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Search Results (14,117)

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14 pages, 491 KB  
Review
Health Impacts of Chronic Radiation Exposure in Northern Kazakhstan: A Comprehensive Epidemiological Review
by Polat Kazymbet, Kuralay Ilbekova, Elena Saifulina, Mulkat Yelshenbek, Yerlan Kashkinbayev, Danara Ibrayeva, Moldir Aumalikova, Dinara Bizhanova, Yerbol Dogalbayev and Meirat Bakhtin
Cancers 2026, 18(9), 1404; https://doi.org/10.3390/cancers18091404 - 28 Apr 2026
Abstract
Chronic exposure to ionizing radiation from uranium legacy sites remains a significant public health concern in Northern Kazakhstan. This review evaluates epidemiological, clinical, and environmental evidence published between 2000 and 2025, with particular emphasis on studies conducted during 2014–2023 in the Stepnogorsk region [...] Read more.
Chronic exposure to ionizing radiation from uranium legacy sites remains a significant public health concern in Northern Kazakhstan. This review evaluates epidemiological, clinical, and environmental evidence published between 2000 and 2025, with particular emphasis on studies conducted during 2014–2023 in the Stepnogorsk region among populations residing near former uranium mining sites. Residents were exposed to annual external gamma doses of approximately 1.0–3.5 mSv and radon-related doses of up to 1.2 mSv. Cancer registry analyses revealed 1913 malignancy cases in the exposed group (vs. 358 controls), with digestive (29%) and respiratory (17%) cancers predominating. Early signs of chronic radiation syndrome (CRS) were consistently observed, including olfactory dysfunction, immunosuppression, vestibular disturbances, hematologic anomalies, and elevated chromosomal aberrations (1.3–1.5× baseline). Non-cancer morbidity was also elevated, including hypertension (32% vs. 24%), chronic bronchitis (14% vs. 8%), and reduced forced expiratory volume in one second (FEV1; −9.7%), indicating broader systemic effects. These results underscore the need for targeted public health strategies incorporating CRS biomarker screening, cancer surveillance, personal dosimetry, and environmental remediation in uranium-impacted communities. Full article
(This article belongs to the Section Cancer Epidemiology and Prevention)
18 pages, 2265 KB  
Article
Impact of the Built Environment of Old Residential Communities on Older Adults’ Health Based on the EVOLVE Tool: A Multidimensional Case Study of Dalian, China
by Wenting Yu, Rui Wang, Yule Fu and Jia Guo
Buildings 2026, 16(9), 1744; https://doi.org/10.3390/buildings16091744 - 28 Apr 2026
Abstract
As the global population ages rapidly, the built environment has become increasingly critical for the health of older adults. In China, although the government has continuously promoted age-friendly retrofitting of old residential communities, these communities often face low usage rates after renovation. This [...] Read more.
As the global population ages rapidly, the built environment has become increasingly critical for the health of older adults. In China, although the government has continuously promoted age-friendly retrofitting of old residential communities, these communities often face low usage rates after renovation. This study evaluated the age-friendliness of eight old residential units in Dalian, China, using the EVOLVE 2010 (Evaluation of Older Adults’ Living Environment) tool and combined semi-structured interviews with older residents. The results analyzed environmental impacts on older adults’ health across three domains: diet, exercise, and emotion. The findings reveal systemic deficiencies in housing units, external spaces, and urban planning, with limited physical accessibility being the predominant concern. Improving spatial functionality or environmental optimization alone is insufficient to enhance health outcomes; instead, expanding the range of activities and improving access to various locations contribute to increased self-esteem, confidence, and engagement in beneficial behaviors such as physical exercise and a healthy diet. The study highlights a gap between current renovation practices and the actual needs of older adults, emphasizing that accessibility should be prioritized in age-friendly design. These findings provide evidence-based policy implications for promoting healthy aging through urban renewal. Full article
22 pages, 295 KB  
Article
Teaching Sustainability Through Ancient Texts: Digital Pedagogy and Environmental Humanities in Higher Education
by Marianna Olivadese
Sustainability 2026, 18(9), 4354; https://doi.org/10.3390/su18094354 - 28 Apr 2026
Abstract
Higher Education Institutions (HEIs) are increasingly called upon to integrate sustainability across curricula and to prepare students to respond critically and responsibly to complex environmental challenges. While sustainability education is often associated with scientific, technological, or policy-oriented disciplines, the contribution of the humanities [...] Read more.
