate soil pH toward neutrality. Meta-regression analyses revealed a diminishing positive effect on total nitrogen (TN), available potassium (AK), and microbial biomass carbon (MBC) with an extended duration of cover cropping, suggesting potential saturation effects. These results underscore the context-dependent efficacy of cover cropping as a strategy for soil quality enhancement. Optimizing cover crop implementation should integrate the consideration of inherent soil characteristics, baseline fertility, and species composition to maximize agroecosystem resilience and sustainability. Full article
(This article belongs to the Section Innovative Cropping Systems)
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22 pages, 9247 KiB  
Article
Enhancing Restoration in Urban Waterfront Spaces: Environmental Features, Visual Behavior, and Design Implications
by Shiqin Zhou, Chang Lin and Quanle Huang
Buildings 2025, 15(14), 2567; https://doi.org/10.3390/buildings15142567 - 21 Jul 2025
Viewed by 245
Abstract
Urbanization poses mental health risks for urban dwellers, whereas natural environments offer mental health benefits by providing restorative experiences through visual stimuli. While urban waterfront spaces are recognized for their mental restorative potential, the specific environmental features and individual visual behaviors that drive [...] Read more.
Urbanization poses mental health risks for urban dwellers, whereas natural environments offer mental health benefits by providing restorative experiences through visual stimuli. While urban waterfront spaces are recognized for their mental restorative potential, the specific environmental features and individual visual behaviors that drive these benefits remain inadequately understood. Grounded in restorative environments theory, this study investigates how these factors jointly influence restoration. Employing a controlled laboratory experiment, subjects viewed real-life images of nine representative spatial locations from the waterfront space of Guangzhou Long Bund. Data collected during the multimodal experiments included subjective scales data (SRRS), physiological measurement data (SCR; LF/HF), and eye-tracking data. Key findings revealed the following: (1) The element visibility rate and visual characteristics of plant and building elements significantly influence restorative benefits. (2) Spatial configuration attributes (degree of enclosure, spatial hierarchy, and depth perception) regulate restorative benefits. (3) Visual behavior patterns (attributes of fixation points, fixation duration, and moderate dispersion of fixations) are significantly associated with restoration benefits. These findings advance the understanding of the mechanisms linking environmental stimuli, visual behavior, and psychological restorative benefits. They translate into evidence-based design principles for urban waterfront spaces. This study provides a refined perspective and empirical foundation for enhancing the restorative benefits of urban waterfront spaces through design. Full article
(This article belongs to the Section Architectural Design, Urban Science, and Real Estate)
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20 pages, 6280 KiB  
Article
The V5-Epitope Tag for Cell Engineering and Its Use in Immunohistochemistry and Quantitative Flow Cytometry
by Katja Fritschle, Marion Mielke, Olga J. Seelbach, Ulrike Mühlthaler, Milica Živanić, Tarik Bozoglu, Sarah Dötsch, Linda Warmuth, Dirk H. Busch, Arne Skerra, Christian Kupatt, Wolfgang A. Weber, Richard E. Randall, Katja Steiger and Volker Morath
Biology 2025, 14(7), 890; https://doi.org/10.3390/biology14070890 - 20 Jul 2025
Viewed by 366
Abstract
Synthetic biology has fundamentally advanced cell engineering and helped to develop effective therapeutics such as chimeric antigen receptor (CAR)-T cells. For these applications, the detection, localization, and quantification of heterologous fusion proteins assembled from interchangeable building blocks is of high importance. The V5 [...] Read more.
