Search Results (127)

Within the context of global climate change, the hydrological and sediment load dynamics in the Huai River Basin are expected to continue evolving due to intensified human activities and environmental changes. Effective river management requires a clear understanding of the magnitude, causes, and characteristics of these changes, coupled with insight into the dynamic response processes of the river channel. This study applied a suite of statistical methods, including the Mann–Kendall test, Sen’s slope estimator, Pettitt’s test, double mass curve, and morphological analysis, to examine trends in streamflow and sediment load at two hydrological stations in the mid-Huai River from 1982 to 2016, and to assess channel evolution between Wujiadu and Xiaoliuxiang. The results indicate that: (1) both hydrological stations exhibited no significant decrease in annual streamflow, but a significant reduction in sediment load, with a change point detected in 1991 at Wujiadu Station; (2) compared to 1982–1990, the mean streamflow and sediment load decreased by 23% and 50% during 1991–2016, with a significant shift in the streamflow-sediment relationship; (3) while temperature and evapotranspiration increased significantly, precipitation remained relatively stable, indicating that climate change had a minor effect on hydrological elements, and sediment load reduction was primarily driven by large-scale ecological restoration and engineering activities; and (4) differential channel adjustments were observed in response to reduced sediment supply and human activities, modulated by local boundary conditions. Erosion occurred in the WJD section, resulting in a transformation from a U-shape to a V-shape cross-section, whereas the XLX section remained stable with a local adverse gradient. This study reveals the complex mechanisms of hydro-sedimentary and channel evolution under human dominance, offering scientific support for the sustainable management of the Huai River basin and similar regulated rivers. Full article

Renewable energy sources are among the most promising alternatives to fossil fuels, and solar thermal energy stands out due to its high conversion efficiency and direct thermal utilization. The performance of solar collectors is evaluated under standardized procedures, including ISO 9806:2025. In the Republic of Korea, KS B 8295:2023 is applied for certification; however, it lacks clear guidance on the selection of the working fluid mass flow rate during experimental testing. This study experimentally investigates the thermal performance of a double-glass evacuated tube solar collector under varying flow rates, tested in accordance with both KS B 8295:2023 and ISO 9806:2025 standards. Three flow rates (0.042, 0.067, 0.092 kg/s) were tested at four inlet temperature levels. Unlike most previous studies, which were primarily based on simulations and lacked standardized experimental validation, this work provides empirical results obtained under fully standard testing conditions, thereby filling an important research gap. Instantaneous efficiency curves were derived, showing that increasing the flow rate enhanced the average thermal output by approximately 6%. These results highlight the necessity of defining optimal flow rate conditions in KS B 8295:2023, and the empirical correction factor proposed herein can support future standard revisions and promote international harmonization. Full article

Water stress represents one of the most critical limiting factors affecting plant distribution, growth rate, biomass accumulation, and crop yield across diverse growth stages. Variations in species’ drought tolerance fundamentally shape global biodiversity patterns by influencing survival rates, distribution ranges, and community composition under changing environmental conditions. This study investigated the physiological responses of six plant species (Haloxylon ammodendron (H.A.), Nitraria tangutorum Bobr. (N.T.B.), Sympegma regelii Bge. (S.R.B.), Tamarix chinensis (T.C.), Potentilla fruticosa (P.F.R.), and Sabina chinensis (Linn.) Ant. (S.C.A.)) to varying water stress levels through controlled water gradient experiments. Four treatment levels were established: W1 (full water supply, >70% field water holding capacity); W2 (mild stress, 50–55%); W3 (moderate stress, 35–40%); and W4 (severe stress, 20–25%). Height growth and leaf mass per area decreased significantly with increasing water stress across all species. S.C.A. consistently exhibited the highest leaf mass per area among the six species, while H.A. showed the lowest values across all treatments. Leaf water content declined progressively with intensifying water stress, with T.C. and P.F.R. showing the most pronounced reductions (T.C.: 16.53%, 18.07%, and 33.37% under W2, W3, and W4, respectively; P.F.R.: 19.45%, 28.52%, and 36.08%), whereas N.T.B. and H.A. demonstrated superior water retention capacity (N.T.B.: 2.44%, 6.64%, and 9.76%; H.A.: 1.44%, 4.39%, and 5.52%). Water saturation deficit increased correspondingly with declining soil moisture. Diurnal leaf water potential patterns exhibited a characteristic V-shaped curve under well-watered (W1) and mildly stressed (W2) conditions, transitioning to a double-valley pattern with unstable fluctuations under moderate (W3) and severe (W4) stress. Leaf water potential showed linear relationships with air temperature and relative humidity, and a quadratic relationship with atmospheric water potential. For all six species, the relationship between pre-dawn leaf water potential and soil water content followed the curve equation y = a + b/x. Under water-deficient conditions, S.C.A. exhibited the greatest water physiological changes, followed by P.F.R. Both logarithmic and power function relationships between leaf and soil water potentials were highly significant (all F > 55.275, all p < 0.01). T.C. leaf water potential was the most sensitive to soil water potential changes, followed by S.C.A., while H.A. demonstrated the least sensitivity. These findings provide essential theoretical foundations for selecting drought-resistant plant species in arid regions of the Qaidam Basin. This study elucidates the response mechanisms of six distinct drought-tolerant plant species under water stress. It provides critical theoretical support for selecting drought-tolerant species, designing community configurations, and implementing water management strategies in vegetation restoration projects within the arid Qaidam Basin. Furthermore, it contributes empirical data at the plant physiological level to understanding the mechanisms sustaining species diversity in arid ecosystems. Full article

