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23 pages, 2663 KiB  
Article
How Nanofluids May Enhance Energy Efficiency and Carbon Footprint in Buildings?
by Sylwia Wciślik
Sustainability 2025, 17(15), 7035; https://doi.org/10.3390/su17157035 (registering DOI) - 2 Aug 2025
Abstract
Nanofluids are an innovative working medium in solar hot water installations (DHWs), thanks to their increased thermal conductivity and heat transfer coefficient. The aim of this work was to assess the effect of Al2O3 nanofluids in a water–ethylene glycol base [...] Read more.
Nanofluids are an innovative working medium in solar hot water installations (DHWs), thanks to their increased thermal conductivity and heat transfer coefficient. The aim of this work was to assess the effect of Al2O3 nanofluids in a water–ethylene glycol base (40:60%) and with the addition of Tween 80 surfactant (0.2 wt%) on thermal efficiency (ε) and exergy (ηex) in a plate heat exchanger at DHW flows of 3 and 12 L/min. The numerical NTU–ε model was used with dynamic updating of thermophysical properties of nanofluids and the solution of the ODE system using the ode45 method, and the validation was carried out against the literature data. The results showed that the nanofluids achieved ε ≈ 0.85 (vs. ε ≈ 0.87 for the base fluid) and ηex ≈ 0.72 (vs. ηex ≈ 0.74), with higher entropy generation. The addition of Tween 80 reduced the viscosity by about 10–15%, resulting in a slight increase of Re and h-factor; however, the impact on ε and ηex was marginal. The environmental analysis with an annual demand of Q = 3000 kWh/year and an emission factor of 0.2 kg CO2/kWh showed that for ε < 0.87 the nanofluids increased the emissions by ≈16 kg CO2/year, while at ε ≈ 0.92, a reduction of ≈5% was possible. This paper highlights the need to optimize nanofluid viscosity and exchanger geometry to maximize energy and environmental benefits. Nowadays, due to the growing problems of global warming, the analysis of energy efficiency and carbon footprint related to the functioning of a building seems to be crucial. Full article
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18 pages, 1583 KiB  
Article
Heat Transfer Characteristics of Thermosyphons Used in Vacuum Water Heaters
by Zied Lataoui, Adel M. Benselama and Abdelmajid Jemni
Fluids 2025, 10(8), 199; https://doi.org/10.3390/fluids10080199 - 31 Jul 2025
Abstract
A two-phase closed thermosyphon (TPCT), a gravity-assisted heat pipe, is a highly efficient heat transmitter involving liquid–vapor phase change. It is used in many applications, including heat spreading, thermal management and control, and energy saving. The main objective of this study is to [...] Read more.
A two-phase closed thermosyphon (TPCT), a gravity-assisted heat pipe, is a highly efficient heat transmitter involving liquid–vapor phase change. It is used in many applications, including heat spreading, thermal management and control, and energy saving. The main objective of this study is to investigate the effects of the operating conditions for a thermosyphon used in solar water heaters. The study particularly focuses on the influence of the inclination angle. Thus, a comprehensive simulation model is developed using the volume of fluid (VOF) approach. Complex and related phenomena, including two-phase flow, phase change, and heat exchange, are taken into account. To implement the model, an open-source CFD toolbox based on finite volume formulation, OpenFOAM, is used. The model is then validated by comparing numerical results to the experimental data from the literature. The obtained results show that the simulation model is reliable for investigating the effects of various operating conditions on the transient and steady-state behavior of the thermosyphon. In fact, bubble creation, growth, and advection can be tracked correctly in the liquid pool at the evaporator. The effects of the designed operating conditions on the heat transfer parameters are also discussed. In particular, the optimal tilt angle is shown to be 60° for the intermediate saturation temperature (<50 °C) and 90° for the larger saturation temperature (>60 °C). Full article
(This article belongs to the Special Issue Convective Flows and Heat Transfer)
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20 pages, 3578 KiB  
Article
Performance Improvement of Proton Exchange Membrane Fuel Cell by a New Coupling Channel in Bipolar Plate
by Qingsong Song, Shuochen Yang, Hongtao Li, Yunguang Ji, Dajun Cai, Guangyu Wang and Yuan Liufu
Energies 2025, 18(15), 4068; https://doi.org/10.3390/en18154068 (registering DOI) - 31 Jul 2025
Abstract
The geometric design of flow channels in bipolar plates is one of the critical features of proton exchange membrane fuel cells (PEMFCs), as it determines the power output of the fuel cell and has a significant impact on its performance and durability. The [...] Read more.