Synthetic biology has fundamentally advanced cell engineering and helped to develop effective therapeutics such as chimeric antigen receptor (CAR)-T cells. For these applications, the detection, localization, and quantification of heterologous fusion proteins assembled from interchangeable building blocks is of high importance. The V5 tag, a 14-residue epitope tag, offers promising characteristics for these applications but has only rarely been used in this context. Thus, we have systematically evaluated the murine anti-V5 tag antibody mu_SV5-Pk1 as well as its humanized version, hu_SV5-Pk1, to analyze cells expressing V5-tagged receptors in samples from various in vitro and in vivo experiments. We found that the V5 tag signal on cells is affected by certain fixation and detachment reagents. Immunohistochemistry (IHC) on formalin-fixed paraffin-embedded (FFPE) mouse tissue samples was performed to sensitively detect cells in tissue. We improved IHC by applying the hu_SV5-Pk1 monoclonal antibody (mAb) to avoid cross-reactivity within and unspecific background signals arising on fixed mouse tissue. Conversely, the absence of unspecific binding by the mu_SV5-Pk1 mAb was evaluated on 46 human normal or cancer tissues. Our findings present a robust toolbox for utilizing the V5 tag and cognate antibodies in synthetic biology applications. Full article
(This article belongs to the Section Biochemistry and Molecular Biology)
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10 pages, 3728 KiB  
Technical Note
Cervical Lateral Mass and Pedicle Fracture Reduced with a Herbert Screw: A Technical Note
by Antonio Colamaria, Francesco Carbone, Augusto Leone, Giuseppe Palmieri, Savino Iodice, Bianca Maria Baldassarre, Giovanni Cirrottola, Valeria Ble, Uwe Spetzger and Giuseppe Di Perna
Med. Sci. 2025, 13(3), 92; https://doi.org/10.3390/medsci13030092 - 19 Jul 2025
Viewed by 296
Abstract
Background: Traumatic fractures of the cervical spine pose significant challenges in management, particularly in young patients, where preserving mobility is crucial. Patient Characteristics: A 30-year-old woman presented with a C3 lateral mass and pedicle fracture following a motor vehicle collision. Initial conservative management [...] Read more.
Background: Traumatic fractures of the cervical spine pose significant challenges in management, particularly in young patients, where preserving mobility is crucial. Patient Characteristics: A 30-year-old woman presented with a C3 lateral mass and pedicle fracture following a motor vehicle collision. Initial conservative management with a rigid cervical collar for three months failed to reduce the diastasis, and the debilitating neck pain worsened. Preoperative imaging confirmed fracture instability without spinal cord compression. Intervention and Outcome: Preoperative screw trajectory planning was conducted with the My Spine MC system (Medacta), and fine-tuning was achieved on a 3D-printed model of the vertebra. A posterior midline approach was employed to expose the C3 vertebra, and a Herbert screw was inserted under fluoroscopic guidance. Imaging at three months demonstrated significant fracture reduction and early bone fusion. The patient achieved substantial improvement in functional mobility without complications. Conclusion: Herbert screw fixation holds potential as a less-invasive alternative to conventional posterior stabilization for selected cervical fractures. This technical note provides the reader with the required information to support surgical planning and execution. Full article
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14 pages, 3647 KiB  
Article
The Characteristics of the Aeolian Environment in the Coastal Sandy Land of Boao Jade Belt Beach, Hainan Island
by Shuai Zhong, Jianjun Qu, Zhizhong Zhao and Penghua Qiu
Atmosphere 2025, 16(7), 845; https://doi.org/10.3390/atmos16070845 - 11 Jul 2025
Viewed by 193
Abstract
Boao Jade Beach, on the east coast of Hainan Island, is a typical sandy beach and is one of the areas where typhoons frequently land in Hainan. This study examined wind speed, wind direction, and sediment transport data obtained from field meteorological stations [...] Read more.
