Search Results (5,241)

Objective: From a family perspective, this study aimed to examine the effects of a 12-week digital platform-based parent–child exercise intervention on children’s behavioral level (physical activity), psychological level (physical exercise attitude), and mental health. Methods: This study included 218 students aged 10–11 years who underwent a 12-week standardized parent–child exercise intervention. The intervention group completed two structured parent–child tasks per week through a digital platform (Ding Talk App) while maintaining regular physical education classes; the control group only maintained their regular physical education classes. Assessments were conducted using the Physical Activity Rating Scale, Exercise Attitude Scale, and mental health scales (The Spence Children’s Anxiety Scale (SCAS) and The Patient Health Questionnaire-9 (PHQ-9)) at four stages: pre-intervention (T1), mid-intervention (T2), post-intervention (T3), and a 2-month follow-up period (T4). The intervention effects and effect sizes (ηp²) were examined using Repeated Measures Analysis of Variance. Results: At the behavioral level, a significant group × time interaction was found for physical activity volume (F = 17.651, p = 0.04, ηp² = 0.138), indicating the presence of a moderate effect. At the psychological level, significant interactions were observed across exercise attitude dimensions (behavioral attitude: F = 3.699, p = 0.002, ηp² = 0.033; perceived behavioral control: F = 4.189, p = 0.006, ηp² = 0.037; subjective norm: F = 4.616, p < 0.001, ηp² = 0.040) and mental health measures (depression: F = 4.009, p = 0.026, ηp² = 0.044; anxiety: F = 3.1, p = 0.016, ηp² = 0.020), though no significant effect was found for behavioral intention (F = 1.346, p = 0.259, ηp² = 0.012), with all significant effects being relatively weak. Conclusions: The home–school collaborative, digital platform-based parent–child exercise intervention demonstrated positive effects on children’s physical activity volume, exercise attitudes, and mental health, offering a feasible and promising strategy to support more integrated child health promotion initiatives. Full article

Background/Objectives: Physical exercise reduces breast cancer (BC) risk and improves survival, yet the biological mechanisms remain incompletely understood. Exercise may modulate systemic immunity and local immune cell infiltration in the tumor microenvironment. In this systematic review and meta-analysis, we examined the effects of exercise on immune cells and immune-related markers in patients with BC. Methods: This study followed PRISMA guidelines and was prospectively registered in PROSPERO (CRD420251082444). Four databases (PubMed, Web of Science, Scopus, and Cochrane Library) were searched from inception through December 2025. Randomized controlled trials evaluating exercise interventions in patients with BC or BC survivors and reporting immune cell outcomes were included. Meta-analyses were performed on studies reporting natural killer cells, natural killer cell activity, T-cell subpopulations, and B cells. Results: A total of 18 studies involving 911 participants (539 in exercise intervention groups) were included in the systematic review, with eight studies included in meta-analyses. Exercise interventions did not show significant effects on circulating natural killer cell counts, natural killer cell activity, T-cell subpopulations (CD3⁺, CD4⁺, and CD8⁺), or B-cell levels when compared to control groups. Conclusions: Exercise does not appear to induce consistent changes in resting circulating immune cell populations in patients with BC or BC survivors, indicating that exercise is immunologically safe while potentially exerting effects beyond circulating cell counts. Further large-scale research is required. Full article

Exercise adaptation depends on a dynamic alternation between catabolic and anabolic states coordinated primarily by AMP-activated protein kinase (AMPK) and mechanistic target of rapamycin (mTOR). While transient activation of these pathways underpins beneficial molecular remodeling, the system-level consequences of sustained anabolic drive remain insufficiently conceptualized in exercise biology. This article presents a conceptual mechanistic narrative review integrating evidence from molecular nutrition, exercise physiology, redox biology, and epigenetic regulation to define limits of adaptive signaling. We propose the Metabolic Overdrive Model, a systems-level framework describing the transition from adaptive AMPK–mTOR oscillation to a high-anabolic lock-in state characterized by persistent mTORC1 activation, suppressed AMPK signaling, altered NAD⁺ economy (SIRT1–PARP imbalance), redox dysregulation, and progressive epigenetic drift. Using exercise and training as models of sustained metabolic stress, we synthesize mechanistic parallels across energy sensing, oxidative signaling, and chromatin regulation without implying pathological causality. The framework generates testable predictions linking prolonged post-exercise anabolic signaling (>24 h) to specific molecular signatures, including AMPK phosphorylation status, NAD⁺ availability, PARylation, histone acetylation, and DNA methylation dynamics. By reframing exercise adaptation as a loss-of-oscillation phenomenon rather than a linear continuum, this model provides a mechanistic language for hypothesis generation, biomarker-guided periodization, and future experimental validation. Full article