The geometric design of flow channels in bipolar plates is one of the critical features of proton exchange membrane fuel cells (PEMFCs), as it determines the power output of the fuel cell and has a significant impact on its performance and durability. The function of the bipolar plate is to guide the transfer of reactant gases to the gas diffusion layer and catalytic layer inside the PEMFC, while removing unreacted gases and gas–liquid byproducts. Therefore, the design of the bipolar plate flow channel is directly related to the water and thermal management of the PEMFC. In order to improve the comprehensive performance of PEMFCs and ensure their safe and stable operation, it is necessary to design the flow channels in bipolar plates rationally and effectively. This study addresses the limitations of existing bipolar plate flow channels by proposing a new coupling of serpentine and radial channels. The distribution of oxygen, water concentrations, and temperature inside the channel is simulated using the multi-physics simulation software COMSOL Multiphysics 6.0. The performance of this novel design is compared with conventional flow channels, with a particular focus on the pressure drop and current density to evaluate changes in the output performance of the PEMFC. The results show that the maximum current density of this novel design is increased by 67.36% and 10.43% compared to straight channel and single serpentine channels, respectively. The main contribution of this research is the innovative design of a new coupling of serpentine and radial channels in bipolar plates, which improves the overall performance of the PEMFC. This study provides theoretical support for the design of bipolar plate flow channels in PEMFCs and holds significant importance for the green development of energy. Full article
(This article belongs to the Special Issue Advanced Energy Storage Technologies)
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22 pages, 6820 KiB  
Article
Bathymetric Profile and Sediment Composition of a Dynamic Subtidal Bedform Habitat for Pacific Sand Lance
by Matthew R. Baker, H. G. Greene, John Aschoff, Michelle Hoge, Elisa Aitoro, Shaila Childers, Junzhe Liu and Jan A. Newton
J. Mar. Sci. Eng. 2025, 13(8), 1469; https://doi.org/10.3390/jmse13081469 - 31 Jul 2025
Viewed by 214
Abstract
The eastern North Pacific Ocean coastline (from the Salish Sea to the western Aleutian Islands) is highly glaciated with relic sediment deposits scattered throughout a highly contoured and variable bathymetry. Oceanographic conditions feature strong currents and tidal exchange. Sand wave fields are prominent [...] Read more.
The eastern North Pacific Ocean coastline (from the Salish Sea to the western Aleutian Islands) is highly glaciated with relic sediment deposits scattered throughout a highly contoured and variable bathymetry. Oceanographic conditions feature strong currents and tidal exchange. Sand wave fields are prominent features within these glaciated shorelines and provide critical habitat to sand lance (Ammodytes spp.). Despite an awareness of the importance of these benthic habitats, attributes related to their structure and characteristics remain undocumented. We explored the micro-bathymetric morphology of a subtidal sand wave field known to be a consistent habitat for sand lance. We calculated geomorphic attributes of the bedform habitat, analyzed sediment composition, and measured oceanographic properties of the associated water column. This feature has a streamlined teardrop form, tapered in the direction of the predominant tidal current. Consistent flow paths along the long axis contribute to well-defined and maintained bedform morphology and margin. Distinct patterns in amplitude and period of sand waves were documented. Strong tidal exchange has resulted in well-sorted medium-to-coarse-grained sediments with coarser sediments, including gravel and cobble, within wave troughs. Extensive mixing related to tidal currents results in a highly oxygenated water column, even to depths of 80 m. Our analysis provides unique insights into the physical characteristics that define high-quality habitat for these fish. Further work is needed to identify, enumerate, and map the presence and relative quality of these benthic habitats and to characterize the oceanographic properties that maintain these benthic habitats over time. Full article
(This article belongs to the Special Issue Dynamics of Marine Sedimentary Basin)
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25 pages, 4584 KiB  
Review
A Review of the State of the Art on Ionic Liquids and Their Physical Properties During Heat Transfer
by Krzysztof Dutkowski, Marcin Kruzel, Małgorzata Smuga-Kogut and Marcin Walczak
Energies 2025, 18(15), 4053; https://doi.org/10.3390/en18154053 - 30 Jul 2025
Viewed by 228
Abstract
This paper presents information on ionic liquids (ILs) and explores their potential applications in heat exchange systems. Basic information on ionic liquids and their selected thermophysical properties is presented in a manner that facilitates their use in future research. The physical properties of [...] Read more.
