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36 pages, 1158 KB  
Article
Smart Cities in the Agentic AI Era: Three Vectors of Urban Transformation
by Esteve Almirall
Appl. Sci. 2026, 16(8), 3847; https://doi.org/10.3390/app16083847 - 15 Apr 2026
Viewed by 183
Abstract
Agentic artificial intelligence—systems that reason, plan, and act autonomously within governed workflows—is converging with autonomous electric mobility and urban robotics to reshape how cities govern, move, and manage physical space. We argue that the simultaneous arrival of these three vectors is triggering a [...] Read more.
Agentic artificial intelligence—systems that reason, plan, and act autonomously within governed workflows—is converging with autonomous electric mobility and urban robotics to reshape how cities govern, move, and manage physical space. We argue that the simultaneous arrival of these three vectors is triggering a transformation comparable in scope to the Industrial Revolution. Cities that deploy across all three domains are becoming the new hubs of innovation: they concentrate talent, accelerate knowledge circulation, enable cross-fertilisation, and generate hybrid proposals that no single vector could produce alone. Just as Manchester, Birmingham, and the Ruhr became the defining centres of industrialisation because steam, textiles, iron, and coal recombined through the proximity of the engineers and entrepreneurs who moved between them, a small number of cities today are pulling ahead because they host the shared talent pool around which agentic governance, autonomous mobility, and urban robotics co-evolve. Conceptually, we extend the mirroring hypothesis in two directions: dynamically, arguing that organisations and urban ecosystems converge toward the configurations new technologies make possible; and ontologically, arguing that agentic AI introduces non-human agents into organisational architectures, requiring hybrid human–AI coordination. We formalise this dynamic as five propositions (P1–P5) of cumulative recursive hybridisation (CRH), operating through four reinforcing feedback loops—data, regulation, infrastructure, and talent. Together, these loops explain why the emerging urban order is path-dependent: early movers accumulate compounding advantages, while latecomers face exponentially rising costs of entry. We demarcate CRH from adjacent frameworks—general-purpose technologies, organisational complementarities, and complex adaptive systems—and test it against counterfactual evidence from failed, stalled, and Global South trajectories (Sidewalk Toronto, the Cruise rollback, Songdo, Bengaluru). We also examine its political-economy, equity, and surveillance limits. Drawing on comparative evidence from public-sector chatbot deployments, autonomous mobility ecosystems in the United States and China, and emerging urban robotics cases, we conclude that what is at stake is not incremental modernisation but the construction of a new urban order. The cities that act as innovation hubs for the agentic AI era will shape global standards, attract global talent, and define the institutional templates that others eventually adopt—much as the industrial cities of the eighteenth and nineteenth centuries did. Full article
19 pages, 5510 KB  
Article
Preliminary Study on Piezoelectric Sensor Signals Embedded in Polymeric Samples
by Vítor Miguel Santos, Sara Valvez, Beatriz Branquinho Gomes, Maria Augusta Neto and Ana Martins Amaro
Sensors 2026, 26(8), 2412; https://doi.org/10.3390/s26082412 - 15 Apr 2026
Viewed by 175
Abstract
Piezoelectric sensors are widely used for force and vibration monitoring in both rigid and flexible structures, yet their performance can be significantly affected by how they are integrated into the host material. Challenges such as limited sensitivity, inconsistent signal transmission, and delays in [...] Read more.
