Prevention and Treatment of Postmastectomy Lymphedema: A Physiotherapy Perspective
Simple Summary
Abstract
1. Introduction
2. Methods
3. Lymphedema: An Underlying Issue
The Lymphatic System: Functions and Significance
4. Lymphedema Pathophysiology: Essential Concepts
5. Diagnosis
- Stage 0 (Latency/Asymptomatic): no visible swelling, but patients may report tingling, heaviness, or fatigue in the limb.
- Stage 1 (Mild): early swelling due to protein-rich interstitial fluid. Pitting edema is present, but reversible with treatment or arm elevation; no permanent tissue damage has occurred.
- Stage 2 (Moderate): persistent swelling not relieved by elevation; pitting is absent. Tissue changes (inflammation, fibrosis, thickening) develop and are irreversible, although treatment can control progression.
- Stage 3 (Severe/Advanced): marked enlargement, fibrosis, and skin hardening. Elephantiasis may be observed in this stage.
6. Prevention
7. Treatment
7.1. Manual Lymphatic Drainage
7.2. Vodder Method
- Fixed circles: fingers (excluding the thumb) are placed on the skin surface without pressure, performing a circular movement that gradually stretches the skin.
- Pumping: the hand is positioned perpendicular to the treated area, with full palmar contact, applying a forward thrust.
- Scoop (“Giving”): the hand is placed crosswise on the treated area, and with joints extended, a turning and pushing motion is performed.
- Rotational: the hand is laid flat with the thumb at a 90° angle; a gentle twisting pressure is applied toward the little finger.
7.3. Leduc’s Method
- Call maneuver: stimulates lymphatic collectors; pressure is applied progressively with shoulder abduction–adduction.
- Ganglionic maneuver: mobilizes lymph nodes; circular movements combined with compression–decompression enhance nodal clearance.
- Reabsorption maneuver: facilitates lymph evacuation from the edematous area; similar to the call maneuver but performed with different manual positioning.
7.4. Godoy and Godoy Method:
- Manual lymphatic drainage (MLD): gentle maneuvers designed to stimulate lymph uptake by capillaries for subsequent transport and evacuation.
- Mechanical lymphatic therapy: use of mechanical devices to stimulate lymphatic flow.
- Exercises and myolymphokinetic activities: the method distinguishes between daily activities (routine actions performed by the patient) and structured exercises (specific movements with repetitions and sets).
- Cervical stimulation: gentle, superficial back-and-forth thumb movements in the supraclavicular fossa to stimulate lymphatic drainage.
- Compression therapy: custom-made garments of gorgurão fabric, valued for their adjustability during the intensive treatment phase, accommodating changes in edema volume. However, this fabric is difficult to obtain in Mexico, as it must be imported from Brazil, increasing treatment costs.
7.4.1. Pneumatic Pressure Therapy
7.4.2. External Compression Devices
- Multilayer bandaging: low-stretch bandages are applied from distal to proximal, creating a decreasing pressure gradient that promotes lymph flow (Laplace’s law). When combined with MLD, pressure gradients follow the same drainage pathway. Bandages are worn continuously during the intensive phase, then replaced by compression sleeves in the maintenance phase. Although effective, multilayer bandaging can be bulky and uncomfortable, requiring patient lifestyle adaptations. It is contraindicated in cases of infection, neuropathy, pain, sensory disorders, or vascular compromise. Application must be performed by trained professionals to ensure proper pressure gradients and avoid complications.
- Elastic compression sleeves: recommended for the maintenance phase. Sleeves are easier to use and better tolerated in daily life but less effective for rapid volume reduction compared with bandaging.