Boao Jade Beach, on the east coast of Hainan Island, is a typical sandy beach and is one of the areas where typhoons frequently land in Hainan. This study examined wind speed, wind direction, and sediment transport data obtained from field meteorological stations and omnidirectional sand accumulation instruments from 2020 to 2024 to study the coastal aeolian environment and sediment transport distribution characteristics in the region. The findings provide a theoretical basis for comprehensive analyses of the evolution of coastal aeolian landforms and the evaluation and control of coastal aeolian hazards. The research results showed the following: (1) The annual average threshold wind velocity for sand movement in the study area was 6.13 m/s, and the wind speed frequency was 20.97%, mainly dominated by easterly winds (NNE, NE) and southerly winds (S). (2) The annual drift potential (DP) and resultant drift potential (RDP) of Boao Jade Belt Beach from 2020 to 2024 were 125.99 VU and 29.59 VU, respectively, indicating a low-energy wind environment. The yearly index of directional wind variability (RDP/DP) was 0.23, which is classified as a small ratio and indicates blunt bimodal wind conditions. The yearly resultant drift direction (RDD) was 329.41°, corresponding to the NNW direction, indicating that the sand on Boao Jade Belt Beach is generally transported in the southwest direction. (3) When the measured data from the sand accumulation instrument in the study area from 2020 to 2024 were used for a statistical analysis, the results showed that the total sediment transport rate in the study area was 39.97 kg/m·a, with the maximum sediment transport rate in the S direction being 17.74 kg/m·a. These results suggest that, when sand fixation systems are constructed for relevant infrastructure in the region, the direction of protective forests and other engineering measures should be perpendicular to the net direction of sand transport. Full article
(This article belongs to the Section Meteorology)
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10 pages, 2080 KiB  
Article
Stress Distribution in Interlocking and Blocking Screw Fixation for Distal Tibial Intramedullary Nailing: A Finite Element Analysis
by Gu-Hee Jung, Se-Lin Jeong and Jungtae Ahn
J. Clin. Med. 2025, 14(13), 4769; https://doi.org/10.3390/jcm14134769 - 5 Jul 2025
Viewed by 475
Abstract
Background/Objectives: This study evaluates the structural strength of various fixation models for distal tibial fractures using finite element analysis, comparing the biomechanical performance of different interlocking and blocking screw configurations in intramedullary nail fixation. Methods: Finite element models were developed for three [...] Read more.
Background/Objectives: This study evaluates the structural strength of various fixation models for distal tibial fractures using finite element analysis, comparing the biomechanical performance of different interlocking and blocking screw configurations in intramedullary nail fixation. Methods: Finite element models were developed for three different screw configurations: two interlocking screws (T2S), three interlocking screws (T3S), and two interlocking screws combined with two blocking screws (T2SBS2). Material properties were assigned using SAWBONES® models, reflecting established biomechanical characteristics. The models were subjected to static axial loading (800 Nm), internal rotation (3500 Nm), and external rotation stresses. The stress distribution and structural integrity of each fixation model were analyzed. Results: The T3S model demonstrated the lowest maximum von Mises stress values across all loading conditions. Under axial loading, the maximum VMS at the medial first screw contact was the lowest in the T3S model (65.96 MPa) compared to T2S (135.68 MPa) and T2SBS2 (150.30 MPa). Similarly, internal rotation loading resulted in the lowest stress at the medial first screw site in T3S (64.86 MPa), compared to significantly higher stresses in T2S (136.29 MPa) and T2SBS2 (158.11 MPa). The T2SBS2 configuration showed effective stress reduction at the distal interlocking screws, highlighting its potential for improved load sharing. Conclusions: The findings underscore the importance of the secure fixation of the initial interlocking screw in distal tibial fractures. The fixation model utilizing three interlocking screws provided the most favorable overall stress distribution, whereas the inclusion of blocking screws effectively reduced stress concentrations at distal screw sites. Full article
(This article belongs to the Section Orthopedics)
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11 pages, 224 KiB  
Article
Who’s on Call? Mandibular Fracture Management at a Level I Trauma Center
by Allyson R. Alfonso, Maxime M. Wang, Alexis K. Gursky, Hailey P. Wyatt, Jonathan M. Bekisz, Karl Bruckman, Spiros G. Frangos and Pierre B. Saadeh
J. Clin. Med. 2025, 14(13), 4707; https://doi.org/10.3390/jcm14134707 - 3 Jul 2025
Viewed by 299
Abstract
Background: Facial trauma is one of the few surgical conditions that is routinely managed by three distinct disciplines, including Oral and Maxillofacial Surgery (OMS), Plastic and Reconstructive Surgery (PRS), and Otolaryngology (ENT). This study aims to evaluate mandibular trauma management strategies and [...] Read more.
