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31 pages, 12308 KB  
Article
An Improved MSEM-Deeplabv3+ Method for Intelligent Detection of Rock Mass Fractures
by Chi Zhang, Shu Gan, Xiping Yuan, Weidong Luo, Chong Ma and Yi Li
Remote Sens. 2026, 18(7), 1041; https://doi.org/10.3390/rs18071041 - 30 Mar 2026
Viewed by 295
Abstract
Fractures as critical discontinuous structural planes in rock masses, directly govern their stability and serve as the core controlling factor in rock mechanics engineering. Existing deep learning models for fracture extraction face persistent challenges, including imbalanced integration of deep and shallow features, limited [...] Read more.
Fractures as critical discontinuous structural planes in rock masses, directly govern their stability and serve as the core controlling factor in rock mechanics engineering. Existing deep learning models for fracture extraction face persistent challenges, including imbalanced integration of deep and shallow features, limited suppression of background noise, inadequate multi-scale feature representation, and large parameter sizes—making it difficult to strike a balance between detection accuracy and deployment efficiency. Focusing on the Wanshanshan quarry in Yunnan, this study first constructs a high-precision digital model using close-range photogrammetry and 3D real-scene reconstruction. A lightweight yet high-accuracy intelligent detection method, termed MSEM-Deeplabv3+, is then proposed for rock mass fracture extraction. The model adopts lightweight MobileNetV2 as the backbone network, incorporating inverted residual modules and depthwise separable convolutions, resulting in a parameter size of only 6.02 MB and FLOPs of 30.170 G—substantially reducing computational overhead. Furthermore, the proposed MAGF (Multi-Scale Attention Gated Fusion) and SCSA (Spatial-Channel Synergistic Attention) modules are integrated to enhance the representation of fracture details and semantic consistency while effectively suppressing multi-source and multi-scale background interference. Experimental results demonstrate that the proposed model achieves an mPA of 89.69%, mIoU of 83.71%, F1-Score of 90.41%, and Kappa coefficient of 80.81%, outperforming the classic Deeplabv3+ model by 5.81%, 6.18%, 4.53%, and 9.2%, respectively. It also significantly surpasses benchmark models such as U-Net and HRNet. The method accurately captures fine and continuous fracture details, preserves the spatial distribution of long-range continuous fractures, and maintains robust performance on the CFD cross-scene dataset, showcasing strong adaptability and generalization capability. This approach effectively mitigates the risks associated with manual high-altitude inspections and provides a lightweight, high-precision, non-contact intelligent solution for fracture detection in high-steep rock slopes. Full article
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22 pages, 9539 KB  
Article
Two Decades of Land Subsidence in Tianjin, China, Measured with Multi-Temporal InSAR Observations
by Haolin Zhao, Hongyue Zhou, Dashan Zhou and Chaoying Zhao
Sensors 2026, 26(4), 1203; https://doi.org/10.3390/s26041203 - 12 Feb 2026
Viewed by 495
Abstract
Land subsidence poses a persistent challenge to Tianjin, a major coastal city in China, with implications for urban infrastructure and sustainable development. This study examines the spatiotemporal evolution of ground subsidence in Tianjin from 2003 to 2024 using multi-source SAR observations from Envisat [...] Read more.