Piezoelectric sensors are widely used for force and vibration monitoring in both rigid and flexible structures, yet their performance can be significantly affected by how they are integrated into the host material. Challenges such as limited sensitivity, inconsistent signal transmission, and delays in response remain particularly relevant in flexible components produced by additive manufacturing. Addressing these limitations requires a better understanding of how integration strategies influence sensor behavior. This study presents preliminary experimental results on the performance of commercial piezoelectric ceramic (PZT) sensors embedded in flexible structures fabricated by additive manufacturing (3D printing). Although the current investigation did not assess variability from mass production, repeated testing of each specimen was performed to reduce this potential error. Filaflex Foamy 95A polyurethane (TPU) samples were produced using Fused Filament Fabrication (FFF) technology in two configurations: with and without a cavity for sensor fitting. A minimum of seven valid compression tests, at each condition, were performed, with ten loading and unloading cycles up to 1000 N of force, using an indentation rate of 0.5 mm/s. In most tests, the two configurations showed different peak amplitudes throughout the cycles. Samples with the sensor embedded in the cavity consistently reached peak signal amplitudes more rapidly. In contrast, samples with the sensor positioned on the material surface without a fitting exhibited similar results across all tests and demonstrated a broader signal distribution over time. These findings indicate that the sensor-integration strategy is the primary factor influencing dynamic force transfer, impact sensitivity, piezoelectric response time, and maximum signal magnitude. Full article
(This article belongs to the Special Issue Functional Nanomaterials in Sensing)
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18 pages, 333 KB  
Article
A Small Patch Hypothesis in Cosmology
by Meir Shimon
Astronomy 2026, 5(1), 4; https://doi.org/10.3390/astronomy5010004 - 9 Feb 2026
Viewed by 570
Abstract
If our observable Universe is only a tiny region of a vastly larger and conformally older spacetime, then the usual formulations of the classical flatness and horizon problems of the Hot Big Bang can be reinterpreted as artifacts manifesting an observational selection effect; [...] Read more.
If our observable Universe is only a tiny region of a vastly larger and conformally older spacetime, then the usual formulations of the classical flatness and horizon problems of the Hot Big Bang can be reinterpreted as artifacts manifesting an observational selection effect; we occupy a small causal domain of a much larger causally-connected and possibly non-flat spacetime. A sufficiently large positive cosmological constant, Λ, sets the future asymptotic horizon scale of the observable Universe, ∼Λ1/2, thereby implying that the observable Universe may simply be a minute patch of a far larger pre-existing one, hereafter a Small Patch Hypothesis. Importantly, this observational bound is purely geometric; regardless of when the Universe is observed, the maximum accessible scale is finite and fixed by Λ, independent of inflationary dynamics, anthropic arguments, or assumptions about the global hosting spacetime. The externally possibly frozen past-eternal state implied by a pre-existing, causally connected spacetime motivates, but does not strictly require, viewing the perturbation field as being in (or arbitrarily close to) a coarse-grained maximum-entropy—equilibrium—configuration. Conditionalizing only on fixed mean and variance, a Gaussian distribution uniquely emerges, while the absence of entropy gradients corresponds to adiabaticity. In this work these features are therefore treated as plausible maximum-ignorance priors for super-horizon perturbations, rather than as rigorously derived consequences of a fully developed microscopic notion of gravitational entropy. In this sense, inflation becomes one viable realization of the proposed Small Patch Hypothesis. Here, one particular non-inflationary alternative is considered for illustrative purposes in which a primordial spectrum Pζ(k) of the gauge-invariant perturbation ζ that pre-dates the Big Bang grows logarithmically toward large scales, k0, and in fact diverges at some finite kc. If kcΛ1/2, then our local cosmic patch probes only the regime where ζ1 and appears exceptionally smooth. Over the comparatively narrow observable window, this Pζ(k) mimics a slightly red-tilted, inflation-like spectrum. Rather than introducing high-energy new fields, this perspective frames large-scale homogeneity, isotropy, Gaussianity, adiabaticity, and the observed thermodynamic Arrow of Time as possible consequences of restricted observational access to a much larger Universe in equilibrium, rather than signatures of a unique early-Universe mechanism. Current observations cannot distinguish this logarithmically running spectrum from the standard power-law one, but future probes—for example high-resolution 21-cm measurements of the Dark Ages—may be able to falsify it. Full article
13 pages, 2005 KB  
Review
Chemical Ecology of Host- and Mate-Finding in the Cypress Bark Beetle Phloeosinus aubei, with Notes on Congeneric Species
by Gábor Bozsik, Armin Tröger, Stefan Schulz, Michael J. Domingue and Gábor Szőcs
Insects 2026, 17(1), 107; https://doi.org/10.3390/insects17010107 - 16 Jan 2026
Viewed by 641
Abstract
Recent intensive research on the cypress bark beetle, Phloeosinus aubei was prompted because of its invasion of Central Europe that caused serious damage to scale-leaved conifer ornamental trees. This dynamic also increased the risk of accidental introduction into North America. In contrast to [...] Read more.