7.5. Compression Sleeves
7.6. Lymphokinetic Exercises
7.7. Other Methods for the Treatment of Lymphedema
7.8. Surgical Methods
8. Discussion
9. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Author (Year) | Objective | Subjects | Level of Prevention | Conclusions |
---|---|---|---|---|
Torres (2010) [18] | To evaluate the efficacy of an early physiotherapy program for the prevention of lymphedema in women undergoing breast surgery with lymphadenectomy. | 116 women | Secondary prevention | Early physiotherapy could be an effective measure to prevent lymphedema in patients treated with breast surgery with lymphadenectomy, in the first year after surgery. |
Stout et al. (2012) [19] | To propose a surveillance model for post-mastectomy patients during the preoperative, immediate postoperative, and survival periods to identify disabilities and limitations associated with breast cancer treatment. | Secondary prevention | The implementation of the care model allows planning the functional rehabilitation of the patient, preventing sequelae. | |
Forner (2003) [20] | To develop and apply a questionnaire to analyze the quality of information that patients receive after surgery in relation to lymphedema and the consequences of breast cancer. | 65 patients | Secondary prevention | Few post-mastectomy patients receive information about the risk of developing lymphedema and its prevention, the content of which is poor and nonspecific. |
Fenglian et al. (2020) [21] | To establish a scoring system to predict the risk of breast-cancer-related lymphedema. | 533 patients | Secondary prevention | The predictive efficiency and accuracy of the scoring system were acceptable, and the system could be used to predict and evaluate groups at high risk of breast-cancer-related lymphedema. |
McNeely et al. (2010) [22]. | To collect information and compare findings regarding the effectiveness of interventions to prevent, minimize, or improve upper limb dysfunctions due to breast cancer treatment. | 24 studies | Secondary prevention | Upper limb exercise is helpful in regaining upper limb movement after breast cancer surgery. Structured exercise programs during the first few weeks after surgery are beneficial for regaining movement. |
Boccardo, et al. (2009) [23] | To evaluate the effectiveness of teaching preventive measures for the management of lymphedema. | 55 patients | Secondary prevention | The population was divided into two groups. The group that received teaching on care, reduction in risk factors, and timely diagnosis of lymphedema had a lower incidence of cases. |
Devoogdt, et al. (2011) [24]. | To evaluate the short- and long-term effects of cancer treatment in terms of the impact they have on shoulder mobility and the appearance of lymphedema. | 77 patients | Secondary prevention | Over time, a significant number of the population continue to suffer from mobility problems and lymphedema has increased detrimentally. |
Josephine (2019) [25] | To evaluate a protocol for the prevention of lymphedema and quality of life in patients with mastectomy. | 120 patients | Secondary prevention | The comparison of the quality of life between the study group and the control group was statistically significant for the improvement in quality of life, preventing the appearance of lymphedema. |
Author (Year) | Applied Technique | Objective | Theoretical Basis | Application and Results |
---|---|---|---|---|
McNeely, et al., (2010) [22] | Multilayer compression bandage Manual lymphatic drainage | To evaluate the efficacy of multilayer compression bandaging with and without manual lymphatic drainage. | Volume reduction by means of compression bandaging acts exclusively on the fluid and not on the proteins concentrated in the subcutaneous tissue, a function that is important to perform by means of DLM. | Lymphedema decreased in both cases without significant differences. |
Badger, et al. (2000) [30] | Compression therapy: Compression sleeve Multilayer bandage. | To compare the effect of multilayer bandaging as an initial phase of lymphedema treatment followed by a compression sleeve, vs. the exclusive use of a compression sleeve. | Multilayer bandaging as the initial phase of treatment for patients with lymphedema, followed by stockings, achieves a greater and more sustained reduction in limb volume than sleeves alone. | In the combined treatment group, there was a two-fold reduction in volume compared to the group that used the compression sleeve alone. |
Todd (2008) [31] | Therapeutic exercise. | To evaluate the benefits of shoulder mobilization in the immediate postoperative period. | It is preferable to perform restricted mobility exercises within the immediate postoperative period to avoid complications associated with the recovery process following surgery. | Patients who performed restricted exercise during the first two weeks after surgery had fewer complications. |