Land subsidence poses a persistent challenge to Tianjin, a major coastal city in China, with implications for urban infrastructure and sustainable development. This study examines the spatiotemporal evolution of ground subsidence in Tianjin from 2003 to 2024 using multi-source SAR observations from Envisat ASAR (C-band), ALOS PALSAR (L-band), and Sentinel-1 (C-band). Surface deformation was derived using SBAS-InSAR with atmospheric phase correction. Due to limitations in data availability, SAR observations are temporally discontinuous; therefore, the long-term subsidence evolution was reconstructed by integrating multi-sensor deformation rates through a model-based time-series fitting approach. The results show pronounced subsidence during 2003–2010 in inland districts such as Wuqing, Beichen, Jinnan, and Jinghai, with maximum rates exceeding 50 mm/yr. After 2017, regional subsidence rates generally declined, while localized deformation became increasingly concentrated in coastal reclamation areas of the Binhai New Area, particularly around Dongjiang Port and Fuzhuang. Spatial and temporal patterns of subsidence exhibit clear correspondence with changes in groundwater use intensity and phases of urban construction and land reclamation. These observations suggest a transition in dominant subsidence controls over time. The results provide a long-term observational perspective on subsidence evolution in Tianjin and offer a geospatial basis for land-use planning and infrastructure risk assessment in coastal cities. Full article
(This article belongs to the Section Radar Sensors)
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21 pages, 41229 KB  
Article
Research on a Sensorless Control Strategy for Permanent Magnet Synchronous Motors Based on Non-Singular Fast Terminal Sliding Mode Theory
by Min Ge, Guozhong Yao, Te Pu and Zhengjiang Wang
Appl. Sci. 2026, 16(4), 1767; https://doi.org/10.3390/app16041767 - 11 Feb 2026
Viewed by 440
Abstract
This study introduces a sensorless control approach for permanent magnet synchronous motors (PMSMs) that employs an Improved Non-Singular Fast Terminal Sliding Mode Controller (IMNFTSMC) and an Improved Non-Singular Fast Terminal Sliding Mode Observer (IMNFTSMO). The IMNFTSMC employs a novel hybrid reaching law and [...] Read more.
This study introduces a sensorless control approach for permanent magnet synchronous motors (PMSMs) that employs an Improved Non-Singular Fast Terminal Sliding Mode Controller (IMNFTSMC) and an Improved Non-Singular Fast Terminal Sliding Mode Observer (IMNFTSMO). The IMNFTSMC employs a novel hybrid reaching law and a continuous piecewise square root switching function to achieve faster convergence and effective chattering reduction over the conventional Sliding Mode Controller (SMC). This design successfully replaces two critical components: the discontinuous constant velocity term (a key component of the traditional SMC reaching law that is a primary source of control chattering in PMSM torque regulation) and the high-gain exponential term (which tends to induce overshoot during transient speed adjustments and degrade steady-state control precision). In the IMNFTSMO, a hybrid approach combining linear and non-singular terminal sliding modes eliminates phase lag associated with low-pass filtering in traditional sliding mode observers, improving rotor position and speed estimation accuracy. Stability of both IMNFTSMC and IMNFTSMO is rigorously proven using Lyapunov stability theory.Validation through extensive simulations and hardware experiments, including challenging zero-speed start, speed stepping, and load disturbance tests, confirms the proposed strategy provides improved dynamic response, effective anti-disturbance capability, and high accuracy for rotor position and speed estimation compared to established benchmark methods, demonstrating its feasibility for mid-to-low speed sensorless PMSM drives. Full article
(This article belongs to the Special Issue Power Electronics and Motor Control)
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24 pages, 5941 KB  
Article
A Fully Implicit Model of Compressible Capillary Flows
by Jean-Paul Caltagirone
Fluids 2026, 11(2), 34; https://doi.org/10.3390/fluids11020034 - 27 Jan 2026
Viewed by 466
Abstract
Small-scale two-phase flows are subject to intense capillary accelerations that must be treated with care in order to avoid artifacts often associated with the numerical methodologies used, such as excessive fragmentation of structures. This analysis proposes a formulation of capillary actions for compressible [...] Read more.
Small-scale two-phase flows are subject to intense capillary accelerations that must be treated with care in order to avoid artifacts often associated with the numerical methodologies used, such as excessive fragmentation of structures. This analysis proposes a formulation of capillary actions for compressible viscous two-phase flows within the framework of discrete mechanics, where the concept of mass is abandoned in favor of a law of motion that describes the conservation of accelerations, one related to inertia and the other to external actions. With the introduction of the capillary term, the sum of a capillary potential gradient and the dual curl of a vector potential is consistent with the other terms of the law of motion, a formal Helmholtz–Hodge decomposition. This fully compressible formulation reproduces the capillary waves generated by the source terms and the contact and shock discontinuities in the two immiscible fluids. This methodology completely eliminates parasitic currents due mainly to the presence of residual curl in the capillary source terms. Several classic examples demonstrate the validity of this approach. Full article
(This article belongs to the Special Issue Multiphase Simulations with the Volume-of-Fluid (VOF) Approach)
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21 pages, 3620 KB  
Article
Geomechanical Analysis of Hot Fluid Injection in Thermal Enhanced Oil Recovery
by Mina S. Khalaf
Energies 2026, 19(2), 386; https://doi.org/10.3390/en19020386 - 13 Jan 2026
Cited by 1 | Viewed by 476
Abstract
Hot-fluid injection in thermal-enhanced oil recovery (thermal-EOR, TEOR) imposes temperature-driven volumetric strains that can substantially alter in situ stresses, fracture geometry, and wellbore/reservoir integrity, yet existing TEOR modeling has not fully captured coupled thermo-poroelastic (thermo-hydro-mechanical) effects on fracture aperture, fracture-tip behavior, and stress [...] Read more.
