Search Results (511)

Plant genetics and chemotaxonomic analysis are considered key parameters in understanding evolution, plant diversity and adaptation. Korean Peninsula has a unique biogeographical landscape that supports various aromatic plant species, each with considerable ecological, ethnobotanical, and pharmacological significance. This review aims to provide a comprehensive overview of the chemotaxonomic traits, biological activities, phylogenetic relationships and potential applications of Korean aromatic plants, highlighting their significance in more accurate identification. Chemotaxonomic investigations employing techniques such as gas chromatography mass spectrometry, high-performance liquid chromatography, and nuclear magnetic resonance spectroscopy have enabled the identification of essential oils and specialized metabolites that serve as valuable taxonomic and diagnostic markers. These chemical traits play essential roles in species delimitation and in clarifying interspecific variation. The biological activities of selected taxa are reviewed, with emphasis on antimicrobial, antioxidant, anti-inflammatory, and cytotoxic effects, supported by bioassay-guided fractionation and compound isolation. In parallel, recent advances in phylogenetic reconstruction employing DNA barcoding, internal transcribed spacer regions, and chloroplast genes such as rbcL and matK are examined for their role in clarifying taxonomic uncertainties and inferring evolutionary lineages. Overall, the search period was from year 2001 to 2025 and total of 268 records were included in the study. By integrating phytochemical profiling, pharmacological evidence, and molecular systematics, this review highlights the multifaceted significance of Korean endemic aromatic plants. The conclusion highlights the importance of multidisciplinary approaches including metabolomics and phylogenomics in advancing our understanding of species diversity, evolutionary adaptation, and potential applications. Future research directions are proposed to support conservation efforts. Full article

Wild edible fruit plants are integral to the cultural, nutritional, medicinal, and economic practices of Indigenous Isan communities in Roi Et Province, northeastern Thailand, a region characterized by plateau and lowland topography and a tropical monsoon climate. This study aimed to document the diversity, traditional uses, phenology, and conservation status of these species to inform sustainable management and conservation efforts. Field surveys and ethnobotanical interviews with 200 informants (100 men, 100 women; random ages) were conducted across 20 local communities to identify species diversity and usage patterns, while phenological observations and conservation assessments were performed to understand reproductive cycles and species vulnerability between January and December 2023. A total of 68 species from 32 families were recorded, with peak flowering in March–April and fruiting in May–June. Analyses of Species Use Value (0.19–0.48) and Relative Frequency of Citation (0.15–0.44) identified key species with significant roles in food security and traditional medicine. Uvaria rufa had the highest SUV (0.48) and RFC (0.44). Informant consensus on medicinal applications was strong for ailments such as gastrointestinal and lymphatic disorders. Economically important species were also identified, with some contributing notable income through local trade. Conservation proposed one species as Critically Endangered and several others as Vulnerable. The results highlight the need for integrated conservation strategies, including community-based initiatives and recognition of Other Effective area-based Conservation Measures (OECMs), to ensure the preservation of biodiversity, traditional knowledge, and local livelihoods. Full article

The Aedes aegypti mosquito, vector of dengue, is a major public health threat in the Caribbean. In Guadeloupe, where dengue outbreaks occur frequently, traditional plant-based remedies are part of the local heritage but remain poorly documented. This study aimed to evaluate the anti-mosquito potential of 38 Guadeloupean plants through an ethnobotanical survey. A semi-structured online questionnaire was conducted over five months, targeting the plant knowledge of residents. Inclusion/exclusion criteria were applied to identify and validate relevant species. Ethnobotanical indices such as Frequency of Citation (FC), Fidelity Level (FL), and Relative Frequency of Citation (RFC) were calculated. Out of the 38 surveyed plants, 22 were confirmed for their traditional anti-mosquito uses. The most cited species included Cymbopogon citratus (93.3%), Artocarpus altilis (25%), and Pimenta racemosa (18.3%). Comparative analysis with existing literature showed that 12 of these plants had not been previously reported for vector control. This highlights the value of ethnobotanical approaches for discovering alternative, eco-friendly vector control options and the importance of preserving traditional knowledge. The study reveals both the high potential of Guadeloupean flora and the risk of cultural erosion, supporting further research into the bioactive compounds of the most cited species. Full article

