Search Results (4,532)

The goals of the European Union towards the energy transition imply profound changes in the energy field, so as to promote sustainable energy development while fostering economic growth. To achieve these changes, the incorporation of sustainable technologies supporting decentralisation, energy efficiency, renewable energy production, and demand flexibility is of vital importance. Blockchain has the potential to change energy services towards this direction. To optimally exploit blockchain, innovative business models need to be designed, identifying the opportunities emerging from unmet needs, while also considering potential risks so as to take action to overcome them. In this context, the scope of this paper is to examine the opportunities and the risks that emerge from the adoption of blockchain in four innovative business models, while also identifying mitigation strategies to support and accelerate the energy transition, thus proposing optimal approaches of exploitation of blockchain in energy services. The business models concern Energy Performance Contracting with P4P guarantees, improved self-consumption in energy cooperatives, energy efficiency and flexibility services for natural gas boilers, and smart energy management for EV chargers and HVAC appliances. Firstly, the value proposition of the business models is analysed and results in a comprehensive SWOT analysis. Based on the findings of the analysis and consultations with relevant market actors, in combination with the examination of the relevant literature, risks are identified and evaluated through a qualitative assessment approach. Subsequently, specific mitigation strategies are proposed to address the detected risks. This research demonstrates that blockchain integration into these business models can significantly improve energy efficiency, reduce operational costs, enhance security, and support a more decentralised energy system, providing actionable insights for stakeholders to implement blockchain solutions effectively. Furthermore, according to the results, technological and legal risks are the most significant, followed by political, economic, and social risks, while environmental risks of blockchain integration are not as important. Strategies to address risks relevant to blockchain exploitation include ensuring policy alignment, emphasising economic feasibility, facilitating social inclusion, prioritising security and interoperability, consulting with legal experts, and using consensus algorithms with low energy consumption. The findings offer clear guidance for energy service providers, policymakers, and technology developers, assisting in the design, deployment, and risk mitigation of blockchain-enabled business models to accelerate sustainable energy development. Full article

A principal factor of the fourth Industrial Revolution is the Internet of Things (IoT), a network of “smart” objects that communicate by exchanging helpful information about themselves and their environment. Our research aims to address the gaps in the existing literature regarding the educational and technological affordances of IoT applications in learning environments in secondary education. Our systematic review using the PRISMA method allowed us to extract 25 empirical studies from the last 10 years. We present the categorization of educational and technological affordances, as well as the devices used in these environments. Moreover, our findings indicate widespread adoption of organized educational activities and design-based learning, often incorporating tangible interfaces, smart objects, and IoT applications, which enhance student engagement and interaction. Additionally, we identify the impact of IoT-based learning on knowledge building, autonomous learning, student attitude, and motivation. The results suggest that the IoT can facilitate personalized and experiential learning, fostering a more immersive and adaptive educational experience. Based on these findings, we discuss key recommendations for educators, policymakers, and researchers, while also addressing this study’s limitations and potential directions for future research. Full article

Epileptic seizure prediction remains a critical challenge in neuroscience and healthcare, with profound implications for enhancing patient safety and quality of life. In this paper, we introduce a novel seizure prediction method that leverages electroencephalogram (EEG) data, combining discrete wavelet transform (DWT)-based time–frequency analysis, advanced feature extraction, and deep learning using Fourier neural networks (FNNs). The proposed approach extracts essential features from EEG signals—including entropy, power, frequency, and amplitude—to effectively capture the brain’s complex and nonstationary dynamics. We measure the method based on the broadly used CHB-MIT EEG dataset, ensuring direct comparability with prior research. Experimental results demonstrate that our DWT-FS-FNN model achieves a prediction accuracy of 98.96 with a zero false positive rate, outperforming several state-of-the-art methods. These findings underscore the potential of integrating advanced signal processing and deep learning methods for reliable, real-time seizure prediction. Future work will focus on optimizing the model for real-world clinical deployment and expanding it to incorporate multimodal physiological data, further enhancing its applicability in clinical practice. Full article

Acute kidney injury (AKI) is a serious clinical condition that is linked to markedly higher rates of morbidity and mortality in cirrhosis patients. Its diagnosis is challenging due to overlapping clinical and laboratory features among causes such as hepatorenal syndrome (HRS), acute tubular injury (ATI), and prerenal hypovolemia. In order to address the distinct pathophysiology and clinical context of cirrhosis, the definitions and classification of AKI have changed over time, moving from RIFLE and AKIN to KDIGO and ICA-AKI. Because cirrhosis patients have altered muscle mass and fluid retention, traditional markers like serum creatinine (sCr) and urine output have significant limitations. Neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), interleukin-18 (IL-18), and cystatin C (CysC) are some of the new biomarkers that have shown promise in early AKI detection and in differentiating structural from functional kidney injury. NGAL and KIM-1 are sensitive indicators of tubular damage with potential prognostic implications. IL-18 reflects inflammatory injury, and CysC offers a more reliable measure of glomerular filtration. Incorporating these markers may improve early diagnosis, risk stratification, and treatment decisions, representing a key direction for future research in managing AKI in cirrhosis. Full article

