Search Results (1,220)

Wireless sensor networks (WSNs) have attracted significant attention due to their widespread applications in various fields such as environmental monitoring, agriculture, intelligent transportation, and healthcare. In these networks, the power cost of a sensor node is closely related to the radius of its coverage area, following a nonlinear relationship where power increases as the coverage radius grows according to an attenuation factor. This means that increasing the coverage radius of a sensor leads to a corresponding increase in its power cost. Consequently, minimizing the total power cost of the network while all clients are served has become a crucial research topic. The power cover problem focuses on adjusting the power levels of sensors to serve all clients while minimizing the total power cost. This survey focuses on the power cover problem and its related variants in WSNs. Specifically, it introduces nonlinear integer programming formulations for the power cover problem and its related variants, all within the specified sensor setting. It also provides a comprehensive overview of the power cover problem and its variants under both specified and unspecified sensor settings, summarizes existing results and approximation algorithms, and outlines potential directions for future research. Full article

Disruption of the intestinal epithelial barrier is a key driver of gut-derived inflammation in various disorders, yet strategies to preserve or restore barrier integrity remain limited. To address this, we evaluated a four-strain Bifidobacterium mixture—selected for complementary anti-inflammatory potency and industrial scalability—in lipopolysaccharide (LPS)-challenged RAW 264.7 macrophages and a Caco-2/THP-1 transwell co-culture model. Pretreatment with the probiotic blend reduced nitric oxide (NO) release in a dose-dependent manner by 25.9–48.3% and significantly down-regulated the pro-inflammatory markers in macrophages. In the co-culture system, the formulation decreased these markers, increased transepithelial electrical resistance (TEER) by up to 31% at 10⁵ colony-forming unit (CFU)/mL after 48 h, and preserved the membrane localization of tight junction (TJ) proteins. Adhesion to Caco-2 cells (≈ 6%) matched that of the benchmark probiotic Lacticaseibacillus rhamnosus GG, suggesting direct epithelial engagement. These in vitro findings demonstrate that this probiotic mixture can attenuate LPS-driven inflammation and reinforce epithelial architecture, providing a mechanistic basis for its further evaluation in animal models and clinical studies of intestinal inflammatory disorders. Full article

Toxoplasma gondii is an intracellular protozoan found worldwide that is capable of infecting nearly all warm-blooded animals, including humans. Its parasitic success lies in its capacity to create chronic infections while avoiding immune detection, altering host immune responses, and disrupting programmed cell death pathways. This review examines the complex relationship between T. gondii and host immunity, focusing on how the parasite influences innate and adaptive immune responses to survive in immune-privileged tissues. We present recent findings on the immune modulation specific to various parasite strains, the immunopathology caused by imbalanced inflammation, and how the parasite undermines host cell death mechanisms such as apoptosis, necroptosis, and pyroptosis. These immune evasion tactics enable prolonged intracellular survival and pose significant challenges for treatment and vaccine development. We also review advancements in therapeutic strategies, including host-directed approaches, nanoparticle drug delivery, and CRISPR-based technologies, along with progress in vaccine development from subunit and DNA vaccines to live-attenuated candidates. This review emphasizes the importance of T. gondii as a model for chronic infections and points out potential avenues for developing innovative therapies and vaccines aimed at toxoplasmosis and similar intracellular pathogens. Full article

Background: Chronic Kidney Disease (CKD) is a major global health issue, with diabetes being its primary cause and cardiovascular disease contributing significantly to patient mortality. Recently, two classes of medications—sodium–glucose cotransporter 2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1 RAs)—have shown promise in protecting both kidney and heart health beyond their effects on blood sugar control. Methods: We conducted a narrative review summarizing the findings of different clinical trials and mechanistic studies evaluating the effect of SGLT2i and GLP-1 RAs on kidney function, cardiovascular outcomes, and overall disease progression in patients with CKD and DKD. Results: SGLT2i significantly mitigate kidney injury by restoring tubuloglomerular feedback, reducing intraglomerular hypertension, and attenuating inflammation, fibrosis, and oxidative stress. GLP-1 RAs complement these effects by enhancing endothelial function, promoting weight and blood pressure control, and exerting direct anti-inflammatory and anti-fibrotic actions on renal tissues. Landmark trials—CREDENCE, DAPA-CKD, and EMPA-KIDNEY—demonstrate that SGLT2i reduce the risk of kidney failure and renal or cardiovascular death by 25–40% in both diabetic and non-diabetic CKD populations. Likewise, trials such as LEADER, SUSTAIN, and AWARD-7 confirm that GLP-1 RAs slow renal function decline and improve cardiovascular outcomes. Early evidence suggests that using both drugs together may offer even greater benefits through multiple mechanisms. Conclusions: SGLT2i and GLP-1 RAs have redefined the therapeutic landscape of CKD by offering organ-protective benefits that extend beyond glycemic control. Whether used individually or in combination, these agents represent a paradigm shift toward integrated cardiorenal-metabolic care. A deeper understanding of their mechanisms and clinical utility in both diabetic and non-diabetic populations can inform evidence-based strategies to slow disease progression, reduce cardiovascular risk, and improve long-term patient outcomes in CKD. Full article