Background: Facial trauma is one of the few surgical conditions that is routinely managed by three distinct disciplines, including Oral and Maxillofacial Surgery (OMS), Plastic and Reconstructive Surgery (PRS), and Otolaryngology (ENT). This study aims to evaluate mandibular trauma management strategies and clinical outcomes among three operating services. Methods: An IRB-approved, retrospective chart review was performed over a ten-year period (2007–2016) at a major, urban, Level I trauma center for all patients treated for an isolated mandibular injury determined by ICD-9 codes. Of the 2299 patients evaluated for traumatic facial injuries, 191 met the inclusion criteria and 137 had longitudinal data. Patient, fracture, and management characteristics and clinical outcomes were compared among three surgical services. Results: Most patients were male (95.3%), and assaults were the most common etiology of injury (79.1%). The angle/ramus was the most common single location (31.4%), and 47.6% of patients had multiple fractures. There was a statistically significant difference between specialties when assessing the use of operative versus non-operative approaches to fracture management (p < 0.001), and within operative management, for the use of open reduction-internal fixation (ORIF) alone versus ORIF with maxillomandibular fixation (MMF) (p = 0.002). There was no significant difference in the overall complications between specialties (p = 0.227). Conclusions: Services differ in their decision to pursue operative versus non-operative management, as well as the decision for postoperative MMF, though these differences in decision-making were not associated with a significant difference in the overall complications. Full article
(This article belongs to the Special Issue Trends in Plastic and Reconstructive Surgery)
14 pages, 396 KiB  
Systematic Review
Minimally Invasive Techniques in Posterior Atlanto-Axial Fixation: State of the Art and Systematic Review
by Gianpaolo Jannelli, Luca Paun, Cédric Y. Barrey, Paola Borrelli, Karl Schaller, Enrico Tessitore and Ivan Cabrilo
J. Clin. Med. 2025, 14(13), 4657; https://doi.org/10.3390/jcm14134657 - 1 Jul 2025
Viewed by 411
Abstract
Background: The atlanto-axial segment is highly mobile and, therefore, prone to instability in the setting of inflammatory disease, infection, tumor or trauma. While minimally invasive surgical (MIS) techniques have gained acceptance in the thoracolumbar spine due to their advantages over traditional approaches, their [...] Read more.
Background: The atlanto-axial segment is highly mobile and, therefore, prone to instability in the setting of inflammatory disease, infection, tumor or trauma. While minimally invasive surgical (MIS) techniques have gained acceptance in the thoracolumbar spine due to their advantages over traditional approaches, their use at the atlanto-axial segment is controversial due to the surgical risk associated with its complex anatomy. To evaluate the current evidence on MIS atlanto-axial fixation, we carried out a systematic review of the literature and compared the reported results with those of open procedures. Methods: This systematic review follows PRISMA-DTA 2020 guidelines. A comprehensive search was conducted in November 2023 across PubMed/Medline, Google Scholar and clinicaltrials.gov using specific keywords related to minimally invasive atlanto-axial fixation. Data regarding study characteristics, patient demographics, surgical techniques, and outcomes were extracted from included studies. Results: This systematic review included 13 articles reporting on the results of surgery in 305 patients, in whom a total of 683 screws were inserted through a posterior MIS approach. N = 162 screws were inserted using the Harms–Goel technique, while N = 521 were placed using the Magerl technique. N = 40 screws were inserted using navigation guidance, while N = 643 were introduced with fluoroscopy assistance. Eight screws were misplaced. A Vertebral Artery (VA) injury was reported in three patients. With a mean value of 26.2 ± 15.3 months, the rate of fusion ranged between 80% and 100%. Conclusions: This study highlights the potential of MIS for posterior atlanto-axial fixation, which was achieved using Magerl transarticular screws in a large majority of cases. Despite technical challenges, MIS approaches appear to achieve satisfactory clinical and radiological outcomes with complication rates similar to those of open techniques. Future studies may help refine the indications for MIS and identify those cases better suited for open approaches. Full article
(This article belongs to the Special Issue Emerging Trends in Cervical Spine Surgery)
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22 pages, 5645 KiB  
Article
Biodegradable Mg-Zn-MgO Composites for Locking Compression Fixation Plates for Pediatric Orthopedics: Improved Mechanical Properties and Corrosion Resistance
by Rajesh Jesudoss Hynes Navasingh, Daniel Asirvatham Amos, Manoj Kumar Gurunathan and Maria P. Nikolova
Processes 2025, 13(7), 2077; https://doi.org/10.3390/pr13072077 - 30 Jun 2025
Viewed by 296
Abstract
Biodegradable magnesium-based composites show potential application in orthopedic implants, with excellent biocompatibility, low density, and biodegradable characteristics inside the human body. In this study, the stir casting procedure was employed to produce magnesium–zinc MMCs (metal matrix composites) reinforced with MgO nanoparticles, and they [...] Read more.