In the mining of deep mineral resources and tunnel engineering, the degradation of mechanical properties and the evolution of energy of through-double-joint sandy slate under triaxial loading and unloading conditions are key scientific issues affecting the stability design of the project. The existing research has insufficiently explored the joint inclination angle effect, damage evolution mechanism, and energy distribution characteristics of this type of rock mass under the path of increasing axial pressure and removing confining pressure. Based on this, in this study, uniaxial compression, conventional triaxial compression and increasing axial pressure, and removing confining pressure tests were conducted on four types of rock-like materials with prefabricated 0°, 30°, 60°, and 90° through-double-joint inclinations under different confining pressures. The axial stress/strain curve, failure characteristics, and energy evolution law were comprehensively analyzed, and damage variables based on dissipated energy were proposed. The test results show that the joint inclination angle significantly affects the bearing capacity of the specimen, and the peak strength shows a trend of first increasing and then decreasing with the increase in the inclination angle. In terms of failure modes, the specimens under conventional triaxial compression exhibit progressive compression/shear failure (accompanied by rock bridge fracture zones), while under increased axial compression and relief of confining pressure, a combined tensioning and shear failure is induced. Moreover, brittleness is more pronounced under high confining pressure, and the joint inclination angle also has a significant control effect on the failure path. In terms of energy, under the same confining pressure, as the joint inclination angle increases, the dissipated energy and total energy of the cemented filling body at the end of triaxial compression first decrease and then increase. The triaxial compression damage constitutive model of jointed rock mass established based on dissipated energy can divide the damage evolution into three stages: initial damage, damage development, and accelerated damage growth. Verified by experimental data, this model can well describe the damage evolution characteristics of rock masses with different joint inclination angles. Moreover, an increase in the joint inclination angle will lead to varying degrees of damage during the loading process of the rock mass. The research results can provide key theoretical support and design basis for the stability assessment of surrounding rock in deep and high-stress plateau tunnels, the optimization of support parameters for jointed rock masses, and early warning of rockburst disasters. Full article