Higher Education Institutions (HEIs) are increasingly called upon to integrate sustainability across curricula and to prepare students to respond critically and responsibly to complex environmental challenges. While sustainability education is often associated with scientific, technological, or policy-oriented disciplines, the contribution of the humanities remains underexplored, particularly in digitally mediated university teaching. This paper argues that ancient texts, approached through the lens of the Environmental Humanities and supported by digital pedagogy, can offer a valuable framework for fostering sustainability literacy in higher education. Drawing on a humanities-based pedagogical model, this article explores how practices such as collaborative close reading, ecocritical discussion, narrative mapping, reflective writing, and digital storytelling can help students connect classical representations of nature, fragility, order, and human responsibility with contemporary ecological concerns. These activities encourage the development of sustainability-related competencies—including critical thinking, ethical reflection, interpretive complexity, and ecological awareness—while also supporting Inner Development Goals such as self-awareness, empathy, relational thinking, and responsible action. Based on a conceptual pedagogical model supported by exploratory qualitative evidence from a small-scale higher education course, this paper suggests that digital pedagogy can make sustainability learning in the humanities more dialogic and reflective. In doing so, this article proposes a practice-based pedagogical framework that may help Higher Education Institutions explore ways of embedding sustainability meaningfully beyond traditionally environmental fields. This article’s primary contribution is therefore pedagogical: it presents a humanities-based model for sustainability education while using exploratory qualitative evidence from one course context to illustrate how such a model may support interpretive, ethical, and sustainability-oriented learning. Full article
(This article belongs to the Special Issue Higher Education for Sustainability)
30 pages, 5697 KB  
Article
Comprehensive Evaluation of Traditional Vernacular Dwelling Heritage Sustainability in Pingyao Ancient City, Shanxi
by Mengchen Lian, Liyue Wu, Yanjun Li and Xiaonan Wang
Sustainability 2026, 18(9), 4352; https://doi.org/10.3390/su18094352 - 28 Apr 2026
Abstract
The sustainability of traditional vernacular dwelling heritage has become an important academic concern. This study takes the traditional vernacular dwellings of the Ancient City of Pingyao as its research object and develops a macro–meso–micro multi-scale analytical framework. Drawing on four dimensions—environment, layout, architecture, [...] Read more.
The sustainability of traditional vernacular dwelling heritage has become an important academic concern. This study takes the traditional vernacular dwellings of the Ancient City of Pingyao as its research object and develops a macro–meso–micro multi-scale analytical framework. Drawing on four dimensions—environment, layout, architecture, and culture—it systematically investigates the geographical environment, spatial pattern, and architectural forms of Pingyao’s traditional vernacular dwellings using GIS spatial analysis, UAV oblique photogrammetry, and 3D laser scanning technologies. On this basis, an AHP–FCE comprehensive evaluation model is introduced to assess their sustainability. The results indicate that the formation and persistence of these dwellings are closely associated with favourable natural environmental conditions, a clear and orderly spatial pattern, and well-structured courtyard and architectural forms. The comprehensive evaluation yields a score of F = 3.23, indicating a moderately high level of sustainability. The four criterion layers are ranked as follows: architecture, layout, environment, and culture. The key determinants are structural safety, material authenticity, spatial integrity, and the continuity of traditional character. By combining multi-scale analysis with comprehensive evaluation, this study aims to clarify the priority directions for the conservation of traditional vernacular dwelling heritage in the Ancient City of Pingyao, thereby providing a scientific basis for its sustainable development. Full article
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31 pages, 39120 KB  
Article
Investigation of the Use of In Situ Material by Geopolymerization Method in Stabilization of Ordinary Clay Soils
by Süleyman Gücek, Gökhan Kürklü, Bojan Žlender and Tamara Bračko
Appl. Sci. 2026, 16(9), 4290; https://doi.org/10.3390/app16094290 - 28 Apr 2026
Abstract
Certain clayey soils are susceptible to swelling and shrinkage due to moisture variations, which can lead to ground deformation and structural damage. Although traditional stabilization methods using lime and cement are effective, they involve high energy consumption and significant CO2 emissions. In [...] Read more.