Hot-fluid injection in thermal-enhanced oil recovery (thermal-EOR, TEOR) imposes temperature-driven volumetric strains that can substantially alter in situ stresses, fracture geometry, and wellbore/reservoir integrity, yet existing TEOR modeling has not fully captured coupled thermo-poroelastic (thermo-hydro-mechanical) effects on fracture aperture, fracture-tip behavior, and stress rotation within a displacement discontinuity method (DDM) framework. This study aims to examine the influence of sustained hot-fluid injection on stress redistribution, hydraulic-fracture deformation, and fracture stability in thermal-EOR by accounting for coupled thermal, hydraulic, and mechanical interactions. This study develops a fully coupled thermo-poroelastic DDM formulation in which fracture-surface normal and shear displacement discontinuities, together with fluid and heat influx, act as boundary sources to compute time-dependent stresses, pore pressure, and temperature, while internal fracture fluid flow (Poiseuille-based volume balance), heat transport (conduction–advection with rock exchange), and mixed-mode propagation criteria are included. A representative scenario considers an initially isothermal hydraulic fracture grown to 32 m, followed by 12 months of hot-fluid injection, with temperature contrasts of ΔT = 0–100 °C and reduced pumping rate. Results show that the hydraulic-fracture aperture increases under isothermal and modest heating (ΔT = 25 °C) and remains nearly stable near ΔT = 50 °C, but progressively narrows for ΔT = 75–100 °C despite continued injection, indicating potential injectivity decline driven by thermally induced compressive stresses. Hot injection also tightens fracture tips, restricting unintended propagation, and produces pronounced near-fracture stress amplification and re-orientation: minimum principal stress increases by 6 MPa for ΔT = 50 °C and 10 MPa for ΔT = 100 °C, with principal-stress rotation reaching 70–90° in regions adjacent to the fracture plane and with markedly elevated shear stresses that may promote natural-fracture activation. These findings show that temperature effects can directly influence injectivity, fracture containment, and the risk of unintended fracture or natural-fracture activation, underscoring the importance of temperature-aware geomechanical planning and injection-strategy design in field operations. Incorporating these effects into project design can help operators anticipate injectivity decline, improve fracture containment, and reduce geomechanical uncertainty during long-term hot-fluid injection. Full article
(This article belongs to the Section H1: Petroleum Engineering)
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31 pages, 6557 KB  
Article
Sustaining CyberWater-VisTrails: A Case Study in Software Upgrades and Reengineering
by Drew Bieger, Ahmed Sheba, Adham M. Hassan, Sherif Aly, Ranran Chen, Xu Liang and Yao Liang
Information 2025, 16(11), 988; https://doi.org/10.3390/info16110988 - 15 Nov 2025
Viewed by 568
Abstract
This study focuses on the process of updating and upgrading a large-scale legacy software system to ensure its compatibility with modern computing environments. The evolution and maintenance of legacy software pose significant challenges in software engineering, especially given the rapid advancements in technology, [...] Read more.