The aim of this study was to improve screening efficiency by establishing reasonable interpretation criteria for the use of flow injection analysis tandem mass spectrometry (FIA-MS/MS) in newborn screening (NBS) for X-linked adrenoleukodystrophy (X-ALD). FIA-MS/MS was employed to analyze very-long-chain acylcarnitines (ACs) and lysophosphatidylcholines (LPCs) and their ratios in dried blood spot (DBS) obtained from five X-ALD patients in the neonatal period (0–7 days old) and 7123 healthy neonate controls. By comparing these results and analyzing receiver operating characteristic (ROC) curves, we identified sensitive indicators for X-ALD screening in newborns. To evaluate the performance of different FIA-MS/MS screening indicators, we simultaneously analyzed 7712 neonatal DBS samples obtained for X-ALD screening using FIA-MS/MS and the established liquid chromatography tandem mass spectrometry (LC-MS/MS) method for quantitative detection of C26:0-lysophosphatidylcholine (C26:0-LPC). Furthermore, 84,268 newborn X-ALD screening results were retrospectively analyzed to further evaluate the screening performance of FIA-MS/MS. After the three-step optimization evaluation, the optimized first-tier sensitive screening indicators of FIA-MS/MS were C24:0-AC, C26:0LPC, and C24:0/C22:0-AC. Among the 7712 newborns screened, one case was confirmed to be double-positive. Within separate statistical analyses, based on LC-MS/MS screening alone (positive cutoff > 0.17 µmol/L), only seven cases (0.09%) were initially positive, with a positive predictive value (PPV) of 42.8%, and two additional ABCD1 VUS hemizygous males were detected. Through the retrospective analysis of 84,268 newborns, eight ABCD1 variants (six hemizygous males and two heterozygous females) were ultimately identified. Our study showed that the optimization of first-tier screening performance is particularly important if second-tier screening is not performed. Using LC-MS/MS for second-tier screening for X-ALD can significantly reduce the number of false positives, but the method still misses some false negatives. If it is used as a first-tier assessment, more VUS variant neonates can be detected. Full article

Background: Crystalline glucosamine sulfate (cGS) claims to be a stabilized form of glucosamine sulfate with a defined crystalline structure intended to enhance chemical stability. It is proposed to offer pharmacokinetic advantages over regular glucosamine sulfate (rGS) which is stabilized with potassium or sodium chloride. However, comparative human bioavailability data are limited. Since both forms dissociate in gastric fluid into constituent ions, the impact of cGS formulation on absorption remains uncertain. This pilot study aimed to compare the bioavailability of cGS and rGS using a randomized, double-blind, crossover design. Methods: Ten healthy adults received a single 1500 mg oral dose of either cGS or rGS with a 7-day washout between interventions. Capillary blood samples were collected over 24 h. Glucosamine and its metabolite concentrations were quantified by Liquid Chromatography-High Resolution Mass Spectrometry (LC-HRMS), and pharmacokinetic parameters—including maximum concentration (C_max), time to reach C_max (T_max), and area under the curve (AUC)—were calculated. Results: Mean AUC_0–24, C_max, T_max, and T_½ values for glucosamine and glucosamine-6-sulfate (GlcN-6-S) were comparable between cGS and rGS. Although the AUC_0–24 for glucosamine was modestly higher with rGS (18,300 ng·h/mL) than with cGS (12,900 ng·h/mL), the difference was not statistically significant (p = 0.136). GlcN-6-S exposure was also similar between formulations (rGS: 50,700 ng·h/mL; cGS: 50,600 ng·h/mL), with a geometric mean ratio of 1.39, a delayed T_max (6–8 h) and longer half-life, consistent with its role as a downstream metabolite. N-acetylglucosamine levels remained stable, indicating potential homeostatic regulation. Conclusions: This pilot study found no significant pharmacokinetic advantage of cGS over rGS. These preliminary findings challenge claims of cGS’ pharmacokinetic superiority, although the small sample size limits definitive conclusions. Larger, adequately powered studies are needed to confirm these results. Full article

We propose a single-phase chiral elastic metamaterial capable of simultaneously exhibiting negative effective mass density and negative bulk modulus in the ultrasonic frequency range. The unit cell consists of a regular hexagonal frame connected to a central circular mass through six obliquely oriented, slender aluminum beams. The design avoids the manufacturing complexity of multi-phase systems by relying solely on geometric topology and chirality to induce dipolar and rotational resonances. Dispersion analysis and effective parameter retrieval confirm a double-negative frequency region from 30.9 kHz to 34 kHz. Finite element simulations further demonstrate negative refraction behavior when the metamaterial is immersed in water and subjected to 32 kHz and 32.7 kHz incident plane wave. Equifrequency curves (EFCs) analysis shows excellent agreement with simulated refraction angles, validating the material’s double-negative performance. This study provides a robust, manufacturable platform for elastic wave manipulation using a single-phase metallic metamaterial design. Full article