Certain clayey soils are susceptible to swelling and shrinkage due to moisture variations, which can lead to ground deformation and structural damage. Although traditional stabilization methods using lime and cement are effective, they involve high energy consumption and significant CO2 emissions. In response to sustainability concerns, this study investigates the potential of in situ geopolymer stabilization of clay soils using industrial by-products as eco-friendly binders. Experimental studies were conducted on clay specimens stabilized with geopolymer binders produced from fly ash and waste brick powder activated by alkaline solutions. The selected clay exhibited stiff to very stiff behavior and was used as a reference material to ensure reliable evaluation without the influence of severe initial degradation. Reference samples with identical water content but without alkaline activation were also prepared. The primary objective was to assess geopolymers as a sustainable alternative to conventional binders, focusing on moisture sensitivity and long-term mechanical performance. Laboratory strength tests demonstrated that geopolymer-treated specimens exhibited significantly higher strength compared to untreated samples, indicating substantial improvement in engineering properties. Furthermore, Scanning Electron Microscopy (SEM) analyses revealed that the combination of dual activators (NS+NH) and thermal curing at 85 °C transformed the weak clay matrix into a dense, fibrous geopolymer network. However, the high curing temperature was primarily used to study the reaction mechanisms; the practical applicability of the method should be evaluated based on results obtained at ambient temperature. This structure enhanced particle bonding and mechanical interlocking by filling voids within the matrix. Overall, the findings confirm that geopolymer stabilization using industrial waste materials is an effective and environmentally sustainable alternative to conventional soil stabilization techniques, contributing to reduced carbon emissions in geotechnical engineering. Full article
(This article belongs to the Special Issue Recent Advancements in Soil Mechanics and Geotechnical Engineering)
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27 pages, 2987 KB  
Article
Laughing with a Message: The Subtle Power of Cartoons in Ghana’s Public Discourse and Communication
by Alexander Angsongna
Arts 2026, 15(5), 88; https://doi.org/10.3390/arts15050088 (registering DOI) - 28 Apr 2026
Abstract
This study investigates the communicative power of editorial cartoons in Ghana’s public discourse, focusing on how they inform, critique, and influence sociopolitical narratives. Drawing on a dataset of cartoons by Tilapia—one of the country’s leading cartoonists—published between May 2024 and May 2025, the [...] Read more.