This paper presents information on ionic liquids (ILs) and explores their potential applications in heat exchange systems. Basic information on ionic liquids and their selected thermophysical properties is presented in a manner that facilitates their use in future research. The physical properties of IL that are important in the area of heat exchange are described in detail, with particular emphasis on heat exchange in flow. Issues related to the melting point, specific heat, thermal conductivity coefficient, and viscosity of selected ionic liquids, as well as the effect of temperature on their changes, are discussed. The physical properties of IL are compared with the physical properties of water treated in heat exchange as a reference substance. The issues of creating aqueous solutions of ionic liquids and the effect of the amount of water on the physical properties of the resulting solution are discussed. It is demonstrated that selected ionic liquids can be considered an alternative to traditional working liquids commonly used in heat exchange systems. Full article
(This article belongs to the Special Issue Heat Transfer in Heat Exchangers: 2nd Edition)
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13 pages, 3081 KiB  
Review
Surface Air-Cooled Oil Coolers (SACOCs) in Turbofan Engines: A Comprehensive Review of Design, Performance, and Optimization
by Wiktor Hoffmann and Magda Joachimiak
Energies 2025, 18(15), 4052; https://doi.org/10.3390/en18154052 - 30 Jul 2025
Viewed by 179
Abstract
Surface Air-Cooled Oil Coolers (SACOCs) can become a critical component in managing the increasing thermal loads of modern turbofan engines. Installed within the bypass duct, SACOCs utilize high-mass flow bypass air for convective heat rejection, reducing reliance on traditional Fuel-Oil Heat Exchangers. This [...] Read more.
Surface Air-Cooled Oil Coolers (SACOCs) can become a critical component in managing the increasing thermal loads of modern turbofan engines. Installed within the bypass duct, SACOCs utilize high-mass flow bypass air for convective heat rejection, reducing reliance on traditional Fuel-Oil Heat Exchangers. This review explores SACOC design principles, integration challenges, aerodynamic impacts, and performance trade-offs. Emphasis is placed on the balance between thermal efficiency and aerodynamic penalties such as pressure drop and flow distortion. Experimental techniques, including wind tunnel testing, are discussed alongside numerical methods, and Conjugate Heat Transfer modeling. Presented studies mostly demonstrate the impact of fin geometry and placement on both heat transfer and drag. Optimization strategies and Additive Manufacturing techniques are also covered. SACOCs are positioned to play a central role in future propulsion systems, especially in ultra-high bypass ratio and hybrid-electric architectures, where traditional cooling strategies are insufficient. This review highlights current advancements, identifies limitations, and outlines research directions to enhance SACOC efficiency in aerospace applications. Full article
(This article belongs to the Special Issue Heat Transfer Analysis: Recent Challenges and Applications)
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20 pages, 3890 KiB  
Article
Numerical Analysis of Pressure Drops in Single-Phase Flow Through Channels of Brazed Plate Heat Exchangers with Dimpled Corrugated Plates
by Lorenzo Giunti, Francesco Giacomelli, Urban Močnik, Giacomo Villi, Adriano Milazzo and Lorenzo Talluri
Appl. Sci. 2025, 15(15), 8431; https://doi.org/10.3390/app15158431 (registering DOI) - 29 Jul 2025
Viewed by 152
Abstract
The presented research examines the performance characteristics of Brazed Plate Heat Exchangers through computational fluid dynamics (CFD), focusing on pressure drop calculations for single-phase flow within full channels of plates featuring dimpled corrugation. This work aims to bridge gaps in the literature, particularly [...] Read more.