This study investigated the effects of a high-fat diet (HFD), particulate matter (PM) exposure, and resistance exercise training on circulating lipid profiles, adipokines, inflammatory responses, neurotrophic factors, and blood–brain barrier (BBB) permeability. Forty-eight 10-week-old male C57BL/6 mice were randomly assigned to four groups (n = 12 per group): normal diet (ND), HFD, HFD with PM exposure (HFD + PM), and HFD with PM exposure plus exercise training (HFD + PM + EX). ND and HFD were administered for 16 weeks, whereas PM exposure and exercise training interventions were initiated after 8 weeks of dietary treatment and continued for an additional 8 weeks. PM was administered via tail vein injection three times per week, and resistance exercise training consisted of a ladder-climbing exercise performed five times per week. The results indicated that body weight, total cholesterol (TC), triglycerides (TGs), low-density lipoprotein cholesterol (LDL-C), leptin, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), S100 calcium-binding protein B (S100B), and neuron-specific enolase (NSE) levels were significantly higher in the HFD group than in the ND group (p < 0.05), whereas adiponectin and brain-derived neurotrophic factor (BDNF) levels were significantly lower (p < 0.05). In addition, the HFD + PM group exhibited significantly lower BDNF and vascular endothelial growth factor (VEGF) levels (p < 0.05) and significantly higher S100B and NSE levels (p < 0.05) than the HFD group. In contrast, the HFD + PM + EX group showed significantly lower TG, LDL-C, leptin, and IL-6 levels than the HFD group (p < 0.05). Moreover, compared with the HFD + PM group, the HFD + PM + EX group demonstrated significantly lower TG, LDL-C, leptin, S100B, and NSE levels (p < 0.05) and significantly higher high-density lipoprotein cholesterol (HDL-C), adiponectin, BDNF, and VEGF levels (p < 0.05). Collectively, these findings suggest that an HFD may contribute to dyslipidemia, heightened inflammatory responses, downregulation of neurotrophic factors, and increased BBB permeability and that concurrent PM exposure under HFD conditions may exacerbate adverse alterations in neurotrophic factors and BBB permeability. The results indicate that an HFD induces metabolic and neurovascular alterations, whereas concurrent PM exposure under HFD conditions is associated with additional changes in neurotrophic factors and BBB-related markers. Resistance exercise training attenuated these changes. Full article

Health training complements rehabilitation of chronic musculoskeletal pain by consolidating therapeutic effects and limiting recurrence. Thirty-eight adults (18 women, 20 men; 19–47 years; 24.6 ± 6.5) underwent ultrasound assessment. Bilateral thickness of the external oblique (EO), internal oblique (IO), transversus abdominis (TrA), and rectus abdominis (RA) was measured at the umbilical level in relaxed supine, prone plank, and side plank. For both plank exercises, measurements were repeated during the abdominal drawing-in maneuver (ADIM). Prone plank increased thickness of all abdominal muscles bilaterally (p < 0.001) and elicited a largely symmetric pattern; ADIM further increased IO and TrA thickness (p < 0.001). Side plank increased muscle thickness predominantly on the support side (p < 0.001), with greater support-side responses for the EO (p < 0.001), IO (p < 0.01), and RA (p < 0.001), while the TrA showed a more bilateral pattern. On the non-support side, IO (p < 0.05), TrA (p < 0.001), and RA (p < 0.01) also increased. ADIM augmented TrA bilaterally (p < 0.001), increased IO on the non-support side (p < 0.001), and promoted symmetry for the EO, IO, and RA. Overall, prone plank was mostly symmetric, while side plank was asymmetric except for the TrA; ADIM amplified TrA responses in both exercises and in prone plank, enhanced IO on the side opposite the support. Full article

