Search Results (5,857)

The study of faults in seismic gap areas is essential for assessing the potential for future seismic activity and developing strategies to mitigate its impact. In this research, we employed a combination of geomorphological analysis, aerophotogrammetry, high-resolution topography, and soil analysis to estimate the age of tectonically exposed fault surfaces in a seismic gap area. Our focus was on the Piano delle Rose Fault in the northern Calabria region, (southern Italy), which is a significant regional tectonic structure associated with seismic hazards. We conducted a field survey to carry out structural and pedological observations and collect soil samples from the fault surface. These samples were analyzed to estimate the fault’s age based on their features and degree of pedogenic development. Additionally, we used high-resolution topography and aerophotogrammetry to create a detailed 3D model of the fault surface, allowing us to identify features such as fault scarps and offsets. Our results indicate recent activity on the fault surface, suggesting that the Piano delle Rose Fault may pose a significant seismic hazard. Soil analysis suggests that the onset of the fault surface is relatively young, estimated in an interval time from 450,000 to ~ 300,000 years old. Considering these age constraints, the long-term slip rates are estimated to range between ~0.12 mm/yr and ~0.33 mm/yr, which are values comparable with those of many other well-known active faults of the Apennines extensional belt. Analyses of key fault exposures document cumulative displacements up to 21 m. These values yield long-term slip rates ranging from ~0.2 mm/yr (100,000 years) to ~1.0 mm/yr (~20,000 years LGM), indicating persistent Late Quaternary activity. A second exposure records ~0.6 m of displacement in very young soils, confirming surface faulting during recent times and suggesting that the fault is potentially capable of generating ground-rupturing earthquakes. High-resolution topography and aerophotogrammetry analyses show evidence of ongoing tectonic deformation, indicating that the area is susceptible to future seismic activity and corresponding risk. Our study highlights the importance of integrating multiple techniques for examining fault surfaces in seismic gap areas. By combining geomorphological analysis, aerophotogrammetry, high-resolution topography, and soil analysis, we gain a comprehensive understanding of the structure and behavior of faults. This approach can help assess the potential for future seismic activity and develop strategies for mitigating its impact. Full article

Type 2 diabetes mellitus (T2DM) is associated with increased cardiovascular risk characterized by low-grade inflammation. The aim of this systematic review and meta-analysis was to assess the effects of resistance exercise training (RET) predominantly on cytokines, along with changes in glucose profile and body composition in T2DM patients. The present systematic review and meta-analysis was conducted utilizing PubMed, Web of Science, Embase, and the Cochrane Library databases from their inception up to July 2024 (PROSPERO; registration number CRD420251149352). We screened only for randomized controlled trials investigating the effects of systematic, supervised RET on C-reactive protein (CRP) and adipokines: adiponectin, interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-α), along with changes in anthropometric indices and glycemic control in adult T2DM patients. Pooled post-exercise weighted mean differences (WMDs) with 95% confidence intervals (CIs) were calculated for all outcomes of interest between exercise-treated patients and controls. Sixteen studies involving a total of 668 T2DM patients were retrieved from the databases for meta-analysis. We used the GRADE framework for assessing the certainty of evidence. Cochran Q-score (I²) was used to estimate heterogeneity among studies (level of significance p < 0.10) and risk of bias analysis was also performed. The cumulative results showed that post-RET inflammatory markers were lower in exercise-treated patients compared to controls regarding CRP (mg/L) (WMD: −0.63; 95%CIs: −1.05, −0.20; p < 0.001); adiponectin (μg/mL) (WMD: −0.94; 95%CIs: −1.49, −0.38; p < 0.001). The results from adiponectin are quite conflicting since they derived from only three studies, where one of them had the greater impact. In parallel, we noticed significant amelioration of fasting glucose and HbA1c (p < 0.001), while body weight remained unaltered. Our meta-analysis demonstrated non-significantly lower levels of IL-6 and TNF-α in RET vs. control group. RET can merely reduce the inflammatory burden in T2DM patients by ameliorating the circulating levels of CRP and adiponectin, while in the rest of the biomarkers, non-significant results were obtained. Hence, the overall clinical impact of those anti-inflammatory effects of RET needs to be determined. Full article

