Search Results (470)

This paper presents a case study of the Local Care Ecosystems developed by the provincial government of Gipuzkoa (Basque Country, Spain) to strengthen coordination between social services, health services, and community-based initiatives at the municipal level. The initiative seeks to personalize care, enhance service integration, and support community-based care with the overarching goal of improving the quality of life for older adults living at home. These ecosystems incorporate social, institutional, and technological innovations aimed at supporting individuals who are frail or vulnerable throughout the care cycle. At present, 18 Local Care Ecosystems are active, providing services to 1202 people over the age of 65 and 167 families. The model addresses a growing global challenge linked to population aging, which has led to increasing demand for care and support services that are often fragmented, under-resourced, and constrained by outdated regulatory frameworks. These structural issues can compromise both the quality and efficiency of care for dependent individuals. Based on the findings, the paper offers policy recommendations to support the transfer and adaptation of this model, with the aim of improving the well-being of older adults who wish to remain in their own homes. Full article

Protein degradation plays a fundamental role in maintaining protein homeostasis and ensures proper cellular function by regulating protein quality and quantity. Heat shock protein 100 (Hsp100), found in bacteria, plants, and fungi, is a unique chaperone family responsible for rescuing misfolded proteins from aggregated states in an ATP-dependent manner. To date, they are primarily known to mediate heat stress adaptation and enhance cellular survival under extreme conditions in higher plants and algae. Resting cyst formation in dinoflagellates is widely recognized as a response to adverse conditions, which offers an adaptive advantage to endure harsh environmental extremes that are unsuitable for vegetative cell growth and survival. In this study, based on a full-length cDNA sequence, we characterized an Hsp100 gene (SaHsp100) from the cosmopolitan bloom-forming dinoflagellate Scrippsiella acuminata, aiming to examine its life stage-specific expression patterns and preliminarily explore its potential functions. The qPCR results revealed that Hsp100 transcript levels were significantly elevated in newly formed resting cysts compared to vegetative cells and continued to increase during storage under simulated marine sediment conditions (darkness, low temperature, and anoxia). Parallel reaction monitoring (PRM)-based quantification further confirmed that Hsp100 protein levels were significantly higher in resting cysts than in vegetative cells and increased after three months of storage. These findings collectively highlighted the fundamental role of Hsp100 in the alteration of the life cycle and dormancy maintenance of S. acuminata, likely by enhancing stress adaptation and promoting cell survival through participation in proteostasis maintenance, particularly under natural sediment-like conditions that trigger severe abiotic stress. Our work deepens the current understanding of Hsp family members in dinoflagellates, paving the way for future investigations into their ecological relevance within this ecologically significant group. Full article

Brassinosteroids (BRs) are steroid hormones that are essential for plant growth, development, and environmental adaptation. They control the division, elongation, and differentiation of various cell types throughout the entire plant life cycle, affecting growth and the stress response. Therefore, fine-tuning of BR biosynthesis and modulation of signaling pathways offer possibilities for developing cultivars characterized by adjusted plant architecture or improved stress tolerance to benefit crop production. Additionally, precise BR treatments can be employed to increase the productivity of crop plants. This review aims to provide a comprehensive summary of the genetic basis of traits related to BR metabolism and signaling in cucurbits, the second largest vegetable family, which contributes significantly to global vegetable production and nutritional security. We summarize the current knowledge concerning BR biosynthesis mutants, the role of BRs in stress mitigation, and the potential of the exogenous application of BRs to alleviate stress during cucurbit production. We also discuss how genes related to BR metabolism can be used to develop gene editing strategies to advance precision breeding in cucurbits. Full article

(1) Background: This study investigates whether older adult individuals support childcare policies not only out of altruism, but also due to extended self-interest arising from intergenerational co-residence. It challenges the conventional view that welfare attitudes are shaped solely by one’s own life-cycle needs. (2) Methods: Using the 2013 and 2016 waves of the Korean Welfare Panel Study waves of the Korean Welfare Panel Study, a difference-in-differences (DiD) approach compares attitudes toward government childcare spending between older adults living with children (Co-residing Older Adults) and those who do not (Non-co-residing Older Adults), before and after universal childcare policies were introduced in 2013. (3) Results: The Co-residing Older Adults consistently expressed stronger support for family policies than their counterparts. However, this support did not significantly increase after the 2013 reform, indicating that extended self-interest may not be sensitive to short-term policy changes. (4) Conclusions: Extended self-interest appears to be a stable orientation shaped by family context rather than a flexible, policy-reactive stance. These findings highlight the role of intergenerational household ties in shaping welfare attitudes and offer implications for fostering generational solidarity in aging societies. Full article