This article explores Schipper’s scholarly contributions to the study of dongtian fudi (grotto heavens and blessed lands) and specifically situates this project in its broader intellectual context and Schipper’s own research. While Schipper was not the first to open discussions on this topic, his research in this direction still offers profound insights, such as the coinage of the concept of “Daoist Ecology” and his views on mountain politics. This article argues that Schipper’s work on dongtian fudi is a response to the school of Deep Ecology and its critics, and also a result of critical reflection on the modern dichotomy between nature and culture. In Schipper’s enquiry of dongtian fudi, the “mountain” stands as the central concept: it is not only the essential component of Daoist sacred geography, but a holistic site in which nature and society are interwoven, endowed with both material and sacred significance. Through his analysis of the Daoist practice of abstinence from grain (duangu), Schipper reveals how mountains serve as spaces for retreat from agrarian society and state control, and how they embody “shatter zones” where the reach of centralized power is relatively attenuated. The article also further links Schipper’s project of Beijing as a Holy City to his study of dongtian fudi. For Schipper, the former affirms the universality of the locality (i.e., the unofficial China, the country of people), while the latter envisages the vision of rewriting China from plural localities. Taken together, these efforts point toward a theoretical framework that moves beyond conventional sociological paradigms, one that embraces a total worldly perspective, in which the livelihoods of local societies and their daily lives are truly appreciated as a totality that encompasses both nature and culture. Schipper’s works related to dongtian fudi, though they are rather concise, still significantly broaden the scope of Daoist studies and, moreover, provide novel insights into the complexity of Chinese religion and society. Full article

Colorectal liver metastasis (CRLM) poses a significant challenge in oncology due to its high incidence and poor prognosis in unresectable cases. Current treatments, including surgical resection, systemic chemotherapy, and liver-directed therapies, often fail to effectively target hypoxic tumor regions, which are inherently more resistant to these interventions. This review examines the potential of a novel therapeutic strategy combining irreversible electroporation (IRE) ablation and Clostridium novyi-nontoxic (C. novyi-NT) bacterial therapy. IRE is a non-thermal tumor ablation technique that uses high-voltage electric pulses to create permanent nanopores in cell membranes, leading to cell death while preserving surrounding structures, and is often associated with temporary tumor hypoxia due to disrupted perfusion. C. novyi-NT is an attenuated, anaerobic bacterium engineered to selectively germinate and proliferate in hypoxic tumor regions, resulting in localized tumor cell lysis while sparing healthy, oxygenated tissue. The synergy between IRE-induced hypoxia and hypoxia-sensitive C. novyi-NT may enhance tumor destruction and stimulate systemic antitumor immunity. Furthermore, the integration of advanced imaging and artificial intelligence can support precise treatment planning and real-time monitoring. This integrated approach holds promise for improving outcomes in patients with CRLM, though further preclinical and clinical validation is needed. Full article

This study aims to address the challenges posed by uneven energy amplitude and a low signal-to-noise ratio (SNR) in the total focus imaging of coarse-crystalline elastic anisotropic materials. A novel method for acoustic field correction vector-coherent total focus imaging, based on the materials’ properties, is proposed. To demonstrate the effectiveness of this method, a test specimen, an austenitic stainless steel nozzle weld, was employed. Seven side-drilled hole defects located at varying positions and depths, each with a diameter of 2 mm, were examined. An ultrasound simulation model was developed based on material backscatter diffraction results, and the scattering attenuation compensation factor was optimized. The acoustic field correction function was derived by combining acoustic field directivity with diffusion attenuation compensation. The phase coherence weighting coefficients were calculated, followed by image reconstruction. The results show that the proposed method significantly improves imaging amplitude uniformity and reduces the structural noise caused by the coarse crystal structure of austenitic stainless steel. Compared to conventional total focus imaging, the detection SNR of the seven defects increased by 2.34 dB to 10.95 dB. Additionally, the defect localization error was reduced from 0.1 mm to 0.05 mm, with a range of 0.70 mm to 0.88 mm. Full article