Background: The multifactorial nature of CrossFit performance remains incompletely understood, particularly regarding sex- and experience-related physiological and biomechanical factors. Methods: Fifteen trained athletes (8 males, 7 females) completed assessments of anthropometry, estimated one-repetition maximums (bench press, back squat, deadlift), squat jump (SJ), maximal oxygen uptake (VO₂max), ventilatory responses ($\dot{\mathrm{V}}$E), and heart rate (HR). Spearman, Pearson, and partial correlations were calculated with Holm and false discovery rate (FDR) corrections. Results: Males displayed greater body mass, lean and muscle mass, maximal strength, and aerobic capacity than females (all Holm-adjusted p < 0.01). Experienced athletes completed Fran faster than beginners despite broadly similar anthropometric and aerobic profiles. In the pooled sample, WOD time showed moderate negative relationships with estimated 1RM back squat (ρ = −0.54), deadlift (ρ = −0.56), and bench press (ρ = −0.65) before correction; none remained significant after Holm/FDR adjustment, and partial correlations controlling for training years were further attenuated. Conclusions: This exploratory study provides preliminary evidence suggesting that maximal strength may contribute to Fran performance, whereas conventional aerobic measures were less influential. However, given the very small sample (n = 15, 8 males and 7 females) and the fact that no relationships remained statistically significant after correction for multiple testing, the results must be regarded as preliminary, hypothesis-generating evidence only, requiring confirmation in larger and adequately powered studies. Full article

Background: Chronic pain affects nearly one in five adults worldwide and is increasingly recognized not only as a disease but as a potential risk factor for neurocognitive decline and dementia. While some evidence supports this association, existing systematic reviews are static and rapidly outdated, and none have leveraged advanced methods for continuous updating and robust uncertainty modeling. Objective: This protocol describes a living systematic review with dose–response Bayesian meta-analysis, enhanced by artificial intelligence (AI) tools, to synthesize and maintain up-to-date evidence on the prospective association between any type of chronic pain and subsequent cognitive decline. Methods: We will systematically search PubMed, Embase, Web of Science, and preprint servers for prospective cohort studies evaluating chronic pain as an exposure and cognitive decline as an outcome. Screening will be semi-automated using natural language processing models (ASReview), with human oversight for quality control. Bayesian hierarchical meta-analysis will estimate pooled effect sizes and accommodate between-study heterogeneity. Meta-regression will explore study-level moderators such as pain type, severity, and cognitive domain assessed. If data permit, a dose–response meta-analysis will be conducted. Living updates will occur biannually using AI-enhanced workflows, with results transparently disseminated through preprints and peer-reviewed updates. Results: This is a protocol; results will be disseminated in future reports. Conclusions: This living Bayesian systematic review aims to provide continuously updated, methodologically rigorous evidence on the link between chronic pain and cognitive decline. The approach integrates innovative AI tools and advanced meta-analytic methods, offering a template for future living evidence syntheses in neurology and pain research. Full article

Lymphedema is a frequent complication associated with breast cancer treatment. It is estimated that up to 30% of patients undergoing mastectomy develop this condition within 12 to 24 months post-surgery. In Mexico, the limited emphasis placed on lymphedema prevention in breast cancer patients is reflected in the insufficient coverage of this issue within official medical guidelines. In this review, research articles, systematic reviews, and official treatment guidelines were retrieved from PubMed, Google Scholar, Elsevier, SciELO, and Redalyc databases, to examine studies about the application and effectiveness of physiotherapy techniques for the prevention, diagnosis, and treatment of postmastectomy lymphedema. Our findings indicate that complex decongestive therapy (CDT) is considered the first-line treatment for lymphedema. Among its components, compression therapy shows the strongest individual evidence base. Nevertheless, studies consistently demonstrate that the combined use of all four components of CDT (manual lymphatic drainage, compression, skin care, and exercise) results in superior patient outcomes. Despite this, CDT is not routinely implemented as a standard of care for patients following mastectomy and/or lymphadenectomy in Mexico. Therefore, there is a pressing need to promote the inclusion of physiotherapy strategies, particularly CDT, in the prevention and management of postmastectomy lymphedema within national healthcare protocols. Full article