Renicolid digeneans parasitise aquatic birds. In molecular trees, they are divided into three clades, one of which, the ‘duck clade’, parasitises anatids. Renicola mollissima, a member of this clade, parasitises sea ducks, mainly eiders. Its life cycle remains unknown. We verified the diagnosis of R. mollissima using integrated morphological and molecular data and provided the first information on its life cycle in northern Palaearctic. We proved that intramolluscan stages of R. mollissima, previously known as Cercaria pacifica 2, develop in intertidal snails Littorina squalida and L. saxatilis. We provided a detailed morphological description of cercariae and adults of R. mollissima and a discriminative analysis with closely related species. Molecular data demonstrated an amphiboreal distribution of R. mollissima and the existence of a single population in Europe and the North Pacific. Using molecular methods, we also found metacercariae of an unknown renicolid species from the ‘duck clade’, designated as Cercaria cf. nordica I, in subtidal mussels of the Barents Sea. All individuals of C. cf. nordica I examined in our study were represented by the same haplotype. We discuss possible ways of formation of this phylogeographic structure, the composition of the ‘duck clade’ and the evolutionary pathways of the family Renicolidae. Full article

This research explores the concept of open building (OB) in the context of low-cost housing, focusing on its historical applications in Egypt during the 1980s. By evaluating past experiences, the study aims to extract key lessons that can inform the design and implementation of contemporary social housing projects. The goal is to foster resilience and diversity in housing typologies to ensure they align with the evolving needs of residents. To achieve these objectives, the research employed a multi-dimensional strategy, beginning with a comprehensive literature review of the open building movement (OB); then, the study traced the evolution of the OB movement in Egypt using a qualitative analysis approach, which involved analyzing its implementation in low-cost housing projects over the past four decades. Through this historical lens, the study identifies design principles and strategies that can enhance social housing projects by applying OB. Considering the life cycle cost, OB enables an incremental process that would align with users’ financial capacities. The research revealed the substantial capacity of open building (OB) to address Egypt’s social housing challenges, primarily by fostering user-driven flexibility in housing unit design and area selection. This empowers occupants to choose spaces perfectly suited to their family’s evolving needs. Moreover, the findings provide a roadmap for revitalizing the OB movement by analyzing and overcoming past implementation difficulties, consequently balancing the initial cost and long-term economics for citizens and significantly reducing the governmental sector’s expenditure. Full article

Urban green spaces are increasingly recognized as important habitats for pollinators, and wildflower seed mixes marketed as pollinator-friendly are gaining popularity, though their actual conservation value remains poorly understood. This study provides the first systematic screening of commercially available seed mixes in Portugal, evaluating their taxonomic composition, origin, life cycle traits, and potential to support pollinator communities. A total of 229 seed mixes were identified. Although these have a predominance of native species (median 86%), the taxonomic diversity was limited, with 91% of mixes comprising species from only one or two families, predominantly Poaceae and Fabaceae, potentially restricting the range of floral resources available to pollinators. Only 21 seed mixes met the criteria for being pollinator-friendly, based on a three-step decision tree prioritizing native species, extended flowering periods, and visual diversity. These showed the highest percentage of native species (median 87%) and a greater representation of flowering plants. However, 76% of all mixes still included at least one non-native species, although none is considered invasive. Perennial species dominated all seed mix types, indicating the potential for the long-term persistence of wildflower meadows in urban spaces. Despite their promise, the ecological quality and transparency of the seed mix composition remain inconsistent, with limited certification or information on species origin. This highlights the need for clearer labeling, regulatory guidance, and ecologically informed formulations. Seed mixes, if properly designed and implemented, represent a largely untapped yet cost-effective tool for enhancing the pollinator habitats and biodiversity within urban landscapes. Full article

A detailed morphological characterization is presented for Oriboglyphus maorianus gen. et sp. nov., a newly discovered modern representative of the relict family Schizoglyphidae, found in a nest of the termite Stolotermes ruficeps in New Zealand. This is the second extant schizoglyphid species known from modern material, and its discovery provides rare insight into a transitional stage in the evolution of astigmatid life cycles. The phoretic stage appears to be a tritonymph—rather than the typical deutonymph—based on key morphological traits including three-segmented palps, three pairs of genital papillae, and the presence of a pharynx. These features suggest that early astigmatid mites evolved multiple ontogenetic routes to dispersal, including tritonymphal, deutonymphal, and possibly adult phoresy, before the canalization of life cycles around deutonymphal dispersal. The persistence of putatively ancestral traits in schizoglyphids, along with their apparent ecological conservatism in termite nests, indicates the role of environmental stability in preserving modes of life history that otherwise appear extinct. We also provide a key to describe Schizoglyphidae species and discuss the implications of this discovery for understanding the origins of phoresy-related metamorphosis in Astigmata. Full article