The Bignoniaceae family encompasses numerous species of ecological, medicinal, and cultural significance, yet its ethnobotanical value remains underexplored in many regions of Thailand. This study investigates the diversity, phenology, cultural relevance, and traditional uses of Bignoniaceae species in Maha Sarakham Province, Northeastern Thailand. Through semi-structured interviews with 260 local informants across 13 districts—alongside field observations and herbarium voucher collections—we documented 27 species across 21 genera. These integrated methods enabled the identification of key culturally significant species and provided insights into their traditional uses. Phenological data revealed clear seasonal patterns in flowering and fruiting, aligned with the regional climatic cycle. Quantitative ethnobotanical indices—including Species Use Value (SUV), Genera Use Value (GUV), Relative Frequency of Citation (RFC), Cultural Importance Index (CI), and Cultural Food Significance Index (CFSI)—were employed to evaluate species significance. Results indicate that species such as Dolichandrone serrulata, D. spathacea, and Oroxylum indicum hold high cultural and practical value, particularly in traditional medicine, spiritual practices, and local landscaping. These findings underscore the critical role of Bignoniaceae in sustaining biocultural diversity and emphasize the urgency of preserving traditional botanical knowledge amid environmental and socio-economic change. Moreover, the insights contribute to broader efforts in cultural heritage preservation and biodiversity conservation across tropical and subtropical regions. Full article

Pain is a protective mechanism that can be classified into acute and chronic types. Ayahuasca is a psychoactive brew rich in dimethyltryptamine or DMT (a 5-HT_2A receptor agonist), and harmine (a monoamine-oxidase (MAO) inhibitor) used for religious and therapeutic purposes. Previous preclinical and anecdotal evidence suggests that ayahuasca and its compounds have antinociceptive and anti-inflammatory effects due to 5-HT_2A agonism and MAO inhibition. Thus, the current study aims to provide a systematic review of the antinociceptive and anti-inflammatory effects of ayahuasca and its alkaloids in preclinical models. All studies published up to December 2024 were screened and evaluated for eligibility. A total of 1535 publications were identified, of which 29 adhered to the predefined criteria. Reviewed articles reported antinociceptive effects of ayahuasca, harmine, and harmaline. Regarding anti-inflammatory effects, the compounds of ayahuasca, especially harmine, have demonstrated a reduction and an increase in pro-inflammatory and anti-inflammatory cytokines, respectively. Although there are promising results regarding the antinociceptive and anti-inflammatory effects of ayahuasca and its alkaloids, further investigation is needed. Full article

Bulgarian botanical gardens harbor more than 3600 plant species from across the world. Some of them are well-known plants widely used by humans, others are underutilized crops or little-known exotic species. The latter group constitutes a rich reservoir of plant resources whose potential to bring benefits to society is still untapped. The aim of this review is to describe the diversity of species and their potentially valuable secondary metabolites in three of the largest Bulgarian botanical gardens, with a focus on underutilized crops and medicinal plants that are typical of Bulgaria. With this, we aim to pave the way for future research on the most promising of these plants. The report includes currently available ethnobotanical data on the properties and composition of their bioactive components, known culinary or therapeutic uses, and nutritional profiles. We also outline the vast potential of these plants in providing healthy diets, as well as for performing future groundbreaking biomedical research. Finally, we present the approach that will be used to screen extracts from these plants for biological activity. Full article

Gastrodia elata, known as Tianma in Chinese, is a valuable medicinal and nutritional resource. The favorable climate of Zhaotong City, Yunnan Province, China, facilitates its growth and nurtures rich biocultural diversity associated with Tianma in the region. Local people not only cultivate Tianma as a traditional crop but have also developed a series of traditional knowledge related to its cultivation, processing, medicinal use, and culinary applications. In this study, field surveys employing ethnobotanical methods were conducted in Yiliang County, Zhaotong City, from August 2020 to May 2024, focusing on Tianma. A total of 114 key informants participated in semi-structured interviews. The survey documented 23 species (and forms) from seven families related to Tianma cultivation. Among them, there were five Gastrodia resource taxa, including one original species, and four forms. These 23 species served as either target cultivated species, symbiotic fungi (promoting early-stage Gastrodia germination), or fungus-cultivating wood. The Fagaceae family, with 10 species, was the most dominant, as its dense, starch-rich wood decomposes slowly, providing Armillaria with a long-term, stable nutrient substrate. The cultural importance (CI) statistics revealed that Castanea mollissima, G. elata, G. elata f. flavida, G. elata f. glauca, G. elata f. viridis, and Xuehong Tianma (unknown form) exhibited relatively high CI values, indicating their crucial cultural significance and substantial value within the local community. In local communities, traditionally processed dried Tianma tubers are mainly used to treat cardiovascular diseases and also serve as a culinary ingredient, with its young shoots and tubers incorporated into dishes such as cold salads and stewed chicken. To protect the essential ecological conditions for Tianma, the local government has implemented forest conservation measures. The sustainable development of the Tianma industry has alleviated poverty, protected biodiversity, and promoted local economic growth. As a distinctive plateau specialty of Zhaotong, Tianma exemplifies how biocultural diversity contributes to ecosystem services and human well-being. This study underscores the importance of biocultural diversity in ecological conservation and the promotion of human welfare. Full article