This study focuses on the process of updating and upgrading a large-scale legacy software system to ensure its compatibility with modern computing environments. The evolution and maintenance of legacy software pose significant challenges in software engineering, especially given the rapid advancements in technology, computing platforms, and dependent libraries. These challenges become even more pronounced when new systems are built upon existing open-source software, which may become outdated due to discontinued maintenance or lack of community support. In this work, we examine the problem from a sustainable computing perspective through the case study of the CyberWater project—an innovative cyberinfrastructure framework designed to support open data access and open model integration in water science and engineering. CyberWater is built on top of VisTrails, an open-source scientific workflow system. VisTrails has not been actively maintained since 2017, requiring an upgrade to ensure CyberWater’s continued functionality, compatibility, and long-term sustainability. This paper presents our work on upgrading VisTrails, including the complete upgrade process, tools developed and utilized, testing strategies, and the final outcomes. We also share key experiences and lessons learned, with a focus on the sustainability challenges and considerations that arise when maintaining and evolving large-scale open-source software systems in scientific computing environments. Full article
(This article belongs to the Special Issue Optimization and Methodology in Software Engineering, 2nd Edition)
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17 pages, 4366 KB  
Article
Total Cloud Cover Variability over the Last 150 Years in Padua, Italy
by Claudio Stefanini, Francesca Becherini, Antonio della Valle, Fabio Zecchini and Dario Camuffo
Geographies 2025, 5(4), 67; https://doi.org/10.3390/geographies5040067 - 12 Nov 2025
Viewed by 826
Abstract
Understanding long-term cloud cover variability is essential for assessing past climate dynamics and human influences on atmospheric conditions. In Padua, instrumental weather records (temperature, precipitation, pressure) and descriptive sky observations date back to 1725, but quantitative cloud cover data, expressed as tenths of [...] Read more.
Understanding long-term cloud cover variability is essential for assessing past climate dynamics and human influences on atmospheric conditions. In Padua, instrumental weather records (temperature, precipitation, pressure) and descriptive sky observations date back to 1725, but quantitative cloud cover data, expressed as tenths of the sky covered by clouds, began in 1872 at the Astronomical Observatory. From 1920 to 1989, observations continued under the authority of the Meteorological Observatory of the Water Magistrate, and from 1951 to 1990, additional records by the Italian Air Force expressed in eighths of sky are available. These visual datasets—based on multiple daily observations—are complemented by satellite records (from 1983) and reanalysis such as ERA5 (from 1940) and NOAA 20CRv3 (from 1872 to 2015). The aim of this study is to reconstruct a homogenized, long-term total cloud cover (TCC) time series for Padua from 1872 to 2024, integrating all available observational sources. By comparing overlapping periods across different subseries and nearby ground-based stations, the analysis not only investigates consistency and potential discontinuities across datasets but also quantifies the reliability and limitations of historical visual observations. This work provides one of the few centennial-scale reconstructions of cloud cover in Europe, offering a valuable contribution to historical climatology and climate change studies. Full article
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28 pages, 23116 KB  
Article
Evaluation of Pedestrian Movement and Sustainable Public Realm in Planned Residential Areas, Mersin, Türkiye
by Züleyha Sara Belge, Burak Belge, Hayriye Oya Saf and Elvan Elif Özdemir
Sustainability 2025, 17(18), 8205; https://doi.org/10.3390/su17188205 - 11 Sep 2025
Viewed by 2296
Abstract
The study investigates the disconnect between formal urban planning standards and experiential walkability outcomes in Viranşehir, a planned neighborhood in Mersin, Türkiye. Although the area complies with national regulations on the provision of public services, it exhibits systemic limitations, including car-oriented street layouts, [...] Read more.