Recent intensive research on the cypress bark beetle, Phloeosinus aubei was prompted because of its invasion of Central Europe that caused serious damage to scale-leaved conifer ornamental trees. This dynamic also increased the risk of accidental introduction into North America. In contrast to other historically well-studied bark beetles infesting spruce, pine or broad-leaf trees, intense study of the pheromones and host plant kairomones of bark beetles associated with cupressaceous trees has only begun in the past decade. This highly specialized clade is represented by the genus Phloeosinus. The pressing need for semiochemical-baited traps demands the identification of behavior-modifying compounds. This challenge involves unraveling the various stimuli interacting in the complex communication system to reveal the composition of signal bouquets and the absolute configuration of their components capable of evoking behavior responses. In this short overview we describe the recent research results on host-finding and intraspecific chemical communication of P. aubei, with a short outlook on the species of this genus. Full article
(This article belongs to the Special Issue Beetles: Biology, Ecology, and Integrated Management)
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17 pages, 2317 KB  
Article
Design and Realization of Dynamically Adjustable Multi-Pulse Real-Time Coherent Integration System
by Jinrui Bi, Hongyu Zhang, Lihua Sun and Qingchao Jiang
Electronics 2026, 15(2), 397; https://doi.org/10.3390/electronics15020397 - 16 Jan 2026
Viewed by 418
Abstract
Radar signal coherent integration technology is a critical method to improve the performance of detection systems. However, existing techniques face challenges regarding real-time performance and the flexibility of multi-pulse coherent accumulation. In this paper, a dynamically configurable multi-pulse multi-frame real-time coherent integration system [...] Read more.
Radar signal coherent integration technology is a critical method to improve the performance of detection systems. However, existing techniques face challenges regarding real-time performance and the flexibility of multi-pulse coherent accumulation. In this paper, a dynamically configurable multi-pulse multi-frame real-time coherent integration system based on FPGA is designed and implemented, and the dynamic configuration of the number of pulses and the number of frames stored for each pulse is realized through the host computer. The experimental results show that the output signal delay of coherent integration is 33 microseconds at 40 pulses, and the energy gain reaches 16 dB at 40 pulses, which provides a dynamically configurable hardware platform and solution for real-time coherent integration of high-frame-count, multi-pulse radar signals. Full article
(This article belongs to the Special Issue From Circuits to Systems: Embedded and FPGA-Based Applications)
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12 pages, 1186 KB  
Article
Three-Dimensional Chiral Metal–Organic Frameworks: Synthesis and Structural Transformations
by Vadim A. Dubskikh, Anna A. Lysova, Denis G. Samsonenko, Konstantin A. Kovalenko, Danil N. Dybtsev and Vladimir P. Fedin
Nanomaterials 2026, 16(1), 22; https://doi.org/10.3390/nano16010022 - 24 Dec 2025
Viewed by 544
Abstract
Four new porous homochiral metal–organic frameworks (MOFs), [M2(camph)2(bpa)]∙Solv (M = Co(II), Ni(II), Cu(II) and Zn(II)), based on (+)-camphoric acid (H2camph) and 1,2-bis(4-pyridyl)ethane (bpa) were synthesized and characterized. The crystal structures of [Ni2(camph)2(bpa)] and [...] Read more.