University campuses in rapidly urbanizing regions face increasing pressure to balance infrastructure development with environmental sustainability, yet their carbon storage potential remains largely unexplored in sub-Saharan Africa. This study assessed land use changes, carbon storage dynamics, and economic valuation across three Ghanaian universities, University of Ghana (UG), Kwame Nkrumah University of Science and Technology (KNUST), and University of Cape Coast (UCC), from 2017 to 2023, and evaluated five future scenarios using the InVEST carbon model. Land use analysis employed ESRI 10 m annual land cover data, while carbon storage was estimated using regionally appropriate carbon pool values, and economic valuation applied Ghana’s social cost of carbon ($0.970/tCO₂). Historical analysis revealed substantial carbon losses: UG declined by 17.1% (19,695 Mg C), KNUST by 29.5% (20,063 Mg C), and UCC by 7.9% (3292 Mg C), due to tree cover conversion to built areas. Scenario modeling demonstrated that infrastructure-focused development would cause additional losses of 4211–6891 Mg C, while extensive tree expansion could increase storage by 1686–5227 Mg C. Economic analysis showed tree expansion generating positive net present values ($1612–$5070), while infrastructure development imposed costs (−$4028 to −$6684). These findings provide quantitative evidence for sustainable campus planning prioritizing carbon conservation in tropical institutional landscapes. Full article

Background: Depression is one of the most common mental disorders among undergraduate students, particularly those in medical training, who face high academic demands and emotional burdens. Biological factors such as lipid abnormalities have been proposed as contributors to depressive symptoms, although evidence in this group is scarce. Therefore, we aimed to evaluate the association between triglyceride and total cholesterol levels and depressive symptoms in medical students. Methods: We conducted a cross-sectional study including 219 medical students from a public university in Mexico. Depressive symptoms were assessed using the CESD-7 scale, validated in the Mexican population. Fasting triglyceride and total cholesterol concentrations were measured with the Accutrend Plus analyzer. Prevalence ratios (PRs) and 95% confidence intervals (CIs) were estimated using robust Poisson regression, adjusting for potential confounders. Results: Overall, 38.8% of students presented depressive symptoms. In adjusted continuous models, each 10 mg/dL increase in triglycerides was associated with a 4% higher prevalence of depression (PR = 1.04, 95% CI 1.03–1.06), while each 10 mg/dL increase in total cholesterol was associated with a 13% higher prevalence (PR = 1.13, 95% CI 1.05–1.21). Analyses using clinically relevant cutoffs confirmed these associations: triglycerides ≥ 150 mg/dL (PR = 1.76, 95% CI 1.24–2.48) and cholesterol ≥ 200 mg/dL (PR = 1.66, 95% CI 1.19–2.31). Conclusions: Dyslipidemias may play a relevant role in the mental health of young adults and highlight the importance of incorporating metabolic risk assessment into strategies to prevent and address depression in medical students. Full article

This study examined the impact of organizational capital (OC) on the cost stickiness of Japanese firms and analyzed whether this effect varies with the magnitude of sales changes. Using 12,727 firm-year observations from Tokyo Stock Exchange-listed firms between 2007 and 2024, we estimated the economic value of OC by capitalizing and amortizing selling, general, and administrative (SG&A) expenses, then classified firms into high- and low-OC groups based on the median. Cost stickiness was then compared across groups using the basic, ABJ, and extended models, with robustness checks based on adjusted OC and two-way fixed effects models. The results indicate that high-OC firms exhibit stronger cost stickiness, while low-OC firms display weaker or insignificant stickiness. The effect depends on the magnitude of sales fluctuations: stickiness is pronounced under small changes but diminishes or disappears under larger shocks. Overall, this study contributes by highlighting the role of organizational resources in shaping asymmetric cost behavior, extending explanations beyond adjustment costs or managerial incentives, and providing novel evidence from Japan, where firms generally exhibit cost stickiness regardless of OC level, reflecting institutional and cultural contexts. Full article

This study numerically investigates the effect of hydrofoil installation on the motion responses and ride comfort of a 20 m monohull vessel operating at 10 knots in regular waves. Linear seakeeping analysis (Maxsurf Motions) and nonlinear computational fluid dynamics (CFD) simulations (STAR-CCM+) are performed to compute response-amplitude operators (RAOs); for the bare hull, the two methods agree within 5%, confirming methodological reliability. The CFD results show that hydrofoils reduce heave and pitch amplitudes by approximately 16% on average. Motion Sickness Incidence (MSI) analysis indicates negligible seasickness under Gentle Breeze conditions, even during prolonged exposure; under Moderate conditions, no seasickness is predicted within 30 min across all encounter frequencies. Although linear analysis cannot directly estimate MSI for hydrofoil-fitted cases, the observed reductions in RAOs imply improved ride comfort. Overall, these findings demonstrate that hydrofoils can enhance motion stability and passenger comfort in small, low-speed vessels, providing quantitative evidence to support design applications. Full article