The study investigates the disconnect between formal urban planning standards and experiential walkability outcomes in Viranşehir, a planned neighborhood in Mersin, Türkiye. Although the area complies with national regulations on the provision of public services, it exhibits systemic limitations, including car-oriented street layouts, fragmented pedestrian networks, and underutilized public spaces. Employing a mixed-methods case study, the research integrates archival sources (aerial imagery, zoning plans, satellite data) with field observations to assess pedestrian environments. A light coding of sidewalk continuity, crossings, and edge conditions indicates that many streets are bounded by extensive inactive walls, protected crossings are absent along critical routes such as the school–park axis, and sidewalks are frequently narrow, obstructed, or discontinuous. These built-form features undermine safety, comfort, and social interaction despite formal regulatory compliance. The findings demonstrate how grid-pattern street systems prioritize vehicular mobility, while gated developments restrict permeability and diminish everyday encounters. In response, the study proposes a hierarchy of interventions: immediate measures such as school streets, protected crossings, and traffic calming, followed by medium- to long-term strategies including shaded seating, sidewalk widening, and participatory design guidelines. By linking statutory standards with lived experience, the paper conceptualizes walkability not only as a technical planning requirement but also as a socio-cultural right, offering transferable insights for the creation of more inclusive urban environments. Full article
(This article belongs to the Section Sustainable Urban and Rural Development)
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26 pages, 1382 KB  
Review
Drug-Induced Sarcoid-like Reactions Associated to Targeted Therapies and Biologic Agents
by Federica Andolfi, Luca Caffarri, Matilde Neviani, Silvia Rubini, Dario Andrisani, Filippo Gozzi, Bianca Beghé, Enrico Clini, Roberto Tonelli and Stefania Cerri
Diagnostics 2025, 15(13), 1658; https://doi.org/10.3390/diagnostics15131658 - 29 Jun 2025
Cited by 3 | Viewed by 4602
Abstract
Background: Sarcoidosis is a multisystem inflammatory disease characterized by the immune-mediated formation of non-necrotizing epithelioid granulomas. Several commonly used medications can induce similar granulomatous reactions, known as drug-induced sarcoid-like reactions (DISRs), which closely mimic sarcoidosis. Despite their specificity in targeting molecular pathways, [...] Read more.
Background: Sarcoidosis is a multisystem inflammatory disease characterized by the immune-mediated formation of non-necrotizing epithelioid granulomas. Several commonly used medications can induce similar granulomatous reactions, known as drug-induced sarcoid-like reactions (DISRs), which closely mimic sarcoidosis. Despite their specificity in targeting molecular pathways, certain therapies—particularly targeted treatments—have increasingly been linked to DISRs. Methods: This narrative review was based on a PubMed search using the terms “SARCOID LIKE REACTION” and “DRUG”. A cross-check was performed with “SARCOID” combined with each identified drug to identify misclassified cases. Drugs with limited evidence or weak pathogenetic plausibility were excluded, leaving only molecularly targeted therapies for consideration. Sources included case reports, case series, and reviews selected based on their clinical and scientific relevance, without any restrictions on time or language. Results: In light of the available data, five main pharmacological groups were found to be associated to DISR: immune checkpoint inhibitors, TNF-α antagonists, BRAF inhibitors, monoclonal antibodies, and miscellaneous agents. Each group has distinct mechanisms of action and clinical indications, which likely affect the frequency, presentation, and timing of DISRs. Conclusions: Diagnosing DISRs is challenging, and a structured approach is crucial for differentiating them from other conditions. To support clinicians, we propose a diagnostic algorithm to guide decision-making in suspected cases. Management should be individualized, as most DISRs either resolve spontaneously or improve after the discontinuation of the causative drug. Important factors influencing therapeutic decisions include the severity of the underlying disease, the availability of alternative treatments, and the extent of DISR manifestations. Full article
(This article belongs to the Special Issue Sarcoidosis: From Diagnosis to Management)
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22 pages, 9142 KB  
Article
Downscaling and Gap-Filling GRACE-Based Terrestrial Water Storage Anomalies in the Qinghai–Tibet Plateau Using Deep Learning and Multi-Source Data
by Jun Chen, Linsong Wang, Chao Chen and Zhenran Peng
Remote Sens. 2025, 17(8), 1333; https://doi.org/10.3390/rs17081333 - 8 Apr 2025
Cited by 3 | Viewed by 2578
Abstract
The Qinghai–Tibet Plateau (QTP), a critical hydrological regulator for Asia through its extensive glacier systems, high-altitude lakes, and intricate network of rivers, exhibits amplified sensitivity to climate-driven alterations in precipitation regimes and ice mass balance. While the Gravity Recovery and Climate Experiment (GRACE) [...] Read more.