Four new porous homochiral metal–organic frameworks (MOFs), [M2(camph)2(bpa)]∙Solv (M = Co(II), Ni(II), Cu(II) and Zn(II)), based on (+)-camphoric acid (H2camph) and 1,2-bis(4-pyridyl)ethane (bpa) were synthesized and characterized. The crystal structures of [Ni2(camph)2(bpa)] and [Zn2(camph)2(bpa)] were established by single-crystal X-ray diffraction analysis. Powder X-ray data prove the phase purity and isostructural nature of all four compounds. The thermal stability of [M2(camph)2(bpa)] was found to depend on the electronic configuration, as well as on the redox properties of the metal cation, and varied from 225 °C (M = Zn2+) to 375 °C (M = Ni2+). The reversible, solvent-induced sponge-like dynamics of the coordination frameworks was thoroughly investigated. Changes in the positions of reflexes, related to the length of the flexible bpa linker, were observed by powder XRD, pointing to transitions between an open-framework phase and a squeezed, non-porous phase in a crystal-to-crystal manner, while the integrity and connectivity of the coordination network were maintained. Size-selective adsorption from a benzene–cyclohexane 1:1 mixture on [Zn2(camph)2(bpa)] was studied by 1H NMR analysis. The benzene-favorable composition of guest molecules (C6H6:C6H12 = 5:1) occluded within the host crystalline sponge revealed a preferable adsorption affinity towards smaller benzene compared with larger cyclohexane. High framework stability in various solvents, as well as successful molecular separation in the liquid state, validates the potential utilization of chiral porous metal(II) camphorate MOFs in important stereoselective applications. Full article
(This article belongs to the Section Inorganic Materials and Metal-Organic Frameworks)
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16 pages, 4181 KB  
Article
Optimizing Pier Arrangement for Flood Hazard Mitigation: A Comparative Mobile-Bed and Fixed-Bed Experimental Study
by Minxia Hao, Guodong Li and Xinyu Sheng
Water 2025, 17(20), 2951; https://doi.org/10.3390/w17202951 - 14 Oct 2025
Cited by 1 | Viewed by 628
Abstract
River bridge engineering alters the hydraulic characteristics of rivers, impacting fluvial morphological stability. To investigate issues concerning flood conveyance capacity within the river reach hosting a new bridge and the safe operation of existing bridges, comparative physical model tests employing both mobile-bed and [...] Read more.
River bridge engineering alters the hydraulic characteristics of rivers, impacting fluvial morphological stability. To investigate issues concerning flood conveyance capacity within the river reach hosting a new bridge and the safe operation of existing bridges, comparative physical model tests employing both mobile-bed and fixed-bed configurations were conducted. A 1:60 scale model was used to test flood peak discharges corresponding to 30-year and 100-year return periods and investigate pier spacings of 30 m and 40 m. These tests evaluated the relative advantages and limitations of each model type in simulating flow patterns, sediment transport, and riverbed evolution. Specifically, mobile-bed models more effectively capture the interaction between water flow and sediment dynamics, while fixed-bed experiments enable more precise measurement of hydraulic parameters. Pier spacing is recognized as one of the most critical factors influencing river flow regimes. Larger pier spacing (40 m) was found to reduce upstream backwater and local scour depth compared to smaller spacing (30 m), particularly under the 30-year flood scenario. Consequently, this study investigated the effects of pier spacing on flow patterns, obtained flood conveyance characteristics under various flood frequencies, and analyzed the underlying mechanisms governing flow fields, velocity variations, and local scour around piers. The research outcomes not only elucidate multiscale coupling mechanisms between water flow and sediment but also quantify the relationship between the extent of pier-induced flow disturbance and subsequent channel morphological adjustments. This quantification provides a dynamic criterion for risk mitigation of river-crossing structures and establishes a hydrodynamic foundation for studying flood hazards in complex river reaches. Full article
(This article belongs to the Section Hydraulics and Hydrodynamics)
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20 pages, 7286 KB  
Article
Design of a Clip-On Modular Tactile Sensing Attachment Based on Fiber Bragg Gratings: Theoretical Modeling and Experimental Validation
by Fengzhi Zhao, Yan Feng, Min Xu, Yaxi Li and Hua Zhang
Sensors 2025, 25(19), 5943; https://doi.org/10.3390/s25195943 - 23 Sep 2025
Viewed by 858
Abstract
Despite widespread modular tooling in robots and automated systems, tactile sensing lags behind, constrained by custom and non-interchangeable sensors. To close this gap, we developed a clip-on cylindrical tactile module that combines a snap-fit Clip-on Cap (CC) with a plug-in Sensor Core (PSC) [...] Read more.