Shiga toxin-producing Escherichia coli (STEC) and enteropathogenic E. coli (EPEC) are E. coli pathovars of particular relevance to infant health. While the intestinal tract of humans and animals constitutes their primary habitat, these bacteria can also persist in natural environments such as sand. The aim of this study was to evaluate the persistence of STEC and EPEC strains in sand microcosms under controlled conditions of heat and desiccation in order to estimate their viability in this matrix and provide evidence regarding the potential risks associated with the use of sandboxes in public spaces. The study included STEC strains belonging to clinically important serotypes (O26:H11, O103:H2, O111:H8, O121:H19, O145:NM, O157:H7 and O174:H28), animal-derived EPEC strains, and a non-pathogenic E. coli strain (NCTC 12900). The strains were inoculated into sterile sand microcosms and maintained at 37 °C. Death curves, persistence in the matrix, presence of virulence genes, and ability to produce biofilm were evaluated. The death and persistence curves varied by serotype; some strains remained viable in the viable but non-culturable state for extended periods. All strains retained their virulence-associated genetic markers throughout the assays. None of the STEC strains was classified as a biofilm producer under the experimental conditions, whereas the two EPEC strains were identified as weak and moderate biofilm producers. However, no association was found between biofilm formation and persistence in the matrix. The findings provide an initial approach and provide relevant evidence of the capacity of STEC and EPEC strains to survive in sand, which could represent a potential risk in recreational environments. Full article

Background and Objectives: The lateral pterygoid muscle (LPM) is typically described as a two-headed muscle within the infratemporal fossa. However, cadaveric and imaging studies have revealed substantial variability in the number of heads, insertion patterns, and relations to neurovascular structures. Materials and Methods: An observational study of 250 brain computed tomography angiographies (CTAs) was performed to assess LPM morphology. Additionally, a systematic review and meta-analysis were conducted in accordance with PRISMA 2020 and Evidence-based Anatomy guidelines. Pooled prevalence estimates were calculated with random-effects models. Results: The current study included 250 CTAs for the original study and 1702 muscles for the meta-analytic evidence. During the original study, the two-headed configuration was most common (74.4%), followed by three-headed (14%), one-headed (10.8%), and four-headed (0.8%) morphologies. Symmetry was observed in 75.2% of patients. Meta-analysis confirmed the predominance of the two-headed type (73.98%, 95% CI: 68.22–79.38), with three-headed (16.82%), one-headed (4.37%), and four-headed (<0.01%) variants occurring less frequently. Subgroup analyses showed no significant differences by study type or sample size, though European populations exhibited a higher prevalence of one-headed forms. Conclusions: The LPM demonstrates considerable morphological variability, extending beyond the traditional two-headed model. Recognition of these variants is essential for understanding temporomandibular joint function, interpreting imaging, and planning surgical or interventional procedures within the infratemporal fossa. Advanced imaging provides a reliable tool for individualized anatomical assessment, supporting safer clinical practice. Full article

Atmospheric sulfur (S) deposition, a key component of acid deposition, poses risks to ecosystems, human health, and sustainable development. In China, decades of coal-dominated energy use caused severe S pollution, but recent emission-control policies and energy restructuring have sought to reverse this trend. However, the effectiveness and regional differences in these measures remain insufficiently quantified. Here, we combined continuous observations from 43 monitoring sites (2013–2023), satellite-derived SO₂ vertical column density, and multi-source environmental datasets to construct a high-resolution record of wet S deposition. A random forest model, validated with R² = 0.52 and RMSE = 1.2 kg ha⁻¹ yr⁻¹, was used to estimate fluxes and spatial patterns, while ridge regression and SHAP analysis quantified the relative contributions of emissions, precipitation, and socioeconomic factors. This framework allows us to assess both the environmental and health-related sustainability implications of sulfur deposition. Results show a nationwide decline of more than 50% in wet S deposition during 2013–2023, with two-thirds of sites and 95% of grids showing significant decreases. Historical hotspots such as the North China Plain and Sichuan Basin improved markedly, while some southern provinces (e.g., Guizhou, Hunan, Jiangxi) still exhibited high deposition (>20 kg ha⁻¹ yr⁻¹). Over 90% of the reduction was attributable to emission declines, confirming the dominant effect of sustained policy-driven measures. This study extends sulfur deposition records to 2023, demonstrates the value of integrating ground monitoring with remote sensing and machine learning, and provides robust evidence that China’s emission reduction policies have delivered significant environmental and sustainability benefits. The findings offer insights for region-specific governance and for developing countries balancing economic growth with ecological protection. Full article