Background/Objectives: Curcumin, the principal bioactive component of Curcuma longa, is known for its anti-inflammatory, antioxidant, and neuroprotective properties. Despite its therapeutic potential, curcumin exhibits poor oral bioavailability due to low solubility, rapid metabolism, and limited gastrointestinal absorption. Various delivery systems have been developed to overcome these limitations. This study aimed to evaluate and compare the pharmacokinetic profile of AQUATURM®, a novel, water-soluble curcumin formulation, with that of a widely available commercial curcumin supplement. Methods: A randomized, double-blind, two-period crossover study was conducted in 12 healthy adult participants (6 male, 6 female; aged 20–45 years). Each participant received a single oral dose of either AQUATURM® or the comparator product, followed by a 7-day washout period before receiving the alternate treatment. Blood samples were collected at multiple time points over a 12-h period post-dosing. Plasma curcumin concentrations were quantified using ultra-performance liquid chromatography with tandem mass spectrometry (UPLC-MS/MS). Results: AQUATURM® achieved a significantly higher systemic exposure compared to the comparator, with a more than 7-fold increase in area under the curve (AUC_0–12h) and higher peak plasma concentrations (Cmax). AQUATURM® also maintained detectable curcumin levels for the full 12-h observation period, whereas levels from the comparator fell below quantification limits in most participants after 4 h. Conclusions: AQUATURM® significantly enhances curcumin bioavailability in humans compared to a standard curcumin formulation. These pharmacokinetic improvements support its potential for greater clinical efficacy and warrant further evaluation in therapeutic setting Full article

Heterozygous mutations in the GBA1 gene, encoding the enzyme glucocerebrosidase (GCase), are major risk factors for Parkinson’s Disease (PD). Ambroxol, a small chaperone originally used as a mucolytic agent, has been shown to cross the blood–brain barrier, enhance GCase activity, and reduce α-synuclein levels, making it a promising therapeutic candidate for disease-modifying effects in GBA1-associated PD (GBA1-PD). This study aimed to develop a method to quantify ambroxol levels in human plasma and cerebrospinal fluid (CSF) using liquid chromatography–tandem mass spectrometry (LC-MS/MS). Ambroxol was determined by online solid-phase extraction (SPE), coupled with LC-MS/MS, by gradient elution on a monolithic column. Detection employed a 3200 QTRAP tandem mass spectrometer in the positive electrospray ionization mode. Calibration curves exhibited linearity across the analyzed ranges in both plasma and CSF. The recovery rate ranged from 106.7% to 113.5% in plasma and from 99.0% to 103.0% in CSF. No significant matrix effect was observed. Intra-day and inter-day precisions were below 11.8% in both matrices, and accuracy ranged from 89.9% to 103.1% in plasma and from 96.3% to 107.8% in CSF. We evaluated and confirmed the stability of the analyte in plasma and CSF across various storage conditions. The method was successfully validated according to European Medicine Agency (EMA) guidelines and its applicability was confirmed in the context of a multicenter, randomized, double-blind, placebo-controlled, phase II study, designed to monitor the ambroxol levels in the plasma and CSF of GBA1-PD. Full article

This study focuses on Neogene red-bed soft rock tunnels in the Huicheng Basin, China. Through engineering geological investigation, remote wireless monitoring systems, and total station multi-parameter monitoring, the deformation characteristics of red-bed soft rock surrounding rock under high in situ stress environments and their influencing factors were systematically analyzed. The findings reveal that the surrounding rock deformation follows a three-stage evolutionary pattern of “rapid, slow, and stable”. Construction disturbances can disrupt the stable state, leading to “deep V-shaped” anomalies or double-step responses in deformation curves. Spatially, the deformation exhibits significant anisotropy, with the haunch area showing the maximum deformation (95 mm) and the vault the minimum (65–73 mm). Deformation stabilization requires 30–42 days, and a reserved deformation of 10 cm is recommended based on specifications. Mechanical behavior analysis indicates that the stress–strain curves of red-bed argillaceous sandstone are stepped, with increased confining pressure enhancing both peak and residual strengths, validating the necessity of timely support. The study elucidates a multi-factor coupling mechanism: rock mass classification, temporal–spatial effects (excavation face constraints and rheological properties), construction methods, in situ stress levels, and support timing (timely support during the rapid phase inhibits strength degradation) significantly influence deformation evolution. The spatiotemporal distribution of surrounding rock pressure shows that invert pressure increases most rapidly, while vault pressure reaches the highest magnitude, with construction disturbances triggering stress redistribution. This research provides theoretical and practical guidance for the design, construction optimization, and disaster prevention of red-bed soft rock tunnels. Full article