Despite widespread modular tooling in robots and automated systems, tactile sensing lags behind, constrained by custom and non-interchangeable sensors. To close this gap, we developed a clip-on cylindrical tactile module that combines a snap-fit Clip-on Cap (CC) with a plug-in Sensor Core (PSC) hosting an array of force sensing and temperature-reference fiber Bragg gratings (FBGs). An opto-mechanical model relates Bragg wavelength shifts to external forces through parameterized dimensions and remains applicable across varied module sizes. Two loading configurations are examined: Case I, a PSC fitted with a compliant PSC-solid insert, and Case II, a hollow PSC. Experiments across both configurations validate the model, with prediction errors below 8%. Case II offers up to twice the force sensitivity of Case I, whereas Case I maintains slightly higher linearity (R2 > 0.95). We propose a metric, Q, for assessing the trade-off among sensitivity, linearity, and dynamic lag; analyses with this metric establish that softer solid inserts enhance tactile force perception. The CC–PSC pair can be rapidly swapped or detached to meet diverse application needs. These results provide a transferable design and modeling framework for equipping robots—or other automated systems—with universally deployable, clip-on tactile perception. Full article
(This article belongs to the Section Physical Sensors)
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22 pages, 501 KB  
Article
Initial Conditions for Tidal Synchronisation of a Planet by Its Moon
by Valeri V. Makarov and Michael Efroimsky
Universe 2025, 11(9), 309; https://doi.org/10.3390/universe11090309 - 10 Sep 2025
Cited by 2 | Viewed by 1241
Abstract
Moons tidally interact with their host planets and stars. A close moon is quickly synchronised by the planet or becomes captured in a higher spin–orbit resonance. However, the planet requires much more time to significantly alter its rotation rate under the influence of [...] Read more.
Moons tidally interact with their host planets and stars. A close moon is quickly synchronised by the planet or becomes captured in a higher spin–orbit resonance. However, the planet requires much more time to significantly alter its rotation rate under the influence of moon-generated tides. The situation becomes more complex for close-in planets, as star-generated tides come into play and compete with moon-generated tides. The synchronisation of the planet by its moon changes the tidal dynamics of the entire star–planet–moon system and can lead to long-term stable configurations. In this paper, we demonstrate that a certain initial condition must be met for this to occur. Based on the angular momentum conservation, the derived condition is universal and bears no dependence upon the planet’s internal structure or tidal dissipation model. It is applicable to dwindling systems as well as to tidally expanding orbits and cases of initially retrograde motion. We present calculations for specific planet–moon systems (Earth and the Moon; Neptune and Triton; Venus and its hypothetical presently extinct moon Neith; Mars, Phobos, and Deimos; and Pluto and Charon) to constrain dynamically plausible formation and evolution scenarios. Among other things, our analysis prompts the question of whether Pluto and Charon evolved into their current state from an initially more compact configuration (as is commonly assumed) or from a wider orbit—a topic that will be discussed at length elsewhere. Our results are equally applicable to exoplanets. For example, if asynchronous close-in exoplanets are detected, the possibility of tidal synchronisation by an exomoon should be considered. Full article
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14 pages, 823 KB  
Article
Synteny Patterns of Class 1 Integrons Reflect Microbial Adaptation and Soil Health in Agroecosystems
by Andrea Visca, Manuela Costanzo, Luciana Di Gregorio, Lorenzo Nolfi, Roberta Bernini and Annamaria Bevivino
Agriculture 2025, 15(17), 1833; https://doi.org/10.3390/agriculture15171833 - 28 Aug 2025
Viewed by 942
Abstract
Mobile genetic elements such as integrons are key drivers of microbial evolution, enabling rapid adaptation to environmental pressures through the acquisition and rearrangement of gene cassettes. In this study, we explored the structural diversity and synteny of class 1 integrons (intI1) [...] Read more.