Air pollution from fine particulate matter (PM2.5) is a recurring crisis in Northern Thailand, largely driven by seasonal biomass burning. This study investigates how socioeconomic and individual characteristics shape labor allocation during high-exposure periods. Using survey data from 400 individuals across eight provinces in April–May 2024, we applied a logit model to estimate the probability of reducing work hours. Results show heterogeneous and non-linear patterns of avoidance. The probability of work reduction rose across higher income strata but peaked in the third stratum before declining in the fourth, reflecting the trade-off between avoidance and the opportunity cost of foregone earnings. Education exhibited a strong awareness effect, with each additional year increasing avoidance behavior. Outdoor workers and individuals with respiratory conditions were most likely to reduce work, indicating rational prioritization under greater exposure risks. Together, these findings demonstrate environmental inequality: lower-income and less-educated groups remain disproportionately exposed due to limited coping capacity. The regional context of Northern Thailand further amplifies these vulnerabilities. Policy interventions should prioritize protective measures for vulnerable groups while promoting long-term alternatives to biomass burning. By highlighting nuanced behavioral responses, this study extends evidence on environmental inequality in developing-country contexts. Full article

The lack of research on the slip behavior of the NW-trending faults in the central Tibetan Plateau constrains our understanding of the deformation models for this region. The Ba Co Fault, located in the central Tibetan Plateau, is a NW–SE-trending right-lateral strike-slip fault. Its eastern section has been active in the Holocene and plays an important accommodating role in the northward compression and east–west extension of the Tibetan Plateau. This study presents a detailed analysis of the geomorphic features of the eastern section of the Ba Co Fault in the Ngari Prefecture of Tibet, precisely measuring the newly discovered surface rupture zone on its eastern side and preliminarily discussing the activity of the fault based on the optically stimulated luminescence (OSL) dating results. The results reveal that the eastern segment of the Ba Co Fault displays geomorphic evidence of offset, including displaced Holocene alluvial–fluvial fans at the mountain front and partially offset ridges. A series of pressure ridges, trenches, counter-slope scarps, and shutter ridge ponds have developed along the fault trace. Some gullies exhibit a cumulative dextral displacement of approximately 16–52 m. The newly discovered co-seismic surface rupture zone extends for a total length of ~21 km, with a width ranging from 30 to 102 m. Pressure ridges within the rupture zone reach heights of 0.3–5.5 m, while trenches exhibit depths of 0.6–15 m. Optically stimulated luminescence (OSL) dating constrains the timing of the surface-rupturing earthquake to after 5.73 ± 0.17 ka. The eastern segment of the Ba Co Fault experienced a NW-trending compressional deformation regime during the Holocene, manifesting as a transpressional dextral strike-slip fault. Magnitude estimation indicates that this segment possesses the potential to generate earthquakes of M ≥ 6. The regional tectonic analysis indicates that the activity of the eastern section of the Ba Co Fault is related to the shear model of the conjugate strike-slip fault zone in the central Tibetan Plateau and may play a boundary role between different shear zones. Full article

The first comprehensive mass balance estimation for the world’s largest tropical icefield is presented. Geodetical mass balance was calculated using photogrammetry from aerial and satellite images spanning from 1955 to 2024. The results meet expected quality standards using some new satellite sources, such as the Peruvian PeruSAT-1, although the quality of airborne imagery is consistently lower than that of satellite sources. The Nevado Coropuna icefield remained almost stable between 1955 and 1986 with −0.04 m dh yr⁻¹. Since then, it has undergone a sustained and accelerated negative mass balance, reaching a maximum annual dh yr⁻¹ of −0.73 ± 0.19 in the 2020–2023 timeframe. The glacier loss is not equal across the entire ice mass, but more acute in the northern and northeastern outlet tongues. Debris-covered ice and rock glaciers show a much weaker negative mass balance signal. The impact of ENSO events is not evident in the overall ice evolution, although their long-term relevance is acknowledged. Overall, the negative response of Nevado Coropuna to global warming (−0.36 ± 0.12 m.w.e. yr⁻¹ for the 2013 to 2024 period) is less pronounced than that of other Peruvian glaciers, but more severe than that reported for the nearby Dry Andes of Chile and Argentina. Full article