This study investigates the communicative power of editorial cartoons in Ghana’s public discourse, focusing on how they inform, critique, and influence sociopolitical narratives. Drawing on a dataset of cartoons by Tilapia—one of the country’s leading cartoonists—published between May 2024 and May 2025, the paper explores how cartoons address themes such as economic hardship, youth addiction, cultural values, environmental degradation, and political hypocrisy. The central question guiding this study is as follows: How do Tilapia’s editorial cartoons visually construct and critique key national issues—such as economic hardship, environmental degradation, youth addiction, and political hypocrisy—in Ghanaian public discourse? Guided by an integrated theoretical framework from semiotics, visual rhetoric, and critical metaphor theory, the analysis reveals how cartoons use humour, caricature, exaggeration, and symbolic imagery to simplify complex realities and foster civic reflection. The study highlights how cartoons serve not only to entertain but also to hold power to account, amplify public concerns, and promote sociopolitical engagement. Through detailed visual analysis of ten selected cartoons, the paper underscores their capacity to critique governance, expose contradictions, and reflect collective sentiment—especially during election cycles. Overall, the research affirms the evolving role of visual satire as a potent medium of resistance, cultural expression, and democratic participation in Ghana. By bridging visual culture and critical discourse, the paper contributes to broader understandings of the role of the media in shaping public perception and fostering informed citizenship. Full article
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27 pages, 39010 KB  
Article
Deep Mining of Narrow, Steeply Dipping Orebodies: Subsidence and Stability in Cut-and-Fill Mining via SBAS-InSAR and 3D Numerical Simulation
by Wenlong Yu, Xingdong Zhao, Shaolong Qin and Yifan Zhao
Appl. Sci. 2026, 16(9), 4289; https://doi.org/10.3390/app16094289 - 28 Apr 2026
Abstract
Deep mining of geologically challenging deposits, such as narrow, steeply dipping orebodies, is increasingly pursued to meet the rising demand for mineral resources. However, the geotechnical stability of operations in such environments remains a persistent challenge. A paramount concern is the insufficiently understood [...] Read more.
Deep mining of geologically challenging deposits, such as narrow, steeply dipping orebodies, is increasingly pursued to meet the rising demand for mineral resources. However, the geotechnical stability of operations in such environments remains a persistent challenge. A paramount concern is the insufficiently understood mechanisms governing the surface subsidence and stability of underground excavations, which diverge significantly from those in flat or gently dipping deposits. This study bridges this gap through an integrated methodology applied to a deep cut-and-fill gold mine in China. We combined nine years (2016–2025) of SBAS-InSAR monitoring, utilizing 120 Sentinel-1 images corrected with precise orbit and atmospheric correction data, with a comprehensive three-dimensional (3D) numerical simulation. The results reveal a unique subsidence pattern: surface subsidence is highly localized, forming an elliptical basin directly above the orebodies, with a footwall movement angle exceeding 90°. Furthermore, the subsidence magnitude showed minimal progression despite increasing mining depth, with a maximum cumulative subsidence of only 9.3 mm. Numerical simulation confirmed these findings and demonstrated that underground shafts and tunnels remained stable under the sequential extraction of multiple orebody levels. This exceptional geotechnical response is attributed to a synergistic mechanism involving the intrinsic geomechanical advantages of the steeply dipping geometry, the low-disturbance nature of narrow-vein mining, and the crucial structural support provided by the backfilling. This study demonstrates the efficacy of cut-and-fill mining for ensuring operational safety and minimizing surface environmental impact in the deep mining of narrow, steeply dipping orebodies, providing critical insights for the sustainable exploitation of deep mineral resources. Full article
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43 pages, 1979 KB  
Review
Chlorpyrifos and Chlorpyrifos-Oxon: A Widening Spectrum of Toxicity
by Sebastian Kalenik, Agnieszka Zaczek and Aleksandra Rodacka
Int. J. Mol. Sci. 2026, 27(9), 3909; https://doi.org/10.3390/ijms27093909 - 28 Apr 2026
Abstract
Chlorpyrifos (CP) remains one of the most globally pervasive organophosphorus pesticides, and its toxicological profile continues to raise substantial public health and environmental concerns. While traditionally characterized by its potent acetylcholinesterase-inhibitory properties, accumulating evidence now shows that chlorpyrifos and its bioactive metabolite, chlorpyrifos-oxon [...] Read more.