Biodegradable magnesium-based composites show potential application in orthopedic implants, with excellent biocompatibility, low density, and biodegradable characteristics inside the human body. In this study, the stir casting procedure was employed to produce magnesium–zinc MMCs (metal matrix composites) reinforced with MgO nanoparticles, and they were characterized intensively. The analyzed compositions were Mg/4Zn, Mg/4Zn/0.4MgO, and Mg/4Zn/0.6MgO. Their mechanical properties, corrosion resistance, and microstructure were then investigated employing tensile, impact, hardness, wear, and corrosion tests, supplemented with SEM analysis. The results indicate that the Mg-4Zn-0.6MgO composite exhibited the highest performance among the tested formulations, with a tensile strength of 150 MPa, a hardness of 65 HRE (Rockwell Hardness, E-scale), and enhanced corrosion resistance. These improvements are attributed to the uniform dispersion of MgO nanoparticles and the formation of a protective Mg(OH)2 layer, which together contribute to mechanical reinforcement and controlled degradation behavior. The combination of superior mechanical properties and customizable biodegradability verifies the engineered Mg/4Zn/0.6MgO composite as a promising candidate for a biodegradable orthopedic fixation plate without secondary surgery. Full article
(This article belongs to the Section Materials Processes)
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14 pages, 1622 KiB  
Article
Neonicotinoid Residues in Tea Products from China: Contamination Patterns and Implications for Human Exposure
by Yulong Fan, Hongwei Jin, Jinru Chen, Kai Lin, Lihua Zhu, Yijia Guo, Jiajia Ji and Xiaming Chen
Toxics 2025, 13(7), 550; https://doi.org/10.3390/toxics13070550 - 29 Jun 2025
Viewed by 464
Abstract
Neonicotinoids (NEOs) are a class of systemic insecticides widely used in agriculture owing to their high efficacy and selectivity. As one of the most globally consumed beverages, tea may represent a potential dietary source of pesticide residues. However, limited research has examined NEO [...] Read more.