The presented research examines the performance characteristics of Brazed Plate Heat Exchangers through computational fluid dynamics (CFD), focusing on pressure drop calculations for single-phase flow within full channels of plates featuring dimpled corrugation. This work aims to bridge gaps in the literature, particularly regarding the underexplored behavior near the ports for the studied technology and establishing a framework for future conjugate heat transfer studies. A methodology for the domain generation was developed, integrating a preliminary forming simulation to reproduce the complex plate geometry. Comprehensive sensitivity analyses were conducted to evaluate the influence of different parameters and identify the optimal settings for obtaining reliable results. The findings indicate that the kε realizable turbulence model with enhanced wall treatment offers superior accuracy in predicting pressure drops, with errors within ±4.4%. Additionally, leveraging the information derived from CFD, a strategy to estimate contributions from different channel sections without a direct reliance on those simulations was developed, offering practical implications for plate design. Full article
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20 pages, 3137 KiB  
Article
The Heat Transfer Coefficient During Pool Boiling of Refrigerants in a Compact Heat Exchanger
by Marcin Kruzel, Tadeusz Bohdal, Krzysztof Dutkowski, Krzysztof J. Wołosz and Grzegorz Robakowski
Energies 2025, 18(15), 4030; https://doi.org/10.3390/en18154030 - 29 Jul 2025
Viewed by 173
Abstract
The results of experimental data on the heat transfer coefficient during the boiling of pro-ecological refrigerants in a compact tube-shell heat exchanger are presented. The boiling process occurred in the micro-space of the exchanger shell on the surface of horizontal tubes, which were [...] Read more.
The results of experimental data on the heat transfer coefficient during the boiling of pro-ecological refrigerants in a compact tube-shell heat exchanger are presented. The boiling process occurred in the micro-space of the exchanger shell on the surface of horizontal tubes, which were heated from the inside with warm water. The flow of the refrigerant was gravity-based. The heat exchanger was practically flooded with liquid refrigerant at a saturation temperature (ts), which flowed out after evaporation in a gaseous form. The tests were conducted for four refrigerants: R1234ze, R1234yf, R134a (a high-pressure refrigerant), and HFE7100 (a low-pressure refrigerant). Thermal characteristics describing the heat transfer process throughout the entire compact heat exchanger, specifically for the boiling process itself, were developed. It was found that in the case of micro-space boiling, there is an exponential dependence of the heat transfer coefficient on the heat flux density on the heated surface. Experimental data were compared to experimental and empirical data presented in other studies. Our own empirical models were proposed to determine the heat transfer coefficient for boiling in a mini-space for individual refrigerants. The proposed calculation models were also generalized for various refrigerants by introducing the value of reduced pressure into the calculation relationship. The developed relationship enables the determination of heat transfer coefficient values during boiling in a micro-space on the surface of horizontal tubes for various refrigerants with an accuracy of ±25%. Full article
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23 pages, 1585 KiB  
Article
The Key Role of Thermal Relaxation Time on the Improved Generalized Bioheat Equation: Analytical Versus Simulated Numerical Approach
by Alexandra Maria Isabel Trefilov, Mihai Oane and Liviu Duta
Materials 2025, 18(15), 3524; https://doi.org/10.3390/ma18153524 - 27 Jul 2025
Viewed by 315
Abstract
The Pennes bioheat equation is the most widely used model for describing heat transfer in living tissue during thermal exposure. It is derived from the classical Fourier law of heat conduction and assumes energy exchange between blood vessels and surrounding tissues. The literature [...] Read more.