Surface runoff change is significantly influenced by both human activities and climate change. Decoupling their respective contributions to runoff change represents a critical frontier in hydrological research and a pressing challenge for water resource management. This study focuses on the Dawen River Basin, a strategic area for ecological conservation and high-quality development in the lower Yellow River region. By integrating three methodological approaches—empirical models (Precipitation–Runoff Double Mass Curve), conceptual models (elasticity coefficient methods), and hydrological models (Soil and Water Assessment Tool, SWAT)—we systematically quantify the impacts of climate change and human activities on runoff change. A correlation analysis was first applied to screen independent runoff drivers and basin characteristic factors, followed by a random forest algorithm to rank their relative importance. This process informed the establishment of a comprehensive framework for runoff attribution analysis. Results demonstrate that hydrological modeling (SWAT) is the most appropriate method for the Dawen River Basin, revealing human activities as the dominant driver of runoff changes, accounting for 70% to 82%. These findings provide critical insights for guiding sustainable water resource planning and management in anthropogenically stressed basins under a changing environment. Full article

Soil erosion poses a significant global environmental challenge, causing land degradation, deforestation, river siltation, and reduced agricultural productivity. Although the Revised Universal Soil Loss Equation (RUSLE) has been widely applied in Brazil, its use in the tropical river basins of the Amazon remains limited. This study aimed to apply a GIS-integrated RUSLE model and compare its soil loss estimates with multiple linear regression (MLR) models based on terrain attributes, aiming to identify priority areas and key geomorphometric drivers of soil erosion in a tropical Amazonian river basin. A digital elevation model based on Shuttle Radar Topography Mission (SRTM) data, land use and land cover (LULC) maps, and rainfall and soil data were applied to the GIS-integrated RUSLE model; we then defined six risk classes—slight (0–2.5 t ha⁻¹ yr⁻¹), slight–moderate (2.5–5), moderate (5–10), moderate–high (10–15), high (15–25), and very high (>25)—and identified priority zones as those in the top two risk classes. The Caeté River Basin (CRB) was classified into six erosion risk categories: low (81.14%), low to moderate (2.97%), moderate (11.88%), moderate to high (0.93%), high (0.03%), and very high (3.05%). The CRB predominantly exhibited a low erosion risk, with higher erosion rates linked to intense rainfall, gentle slopes covered by Arenosols, and human activities. The average annual soil loss was estimated at 2.0 t ha⁻¹ yr⁻¹, with a total loss of 1005.44 t ha⁻¹ yr⁻¹. Additionally, geomorphological and multiple linear regression (MLR) analyses identified seven key variables influencing soil erosion: the convergence index, closed depressions, the topographic wetness index, the channel network distance, and the local curvature, upslope curvature, and local downslope curvature. These variables collectively explained 26% of the variability in soil loss (R² = 0.26), highlighting the significant role of terrain characteristics in erosion processes. These findings indicate that soil erosion control efforts should focus primarily on areas with Arenosols and regions experiencing increased anthropogenic activity, where the erosion risks are higher. The identification of priority erosion areas enables the development of targeted conservation strategies, particularly for Arenosols and regions under anthropogenic pressure, where the soil losses exceed the tolerance threshold of 10.48 t ha⁻¹ yr⁻¹. These findings directly support the formulation of local environmental policies aimed at mitigating soil degradation by stabilizing vulnerable soils, regulating high-impact land uses, and promoting sustainable practices in critical zones. The GIS-RUSLE framework is supported by consistent rainfall data, as verified by a double mass curve analysis (R² ranging from 0.64 to 0.77), and offers a replicable methodology for soil conservation planning in tropical basins with similar erosion drivers. This approach offers a science-based foundation to guide soil conservation planning in tropical basins. While effective in identifying erosion-prone areas, it should be complemented in future studies by dynamic models and temporal analyses to better capture the complex erosion processes and land use change impacts in the Amazon. Full article