Neonicotinoids (NEOs) are a class of systemic insecticides widely used in agriculture owing to their high efficacy and selectivity. As one of the most globally consumed beverages, tea may represent a potential dietary source of pesticide residues. However, limited research has examined NEO contamination in tea and its implications for human exposure, highlighting the need for further investigation. Therefore, this study comprehensively evaluated the residue characteristics, processing effects, and human exposure risks of six NEOs—dinotefuran (DIN), imidacloprid (IMI), acetamiprid (ACE), thiamethoxam (THM), clothianidin (CLO), and thiacloprid (THI)—in Chinese tea products. According to the findings, the primary pollutants, ACE, DIN, and IMI, accounted for 95.65% of the total NEO residues in 137 tea samples, including green, oolong, white, black, dark, and herbal teas. The highest total target NEO (∑6NEOs) residue level was detected in oolong tea (mean: 57.86 ng/g). Meanwhile, IMI exhibited the highest residue level (78.88 ng/g) in herbal tea due to the absence of high-temperature fixation procedures. Concentrations of DIN in 61 samples (44.5%) exceeded the European Union’s maximum residue limit of 10 ng/g. Health risk assessment indicated that both the chronic hazard quotient (cHQ) and acute hazard quotient (aHQ) for adults and children were below the safety threshold (<1). However, children required special attention, as their exposure risk was 1.28 times higher than that of adults. The distribution of NEO residues was significantly influenced by tea processing techniques, such as full fermentation in black tea. Optimizing processing methods (e.g., using infrared enzyme deactivation) and implementing targeted pesticide application strategies may help mitigate risk. These results provide a scientific foundation for enhancing tea safety regulations and protecting consumer health. Full article
(This article belongs to the Special Issue Human Biomonitoring in Health Risk Assessment of Emerging Chemicals)
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20 pages, 747 KiB  
Systematic Review
Advancements in Visual Field Testing: A Systematic Review of the 24-2C Test Grid
by Eric Jin, Natalie Shi Qi Wong, Claire Xin Yi Goh, Michael W. Stewart, Syril Dorairaj and Bryan Chin Hou Ang
Bioengineering 2025, 12(7), 711; https://doi.org/10.3390/bioengineering12070711 - 29 Jun 2025
Viewed by 367
Abstract
A systematic review was conducted of studies published up to 30 August 2024. Studies comparing conventional visual field (VF) indices, ability to detect central visual field defects (CVFDs), structure–function (S-F) concordance, and test characteristics across the HVF 24-2C SITA-Faster, 24-2 SITA-Standard/Faster, and 10-2 [...] Read more.
A systematic review was conducted of studies published up to 30 August 2024. Studies comparing conventional visual field (VF) indices, ability to detect central visual field defects (CVFDs), structure–function (S-F) concordance, and test characteristics across the HVF 24-2C SITA-Faster, 24-2 SITA-Standard/Faster, and 10-2 SITA-Standard/Fast tests were included. Eight studies with 1239 subjects (49.1% male; mean age, 54.8–66.9 years) were analyzed. The 24-2C produced similar global VF indices compared to the 10-2 and 24-2 (Standard/Faster) (ICC = 0.95 and 0.80, p < 0.001), detected more VF defects and CVFD clusters, and demonstrated greater S-F concordance than the 24-2 (Standard/Faster). Although the 10-2 (Standard/Fast) detected significantly more CVFDs and had a greater S-F concordance, the agreement between the 24-2C and 10-2 grids was substantial (ĸ = 0.488 to 0.708). The 24-2C was also faster compared to the 24-2 Standard and 10-2 (Standard/Fast), with comparable false positives, higher false negatives, and fewer fixation losses than the 24-2 Standard. In conclusion, the HVF 24-2C is quicker and identifies more CVFDs than the 24-2 grid, demonstrates high agreement with the 10-2 grid, and aids in CVFD screening. Full article
(This article belongs to the Section Biomedical Engineering and Biomaterials)
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14 pages, 1830 KiB  
Article
Intramedullary Nails vs. Locking Plates for Displaced Proximal Humerus Fractures in Patients over 60: A Comparative Clinical Study
by Marco Simone Vaccalluzzo, Marco Sapienza, Sergio Valenti, Benedetta Di Tomasi, Ludovico Lucenti, Vito Pavone and Gianluca Testa
J. Clin. Med. 2025, 14(13), 4563; https://doi.org/10.3390/jcm14134563 - 27 Jun 2025
Viewed by 361
Abstract
Background: Displaced proximal humerus fractures (PHFs) in adults represent a common orthopedic challenge, especially in elderly patients with compromised bone quality. Intramedullary nails (IM) and locking plates (LP) are the most widely used fixation techniques, though the literature remains inconclusive regarding their comparative [...] Read more.