Chlorpyrifos (CP) remains one of the most globally pervasive organophosphorus pesticides, and its toxicological profile continues to raise substantial public health and environmental concerns. While traditionally characterized by its potent acetylcholinesterase-inhibitory properties, accumulating evidence now shows that chlorpyrifos and its bioactive metabolite, chlorpyrifos-oxon (CPO), exert far broader toxic effects, including the induction of oxidative stress, enhancement of neuroinflammatory processes, and the triggering of persistent epigenetic alterations. In this review, we synthesize current findings to highlight the expanding spectrum of CP-induced toxicity, while also providing a multidisciplinary overview of chlorpyrifos characteristics, including its environmental fate, metabolism, and transformation pathways. The analysis encompasses not only classical neurotoxicity but also disruptions in neurodevelopment, endocrine signaling, gut microbiota composition, hepatic function, musculoskeletal integrity and carcinogenic pathways. By synthesizing results across human, animal, and environmental studies, this review offers a comprehensive overview of CP’s multidimensional toxicity and highlights the urgent need for improved biomonitoring, regulatory harmonization, and global strategies to reduce exposure. Full article
(This article belongs to the Special Issue Toxicity Mechanism of Emerging Pollutants: 2nd Edition)
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19 pages, 535 KB  
Article
Latent Profiles of Eco-Anxiety: Resilience, and Vulnerability Factors in a Portuguese-Sample
by Paulo Ferrajão, Nuno Torres and Amadeu Quelhas Martins
Sustainability 2026, 18(9), 4345; https://doi.org/10.3390/su18094345 - 28 Apr 2026
Abstract
Eco-anxiety refers to emotional and cognitive responses to environmental degradation and can manifest in both adaptive and maladaptive forms. This study aimed to identify distinct eco-anxiety profiles and examine their associations with resilience and vulnerability factors in a sample of 917 Portuguese-speaking adults. [...] Read more.
Eco-anxiety refers to emotional and cognitive responses to environmental degradation and can manifest in both adaptive and maladaptive forms. This study aimed to identify distinct eco-anxiety profiles and examine their associations with resilience and vulnerability factors in a sample of 917 Portuguese-speaking adults. Latent profile analysis revealed five profiles: adaptive eco-anxiety, highly impaired maladaptive eco-anxiety, psychological distress independent of eco-anxiety, non-anxious/disengaged, and moderate I I have separated the addresses into different affiliations.have separated the addresses into different affiliations.eco-anxiety. These profiles differed significantly in psychological symptomatology, nature connectedness, pro-environmental attitudes, and prior exposure to cumulative social and environmental stressors. Higher-distress profiles were more likely among younger individuals, women, urban residents, unemployed participants, those without children, individuals with a prior psychiatric history, and those reporting direct exposure to drought. In contrast, stronger environmental identity and greater engagement with natural environments were associated with adaptive eco-anxiety, suggesting protective and resilience-promoting mechanisms. Overall, the findings highlight the multidimensional and heterogeneous nature of eco-anxiety and its complex relationship with psychological well-being and environmental engagement. Tailored interventions that promote adaptive coping, strengthen psychological resources, and facilitate access to natural environments may help mitigate maladaptive distress while supporting constructive environmental concern and action. Full article
(This article belongs to the Special Issue Sustainable Disaster Management and Community Resilience)
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14 pages, 3061 KB  
Article
Comparative Biodegradation of Agro-Industrial and Recycled Fiber-Based Facestocks for Pressure-Sensitive Labels Under Aerobic Soil Conditions
by Ana Marošević Dolovski, Katarina Itrić Ivanda, Rahela Kulčar and Marina Vukoje Bezjak
Sci 2026, 8(5), 99; https://doi.org/10.3390/sci8050099 (registering DOI) - 28 Apr 2026
Abstract
The increasing use of pressure-sensitive labels (PSLs), driven by growth in the packaging sector, raises concerns regarding material consumption and end-of-life management under evolving European packaging regulations. This study investigates the biodegradation potential of sustainable PSL facestocks produced from 15% agro-industrial by-products, 40% [...] Read more.