The Pennes bioheat equation is the most widely used model for describing heat transfer in living tissue during thermal exposure. It is derived from the classical Fourier law of heat conduction and assumes energy exchange between blood vessels and surrounding tissues. The literature presents various numerical methods for solving the bioheat equation, with exact solutions developed for different boundary conditions and geometries. However, analytical models based on this framework are rarely reported. This study aims to develop an analytical three-dimensional model using MATHEMATICA software, with subsequent mathematical validation performed through COMSOL simulations, to characterize heat transfer in biological tissues induced by laser irradiation under various therapeutic conditions. The objective is to refine the conventional bioheat equation by introducing three key improvements: (a) incorporating a non-Fourier framework for the Pennes equation, thereby accounting for the relaxation time in thermal response; (b) integrating Dirac functions and the telegraph equation into the bioheat model to simulate localized point heating of diseased tissue; and (c) deriving a closed-form analytical solution for the Pennes equation in both its classical (Fourier-based) and improved (non-Fourier-based) formulations. This paper investigates the nuanced relationship between the relaxation time parameter in the telegraph equation and the thermal relaxation time employed in the bioheat transfer equation. Considering all these aspects, the optimal thermal relaxation time determined for these simulations was 1.16 s, while the investigated thermal exposure time ranged from 0.01 s to 120 s. This study introduces a generalized version of the model, providing a more realistic representation of heat exchange between biological tissue and blood flow by accounting for non-uniform temperature distribution. It is important to note that a reasonable agreement was observed between the two modeling approaches: analytical (MATHEMATICA) and numerical (COMSOL) simulations. As a result, this research paves the way for advancements in laser-based medical treatments and thermal therapies, ultimately contributing to more optimized therapeutic outcomes. Full article
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25 pages, 946 KiB  
Review
Airway Management in Obstructive Sleep Apnea: A Comprehensive Review of Assessment Strategies, Techniques, and Technological Advances
by Mario Giuseppe Bellizzi, Annalisa Pace, Giannicola Iannella, Antonino Maniaci, Daniele Salvatore Paternò, Simona Tutino, Massimiliano Sorbello, Salvatore Maria Ronsivalle, Giuseppe Magliulo, Antonio Greco, Armando De Virgilio, Patrizia Mancini, Enrica Croce, Giulia Molinari, Daniela Lucidi, Jerome R. Lechien, Antonio Moffa, Alberto Caranti and Luigi La Via
Healthcare 2025, 13(15), 1823; https://doi.org/10.3390/healthcare13151823 - 26 Jul 2025
Viewed by 140
Abstract
Background: Airway management in patients with obstructive sleep apnea (OSA) presents unique challenges for anesthesiologists and other airway practitioners. This comprehensive review examines current evidence and clinical practices for managing difficult airways in this high-risk population. OSA is characterized by specific anatomical [...] Read more.
Background: Airway management in patients with obstructive sleep apnea (OSA) presents unique challenges for anesthesiologists and other airway practitioners. This comprehensive review examines current evidence and clinical practices for managing difficult airways in this high-risk population. OSA is characterized by specific anatomical and physiological alterations that increase both the likelihood of encountering difficult intubation and the risk of rapid desaturation during airway manipulation. Methods: Preoperative assessment of OSA patients requires integration of traditional difficult airway evaluation with OSA-specific considerations, including severity indices, oxygen desaturation patterns, and continuous positive airway pressure dependency. Conventional direct laryngoscopy often proves inadequate in these patients, prompting the development and refinement of alternative approaches. Videolaryngoscopy has emerged as a particularly valuable technique in OSA patients, offering improved glottic visualization while maintaining physiologic positioning. Flexible endoscopic techniques, particularly awake flexible bronchoscopic intubation, remain essential for high-risk scenarios, though they require considerable expertise. Results: Recent technological innovations have produced hybrid devices combining multiple modalities to address the specific challenges presented by OSA patients. Adjunctive tools and techniques, including specialized introducers, exchange catheters, and high-flow nasal oxygen, play critical roles in extending safe apnea time and facilitating successful intubation. Professional society guidelines now incorporate OSA-specific recommendations, emphasizing thorough preparation, appropriate device selection, and comprehensive monitoring. Conclusions: Effective management ultimately requires not only appropriate technology but also systematic preparation, strategic device selection, and meticulous execution. As OSA prevalence continues to rise globally, optimizing airway management approaches for this challenging population remains a critical priority for patient safety. Full article
(This article belongs to the Special Issue New Developments in Endotracheal Intubation and Airway Management)
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25 pages, 3454 KiB  
Article
Dynamic Temperature–Vacuum Swing Adsorption for Sustainable Direct Air Capture: Parametric Optimisation for High-Purity CO2 Removal
by Maryam Nasiri Ghiri, Hamid Reza Nasriani, Leila Khajenoori, Samira Mohammadkhani and Karl S. Williams
Sustainability 2025, 17(15), 6796; https://doi.org/10.3390/su17156796 - 25 Jul 2025
Viewed by 467
Abstract
Direct air capture (DAC), as a complementary strategy to carbon capture and storage (CCS), offers a scalable and sustainable pathway to remove CO2 directly from the ambient air. This study presents a detailed evaluation of the amine-functionalised metal-organic framework (MOF) sorbent, mmen-Mg [...] Read more.