Cost reduction has always been a high priority target in modern management. Concentrating on material strength, the huge potential is recognized for cost reduction in finding the material fatigue coefficients by reduction the number and time required for testing specimens. The aim of this study is to evaluate the accuracy of several fatigue parameter estimation methods by comparing them with reference test data obtained for six different steel materials. In the literature, several estimation methods can be found. Those methods rely on tension or hardness tests. The concern is about the accuracy of those methods; therefore, a basic case was investigated involving estimation methods and comparing them to reference data from a physical test. The case was selected in a manner that allowed the verification of combined low and high cycle fatigue. As a result, the estimation methods produced a very wide range of fatigue life predictions, but some of them were quite accurate. This leads to the conclusion that estimation methods can be a step forward for finding the fatigue material properties; however, a study should be undertaken on which methods are the most suitable for the material family used. Full article

Herpes simplex virus (HSV) is a prevalent and persistent human pathogen belonging to the family Herpesviridae and classified as an alpha-herpesvirus. It comprises two distinct types, HSV-1 and HSV-2, which together infect a significant portion of the global population and pose substantial public health challenges. HSV-1 is typically associated with oral herpes, while HSV-2 primarily causes genital herpes; both are characterized by recurrent lesions, latent infection, and mucocutaneous discomfort. Conventional antiviral drugs such as acyclovir and its derivatives are limited by drug resistance, potential toxicity, and their inability to eradicate latent viral reservoirs. These limitations have prompted increasing interest in alternative therapeutic strategies. Phenolic acids and tannins, plant-derived polyphenolic compounds, have attracted considerable attention due to their potent antiviral properties against various viruses, including HSV. This review summarizes current research on phenolic acids and tannins as promising natural antivirals against HSV, with a focus on their mechanisms of action and efficacy in disrupting multiple stages of the HSV life cycle. Full article

The building sector significantly contributes to global energy consumption and carbon emissions, primarily due to the extensive use of carbon-intensive materials such as concrete and steel. Mass timber construction, particularly using cross-laminated timber (CLT), offers a promising low-carbon alternative. This study aims to calculate the embodied carbon emissions and biogenic carbon storage of a CLT-based affordable housing project, 340+ Dixwell in New Haven, Connecticut. This project was designed using a honeycomb structural system, where mass timber floors and roofs are supported by mass timber-bearing walls. The authors are not aware of a prior study that has evaluated the life cycle impacts of honeycomb mass timber construction while considering Timber Use Intensity (TUI). Unlike traditional post-and-beam systems, the honeycomb design uses nearly twice the amount of timber, resulting in higher carbon sequestration. This makes the study significant from a sustainability perspective. This study follows International Standard Organization (ISO) standards 14044, 21930, and 21931 and reports the results for both lifecycle stages A1–A3 and A1–A5. The analysis covers key building components, including the substructure, superstructure, and enclosure, with timber, concrete, metals, glass, and insulation as the materials assessed. Material quantities were extracted using Autodesk Revit^®, and the life cycle assessment (LCA) was evaluated using One Click LCA (2015)^®. The A1 to A3 stage results of this honeycomb building revealed that, compared to conventional mass timber housing structures such as Adohi Hall and Heartwood, it demonstrates the lowest embodiedf carbon emissions and the highest biogenic carbon storage per square foot. This outcome is largely influenced by its higher Timber Use Intensity (TUI). Similarly, the A1-A5 findings indicate that the embodied carbon emissions of this honeycomb construction are 40% lower than the median value for other multi-family residential buildings, as assessed using the Carbon Leadership Forum (CLF) Embodied Carbon Emissions Benchmark Study of various buildings. Moreover, the biogenic carbon storage per square foot of this building is 60% higher than the average biogenic carbon storage of reference mass timber construction types. Full article