Despite the successes achieved in recent years in the treatment of childhood acute lymphoblastic leukemia (ALL), high-risk ALL in particular still represents a considerable challenge, with poorer outcomes. The PI3K/AKT/mTOR signaling pathway is frequently constitutively activated in ALL and consequently leads to unrestricted cell proliferation, without showing frequent mutations in the most important representatives of the signaling pathway. Recent studies have shown that fine balanced protein expression is a common way to adjust oncogenic B cell directed receptor signaling and to mediate malignant cell proliferation and survival in leukemic cells. Too low expression of inhibitory phosphatases can lead to constitutive signaling of kinases, which are important for cell proliferation and survival. In contrast, marked high expression levels of key phosphatases enable cells with distinct pronounced oncogenic B cell directed receptor signaling to escape negative selection by attenuating signal strength and thus raising the threshold for deletion checkpoint activation. One of the most important B cell receptor-dependent signaling cascades is the PI3K/AKT signaling pathway, with its important antagonist SHIP1. However, recent data show that the inositol-5-phosphatase SHIP1 is differentially expressed across the heterogeneity of the ALL subtypes, making the overall therapeutic strategy targeting SHIP1 more complex. The aim of this article is therefore to provide an overview of the current knowledge about SHIP1, its expression in the various subtypes of ALL, its regulation, and the molecules that influence its gene and protein expression, to better understand its role in the pathogenesis of leukemia and other human cancers. Full article

The spontaneous combustion disaster of coal not only causes a waste of resources but also affects the safe production of coal mines. In order to accurately detect the range and location of the spontaneous combustion source of coal, this paper studies and summarizes previous research results, and based on the principles and research and development progress of existing detection technologies such as the surface temperature measurement method, ground temperature measurement method, wellbore temperature measurement method, and infrared remote sensing detection method, it briefly reviews the application of various detection technologies in engineering practice at this stage and briefly explains the advantages and disadvantages of each application. Research shows that the existing technologies are generally limited by the interference of complex environmental conditions (such as temperature measurement deviations caused by atmospheric turbulence and the influence of rock layer structure on ground temperature conduction) and the implementation difficulties of geophysical methods in mining applications (such as the interference of stray currents in the ground by electromagnetic methods and the fast attenuation speed of waves detected by geological radar methods), resulting in the insufficient accuracy of fire source location and difficulties in identifying concealed fire sources. In response to the above bottlenecks, the ”air–ground integrated” fire source location determination technology that breaks through environmental constraints and the location determination method of a CSC fire source based on a multi-physics coupling mechanism are proposed. By significantly weakening the deficiency in obtaining parameters through a single detection method, a new direction is provided for the detection of coal spontaneous combustion fire sources in the future. Full article

Sparse code multiple access (SCMA) has been a competitive multiple access candidate for future communication networks due to its superiority in spectrum efficiency and providing massive connectivity. However, cell edge users may suffer from great performance degradations due to signal attenuation. Therefore, a cooperative downlink SCMA system is proposed to improve transmission reliability. To the best of our knowledge, multiuser detection is still an open issue for this cooperative downlink SCMA system. To this end, we propose a joint iterative decoding design of the cooperative downlink SCMA system by using the joint factor graph stemming from direct and relay transmission. The closed form bit-error rate (BER) performance of the cooperative downlink SCMA system is also derived. Simulation results verify that the proposed cooperative downlink SCMA system performs better than the non-cooperative one. Full article

Intrauterine growth restriction (IUGR) is a critical challenge in perinatal medicine and is associated with significant morbidity and mortality. This review explores the intricate involvement of early developmental senescence in IUGR. We highlight the dual role of cellular senescence in both normal development and pathological conditions, emphasizing the need for further research to elucidate these mechanisms and develop targeted interventions. We discuss how oxidative stress and mitochondrial dysfunction affect senescence determinants. We present emerging therapeutic strategies aimed at targeting senescence and inflammation in the placenta. We also introduce Rytvela, an interleukin-1 (IL-1) receptor modulator developed in our laboratory, which selectively attenuates pro-inflammatory signaling while preserving essential immune responses, which in turn mitigate senescence. By addressing senescence-related dysfunctions, such interventions may improve placental performance and fetal outcomes, opening up new directions for the clinical management of IUGR. Full article

Background/Objectives: The work presented herein focused on the development and characterization of a transdermal caffeine platform fabricated from ultrathin micro- and submicron fibers produced via electrospinning. Methods: The formulations incorporated caffeine encapsulated in a polyethylene oxide (PEO) matrix, combined with various permeation enhancers. A backing layer made of annealed electrospun polycaprolactone (PCL) facilitated the lamination of the two layers to form the final multilayer patch. Comprehensive characterization was conducted, utilizing scanning electron microscopy (SEM) to assess the fiber morphology, attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) for chemical detection and to assess the stability of the caffeine, and differential scanning calorimetry (DSC) along with wide-angle X-ray scattering (WAXS) to analyze the physical state of the caffeine within the fibers of the active layer. Additionally, Franz cell permeation studies were performed using both synthetic membranes (Strat-M) and ex vivo human stratum corneum (SC) to evaluate and model the permeation kinetics. Results: These experiments demonstrated the significant role of enhancers in modulating the caffeine permeation rates provided by the patch, achieving permeation rates of up to 0.73 mg/cm² within 24 h. Conclusions: This work highlights the potential of using electro-hydrodynamic processing technology to develop innovative transdermal delivery systems for drugs, offering a promising strategy for enhancing efficacy and innovative therapeutic direct plasma administration. Full article