Mobile genetic elements such as integrons are key drivers of microbial evolution, enabling rapid adaptation to environmental pressures through the acquisition and rearrangement of gene cassettes. In this study, we explored the structural diversity and synteny of class 1 integrons (intI1) across a set of agroecosystem-related environments, including digestate, compost, and rhizosphere soils from wheat crops (Triticum durum and T. aestivum). Our results reveal distinct gene cassette architectures shaped by the origin of the samples: digestate harbored the most diverse and complex arrays, while compost displayed streamlined structures. Rhizosphere soils exhibited intermediate configurations, reflecting a dynamic balance between environmental exposure and host influence. Genes associated with resistance to antibiotics and heavy metals, such as qacEΔ1 and ebrA, were differentially distributed, suggesting site-specific selective pressures. The observed patterns of cassette organization and diversity underscore the role of integron synteny as a molecular fingerprint of microbial adaptation. These findings position class 1 integrons as promising bioindicators of soil health and functional resilience, supporting a One Health approach to sustainable agriculture and microbial risk monitoring. Full article
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32 pages, 1447 KB  
Article
Haplotypes of Echinococcus granulosus sensu stricto in Chile and Their Comparison Through Sequences of the Mitochondrial cox1 Gene with Haplotypes from South America and Other Continents
by Nicole Urriola-Urriola, Gabriela Rossi-Vargas and Yenny Nilo-Bustios
Parasitologia 2025, 5(3), 40; https://doi.org/10.3390/parasitologia5030040 - 1 Aug 2025
Cited by 1 | Viewed by 1285
Abstract
Cystic echinococcosis is a zoonosis caused by the cestode Echinococcus granulosus sensu stricto. Population genetic studies and phylogeographic patterns are essential to understanding the transmission dynamics of this parasite under varying environmental conditions. In this study, the genetic diversity of E. granulosus [...] Read more.
Cystic echinococcosis is a zoonosis caused by the cestode Echinococcus granulosus sensu stricto. Population genetic studies and phylogeographic patterns are essential to understanding the transmission dynamics of this parasite under varying environmental conditions. In this study, the genetic diversity of E. granulosus s.s. was evaluated using 46 hydatid cyst samples obtained from sheep, goats, cattle, and humans across three regions of Chile: Coquimbo, La Araucanía, and Magallanes. Mitochondrial cox1 gene sequences were analyzed and compared with reference sequences reported from South America, Europe, Africa, Asia, and Oceania. In Chile, the EG01 haplotype was the predominant haplotype. A total of four haplotypes were identified, with low haplotype diversity (Hd = 0.461 ± 0.00637) and low nucleotide diversity (π = 0.00181 ± 0.00036). The haplotype network displayed a star-like configuration, with the EG01 genotype at the center, suggesting a potentially ancestral or widely distributed lineage. In Coquimbo (Tajima’s D = −0.93302, p = 0.061; Fu’s Fs = −0.003, p = 0.502) and Magallanes (Tajima’s D = −0.17406, p = 0.386; Fu’s Fs = −0.121, p = 0.414), both neutrality tests were non-significant, indicating no strong evidence for recent population expansion or selection. Star-like haplotype network patterns were also observed in populations from Europe, the Middle East, Asia, Africa, and Oceania, with the EG01 genotype occupying the central position. The population genetic structure of Echinococcus granulosus s.s. in Chile demonstrates considerable complexity, with EG01 as the predominant haplotype. Further comprehensive studies are required to assess the intraspecific genetic variability of E. granulosus s.s. throughout Chile and to determine whether this variability influences the key biological traits of the parasite. This structure may prove even more complex when longer fragments are analyzed, which could allow for the detection of finer-scale microdiversity among isolates from different hosts. We recommended that future cystic echinococcosis control programs take into account the genetic variability of E. granulosus s.s. strains circulating in each endemic region, to better understand their epidemiological, immunological, and possibly pathological differences. Full article
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14 pages, 3788 KB  
Article
Identification of Streptococcus pneumoniae Sortase A Inhibitors and the Interactive Mechanism
by Guizhen Wang, Jiahui Lu, Jingyao Wen, Yifan Duan, Hanbing Zhou, Xinli Peng and Zhandong Li
Crystals 2025, 15(7), 594; https://doi.org/10.3390/cryst15070594 - 24 Jun 2025
Viewed by 1054
Abstract
Streptococcus pneumoniae (S. pneumoniae) Sortase A (SrtA) anchors virulence proteins to the surface of the cell wall by recognizing and cleaving the LPXTG motif. These toxins help bacteria adhere to and colonize host cells, promote biofilm formation, and trigger host inflammatory [...] Read more.