Direct air capture (DAC), as a complementary strategy to carbon capture and storage (CCS), offers a scalable and sustainable pathway to remove CO2 directly from the ambient air. This study presents a detailed evaluation of the amine-functionalised metal-organic framework (MOF) sorbent, mmen-Mg2(dobpdc), for DAC using a temperature–vacuum swing adsorption (TVSA) process. While this sorbent has demonstrated promising performance in point-source CO2 capture, this is the first dynamic simulation-based study to rigorously assess its effectiveness for low-concentration atmospheric CO2 removal. A transient one-dimensional TVSA model was developed in Aspen Adsorption and validated against experimental breakthrough data to ensure accuracy in capturing both the sharp and gradual adsorption kinetics. To enhance process efficiency and sustainability, this work provides a comprehensive parametric analysis of key operational factors, including air flow rate, temperature, adsorption/desorption durations, vacuum pressure, and heat exchanger temperature, on process performance, including CO2 purity, recovery, productivity, and specific energy consumption. Under optimal conditions for this sorbent (vacuum pressure lower than 0.15 bar and feed temperature below 15 °C), the TVSA process achieved ~98% CO2 purity, recovery over 70%, and specific energy consumption of about 3.5 MJ/KgCO2. These findings demonstrate that mmen-Mg2(dobpdc) can achieve performance comparable to benchmark DAC sorbents in terms of CO2 purity and recovery, underscoring its potential for scalable DAC applications. This work advances the development of energy-efficient carbon removal technologies and highlights the value of step-shape isotherm adsorbents in supporting global carbon-neutrality goals. Full article
(This article belongs to the Section Waste and Recycling)
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28 pages, 2549 KiB  
Article
A 25K Wheat SNP Array Revealed the Genetic Diversity and Population Structure of Durum Wheat (Triticum turgidum subsp. durum) Landraces and Cultivars
by Lalise Ararsa, Behailu Mulugeta, Endashaw Bekele, Negash Geleta, Kibrom B. Abreha and Mulatu Geleta
Int. J. Mol. Sci. 2025, 26(15), 7220; https://doi.org/10.3390/ijms26157220 - 25 Jul 2025
Viewed by 1003
Abstract
Durum wheat, the world’s second most cultivated wheat species, is a staple crop, critical for global food security, including in Ethiopia where it serves as a center of diversity. However, climate change and genetic erosion threaten its genetic resources, necessitating genomic studies to [...] Read more.