Animal and human studies show that exercise induces organism-wide molecular adaptations that are partly mediated by exerkines which are secreted factors that enable inter-organ communication between tissues such as skeletal muscle, adipose tissue, liver and the brain. However, the tissue-specific responsiveness of individual exerkines and how these responses differ across species, exercise conditions and sexes remain poorly understood. To address this gap, we systematically analyzed skeletal muscle transcriptomic responses of 40 exerkines using three publicly available datasets including MetaMEx, Extrameta and the MoTrPAC 6-month-old rat training dataset. We reviewed exerkine-specific regulation in humans, mice and rats across acute and chronic exercise and inactivity. We determined conserved, non-conserved, and discordant exerkines across species and whether they were dependent on exercise modality or sex. Our review reveals substantial heterogeneity in skeletal muscle transcriptomic exerkine regulation with only a small subset showing conserved changes across species. Additionally, a key limitation is that our analysis was limited to transcriptomic data and may not reflect protein-level abundance, secretion, or uptake by recipient tissues. Therefore, we highlight a need for multi species and multi condition approaches when selecting exerkines as biomarkers or surrogate therapeutic targets. Full article

Objectives: Our objective was to evaluate the acute effect of L-leucine supplementation and high-intensity sprint exercise on appetite-controlling neuropeptides and their association with the subjective perception of appetite (SPA), satiety (SPS), food intake, and inflammatory response in overweight participants. Methods: In a double-masked, randomized, counterbalanced, and crossover design, 12 sedentary overweight adult men performed four experiments: (1) exercise and L-leucine (EX-Leu), (2) exercise and placebo (EX-PLA), (3) L-leucine without exercise (SED-Leu), and (4) placebo without exercise (SED-PLA). The supplementation consisted of three daily doses of 70 mg/kg body weight of L-leucine or placebo (on the day of exercise and one day after). During the experiments, we recorded the food intake, SPA, and SPS, and evaluated the neuropeptides (GLP-1, PYY, CCK, and ghrelin) and cytokines (IL1-beta, IL-6, IL-10, and TNF-α) in peripheral blood. The acute exercise trial consisted of four sets of 30 sec cycle ergometer sprint exercises. Results: EX-Leu, EX-PLA, and SED-Leu decreased SPA, compared to SED-PLA; only EX-PLA improved SPS; EX-PLA and EX-Leu reduced food intake. GLP-1 decreased in the EX-PLA trial compared to SED-Leu. IL-6 and IL1-β levels increased in the EX-Leu trial compared to SED-PLA. An anti-inflammatory profile was identified in the EX-PLA trial compared to the other trials. Both neuropeptides (increased) and cytokines (a pro-inflammatory profile) were associated with changes in SPA, SPS, and food intake. Conclusions: The acute inflammatory balance induced by EX-Leu seems to improve appetite control. Sprint exercise had a consistent acute anorexic effect, while isolated L-leucine decreased SPA, but their impact on SPS and food intake is not clear (FAPESP grants: 2020/09936-2 and 2021/03601-1). Full article

This prospective, single-center, case-control study investigated circulating autoantibodies (AAbs) targeting G protein-coupled receptors (GPCRs) in Long COVID (LC) patients to identify potential diagnostic biomarkers and therapeutic targets. Fifteen participants were enrolled at the LC clinic in Rome: eleven with severe LC—defined as >4 persistent symptoms (fatigue, cognitive impairment, poor exercise tolerance, dyspnea, arthralgia, or dysautonomic manifestations) >3 months post-infection—and four asymptomatic post-COVID (APC) individuals. Fatigue was assessed using the Fatigue Assessment Scale (FAS ≥ 22; severe ≥ 35). Auto-Abs against AT1R, endothelin receptor A, adrenergic (α1, α2, β1, β2), and muscarinic (M1–M5) receptors were quantified, along with blood cortisol and ACTH levels. SARS-CoV-2-specific T-cell responses to Spike and Nucleocapsid proteins were evaluated by ELISpot assay. In our small cohort, LC patients were younger, had fewer comorbidities (p = 0.03), fewer vaccine doses (p = 0.03), and higher FAS scores (33 vs. 12; p = 0.001). Mean GPCR AAbs levels were higher in LC than in APC (8.88 vs. 5.45 Units/mL; p = 0.17), indicating a coherent autoimmune signature in LC that correlates with symptom development. Morning cortisol was lower in LC (12.7 vs. 17 mg/dL; p = 0.01), and T-cell responses tended to be weaker. These findings suggest GPCR AAbs may serve as biomarkers and therapeutic targets for a subset of patients, guiding diagnosis and treatments with IV immunoglobulin or immunoadsorption. Full article