The increasing use of pressure-sensitive labels (PSLs), driven by growth in the packaging sector, raises concerns regarding material consumption and end-of-life management under evolving European packaging regulations. This study investigates the biodegradation potential of sustainable PSL facestocks produced from 15% agro-industrial by-products, 40% post-consumer recycled fibers, and 45% virgin wood pulp. Their biodegradation behavior was compared with bio-based polyethylene (PE) facestocks using laboratory-scale aerobic soil burial tests conducted for up to 28 days. Biodegradation was assessed through weight loss measurements, visual evaluation, Fourier transform infrared (FTIR) spectroscopy, and fluorescence analysis. Fiber-based facestocks exhibited significant degradation, reaching approximately 50–55% weight loss after 28 days, accompanied by structural changes in the cellulose matrix and reduced fluorescence intensity. In contrast, bio-based polyethylene facestocks showed negligible weight loss and only minor spectroscopic changes, indicating high stability under the tested conditions. The results demonstrate that fiber-based samples derived from agro-industrial and recycled sources possess substantially higher biodegradation potential than bio-based polymeric alternatives. These findings support the use of fiber-based PSL facestocks in applications requiring improved environmental compatibility. Full article
(This article belongs to the Section Biology Research and Life Sciences)
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16 pages, 2130 KB  
Article
Environmental Performance of Mature Precast Slabs in Permeable Pavements: Hydraulic Functionality and Pollutant Retention Under Real-Life Conditions
by Darío Calzadilla-Cabrera, Eduardo García-Haba, Carmen Hernández-Crespo, Miguel Martín and Ignacio Andrés-Doménech
Water 2026, 18(9), 1042; https://doi.org/10.3390/w18091042 - 28 Apr 2026
Abstract
Permeable pavements are increasingly integrated into urban environments as sustainable systems that enhance stormwater infiltration, mitigate runoff, and contribute to pollutant control. However, long-term accumulation of contaminants within their porous structure may impair hydraulic performance and environmental functionality, particularly regarding microplastics (MPs), an [...] Read more.
Permeable pavements are increasingly integrated into urban environments as sustainable systems that enhance stormwater infiltration, mitigate runoff, and contribute to pollutant control. However, long-term accumulation of contaminants within their porous structure may impair hydraulic performance and environmental functionality, particularly regarding microplastics (MPs), an emerging pollutant of growing concern. This study investigates the five-year environmental performance of porous concrete pavement slabs operating under real urban conditions, focusing on infiltration capacity and retention of nutrients, suspended solids, and MPs. A dual methodology combining continuous on-site permeability monitoring with laboratory analyses of aged slabs was used to assess performance decline and recovery after maintenance. Results show a 48% reduction in infiltration over five years, while maintaining effective functionality, and a 42.5% recovery after pressure cleaning. Used slabs exhibited substantial pollutant accumulation relative to new slabs, including increases of +258% in COD, +123% in total phosphorus, +28% in total nitrogen, and +48% in suspended solids. MP abundance reached 10,272 ± 5829 MPs/m2, 7.5 times higher than in new slabs, dominated by fibers (~70%) and polymers such as PE, PP, and PET. These findings highlight the pavement surface layer as both hydraulic infrastructure and contaminant sink supporting improved maintenance and sustainable urban stormwater management. Full article
(This article belongs to the Section Urban Water Management)
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39 pages, 44033 KB  
Article
Valorization of Multi-Waste Materials in Eco-Friendly Engineered Cementitious Composites
by Rabie A. M. Amnisi, Mohamed E. El-Zoughiby, Basem S. Abdelwahed and Osama Youssf
Infrastructures 2026, 11(5), 149; https://doi.org/10.3390/infrastructures11050149 - 28 Apr 2026
Abstract
Engineered cementitious composite (ECC) is an advanced material known for its superior flexibility, high durability, and crack resistance, making it ideal for a variety of structural applications. However, it uses cement at a rate of 2–3 times more than conventional concrete which raises [...] Read more.
