Cognitive Impairment and Neuropsychiatric Dysfunctions in Multiple Sclerosis (Volume II)

A special issue of NeuroSci (ISSN 2673-4087).

Deadline for manuscript submissions: 15 June 2025 | Viewed by 2859

Special Issue Editor


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Guest Editor
1. Fondazione Santa Lucia IRCCS, 00179 Rome, Italy
2. Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, 00133 Rome, Italy
Interests: neurorehabilitation; neuropsychology; cognitive assessment; multiple sclerosis (cognition in MS); social cognition; disability assessment
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Special Issue Information

Dear Colleagues,

This collection is the second edition of the Special Issue “Cognitive Impairment and Neuropsychiatric Dysfunctions in Multiple Sclerosis”.

Cognitive deficits have been reported in 45–70% of patients with multiple sclerosis (MS). Like other symptoms of MS, cognitive deficits are highly variable. Slowed information processing, and memory and learning dysfunction are regarded as the most frequent cognitive deficits in MS. Both white and gray matter damages have been suggested to contribute to cognitive impairments in MS. In addition to cognitive impairments, neuropsychiatric symptoms are observed in MS, the most common being alterations in mood state, which have multidimensional effects on patients’ quality of life. Consequently, attention should be paid to cognitive impairment and neuropsychiatric dysfunctions in multiple sclerosis, which this Special Issue aims to address.

The scope of this Special Issue includes, but is not limited to, the following:

  • Historical background;
  • Cognitive impairment in MS: last developments and future prospects;
  • Neuropsychiatric dysfunctions in MS;
  • Personality, behavior and MS;
  • Neuroimaging of cognitive impairment and neuropsychiatric dysfunctions in MS;
  • Neurochemistry of cognitive impairment and neuropsychiatric dysfunctions in MS;
  • Non-pharmacological treatments of cognitive impairment in MS.

Dr. Ugo Nocentini
Guest Editor

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Keywords

  • multiple sclerosis
  • cognitive impairment
  • cognitive deficits
  • neuropsychiatric dysfunctions
  • neuropsychiatric symptoms

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Published Papers (2 papers)

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Research

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17 pages, 1334 KiB  
Article
Nutritional Intervention in Patients with Multiple Sclerosis, Correlation with Quality of Life and Disability—A Prospective and Quasi-Experimental Study
by Konstantina Metaxouli, Chrysoula Tsiou, Eleni Dokoutsidou and Nikoletta Margari
NeuroSci 2025, 6(1), 4; https://doi.org/10.3390/neurosci6010004 - 6 Jan 2025
Viewed by 1089
Abstract
Multiple sclerosis (MS) is a multifactorial disease, with diet and lifestyle playing an important role in its development. The Mediterranean diet has been considered to be particularly beneficial for MS patients. The aim of the present study was to investigate the relationship between [...] Read more.
Multiple sclerosis (MS) is a multifactorial disease, with diet and lifestyle playing an important role in its development. The Mediterranean diet has been considered to be particularly beneficial for MS patients. The aim of the present study was to investigate the relationship between diet and MS, as well as evaluate the effect of the Mediterranean diet on patients’ quality of life and level of disability. The six-month study included 130 patients, divided into a control and intervention group. Data collection instruments were used for the collection of demographic and medical characteristics of the participants, as well as data regarding disability [(Multiple Sclerosis Rating Scale-Revised (MSRS-R) and Multiple Sclerosis Impact Scale-29 (MSIS-29)], nutrition [Mediterranean Diet Score (MedDiet Score) and Mini Nutritional Assessment (MNA)], and quality of life [Multiple Sclerosis Quality of Life-54 (MSQOL-54)]. The results indicated that the demographic characteristics of the groups were similar. The MNA score was positively associated with physical (p = 0.002) and mental health (p = 0.001). The intervention group reported an improvement in adherence to the Mediterranean diet, an increase in the MedDiet Score, and a decrease in the MSRS-R Score, indicating an improvement in functional capacity, nutritional status, and quality of life. In conclusion, the Mediterranean diet can improve the functionality and quality of life of patients with MS. Nutrition education is therefore deemed critical, and further research is required to reinforce these findings. Full article
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17 pages, 267 KiB  
Review
The Connection Between Oxidative Stress, Mitochondrial Dysfunction, Iron Metabolism and Microglia in Multiple Sclerosis: A Narrative Review
by Simonida Delic, Svetlana Miletic Drakulic, Milos Stepovic, Jovana Milosavljevic, Marija Kovacevic Dimitrijevic, Kristijan Jovanovic, Ivona Marinkovic, Melanija Tepavcevic, Nikoleta Janicijevic, Aleksandra Mitrovic, Danica Igrutinovic and Maja Vulovic
NeuroSci 2025, 6(1), 23; https://doi.org/10.3390/neurosci6010023 - 4 Mar 2025
Viewed by 1361
Abstract
In recent years, in the pathogenesis of multiple sclerosis, emphasis has been placed on mitochondrial processes that influence the onset of the disease. Oxidative stress would be one of the consequences of mitochondrial dysfunction, and its impact on brain tissue is well described. [...] Read more.
In recent years, in the pathogenesis of multiple sclerosis, emphasis has been placed on mitochondrial processes that influence the onset of the disease. Oxidative stress would be one of the consequences of mitochondrial dysfunction, and its impact on brain tissue is well described. Microglia, as a brain macrophage, have an important function in removing unwanted metabolites, as well as iron, which is an amplifier of oxidative stress. There are novelties in terms of the connection between these processes, which have redirected research more towards the process of neurodegeneration itself, so that the emphasis is no longer on neuroinflammation, which would initiate the pathological process itself and still exist in the vicinity of lesions with reduced intensity. The aim of this review is to summarize the current knowledge from the literature regarding oxidative stress, mitochondrial dysfunction and iron metabolism and how microglia are involved in these processes in multiple sclerosis. Full article
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