Background/Objectives: Hypertensive disorders of pregnancy (HDP) increase the risk of cardiovascular disease (CVD), but few studies have explored the efficacy of lifestyle interventions to improve CVD risk post-HDP. This study compared the 6 month (6M) and 12 month (12M) dietary and physical activity outcomes of women post-HDP participating in one of three lifestyle interventions. Methods: This sub-study of the Blood Pressure Postpartum (BP²) randomised controlled trial included participants from six hospitals across Sydney, Australia, randomly assigned to one of three groups: Group 1 (usual care) received general postpartum health information; Group 2 (brief education) received usual care plus an individualised cardiovascular risk assessment and lifestyle counselling; Group 3 (extended lifestyle) received all Group 2 components plus enrolment in a six-month telephone coaching programme. Baseline and post-intervention data were collected at 6M and 12M, respectively. Diet and physical activity were assessed using the NSW Population Health Survey, alongside cardiometabolic measures. Results: Overall, 405 women provided complete 6M and 12M data (Group 1 n = 129, Group 2 n = 137, Group 3 n = 139). From 6M to 12M, Group 3 increased their vegetable serves/day (3.0 vs. 2.0, p = 0.001). No significant changes in fruit intake and physical activity levels were observed among groups. Groups 2 and 3 reported that nutritional information had a greater influence on their food choices at 12M (p = 0.010 and p < 0.001, respectively). At 12M, higher vegetable and fruit intake correlated with lower body mass index (BMI) (p = 0.006, p = 0.003) and waist circumference (p = 0.035, p = 0.014), and increased vigorous and strength exercise correlated with lower BMI (p = 0.005, p = 0.003) and waist circumference (p < 0.001, p < 0.001). Conclusions: Intensive lifestyle interventions improved vegetable intake and nutrition awareness in post-HDP women at 12M, holding promise for long-term cardiometabolic health benefits. Full article

Parkinson’s disease (PD) is a heterogeneous clinical syndrome representing the final stage of a complex and long-lasting neurodegenerative process that involves not only dysfunction of the dopaminergic system but also impairments in other neurotransmitter systems. The diversity of the clinical presentation of PD, together with the existence of Parkinsonian syndromes and atypical Parkinsonism—such as multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and dementia with Lewy bodies (DLB)—has important implications for rehabilitation outcomes and underscores the need for individualized, stage-dependent therapeutic approaches. Juggling is a complex motor activity that integrates cognitive, visuomotor, and balance processes, requiring a high level of concentration, precision, and motor adaptation. In recent years, there has been growing interest in this form of activity as a potential tool for supporting neuroplasticity, cognitive functions, and neurological rehabilitation. The aim of this review was to summarize current scientific evidence on the effects of juggling training on cognitive functions, visuomotor coordination, and balance, as well as to discuss the potential benefits of combining it with controlled hypoxia in patients with Parkinson’s disease (PD). This narrative review additionally considers how disease heterogeneity and stage of progression may influence the effectiveness of such multimodal interventions. This paper reviews the literature concerning the neurophysiological basis of learning to juggle and the mechanisms of brain plasticity, including increases in gray matter volume, improvements in white matter integrity, and reorganization of neuronal networks in motor and associative regions. Attention is drawn to the synergistic potential of combining juggling training with exposure to moderate, controlled hypoxia, which may induce an adaptive response involving the transcription factor HIF-1α, enhance the expression of brain-derived neurotrophic factor (BDNF), and promote angiogenesis and mitochondrial biogenesis. Although juggling and hypoxia are not directly related to training stimuli, both interventions activate overlapping and complementary neuroplastic pathways, providing a conceptual rationale for their parallel consideration and potential integration within future rehabilitation protocols. Juggling delivers task-specific motor–cognitive learning, whereas hypoxia may amplify molecular plasticity signaling, potentially enhancing responsiveness to motor interventions, particularly in patients at early stages of PD when compensatory mechanisms and neuroplastic capacity are relatively preserved. Findings from existing studies suggest that juggling under controlled hypoxic conditions may represent an innovative, safe, and multimodal form of training that supports both cognitive and motor components. Such effects may be particularly relevant in patients at early stages of PD, when compensatory mechanisms and neuroplastic potential are relatively preserved. Such an intervention may contribute to improvements in balance, attention, executive functions, and cognitive flexibility, which is particularly relevant in the context of rehabilitation for patients with neurodegenerative diseases. Importantly, to date, no randomized clinical trials have directly examined juggling performed under controlled hypoxic conditions in PD. Therefore, the present concept should be regarded as translational and exploratory, integrating evidence from juggling-induced neuroplasticity and hypoxia-related physiological adaptations. In this context, the proposed approach represents a proof-of-concept framework for future multimodal interventions rather than an established therapeutic strategy. Available evidence suggests that combining complex sensorimotor skill training with physiological modulation of the internal environment may constitute a novel direction in PD rehabilitation, extending beyond conventional exercise-based models. Despite promising reports, further well-designed clinical studies are needed to determine the optimal training parameters (frequency, intensity, duration, and degree of hypoxia), to evaluate the long-term sustainability of therapeutic effects, and to account for the heterogeneity of PD and related Parkinsonian disorders. Full article