Aiming to solve the difficult problem of the miniaturization of servo valves, this paper designs a subminiature two-dimensional (2D) electro-hydraulic servo valve, which realizes the integration of the pilot stage and the power stage and significantly improves the work-to-weight ratio. Meanwhile, a high-power-density brushless DC motor (BLDC) is adopted as the electro-mechanical converter to further reduce the volume and mass. Firstly, the structure and working principle of the two-dimensional (2D) servo valve are described, and the mathematical model of the electro-mechanical converter is established. Aiming at the special working condition of the electro-mechanical converter with high-frequency oscillation at a small turning angle, this paper designs a position–current double closed-loop PID control algorithm based on the framework of the vector control algorithm (FOC). At the same time, the current feedforward compensation technique is included to cope with the high-frequency nonlinear disturbance problem of the electro-mechanical converter. The stability conditions of the electro-mechanical converter and the main valve were established based on the Routh–Hurwitz criterion, and the effects of the control algorithm of the electro-mechanical converter and the main parameters of the main valve on the stability of the system were analyzed. The dynamic and static characteristics of the 2D valve were simulated and analyzed by establishing a joint simulation model in Matlab/Simulink and AMESim. The prototype was fabricated, and the experimental bench was built; the size of the experimental prototype was 31.7 mm × 29.3 mm × 31 mm, and its mass was 73 g. Under a system pressure of 7 MPa, the flow rate of this valve was 5 L/min; the hysteresis loop of the spool-displacement input–output curve was 4.8%, and the linearity was 2.54%, which indicated that it had the ability of high-precision control and that it was suitable for the precision fluid system. The step response time was 7.5 ms, with no overshoot; the frequency response amplitude bandwidth was about 90 Hz (−3 dB); the phase bandwidth was about 95 Hz (−90°); and the dynamic characterization experiment showed that it had a fast response characteristic, which can satisfy the demand of high-frequency and high-dynamic working conditions. Full article

Muscle mass and physical function are key risk factors for sarcopenia, with emerging evidence suggesting links to gait variability in older adults. This study investigated the relationships between muscle mass decline, poor physical performance, sarcopenia, and spatiotemporal gait parameters in 242 Korean older adults (mean age: 79.1 ± 4.2 years). Muscle mass (MM) was measured via dual-energy X-ray absorptiometry (DXA), physical performance (PP) via the Short Physical Performance Battery (SPPB), and gait parameters (gait speed, stride length, double-limb stance) via the Optogait^® system. Stride length significantly influenced low MM, while double-limb stance was linked to increased risks of poor PP and sarcopenia. The area under the curve (AUC) for double-limb stance was 0.698 (95% CI: 0.633–0.763, p < 0.001) for poor PP and 0.647 (95% CI: 0.568–0.726, p = 0.001) for sarcopenia. A novel model combining gait speed and double-limb stance achieved an AUC of 0.702 (95% CI: 0.622–0.781, p < 0.001) with 78.9% sensitivity and 76.3% specificity. These findings highlight spatiotemporal gait analysis as a promising tool for early sarcopenia detection and management in older adults. Full article

It is essential to understand the characteristics of surface runoff generating processes under different heavy rainfall events in mountainous areas. The intensity and duration of precipitation play an important role in surface runoff processes. In this study, annual rainfall characteristics from 1987 to 2023 in the Taihang Mountains were analyzed using the Pearson-III frequency curve, homogeneity tests, and the Mann–Kendall (MK) test. Four surface runoff generation events between 2014 and 2023 were monitored. The contribution of rainfall to runoff variations was quantified through the double mass curve method. Results indicate a significant increase in the frequency of moderate and heavy rainfall events over the last decade. Spatial variability of rainfall and elevation effects in the Taihang Mountains becomes less pronounced when 24 h rainfall is below 50 mm. The two surface runoff processes in 2016 and 2023 were typical runoff resulting from excess rain, which belonged to the storm runoff. The two surface runoff processes in 2021 were runoff generation under saturated conditions. For runoff generation under saturated conditions, the contribution of rainfall was only 58.17%. When the runoff coefficient exceeded 0.5, the surface runoff generating processes were entirely determined by rainfall. This study suggested that for semi-arid regions, where rainfall is unevenly distributed over the seasons, more soil water is needed to maintain local and downstream water demand during the non-rainy season. The limitations of the study are the lack of research on factors other than rainfall that intrinsically affect the surface runoff generating process. Full article