Traditional medicinal plants are valued for their therapeutic potential, yet the full spectrum of their bioactive compounds often remains underexplored. Recent advances in multiomics technologies, including metabolomics, proteomics, and transcriptomics, combined with in vitro culture systems and elicitor-based strategies, have revolutionized our ability to characterize and enhance the production of valuable secondary metabolites. This review synthesizes current findings on the integration of these approaches to help us understand phytochemical pathways optimising bioactive compound yields. We explore how metabolomic profiling links chemical diversity with antioxidant and antimicrobial activities, how proteomic insights reveal regulatory mechanisms activated during elicitation, and how in vitro systems enable controlled manipulation of metabolic outputs. Both biotic and abiotic elicitors, such as methyl jasmonate and salicylic acid, are discussed as key triggers of phytochemical defense pathways. Further, we examine the potential of multiomics-informed metabolic engineering and synthetic biology to scale production and discover novel compounds. By aligning traditional ethnobotanical knowledge with modern biotechnology, this integrative framework offers a powerful avenue to unlock the pharmacological potential of medicinal plants for sustainable and innovative therapeutic development. Full article

One of the medicinal plants used in Ecuador that has the best prospects for industrialization is guayusa (Ilex guayusa Loes.). This review shows the potential of the species, analyzing the ethnobotanical aspects, ancestral uses, secondary metabolites, and research. The plant has been consumed for thousands of years by the high Amazonian peoples of Ecuador and currently forms part of the gardens of ancestral peoples and mestizo settlers. The most relevant secondary metabolites that have been investigated are xanthine alkaloids, terpenes, and phenolic compounds, while from the pharmacological point of view, the following uses stand out: physical and mental stimulants, analgesic, antioxidant, antimicrobial, anti-inflammatory, anti-diabetic, and phytohormonal. The goal of this review is to make known the benefits of guayusa, with the purpose of representing a resource that will provide benefits to the Amazonian inhabitants in the future. Full article

Mediterranean countries represent a dynamic hub of cultural exchange, where wild plants play a significant role in culinary traditions. A substantial number of these plants belong to the Asteraceae family. The climate similarities across the region contribute to the common distribution ranges of the plants. While many species are widely distributed, others are confined to specific subregions, such as the western Mediterranean, eastern Mediterranean, or North Africa. Only six taxa of the traditionally consumed wild Asteraceae plants are endemic to just one country. This review focuses on wild plants from the Asteraceae family traditionally used as food across 13 study sites, comprising 11 countries in the Mediterranean and adjacent territories, including both mainland areas and three islands. The objective is to identify and analyze patterns of native distribution in relation to actual consumption. As a result, 167 edible wild plants from the Asteraceae family were identified. Their patterns of distribution and consumption are described and analyzed. The highest number of these edible wild plants from the Asteraceae family is consumed in Spain (n = 65), followed by southern Italy (n = 44) and Morocco (n = 32). A similar pattern of consumption is seen in Turkey (n = 24), Sicily (n = 23), Jordan and Palestine (n = 21), and Bulgaria (n = 21). It is notable that 106 plants are used as food in one particular country only, although most of them are distributed in several other countries. Many of the species consumed in certain countries are not used by neighboring populations, highlighting a limited cross-border transmission of ethnobotanical knowledge. The findings from a Jaccard index statistical analysis are discussed. Full article

Plants have historically served as key sources of nutrition and popular medicine, which persists in current applications. The increasing demand for natural bioactive compounds has intensified the incorporation of plant-derived ingredients in both the food and pharmaceutical industries. This narrative review focuses on the fruits of Crataegus monogyna Jacq., Sorbus aria (L.) Crantz, and Prunus spinosa L. (Rosaceae), traditionally utilized in Europe and characterized by a high content of phenolic compounds, flavonoids, and anthocyanins. These metabolites are associated with antioxidant, anti-inflammatory, and cardioprotective properties. The available literature on their phytochemical profiles, biological activities, and integration into the Mediterranean Diet is critically assessed. Evidence supports their potential as functional food components. Despite encouraging in vitro results, the scarcity of in vivo and clinical studies limits the translational potential of these findings. Further research is warranted to validate their efficacy and safety in human health. This review underscores the value of integrating traditional ethnobotanical and ethnopharmacological knowledge with contemporary scientific research to explore novel applications of these underutilized wild fruits. Full article