Physical activity (PA) is an important factor for maintaining health and well-being, especially in older adults. This study aims to apply machine learning methods to predict PA patterns and identify key factors influencing these behaviors among community-dwelling older adults. Linear and Logistic Regression, Elastic Net, and Light Gradient Boosting Machine (LightGBM) models were used to analyze cross-sectional data. While longitudinal data collected over 14 days were analyzed using LightGBM, Gated Recurrent Unit (GRU), and Long Short-Term Memory (LSTM). The most important predictors identified in the cross-sectional analysis were the Exercise Self-efficacy Scale (ESES) for PA levels and the Geriatric Depression Scale (GDS) for the International Physical Activity Questionnaire (IPAQ) as a continuous measurement. In the longitudinal analysis, using a seven-day sequence of step count data provided the best performance for forecasting physical activity for the entire next day. Overall, the findings indicate that combining wearable sensor data with machine learning and deep learning methods can provide valuable insights into physical activity behaviors among older adults. In the cross-sectional analysis, psychological and motivational factors such as self-efficacy were identified as important factors for activity levels, while in the longitudinal analysis, using a week of past step count data provided the most reliable predictions of future-day physical activity. Full article

Background: To evaluate the effects of a motion-triggered neuromuscular electrical stimulation (NMES) shoulder strengthening program on rotational shoulder strength and throwing velocity in healthy, elite-level handball players. Methods: Fourteen male handball players were randomly allocated (1:1) to either the NMES or control group. Participants were assessed by a blinded investigator at baseline and after 6 weeks for clinical status, isometric dynamometer-based external (ER) and internal rotational (IR) maximal shoulder strength, and handball endurance and maximal throwing velocity (7 m free throw). Between time points, NMES subjects completed a standardized motion-triggered NMES shoulder strengthening program (3 sessions/week, 30 min for 6 weeks), whereas controls performed a conventional standardized strength program. Results: After completion of the motion-triggered NMES program, all NMES participants (100%) demonstrated significant gains in isometric ER strength (+1.4 ± 1.1 kg, p = 0.016) compared with 43% of controls, who demonstrated no overall improvement (−0.2 ± 1.8 kg, p = 0.740). Similarly, a significantly greater proportion of NMES participants improved endurance throwing velocity compared with controls (100% vs. 29%, p = 0.004), with a mean increase of +2.9 ± 2.8 km·h⁻¹ (p = 0.0.56). Maximum throwing velocity showed no between-group differences in the proportion of athletes with improved results (p = 0.899). Conclusions: A six-week motion-triggered NMES shoulder strengthening program improved external rotation strength and increased the proportion of athletes demonstrating enhanced endurance throwing velocity under fatigued conditions. However, when compared with conventional exercise alone, NMES did not confer additional benefits for maximal throwing velocity in this study. Therefore, NMES should be regarded as a complementary modality rather than a substitute for established shoulder strengthening exercises. Full article