Streptococcus pneumoniae (S. pneumoniae) Sortase A (SrtA) anchors virulence proteins to the surface of the cell wall by recognizing and cleaving the LPXTG motif. These toxins help bacteria adhere to and colonize host cells, promote biofilm formation, and trigger host inflammatory responses. Therefore, SrtA is an ideal target for the development of new preparations for S. pneumoniae. In this study, we found that phloretin (pht) and phlorizin (phz) exhibited excellent affinities for SrtA based on virtual screening experiments. We analyzed the interactive mechanism between pht, phz, and alnusone (aln, a reported S. pneumoniae SrtA inhibitor) and SrtA based on molecular dynamics simulation experiments. The results showed that these inhibitors bound to the active pocket of SrtA, and the root mean square deviation (RMSD) and distance analyses showed that these compounds and SrtA maintained stable configuration and binding during the assay. The binding free energy analysis showed that both electrostatic forces (ele), van der Waals forces (vdw), and hydrogen bonds (Hbonds) promoted the binding between pht, phz, and SrtA; however, for the binding of aln and SrtA, the vdw force was much stronger than ele, and Hbonds were not found. The binding free energy decomposition showed that HIS141, ILE143, and PHE119 contributed more energy to promote pht and SrtA binding; ARG215, ASP188, and LEU210 contributed more energy to promote phz and SrtA binding; and HIS141, ASP209, and ARG215 contributed more energy to promote aln and SrtA binding. Finally, the transpeptidase activity of SrtA decreased significantly when treated with different concentrations of pht, phz, or aln, which inhibited S. pneumoniae biofilm formation and adhesion to A549 cells without affecting normal bacterial growth. These results suggest that pht, phtz, and aln are potential materials for the development of novel inhibitors against S. pneumoniae infection. Full article
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24 pages, 6298 KB  
Article
Design and Simulation of Mobile Robots Operating Within Networked Architectures Tailored for Emergency Situations
by Marco Mărieș and Mihai Olimpiu Tătar
Appl. Sci. 2025, 15(11), 6287; https://doi.org/10.3390/app15116287 - 3 Jun 2025
Cited by 1 | Viewed by 1824
Abstract
This paper presents a simulation approach for mobile robots designed to operate within networks intended for emergency response scenarios. The simulation component is part of a broader and more complex system architecture focused on enhancing communication efficiency and operational coordination within robotic networks. [...] Read more.
This paper presents a simulation approach for mobile robots designed to operate within networks intended for emergency response scenarios. The simulation component is part of a broader and more complex system architecture focused on enhancing communication efficiency and operational coordination within robotic networks. This study leverages virtualization and robotic simulation technologies to develop a controlled environment in which the behavior and coordination of mobile robots can be analyzed and validated under simulated emergency conditions. To achieve this, a virtual machine was configured to host a ROS2 and Gazebo-based simulation environment. Custom packages were developed to enable the dynamic instantiation of mobile robots and the integration of essential sensing and control functionalities. The simulation process was carried out in two stages: initially, a single mobile robot was deployed and evaluated; subsequently, the configuration was extended to support a second robot, enabling multi-agent interaction within the simulated environment using flat surfaces. The proposed architecture demonstrates the potential for scalable deployment and simulation of mobile robotic instances. As a future direction, the authors aim to extend the system by optimizing data extraction from the simulation environment and implementing ROS2 microservices to facilitate secure and efficient communication with a centralized server deployed within a Kubernetes cluster. This integration will enable real-time coordination and data exchange between simulated agents and backend services, forming the foundation for a robust, distributed robotic system tailored to emergency operations. Full article
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13 pages, 5610 KB  
Article
An Approach to Thermal Management and Performance Throttling for Federated Computation on a Low-Cost 3D ESP32-S3 Package Stack
by Yi Liu, Parth Sandeepbhai Shah, Tian Xia and Dryver Huston
Computers 2025, 14(4), 147; https://doi.org/10.3390/computers14040147 - 11 Apr 2025
Cited by 1 | Viewed by 2466
Abstract
The rise of 3D heterogeneous packaging holds promise for increased performance in applications such as AI by bringing compute and memory modules into close proximity. This increased performance comes with increased thermal management challenges. This research explores the use of thermal sensing and [...] Read more.