Engineered cementitious composite (ECC) is an advanced material known for its superior flexibility, high durability, and crack resistance, making it ideal for a variety of structural applications. However, it uses cement at a rate of 2–3 times more than conventional concrete which raises environmental concerns. This study focused on the production of eco-friendly ECC by incorporating various waste materials as partial cement and sand substitutes. Cement kiln dust (CKD), ceramic powder waste (CPW), and eggshell waste (ESW) were used as partial substitutes for cement in doses of 10% and 20%. Crumb rubber (CR) was used as a partial substitute for sand in doses of 25, 50, 75, and 100%. Chemical treatments using sodium hydroxide, sodium silicate, and a mix of both of them were carried out for the CR in the production of the proposed ECC. Physical treatment using the same cement substitute materials (CKD, CP and ESP) was also carried out for the CR. The effect of fiber type—such as basalt fibers (BF), polypropylene fibers (PPF), and steel fibers (StF)—on the performance of ECC was also investigated. Slump, compressive strength, uniaxial tensile strength, flexural strength, and sorptivity were the measured properties for the proposed ECC. Microstructure analyses were also conducted on some selected ECC mixtures. Among the tested mixtures, the results showed that replacing 10% of the cement with CKD improved the compressive strength by up to 22.6% and the tensile strength by up to 18.3%. Using 50% untreated CR reduced compressive and tensile strength by 32.8% and 28.1%, respectively, compared to the control ECC. The physical treatment of CR using CKD improved the compressive strength by up to 12.7% and the tensile strength by up to 3.2% compared to untreated CR. The microstructure analyses revealed an improvement in fiber-matrix bonding and a reduction in crack width in the mixtures, especially in the BF and PPF blends. Full article
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20 pages, 511 KB  
Article
Relative Leukocyte Telomere Length Is Shorter in Children and Adolescents with Type 1 Diabetes: Screening of Basic Psychosocial Aspects
by Georgia Papavasileiou, Eleni Dragona, Nicolas C. Nicolaides, Tania Siahanidou, Maria Michou, Emmanouil Zoumakis, Sarantis Gagos and Christina Kanaka-Gantenbein
Int. J. Mol. Sci. 2026, 27(9), 3895; https://doi.org/10.3390/ijms27093895 - 27 Apr 2026
Abstract
Leukocyte telomere length (LTL) is shortened in adults with type 1 diabetes (T1D), but less data is available concerning pediatric cases. Multiple factors affect LTL, namely genes, epigenetics, environmental factors, oxidation, and psychological stress. Children with T1D and their families experience chronic stress. [...] Read more.
Leukocyte telomere length (LTL) is shortened in adults with type 1 diabetes (T1D), but less data is available concerning pediatric cases. Multiple factors affect LTL, namely genes, epigenetics, environmental factors, oxidation, and psychological stress. Children with T1D and their families experience chronic stress. This study aimed to investigate LTL in children with T1D (n = 35) aged 6–13 years old, in comparison to age-matched healthy counterparts (n = 35), and assess any correlation of LTL with perceived stress. Relative LTL (rLTL) was assessed through real-time qPCR. Morning serum cortisol, high-sensitivity C-Reactive Protein (hsCRP), and glycated hemoglobin (HbA1c) were measured. Children completed the validated questionnaires “Stress in Children” and “Pediatric Quality of Life”. Parents answered the “Perceived Stress Scale”. Children with T1D had a lower rLTL (p = 0.02) compared to age-matched healthy controls, higher hsCRP (p = 0.031), and a lower estimated quality of life (p = 0.01). RLTL was found to be lower in females with T1D (p < 0.001) and was positively related to the ‘gender–social support’ factor (p = 0.002) and diabetes duration (p = 0.045), adjusted for children’s age, parental age, and sociodemographic characteristics. These pilot findings indicate early emergence of shorter rLTL in T1D, pointing to a sexual dimorphism pattern. Insights into preventing LTL shortening in pediatric T1D can be gained from large-scale studies examining the impact of gender and social support. Full article
(This article belongs to the Section Molecular Endocrinology and Metabolism)
20 pages, 1353 KB  
Article
Lignin-Acrylic Acid Copolymer as an Effective Emulsifier for Oil-Water Emulsion
by Shirin Fatehi, Pedram Fatehi, Ehsan Behzadfar and Leila Pakzad
Polymers 2026, 18(9), 1056; https://doi.org/10.3390/polym18091056 - 27 Apr 2026
Abstract
Oil–water emulsions constitute essential components in a wide range of industries. Despite their extensive use in emulsion systems, synthetic emulsifiers are often associated with environmental concerns and high costs. In this study, lignin—a by-product of the pulping industry—was polymerized with acrylic acid and [...] Read more.