Background: Basketball performance depends strongly on physical preparation. A novel approach is accentuated eccentric loading within contrast training, though its acute effects using dumbbells remain underexplored. Methods: Twelve youth basketball players (age = 16.0 ± 0.3 years; body mass = 81.5 ± 7.6 kg) completed three sessions with dumbbell loads equivalent to 15%, 30% and 45% BW. CMJ performance was measured using dual wireless dual force plates. Assessments were conducted before the protocol and at 3, 9, and 15 min post intervention. Subjective responses were collected via wellness, RPE and readiness questionnaires. A two-way repeated measures ANOVA with Bonferroni corrections was applied, and the significance level was set to α = 0.05. Results: Significant decreases in jump height (p = 0.010) and average propulsive power (p = 0.005) were observed in the 45% BW condition at 3 and 9 min. Jump momentum decreased significantly at 30% and 45% BW at 3 and 9 min (p = 0.010; p = 0.033). No significant differences were detected in other CMJ force–time metrics (p > 0.05). Conclusions: Dumbbell-loaded CMJs as an accentuated eccentric loading contrast exercise did not produce generalized improvements but induced acute decreases at higher loads. However, they may still be useful in individual cases for athletes with favorable responses after monitoring. Full article

Background: The viscoelastic properties of muscle tissue are important factors affecting muscle performance; they play a significant role in maintaining spinal stability, as well as muscle contraction and function. Changes in these properties can result in pain, restricted movement, or poor posture. However, there is limited information in the literature regarding the viscoelastic properties of the paraspinal muscles, such as tone and stiffness, in individuals with chronic low back pain, which is one of the most common musculoskeletal disorders. The main aim of our study was to investigate the effects of reformer Pilates exercises on muscle viscoelastic properties in individuals with chronic low back pain for 4 weeks. In addition, our secondary aim was to examine the effects of Pilates-based exercises on body anthropometric values, pain intensity, functionality and kinesiophobia levels, sleep, and quality of life in individuals with chronic low back pain and to compare these parameters with a healthy group without low back pain. Methods: The study was carried out in a private clinic center and involved a total of 52 participants: 24 healthy subjects (control group) and 28 subjects with chronic low back pain (CLBP group). Pilates-based exercises were applied 2 days a week for 8 sessions for a total of 4 weeks. Muscle viscoelastic properties, body anthropometric values, pain intensity, functional status, kinesiophobia, sleep quality, and quality of life of all cases were evaluated. Muscle viscoelastic values were measured with a portable myotonometer, MyotonPro. Results: After 4 weeks of Pilates-based training, no significant improvements were observed in the parameters of muscle tone and stiffness in both groups (p > 0.05). It was found that pain intensity (p = 0.001), sleep quality (p = 0.004), quality of life (p = 0.019), and disability level (p = 0.003) improved after 4 weeks of Pilates-based training in subjects with chronic low back pain. In addition, there were significant differences in the parameters of the chest, waist, hip, and thigh circumferences after 4 weeks of Pilates-based training, except for the abdomen, in both groups (p < 0.05). Conclusions: A period of four weeks of Pilates exercises did not lead to significant changes in the muscle viscoelastic properties of the lumbar and abdominal muscles, although performing these exercises did result in regional thinning. The efficacy of Pilates exercises in reducing pain, disability, and kinesiophobia and in improving sleep and quality of life has been demonstrated in individuals suffering from chronic low back pain. Full article

In a certain sense, the experience of beauty is objectless. Obviously, only in a certain sense: for the experience evidently makes some objects manifest—namely, the object found beautiful. Yet to find an object beautiful means finding that it somehow, given the juxtaposition of its material elements, expresses something beyond conception, which thus directs us towards something that could never be given as an object of experience. Kant thus claimed that beauty ultimately expresses the purportedly supersensible basis of all being, accounting for the sense of meaningfulness and repose engendered by the experience of beauty. Levinas, expanding on such ideas, calls this an expression of the sacred. Levinas, however, thus worries about our appreciation of beauty: for if the sacred, as he argues, discloses an ostensibly unmanifestable mystical or metaphysical absolute as if it were at one with the material forces that traverse and underlie beings, then beauty’s repose ultimately represents the moral complacency of a disclosure that all is right on some “deeper level.” By contrast, the holy, which reveals itself in the relation to another and which Levinas opposes to the sacred, represents a different unmanifestability—of the other as such and of the infinite responsibility to which the other’s appeal, by decentering one absolutely, subjects one thereby—but this encounter, instead of inviting complacency, thus incessantly challenges us. In the following, I clarify Levinas’s position by explicating his account of beauty and his claim that beauty manifests an unmanifestable sacred and then discussing Levinas’s distinction between the sacred and holy and explicating his worries about the sacred. I conclude by discussing the caution he believes we should exercise in appreciating beauty, but also the latter’s exigency, a consideration that can help resolve issues in Levinas scholarship as well as current debates on the moral value of art. Full article