Durum wheat, the world’s second most cultivated wheat species, is a staple crop, critical for global food security, including in Ethiopia where it serves as a center of diversity. However, climate change and genetic erosion threaten its genetic resources, necessitating genomic studies to support conservation and breeding efforts. This study characterized genome-wide diversity, population structure (STRUCTURE, principal coordinate analysis (PCoA), neighbor-joining trees, analysis of molecular variance (AMOVA)), and selection signatures (FST, Hardy–Weinberg deviations) in Ethiopian durum wheat by analyzing 376 genotypes (148 accessions) using an Illumina Infinium 25K single nucleotide polymorphism (SNP) array. A set of 7842 high-quality SNPs enabled the assessments, comparing landraces with cultivars and breeding populations. Results revealed moderate genetic diversity (mean polymorphism information content (PIC) = 0.17; gene diversity = 0.20) and identified 26 loci under selection, associated with key traits like grain yield, stress tolerance, and disease resistance. AMOVA revealed 80.1% variation among accessions, with no significant differentiation by altitude, region, or spike density. Landraces formed distinct clusters, harboring unique alleles, while admixture suggested gene flow via informal seed exchange. The findings highlight Ethiopia’s rich durum wheat diversity, emphasizing landraces as reservoirs of adaptive alleles for breeding. This study provides genomic insights to guide conservation and the development of climate-resilient cultivars, supporting sustainable wheat production globally. Full article
(This article belongs to the Special Issue Latest Research on Plant Genomics and Genome Editing, 2nd Edition)
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15 pages, 798 KiB  
Article
Associations Between Serum Gut-Derived Tryptophan Metabolites and Cardiovascular Health Markers in Adolescents with Obesity
by Jeny E. Rivera, Renny Lan, Mario G. Ferruzzi, Elisabet Børsheim, Emir Tas and Eva C. Diaz
Nutrients 2025, 17(15), 2430; https://doi.org/10.3390/nu17152430 - 25 Jul 2025
Viewed by 260
Abstract
Background/Objectives: Gut-derived tryptophan (Trp) metabolites play important roles in metabolic and cardiovascular regulation. Although animal studies suggest their protective effects against metabolic dysfunction, data in adolescents, particularly those with obesity, remain limited. The objective of this study was to evaluate associations between circulating [...] Read more.
Background/Objectives: Gut-derived tryptophan (Trp) metabolites play important roles in metabolic and cardiovascular regulation. Although animal studies suggest their protective effects against metabolic dysfunction, data in adolescents, particularly those with obesity, remain limited. The objective of this study was to evaluate associations between circulating gut-derived Trp metabolites and markers of cardiometabolic, vascular, and platelet health in adolescents with obesity. Methods: Data were analyzed from 28 adolescents (ages 13–18; mean BMI = 36 ± 6.4 kg/m2). Fasting blood was collected to assess lipid profiles using a clinical analyzer and insulin resistance using the homeostatic model assessment for insulin resistance (HOMA-IR). Gut-derived Trp metabolites were measured by UPLC–mass spectrometry, peak oxygen uptake (VO2 peak) by gas exchange during an incremental cycle ergometer test, and body composition by dual-energy X-ray absorptiometry. Platelet spare respiratory capacity (SRC), endothelial function, and liver fat were measured using high-resolution respirometry, flow-mediated dilation (FMD) of the brachial artery, and magnetic resonance imaging respectively. Results: Indole-3-propionic acid was inversely associated with diastolic blood pressure (rho = −0.39, p = 0.047), total cholesterol (rho = −0.55, p = 0.002), and LDL-C (rho = −0.57, p = 0.0014), independent of sex and obesity severity. Indoxyl sulfate was positively correlated with fasting glucose (rho = 0.47, p = 0.012), and adolescents with impaired fasting glucose had 1.6-fold higher IS levels. Indole-3-acetaldehyde declined with age (rho = −0.50, p = 0.007), and Indole-3-acetic acid and indole were higher in Hispanics vs. non-Hispanics. No significant associations were observed between Trp metabolites and FMD, VO2 peak, or SRC. Conclusions: Gut-derived Trp metabolites, particularly indole-3-propionic and indoxyl sulfate, are associated with markers of cardiometabolic risk in adolescents with obesity. These findings support their potential relevance in early-onset cardiovascular disease risk. Full article
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16 pages, 2673 KiB  
Article
Thermal and Volumetric Signatures of the Mullins Effect in Carbon Black Reinforced Styrene-Butadiene Rubber Composites
by Nicolas Candau, Guillaume Corvec, Noel León-Albiter and Miguel Mudarra Lopez
J. Compos. Sci. 2025, 9(8), 393; https://doi.org/10.3390/jcs9080393 - 24 Jul 2025
Viewed by 265
Abstract
This paper investigates the interplay between rubber network damage, carbon black (CB) network damage, heat exchange, and voiding mechanisms in filled Styrene-butadiene rubber (SBR) under cyclic loading. To do so, three carbon black filled SBR composites, SBR5, SBR30 and SBR60 are studied. The [...] Read more.