Oil–water emulsions constitute essential components in a wide range of industries. Despite their extensive use in emulsion systems, synthetic emulsifiers are often associated with environmental concerns and high costs. In this study, lignin—a by-product of the pulping industry—was polymerized with acrylic acid and employed as an emulsifier in a xylene–water system to address this challenge. When testing two lignin–acrylic acid copolymers, the results confirmed that the one possessing a higher molecular weight (7.99 × 105 g/mol) and charge density (4.7 mmol/g) (KL-AA-10) generated xylene–water emulsions with improved stability, and higher viscosity and viscoelastic moduli. These observations were consistent with the greater adsorption of this polymer, relative to the counterparts with a lower molecular weight and charge density at the xylene–water interface, as monitored using a Quartz Crystal Microbalance. The adsorption of KL-AA-10 resulted in the formation of smaller emulsion droplets (D50 = 0.6 µm) within the system, as evidenced by confocal microscopy analysis. This study underscores the potential of lignin as a renewable emulsifier for diverse applications. Full article
(This article belongs to the Section Biobased and Biodegradable Polymers)
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16 pages, 2406 KB  
Article
Genomic and Proteomic Insights into Arsenic Detoxification and Alternative Transformation Pathways in Microbacterium oxydans AE038-20
by Florencia Cecilia Spuches, Andrés Hernán Morales, Johan Sebastian Hero, José Horacio Pisa, Adriana Emilce Galván, Marcela Alejandra Ferrero and Cintia Mariana Romero
Processes 2026, 14(9), 1395; https://doi.org/10.3390/pr14091395 - 27 Apr 2026
Abstract
Arsenic-contaminated groundwater is a major environmental concern, particularly in northern Argentina. Here, Microbacterium oxydans AE038-20, isolated from arsenic-rich groundwater, was investigated to elucidate its tolerance and transformation capacity. Growth assays showed that the strain tolerates inorganic arsenic [As(III), As(V)] and methylarsenite [MAs(III)] without [...] Read more.
Arsenic-contaminated groundwater is a major environmental concern, particularly in northern Argentina. Here, Microbacterium oxydans AE038-20, isolated from arsenic-rich groundwater, was investigated to elucidate its tolerance and transformation capacity. Growth assays showed that the strain tolerates inorganic arsenic [As(III), As(V)] and methylarsenite [MAs(III)] without significant inhibition. Speciation analyses revealed progressive oxidation of As(III) to As(V), reaching near-complete conversion after 10 days. Similarly, MAs(III) was fully oxidized to MAs(V). Genome sequencing identified ars-related determinants, including arsR, arsC, putative arsenite efflux systems, and arsP, supporting detoxification via arsenate reduction and arsenite efflux. Proteomic analyses confirmed the expression of proteins related to arsenic resistance, oxidative stress response, and metal transport. However, no canonical arsenite oxidases were detected at either the genomic or proteomic level. Despite this, M. oxydans AE038-20 exhibited clear arsenic oxidation activity. The detection of pigment-associated proteins and in vitro oxidation assays suggest an alternative mechanism potentially mediated by redox-active pigments. These findings highlight an alternative pathway for arsenic transformation in environmental bacteria. Full article
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