The Qinghai–Tibet Plateau (QTP), a critical hydrological regulator for Asia through its extensive glacier systems, high-altitude lakes, and intricate network of rivers, exhibits amplified sensitivity to climate-driven alterations in precipitation regimes and ice mass balance. While the Gravity Recovery and Climate Experiment (GRACE) and its Follow-On (GRACE-FO) missions have revolutionized monitoring of terrestrial water storage anomalies (TWSAs) across this hydrologically sensitive region, spatial resolution limitations (3°, equivalent to ~300 km) constrain process-scale analysis, compounded by mission temporal discontinuity (data gaps). In this study, we present a novel downscaling framework integrating temporal gap compensation and spatial refinement to a 0.25° resolution through Gated Recurrent Unit (GRU) neural networks, an architecture optimized for univariate time series modeling. Through the assimilation of multi-source hydrological parameters (glacier mass flux, cryosphere–precipitation interactions, and land surface processes), the GRU-based result resolves nonlinear storage dynamics while bridging inter-mission observational gaps. Grid-level implementation preserves mass conservation principles across heterogeneous topographies, successfully reconstructing seasonal-to-interannual TWSA variability and also its long-term trends. Comparative validation against GRACE mascon solutions and process-based hydrological models demonstrates enhanced capacity in resolving sub-basin heterogeneity. This GRU-derived high-resolution TWSA is especially valuable for dissecting local variability in areas such as the Brahmaputra Basin, where complex water cycling can affect downstream water security. Our study provides transferable methodologies for mountainous hydrogeodesy analysis under evolving climate regimes. Future enhancements through physics-informed deep learning and next-generation climatology–hydrology–gravimetry synergy (e.g., observations and models) could further constrain uncertainties in extreme elevation zones, advancing the predictive understanding of Asia’s water tower sustainability. Full article
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11 pages, 3295 KB  
Article
Leontodon albanicus subsp. acroceraunicus (Asteraceae, Cichorieae): A New Subspecies from Southern Albania
by Fabio Conti, Luca Bracchetti, Marco Dorfner, Nadine Benda and Christoph Oberprieler
Biology 2025, 14(3), 259; https://doi.org/10.3390/biology14030259 - 4 Mar 2025
Cited by 1 | Viewed by 1312
Abstract
Some plants belonging to the Leontodon sect. Asterothrix were collected from southern Albania. They were compared with the closest taxon (L. albanicus s.str.) from morphological and molecular (AFLPseq fingerprinting) points of view. Uni- and multivariate statistical analyses of morphological data revealed distinctive [...] Read more.
Some plants belonging to the Leontodon sect. Asterothrix were collected from southern Albania. They were compared with the closest taxon (L. albanicus s.str.) from morphological and molecular (AFLPseq fingerprinting) points of view. Uni- and multivariate statistical analyses of morphological data revealed distinctive discontinuities—especially in terms of the characteristics of the indumentum–that are paralleled by separation into two genetic clusters in AFLPseq fingerprinting. Following an integrated taxonomic approach based on morphological, genetic, and geographical sources of evidence, we show that the newly discovered population should be regarded as a new subspecies named Leontodon albanicus subsp. acroceraunicus. The new taxon is described and illustrated, and its relationship with L. albanicus subsp. albanicus is also discussed. We have no data to assess conservation status according to IUCN categories and criteria; however, considering that it is probably limited to the Acroceraunian Mountains, it deserves particular conservation interest. Full article
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28 pages, 3773 KB  
Article
Impact of Prenatal Dietary Soy on Cerebellar Neurodevelopment and Function in Experimental Fetal Alcohol Spectrum Disorder
by Suzanne M. de la Monte, Ming Tong, Jason Ziplow, Princess Mark, Stephanie Van and Van Ahn Nguyen
Nutrients 2025, 17(5), 812; https://doi.org/10.3390/nu17050812 - 26 Feb 2025
Cited by 1 | Viewed by 1620
Abstract
Background: Prenatal alcohol exposure (PAE) models can cause neurodevelopmental abnormalities like those observed in fetal alcohol spectrum disorder (FASD). Previous studies link experimental PAE effects in the brain to impaired signaling through insulin/IGF and Notch pathways that mediate neuronal survival, growth, migration, energy [...] Read more.