This paper investigates the interplay between rubber network damage, carbon black (CB) network damage, heat exchange, and voiding mechanisms in filled Styrene-butadiene rubber (SBR) under cyclic loading. To do so, three carbon black filled SBR composites, SBR5, SBR30 and SBR60 are studied. The study aims to quantify molecular damage and its role in inducing reversible or irreversible heat flow and voiding behavior to inform the design of more resilient rubber composites with improved fatigue life and thermal management capabilities. The study effectively demonstrated how increasing carbon black content, particularly in SBR60, leads to a shift from mostly reversible to irreversible and cumulative damage mechanisms during cyclic loading, as evidenced by thermal, volumetric, and electrical resistivity changes. In particular, we identify a critical mechanical energy of 7 MJ.m−3 associated with such transition. These irreversible changes are strongly linked to the damage and re-arrangement of the carbon black filler network, as well as the rubber chains network and the formation/growth of voids, while reversible mechanisms are likely related to rubber chains alignment associated with entropic elasticity. Full article
(This article belongs to the Special Issue Composites: A Sustainable Material Solution, 2nd Edition)
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18 pages, 4202 KiB  
Article
Genetic Impacts of Sustained Stock Enhancement on Wild Populations: A Case Study of Penaeus penicillatus in the Beibu Gulf, China
by Yaxuan Wu, Dianrong Sun, Liangming Wang, Yan Liu, Changping Yang, Manting Liu, Qijian Xie, Cheng Chen, Jianwei Zou, Dajuan Zhang and Binbin Shan
Diversity 2025, 17(8), 511; https://doi.org/10.3390/d17080511 - 24 Jul 2025
Viewed by 166
Abstract
In recent decades, fishery stock enhancement has been increasingly utilized as a restoration tool to mitigate population declines and enhance the resilience of marine fisheries. Nevertheless, persistent enhancement efforts risk eroding the evolutionary potential of wild populations via genetic homogenization and maladaptive gene [...] Read more.
In recent decades, fishery stock enhancement has been increasingly utilized as a restoration tool to mitigate population declines and enhance the resilience of marine fisheries. Nevertheless, persistent enhancement efforts risk eroding the evolutionary potential of wild populations via genetic homogenization and maladaptive gene flow. Using long-term monitoring data (2017–2023), we quantified the effects of large-scale Penaeus penicillatus stock enhancement (~108 juveniles/yr) on wild population dynamics and genetic integrity in the Beibu Gulf ecosystem. Temporal genetic changes were assessed using eight highly polymorphic microsatellite loci, comparing founder (2017) and enhanced (2024) populations to quantify stocking impacts. Insignificantly lower expected heterozygosity was observed in the stocked population (He = 0.60, 2024) relative to natural populations (He = 0.62–0.66; p > 0.1), indicating genetic dilution effects from enhancement activities. No significant erosion of genetic diversity was detected post-enhancement, suggesting current stocking practices maintain short-term population genetic integrity. Despite conserved heterozygosity, pairwise Fst analysis detected significant genetic shifts between temporal cohorts (pre-enhancement—2017 vs. post-enhancement—2024; Fst = 0.25, p < 0.05), demonstrating stocking-induced population restructuring. Genetic connectivity analysis revealed that while the enhanced Beihai population (A-BH) maintained predominant self-recruitment (>90%), it experienced substantial stocking-derived gene flow (17% SW → A-BH). The post-stocking period showed both reduced genetic exchange with adjacent populations and increased asymmetric dispersal from A-BH (e.g., 5% to YJ), indicating that hatchery releases simultaneously enhanced population isolation while altering regional genetic structure. Our findings revealed the paradoxical dual effects of stock enhancement and allelic diversity while disrupting natural genetic architecture. This underscores the need for evolutionary-impact assessments in marine resource management. Full article
(This article belongs to the Special Issue Ecological Dynamics and Conservation of Marine Fisheries)
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