This paper examines the impact of carbon capture and storage (CCS) deployment on national carbon intensity (CI) across 43 countries from 2010 to 2020. Using a dynamic common correlated effects (DCCE) log–log panel, we estimate the elasticity of CI with respect to sectoral CCS facility counts within four income-group panels and the full sample. In the high-income panel, CCS in direct air capture, cement, iron and steel, power and heat, and natural gas processing sectors produces statistically significant CI declines of 0.15%, 0.13%, 0.095%, 0.092%, and 0.087% per 1% increase in facilities, respectively (all p < 0.05). Upper-middle-income countries exhibit strong CI reductions in direct air capture (–0.22%) and cement (–0.21%) but mixed results in other sectors. Lower-middle- and low-income panels show attenuated or positive elasticities—reflecting early-stage CCS adoption and infrastructure barriers. Robustness checks confirm these patterns both before and after the 2015 Paris Agreement and between emerging and developed economy panels. Spatial analysis reveals that the United States and United Kingdom achieved 30–40% CI reductions over the decade, whereas China, India, and Indonesia realized only 10–20% declines (relative to a 2010 baseline), highlighting regional deployment gaps. Drawing on these detailed income-group insights, we propose tailored policy pathways: in high-income settings, expand tax credits and public–private infrastructure partnerships; in upper-middle-income regions, utilize blended finance and technology-transfer programs; and in lower-income contexts, establish pilot CCS hubs with international support and shared storage networks. We further recommend measures to manage CCS’s energy and water penalties, implement rigorous monitoring to mitigate leakage risks, and design risk-sharing contracts to address economic uncertainties. Full article

Dust emissions from unpaved haul roads in open-pit coal mining pose a significant risk to air quality, health, and operational efficiency of mining operations. This study integrated real-time field monitoring with numerical simulations using ANSYS Fluent 2023 R1 to investigate the generation, dispersion, and migration of particulate matter (PM) at the Ha’erwusu open-pit coal mine under varying meteorological conditions. Real-time measurements of PM2.5, PM10, and TSP, along with meteorological variables (wind speed, wind direction, humidity, temperature, and air pressure), were collected and analyzed using Pearson’s correlation and multivariate linear regression analyses. Wind speed and air pressure emerged as dominant factors in winter, whereas wind and temperature were more influential in summer (R² = 0.391 for temperature vs. PM2.5). External airflow simulations revealed that truck-induced turbulence and high wind speeds generated wake vortices with turbulent kinetic energy (TKE) peaking at 5.02 m²/s², thereby accelerating particle dispersion. The dust migration rates reached 3.33 m/s within 6 s after emission and gradually decreased with distance. The particle settling velocities ranged from 0.218 m/s for coarse dust to 0.035 m/s for PM2.5, with dispersion extending up to 37 m downwind. The highest simulated dust concentration reached 4.34 × 10⁻² g/m³ near a single truck and increased to 2.51 × 10⁻¹ g/m³ under multiple-truck operations. Based on spatial attenuation trends, a minimum safety buffer of 55 m downwind and 45 m crosswind is recommended to minimize occupational exposure. These findings contribute to data-driven, weather-responsive dust suppression planning in open-pit mining operations and establish a validated modeling framework for future mitigation strategies in this field. Full article

Varicella-zoster virus (VZV) poses significant public health challenges as the etiological agent of varicella (chickenpox) and herpes zoster (HZ), given its high transmissibility and potential for severe complications. The introduction of VZV vaccines—particularly the vOka-based live attenuated and glycoprotein gE-based recombinant subunit vaccines—has substantially reduced the global incidence of these diseases. However, live attenuated vaccines raise concerns regarding safety and immunogenicity, especially in immunocompromised populations, while recombinant subunit vaccines, such as Shingrix, exhibit high efficacy but are associated with side effects and adjuvant limitations. Recent advancements in vaccine technology, including mRNA vaccines, viral vector vaccines, and virus-like particle (VLP) vaccines, offer promising alternatives with improved safety profiles and durable immunity. This review synthesizes current knowledge on VZV vaccine mechanisms, clinical applications, and immunization strategies, while also examining future directions in vaccine development. The findings underscore the pivotal role of VZV vaccines in disease prevention and highlight the need for continued research to enhance their public health impact. Full article