Background: Prenatal alcohol exposure (PAE) models can cause neurodevelopmental abnormalities like those observed in fetal alcohol spectrum disorder (FASD). Previous studies link experimental PAE effects in the brain to impaired signaling through insulin/IGF and Notch pathways that mediate neuronal survival, growth, migration, energy metabolism, and plasticity. Importantly, concurrent administration of peroxisome proliferator-activated receptor agonists or dietary soy prevented many aspects of FASD due to their insulin-sensitizing, anti-inflammatory, and antioxidant properties. Objective: To determine if dietary soy interventions during pregnancy would be sufficient to normalize central nervous system structure and function, we examined the effects of maternal gestation-limited dietary soy on cerebellar postnatal development, motor function, and critical signaling pathways. Methods: Pregnant Long Evans rats were fed isocaloric liquid diets containing 0% or 26% caloric ethanol with casein or soy isolate as the protein source. The ethanol and soy feedings were discontinued upon delivery. The offspring were subjected to rotarod motor function tests, and on postnatal day 35, they were sacrificed to harvest cerebella for histological and molecular studies. Results: Despite the postnatal cessation of alcohol exposure, chronic gestational exposure reduced brain weight, caused cerebellar hypoplasia, and impaired motor performance. Gestational dietary soy prevented the ethanol-associated reduction in brain weight and largely restored the histological integrity of the cerebellum but failed to normalize motor performance. Ethanol withdrawal abolished the impairments in insulin/IGF signaling that were previously associated with ongoing ethanol exposures, but ethanol’s inhibitory effects on Notch and Wnt signaling persisted. Soy significantly increased cerebellar expression of the insulin and IGF-1 receptors and abrogated several ethanol-associated impairments in Notch and Wnt signaling. Conclusions: Although gestation-restricted dietary soy has significant positive effects on neurodevelopment, optimum prevention of FASD’s long-term effects will likely require dietary soy intervention during the critical periods of postnatal development, even after alcohol exposures have ceased. Full article
(This article belongs to the Special Issue Prenatal and Early Postnatal Nutrition to Promote Offspring's Health)
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28 pages, 2848 KB  
Article
Classical Layer-Resolving Scheme for a System of Two Singularly Perturbed Time-Dependent Problems with Discontinuous Source Terms and Spatial Delay
by Joseph Paramasivam Mathiyazhagan, Ramiya Bharathi Karuppusamy, George E. Chatzarakis and S. L. Panetsos
Mathematics 2025, 13(3), 511; https://doi.org/10.3390/math13030511 - 4 Feb 2025
Viewed by 948
Abstract
In this paper, a classical layer-resolving finite difference scheme is formulated to solve a system of two singularly perturbed time-dependent initial value problems with discontinuity occurring at (y,t) in the source terms and Robin initial conditions. The delay term [...] Read more.
In this paper, a classical layer-resolving finite difference scheme is formulated to solve a system of two singularly perturbed time-dependent initial value problems with discontinuity occurring at (y,t) in the source terms and Robin initial conditions. The delay term occurs in the spatial variable, and the leading term of the spatial derivative of each equation is multiplied by a distinct small positive perturbation parameter, inducing layer behaviors in the solution domain. Due to the presence of perturbation parameters, discontinuous source terms, and delay terms, initial and interior layers occur in the solution domain. In order to capture the abrupt change that occurs due to the behavior of these layers, the solution is further decomposed into smooth and singular components. Layer functions are also formulated in accordance with layer behavior. Analytical results and bounds of the solution and its components are derived. The formulation of a finite difference scheme involves discretization of temporal and spatial axes by uniform and piecewise uniform meshes, respectively. The formulated scheme achieves first-order convergence in both time and space. At last, to bolster the numerical scheme, example problems are computed to prove the efficacy and accuracy of our scheme. Full article
(This article belongs to the Section E: Applied Mathematics)
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14 pages, 974 KB  
Review
A Scoping Review of Eosinophilic Pneumonia and Antidepressants: An Association Not to Be Overlooked
by Jaron Steiner, Leonie Steuernagel, Fotios Drakopanagiotakis, Konstantinos Bonelis and Paschalis Steiropoulos
Diseases 2025, 13(1), 13; https://doi.org/10.3390/diseases13010013 - 13 Jan 2025
Cited by 1 | Viewed by 3727
Abstract
Background: Eosinophilic pneumonias denote a rare condition, wherein infiltrating eosinophilic granulocytes accumulate within the lung parenchyma. Although eosinophilic pneumonias may be idiopathic, they are also associated with secondary causes. More than 110 medications have been linked to eosinophilic pneumonia, including several antidepressants. [...] Read more.