Background: Displaced proximal humerus fractures (PHFs) in adults represent a common orthopedic challenge, especially in elderly patients with compromised bone quality. Intramedullary nails (IM) and locking plates (LP) are the most widely used fixation techniques, though the literature remains inconclusive regarding their comparative efficacy. Methods: This retrospective cohort study included 187 patients (mean age: 65.4 years) treated surgically for Neer ≥ 2-part proximal humerus fractures at a single tertiary referral center between 2018 and 2023. Patients underwent either IM nailing or LP fixation. Baseline characteristics included age, sex, smoking status, ASA score, trauma mechanism, and bone quality (assessed by the Deltoid Tuberosity Index). Functional outcomes (DASH and Constant–Murley scores), range of motion (ROM), radiographic healing, and complications were evaluated at 1, 3, 6, and 12 months postoperatively. Results were stratified by fracture type (two-, three-, and four-part fractures) and treatment group. Results: At 12 months, no statistically significant differences were found between groups in terms of DASH (p = 0.484) or Constant–Murley scores (p = 0.057). ROM recovery was comparable across all time points. Stratified analysis showed similar outcomes across fracture types. Age, smoking, and bone quality did not significantly influence clinical results. The overall complication rate was 11.8%, with no significant difference between groups. Avascular necrosis and hardware-related issues occurred predominantly in four-part fractures. Conclusions: Both intramedullary nailing and locking plate fixation provided comparable short-term outcomes for displaced PHFs. Functional recovery appeared more dependent on fracture complexity than on the choice of implant. Surgical technique should therefore be selected based on fracture morphology, patient characteristics, and surgeon experience. Full article
(This article belongs to the Special Issue Diagnosis, Treatment, Prevention and Rehabilitation in Osteoporosis)
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Article
Coupling Marxan and InVEST Models to Identify Ecological Protection Areas: A Case Study of Anhui Province
by Xinmu Zhang, Xinran Zhang, Lei Zhang, Kangkang Gu and Xinchen Gu
Land 2025, 14(7), 1314; https://doi.org/10.3390/land14071314 - 20 Jun 2025
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Abstract
This study, taking Anhui Province as a case study, systematically evaluated the spatiotemporal differentiation characteristics of six ecosystem services (biodiversity maintenance, water yield, carbon fixation, vegetation net primary productivity (NPP), soil retention, and crop production) from 2000 to 2020 through the integration of [...] Read more.
This study, taking Anhui Province as a case study, systematically evaluated the spatiotemporal differentiation characteristics of six ecosystem services (biodiversity maintenance, water yield, carbon fixation, vegetation net primary productivity (NPP), soil retention, and crop production) from 2000 to 2020 through the integration of multi-stakeholder decision-making preferences and the Marxan model. Four conservation scenarios (ecological security priority, social benefit orientation, minimum cost constraint, and balance synergy) were established to explore the spatial optimization pathways of ecological protection zones under differentiated policy objectives. The findings indicated that: (1) The ecosystem services in Anhui Province exhibited a “low north and high south” spatial gradient, with significant synergies observed in natural ecosystem services in the southern Anhui mountainous areas, while the northern Anhui agricultural areas were subjected to significant trade-offs due to intensive development. (2) High service provision in the southern Anhui mountainous areas was maintained by topographic barriers and forest protection policies (significant NPP improvement zones accounted for 50.125%), whereas soil–water services degradation in the northern Anhui plains was caused by agricultural intensification and groundwater overexploitation (slight soil retention degradation covered 24.505%, and water yield degradation areas reached 29.766%). Urbanization demonstrated a double-edged sword effect—the expansion of the Hefei metropolitan area triggered suburban biodiversity degradation (significant degradation patches occupied 0.0758%), while ecological restoration projects promoted mountain NPP growth, highlighting the necessity of synergizing natural recovery and artificial interventions. (3) Multi-scenario planning revealed that the spatial congruence between the ecological security priority scenario and traditional ecological protection redlines reached 46.57%, whereas the social benefit scenario achieved only 12.13%, exposing the inadequate responsiveness of the current conservation framework to service demands in densely populated areas. This research validated the technical superiority of multi-objective systematic planning in reconciling ecological protection and development conflicts, providing scientific support for optimizing ecological security patterns in the Yangtze River Delta region. Full article
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