Zasadzka et al. (2018) [32] | Complex decongestive therapy Multilayer compression bandage. | To compare the effectiveness of using multilayer bandage and complex decongestive therapy. | Multilayer compression bandage is an element of CDT, its isolated use saves treatment costs and therapy time, with favorable volume reduction benefits. | Multilayer bandaging is essential for TDC, which alone can provide the desired results such as volume reduction. |
Luz et al. (2018) [33] | Complex decongestive therapy | To compare a complex decongestive therapy protocol alone or combined with muscle strength training in patients with lymphedema. | Studies suggest that patients with lymphedema should not perform high-intensity exercise. However, other studies have shown that properly guided strength exercises can help reduce lymphedema. | There was no difference in limb volume. Patients with lymphedema can safely perform strengthening exercises without the risk of increasing the volume of the edema-affected upper limbs. |
Cruz-Ramos et al. (2017) [34] | Complex decongestive therapy | To evaluate the effects of CDT for reducing limb volume in lymphedema. | Intensive phase treatment was carried out for five days, covering all the elements of CDT. | CDT helps to reduce the volume of the limb with lymphedema, despite having a short intervention period. |
Huang et al. (2013) [35] | Manual lymphatic drainage | To conduct a systematic review of randomized controlled trials to assess the efficacy of MLD in preventing and treating breast-cancer-related lymphedema. | DLM, in conjunction with skin care, exercise, and compression bandaging, provides optimal management of lymphedema. | Current evidence does not support the use of MLD to prevent or treat lymphedema. However, methodological inconsistencies were found in the studies analyzed. |
Liang et al. (2020) [36] | Manual lymphatic drainage | To summarize the current evidence to assess the effectiveness of MLD in preventing and treating lymphedema in patients after breast cancer surgery. | Studies have shown that DLM has a beneficial effect on lymphedema related to breast cancer surgery. | DLM may not have any isolated effect for the prevention and treatment of lymphedema. Further research should be carried out as there was no adequate level of evidence to prove whether it is effective or not. |
Medina et al. (2019) [37] | Manual lymphatic drainage | To identify and describe the presence of collateral drainage areas and pathways, using lymphofluoroscopy with indocyanine green, in patients with secondary lymphedema of the upper limbs after breast cancer, treated with DLM. | Manual lymphatic drainage appears to stimulate lymphatic contraction, helping the development of secondary pathways and stimulating the appearance of collateral pathways that could function as the main drainage pathways of the limb in cases of lymphedema. | Additional pathways were observed after MLD, the use of lymphofluoroscopy techniques with indocyanine green is a useful tool to know the effective drainage pathways in lymphedema secondary to cancer treatment. |
Ochalek et al. (2017) [38] | Compression sleeve | To evaluate the role of compression sleeves in the prevention and management of post-mastectomy lymphedema. | The use of compression media facilitates lymph flow. The compression sleeve is an easily accessible device for the patient, and its daily use facilitates lymph flow. | The use of compression sleeves is a safe and effective option to prevent post-mastectomy lymphedema, especially between 3 and 12 months after use. |
Damstra and Partsch (2019) [39] | Multilayer bandage | To determine whether there is a difference in results between low- and high-pressure multilayer bandages, in relation to volume reduction and patient tolerance to the bandage. | Using low pressure generates better adherence to the treatment since it is better tolerated by the patient. | The low pressure group had better results in terms of volume reduction and better pressure tolerance. |
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León-Díaz, R.; Medina-Otero, A. Prevention and Treatment of Postmastectomy Lymphedema: A Physiotherapy Perspective. Curr. Oncol. 2025, 32, 555. https://doi.org/10.3390/curroncol32100555
León-Díaz R, Medina-Otero A. Prevention and Treatment of Postmastectomy Lymphedema: A Physiotherapy Perspective. Current Oncology. 2025; 32(10):555. https://doi.org/10.3390/curroncol32100555
Chicago/Turabian StyleLeón-Díaz, Rosalba, and Andrea Medina-Otero. 2025. "Prevention and Treatment of Postmastectomy Lymphedema: A Physiotherapy Perspective" Current Oncology 32, no. 10: 555. https://doi.org/10.3390/curroncol32100555
APA StyleLeón-Díaz, R., & Medina-Otero, A. (2025). Prevention and Treatment of Postmastectomy Lymphedema: A Physiotherapy Perspective. Current Oncology, 32(10), 555. https://doi.org/10.3390/curroncol32100555