Background: Eosinophilic pneumonias denote a rare condition, wherein infiltrating eosinophilic granulocytes accumulate within the lung parenchyma. Although eosinophilic pneumonias may be idiopathic, they are also associated with secondary causes. More than 110 medications have been linked to eosinophilic pneumonia, including several antidepressants. This review presents an analysis of case reports of eosinophilic pneumonia correlated to antidepressants. Objectives: The objectives of this study are to provide a contemporary overview of the literature delineating eosinophilic pneumonia as a potential sequela of antidepressant medication treatment, and to discuss possible pathogenetic mechanisms linking antidepressants to eosinophilic pneumonia. Methods and Data Selection: A literature search was performed in PubMed and Scopus databases from 1963 to October 2024. The search strategy used the terms “eosinophilic pneumonia AND antidepressants”. Sources included in this review were screened for relevance, focusing on references discussing eosinophilic pneumonia associated with any class of antidepressants. Case reports meeting the diagnostic criteria for acute eosinophilic pneumonia (AEP) or chronic eosinophilic pneumonia (CEP) were included in the review. Clinical, epidemiological, laboratory, radiology and bronchoscopy data, implicated antidepressant and dosage, and therapeutic interventions were reported. Results: This study found that various types of antidepressants are associated with AEP and CEP. The clinical presentation ranges from mild symptoms to respiratory failure and intubation. Outcomes were favorable in most cases, with complete remission achieved after discontinuation of the causative drug and, in severe cases, a short course of corticosteroids. Conclusions: Although a rare cause, antidepressants may lead to eosinophilic pneumonia, and should be considered in the differential diagnosis of unexplained pulmonary infiltrates. Clinical suspicion must be aroused, as early recognition would prevent unnecessary work-up and navigation of the diagnosis. Full article
(This article belongs to the Section Respiratory Diseases)
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27 pages, 17020 KB  
Article
Evaluation of the Wear of Ni 200 Alloy After Long-Term Carbon Capture in Molten Salts Process
by Piotr Palimąka, Stanisław Pietrzyk, Maciej Balcerzak, Krzysztof Żaba, Beata Leszczyńska-Madej and Justyna Jaskowska-Lemańska
Materials 2024, 17(24), 6302; https://doi.org/10.3390/ma17246302 - 23 Dec 2024
Cited by 2 | Viewed by 1173
Abstract
Reducing CO2 emissions is one of the major challenges facing the modern world. The overall goal is to limit global warming and prevent catastrophic climate change. One of the many methods for reducing carbon dioxide emissions involves capturing, utilizing, and storing it [...] Read more.
Reducing CO2 emissions is one of the major challenges facing the modern world. The overall goal is to limit global warming and prevent catastrophic climate change. One of the many methods for reducing carbon dioxide emissions involves capturing, utilizing, and storing it at the source. The Carbon Capture in Molten Salts (CCMS) technique is considered potentially attractive and promising, although it has so far only been tested at the laboratory scale. This study evaluates the wear of the main structural components of a prototype for CO2 capture in molten salts—a device designed and tested in the laboratories of AGH University of Kraków. The evaluation focused on a gas barbotage lance and a reactor chamber (made from Nickel 200 Alloy), which were in continuous, long-term (800 h) contact with molten salts CaCl2-CaF2-CaO-CaCO3 at temperatures of 700–940 °C in an atmosphere of N2-CO2. The research used light microscopy, SEM, X-ray, computed tomography (CT), and 3D scanning. The results indicate the greatest wear on the part of the lance submerged in the molten salts (3.9 mm/year). The most likely wear mechanism involves grain growth and intergranular corrosion. Nickel reactions with the aggressive salt environment and its components cannot be ruled out. Additionally, the applied research methods enabled the identification of material discontinuities in the reactor chamber (mainly in welded areas), pitting on its surface, and uneven wear in different zones. Full article
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