The ecological consequences of the construction and operation of the Three Gorges Reservoir, particularly its unique operation strategy of storing clear water and releasing turbid water, exerts a profound influence on the composition and dynamics of local fish communities. To date, detailed and comprehensive research on seasonal changes in the fish community across the entire reservoir remains scarce. This study aims to fill this research gap by systematically investigating fish diversity through a comprehensive assessment of six main river reaches and eight major tributaries. The investigation employs environmental DNA (eDNA) technology across three critical life-cycle stages: breeding, feeding, and overwintering periods. A total of 124 fish species were recorded, comprising 10 orders, 20 families, and 80 genera. The comparative analyses of historical data suggest a significant decline in lotic and endemic fish populations, accompanied by a concurrent increase in lentic, eurytopic, and non-native fish species. Notably, the composition of fish communities exhibited similarities between breeding and overwintering periods. This study highlights the occurrence of significant seasonal fluctuations in the fish communities, showing a preference for reservoir tails and tributaries as optimal habitats. Water temperature has a predominant influence on structuring fish communities within aquatic ecosystems. This study investigates variations in the biodiversity of fish communities using historical data, with a focus on changes linked to reservoir operations and water impoundment activities. By integrating historical data, this research examines changes in fish diversity that are associated with water storage processes. It provides foundational data on the current composition and diversity of fish communities within the watershed, elucidating the spatiotemporal variations in fish diversity and the mechanisms by which environmental factors influence these communities. Furthermore, the current study serves as a valuable reference for understanding the changes in fish communities within other large reservoirs. Full article

Camelina sativa (L.) Crantz, a native European oilseed crop of the Brassicaceae family, is notable for its short life cycle, making it well-suited for crop rotation and diversification. Its seeds contain a high content of oil (36–47%) that is rich in polyunsaturated fatty acids (PUFAs) such as alpha-linolenic acid (ALA, C18:3, Ω-3) and linoleic acid (LA, C18:2, Ω-6). This oil has diverse industrial applications, including low-emission biofuels, animal feed, pharmaceuticals, biolubricants, bioplastics, and cosmetics. We analyzed the expression of seven key enzymes involved in fatty acid biosynthesis across nine C. sativa accessions at three stages of silique development using highly efficient qRT-PCR assays designed for the target genes and a normalizing control. Our detailed expression analysis revealed significant variation across varieties, with only the gene FAB2c exhibiting genotype-independent expression, indicating a constitutive and essential role in monounsaturated fatty acid (MUFA) biosynthesis. Other genes showed significant interactions between the variety and developmental stage, highlighting the combined influences of genetic background and silique maturation on gene regulation. V18 emerges as particularly promising, exhibiting elevated expression of genes linked to PUFA and VLCFA biosynthesis—traits of significance for food, biofuel, and industrial applications. These findings, together with the developed qRT-PCR assays, provide valuable tools for selecting Camelina varieties with optimized genetic profiles, highlighting the potential of harnessing natural transcriptional diversity for crop improvement. Full article

This study explores the ethnobotanical significance of plant species used in the Heet Sip Song (Twelve Monthly Merit-Making) ceremonies in Roi Et Province, Northeastern Thailand. A total of 80 plant species across 73 genera and 42 families were documented. The findings reveal that plants play multifaceted roles in ceremonial life, serving both symbolic and practical purposes rooted in spiritual belief systems and seasonal agricultural cycles. Quantitative analyses using Cultural Significance Index (CSI), Species Use Value (SUV), Genera Use Value (GUV), and Relative Frequency of Citation (RFC) highlighted the prominence of key species such as Oryza sativa, Musa acuminata, and Saccharum officinarum in ritual contexts. While staple crops dominate in frequency and cultural value, less commonly cited wild species fulfill specialized functions, reflecting deep local ecological knowledge. The integration of ritual and plant use promotes biodiversity conservation by maintaining plant populations and reinforcing sustainable harvesting practices. These results emphasize the vital role of traditional knowledge in conserving both biological and cultural diversity. As environmental pressures increase, this study underscores the importance of supporting community-led conservation efforts that honor indigenous practices and their contributions to ecological resilience. Full article

The rapid growth in lithium-ion battery (LIB) demand has underscored the urgent need for sustainable recycling methods to recover critical metals such as lithium, cobalt, nickel, and manganese. Traditional pyrometallurgical and hydrometallurgical approaches often suffer from high energy consumption, environmental impact, and limited metal selectivity. As an emerging alternative, solvometallurgy, and in particular the use of low-melting mixtures solvents, including deep eutectic solvents, offers a low-temperature, tunable, and potentially more environmentally compatible pathway for black mass processing. This review presents a comprehensive assessment of the recent advances (2020–2025) in the application of LoMMSs for metal recovery from LCO and NCM cathodes, analyzing 71 reported systems across binary, ternary, hydrated, and non-ChCl-based solvent families. Extraction efficiencies, reaction kinetics, coordination mechanisms, and solvent recyclability are critically evaluated, highlighting how solvent structure influences performance and selectivity. Particular attention is given to the challenges of lithium recovery, solvent degradation, and environmental trade-offs such as energy usage, waste generation, and chemical stability. A comparative synthesis identifies the most promising systems based on their mechanistic behavior and industrial relevance. The future outlook emphasizes the need for greener formulations, enhanced lithium selectivity, and life-cycle integration to support circular economy goals in battery recycling. Full article