Elsholtzia blanda (Benth.) Benth. (EBB) is a traditional plant in Nepal with bioactive properties, including antioxidant, cytotoxic, and antitumor activities. In this study, a methanol EBB extract was tested to evaluate the anti-inflammatory effect against lipopolysaccharide (LPS)-induced microglial (BV2) cells. EBB effectively suppressed LPS-induced nitric oxide production and inhibited the secretion of proinflammatory cytokines such as tumor necrosis factor-alpha (TNF-α) and interleukin (IL)-6. In LPS-stimulated BV2 cells, EBB significantly inhibited inducible nitric oxide synthase (iNOS), TNF-α, IL-6, IL-1β, IL-8, IL-18, and IL-10 mRNA expression in a concentration-dependent manner. In particular, EBB significantly reduced the protein expression of iNOS and cyclooxygenase-2, which were upregulated by LPS. Further, EBB could alleviate the inflammatory response in microglia by suppressing the phosphorylation of mitogen-activated protein kinases. EBB also attenuated LPS-induced reactive oxygen species (ROS) in BV2 cells. In addition, EBB enhanced heme oxygenase-1 (HO-1) protein and mRNA expression. The present results show that an EBB extract could effectively suppress the neuroinflammatory response induced by LPS in BV2 cells. Accordingly, an EBB extract is a promising preventive agent against diseases involving neuroinflammatory responses. Full article

Erica species native to the Mediterranean basin are the principal Ericas that have found use in traditional medicine. Examples include treatments for urinary tract disorders, inflammatory conditions, gastrointestinal ailments and weight loss. This review critically evaluates the ethnobotanical usage, phytochemical profiles and pharmacological potential of the Mediterranean Erica species, including Erica arborea L., Erica multiflora L. and Erica manipuliflora Salisb. A wide spectrum of bioactive secondary metabolites has been identified across these species, notably pentacyclic triterpenes (e.g., lupeol, ursolic acid and oleanolic acid) and polyphenolics (e.g., myricetin and quercetin glycosides). Extracts of these species have demonstrated antioxidant, anti-inflammatory, analgesic, antimicrobial and diuretic activities in vitro and/or in vivo, providing pharmacological support for traditional uses. Phytochemical profiles vary by species, plant part, geography and extraction technique. Filsuvez^®, comprising pentacyclic triterpenes from birch bark, has clinical approval for the treatment of partial thickness wounds associated with dystrophic and junctional epidermolysis bullosa. The undoubted reservoir of pentacyclic triterpenes and flavonoid glycosides in Mediterranean Erica species warrants further comprehensive mechanistic studies, toxicological evaluations and clinical validation. Full article

Ethnobotanical knowledge and biodiversity are critical components of sustainable natural resource management, especially in regions undergoing rapid environmental and socio-economic change. In Northeast Thailand, traditional plant knowledge is deeply intertwined with local cultural identity but faces increasing threats from urbanization, agricultural expansion, and generational shifts. This study presents a floristic and ethnobotanical survey of the Khanthararat Public Benefit Forest, a community-managed remnant forest in Maha Sarakham Province, documenting 110 plant species from 42 families. The Fabaceae family was the most diverse, consistent with other tropical ecosystems. Predominantly native species (85.45%) indicate minimal disturbance, while introduced (11.82%) and endemic species (2.73%) reflect ecological complexity. Ethnobotanical data revealed 34 wild edible species, 33 medicinal plants, and 19 ornamental species used by the local community, highlighting the forest’s vital role in supporting livelihoods and cultural practices. High Use Values (UVs) for species such as Spondias pinnata and Coccinia grandis underline their dual importance in food and medicine. Informant Consensus Factor (Fic) values demonstrate strong agreement on plant use for reproductive and musculoskeletal health, reflecting well-established traditional knowledge. The findings underscore the forest’s dual significance as an ecological hotspot and a repository of cultural heritage, providing essential ecosystem services including biodiversity conservation, climate regulation, and cultural provisioning. By integrating traditional knowledge with biodiversity assessment, this study offers valuable insights for community-based conservation strategies that sustain both ecological integrity and cultural resilience in Northeast Thailand. Full article

Indigenous top-priority fruit trees, like Vangueria infausta subsp. infausta. Burch (wild medlar), are essential for food security, climate resilience, and biodiversity. However, they remain underutilized due to limited documentation and integration into agricultural systems. This study presents the first ethnobotanical assessment of the wild medlar in Oyemeni, northeastern KwaZulu-Natal, South Africa. Surveys and interviews were conducted with 100 rural participants to explore its traditional uses, commercialization potential, and knowledge transmission. The findings reveal that the fruit is widely used in porridges, juices, and traditional beer, offering nutritional benefits such as vitamin C. Medicinally, it is valued for promoting oral health, wound healing, and spiritual protection. However, traditional knowledge is declining, particularly among the youth, due to generational shifts and modernization. The study highlights sustainable commercialization opportunities, such as value-added products and agroforestry integration, while emphasizing the need to preserve indigenous knowledge. These findings contribute to food security, biodiversity conservation, and cultural preservation in a changing socio-economic landscape. Future research should focus on biochemical evaluation of the plant’s medicinal properties and cross-regional comparisons. Full article