The rise of 3D heterogeneous packaging holds promise for increased performance in applications such as AI by bringing compute and memory modules into close proximity. This increased performance comes with increased thermal management challenges. This research explores the use of thermal sensing and load throttling combined with federated computation to manage localized internal heating in a multi-3D chip package. The overall concept is that individual chiplets may heat at different rates due to operational and geometric factors. Shifting computational loads from hot to cooler chiplets can prevent local overheating while maintaining overall computational output. This concept is verified with experiments in a low-cost test vehicle. The test vehicle mimics a 3D chiplet stack with a tightly stacked assembly of SoC devices. These devices can sense and report internal temperature and dynamically adjust frequency. The configuration is for ESP32-S3 microcontrollers to work on a federated computational task, while reporting internal temperature to a host controller. The tight packing of processors causes temperatures to rise, with those internal to the stack rising more quickly than external ones. With real-time temperature monitoring, when the temperatures exceed a threshold, the AI system reduces the processor frequency, i.e., throttles the processor, to save power and dynamically shifts part of the workload to other ESP32-S3s with lower temperatures. This approach maximizes overall efficiency while maintaining thermal safety without compromising computational power. Experimental results with up to six processors confirm the validity of the concept. Full article
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18 pages, 12931 KB  
Article
H2 Optimization of a New Type of Tuned Lever Inerter-like Mass Damper (TLIMD) for Attenuating Structure Vibrations
by Kai Xu, Weiwei Wang, Hui Liang, Aifeng Liu, Jianmin Yang, Jingzhou Gao and Bei Chen
Appl. Sci. 2024, 14(21), 10059; https://doi.org/10.3390/app142110059 - 4 Nov 2024
Cited by 1 | Viewed by 1704
Abstract
The lever or the lever-type mechanism can achieve an inertia amplification effect by appropriately calibrating its structural configuration, and it is also proven to be one of the most cost-effective solution for the inerter realization compared with other mechanical devices. Benefitting from this [...] Read more.
The lever or the lever-type mechanism can achieve an inertia amplification effect by appropriately calibrating its structural configuration, and it is also proven to be one of the most cost-effective solution for the inerter realization compared with other mechanical devices. Benefitting from this property, the present paper adopted a new type of tuned lever inerter-like mass damper (TLIMD) for attenuating stochastic load-induced structure dynamic responses. A set of closed-form formulae for the TLIMD optimal parameters are developed by the use of H2 norm optimization criterion, wherein the structure’s inherent damping is explicitly accounted for. It is theoretically demonstrated that the TLIMD optimal parameters are mainly dominated by three critical parameters, i.e., the damper mass ratio, the lever length ratio (known as the inertia amplification ratio) and also the host structural damping. The proposed formulae for the TLIMD optimization are validated through the seismic analysis, where two classic inerter-based dampers (i.e., the tuned mass damper inerter (TMDI) and the tuned inerter damper (TID)) optimized by the numerical technique are included in the discussion. It is found that the TLIMD has a superior advantage in reducing the structure responses and also exhibits stronger robustness for the detuning condition than the classic inerter-based dampers. Furthermore, the increase in the damper mass ratio and the lever length ratio can be beneficial for enhancing its performance. Full article
(This article belongs to the Special Issue Monitoring and Reducing Structural Vibrations in Civil Engineering)
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