The relationship between metabolic dysfunction and mental health disorders is complex and has received increasing attention. This review integrates current research to explore how stress-related growth differentiation factor 15 (GDF15) signaling, ceramides derived from gut microbiota, and mitochondrial dysfunction in the brain interact to influence both metabolic and psychiatric conditions. Evidence suggests that these pathways converge to regulate brain energy homeostasis through feedback mechanisms involving the autonomic nervous system and the hypothalamic–pituitary–adrenal axis. GDF15 emerges as a key stress-responsive biomarker that links peripheral metabolism with brainstem GDNF family receptor alpha-like (GFRAL)-mediated anxiety circuits. Meanwhile, ceramides impair hippocampal mitochondrial function via membrane incorporation and disruption of the respiratory chain. These disruptions may contribute to sustained pathological states such as depression, anxiety, and cognitive dysfunction. Although direct mechanistic data are limited, integrating these pathways provides a conceptual framework for understanding metabolic–psychiatric comorbidities. Furthermore, differences in age, sex, and genetics may influence these systems, highlighting the need for personalized interventions. Targeting mitochondrial function, GDF15-GFRAL signaling, and gut microbiota composition may offer new therapeutic strategies. This integrative perspective helps conceptualize how metabolic and psychiatric mechanisms interact for understanding the pathophysiology of metabolic and psychiatric comorbidities and highlights therapeutic targets for precision medicine. Full article

This study evaluates the effectiveness of various rejuvenating oils, including soybean oil (N-oil), waste frying oil (F-oil), byproduct oil (W-oil), and aromatic hydrocarbon oil (A-oil), in restoring aged asphalt coatings by reducing asphaltene flocculation and improving colloidal stability. The rejuvenators were incorporated into aged asphalt binder via direct mixing at controlled dosages. Their effects were assessed using microscopy, droplet diffusion analysis, rheological testing (DSR and BBR), and molecular dynamics simulations. The aim is to compare the compatibility, solubility behavior, and rejuvenation potential of plant-based and mineral-based oils. The results indicate that N-oil and F-oil promote asphaltene aggregation, which supports structural rebuilding. In contrast, A-oil and W-oil act as solvents that disperse asphaltenes. Among the tested oils, N-oil exhibited the best overall performance in enhancing flowability, low-temperature flexibility, and chemical compatibility. This study presents a novel method to evaluate rejuvenator effectiveness by quantifying colloidal stability through grayscale analysis of droplet diffusion patterns. This integrated approach offers both mechanistic insights and practical guidance for selecting bio-based rejuvenators in asphalt recycling. Full article

Amblyopia, commonly affecting children aged 0–6 years, results from disrupted visual processing during early development and often leads to reduced visual acuity in one eye. This study presents the development and preliminary usability assessment of a non-invasive ocular monitoring device designed to support oculomotor engagement and therapy adherence in amblyopia management. The system incorporates an interactive maze-navigation task controlled via gaze direction, implemented during monocular and binocular sessions. The device tracks lateral and anteroposterior eye movements and generates visual reports, including displacement metrics and elliptical movement graphs. Usability testing was conducted with a non-probabilistic adult sample (n = 15), including individuals with and without amblyopia. The System Usability Scale (SUS) yielded an average score of 75, indicating good usability. Preliminary tests with two adults diagnosed with amblyopia suggested increased eye displacement during monocular sessions, potentially reflecting enhanced engagement rather than direct therapeutic improvement. This feasibility study demonstrates the device’s potential as a supportive, gaze-controlled platform for visual engagement monitoring in amblyopia rehabilitation. Future clinical studies involving pediatric populations and integration of visual stimuli modulation are recommended to evaluate therapeutic efficacy and adaptability for early intervention. Full article

Heart failure (HF) is a major global health challenge, characterized by high morbidity, mortality, and frequent hospital readmissions. Despite the advent of guideline-directed medical therapies (GDMTs), the burden of HF continues to grow, necessitating a shift toward comprehensive, multidisciplinary care models. Heart Failure Disease Management Programs (HF-DMPs) have emerged as structured frameworks that integrate evidence-based medical therapy, patient education, telemonitoring, and support for social determinants of health to optimize outcomes and reduce healthcare costs. This review outlines the key components of HF-DMPs, including patient identification and risk stratification, pharmacologic optimization, team-based care, transitional follow-up, remote monitoring, performance metrics, and social support systems. Incorporating tools such as artificial intelligence, pharmacist-led titration, and community health worker support, HF-DMPs represent a scalable approach to improving care delivery. The success of these programs depends on tailored interventions, interdisciplinary collaboration, and health equity-driven strategies. Full article

The construction industry is a major consumer of raw materials and a significant contributor to environmental emissions. Life cycle assessment (LCA) using digital models is a valuable tool for conducting a science-based analysis to reduce these impacts. However, transferring data from environmental product declarations (EPDs) to BIM for the purpose of sustainability assessment requires significant resources for its interpretation and integration. This study is founded on a comprehensive review of the scientific literature and standards, an analysis of published digital EPDs, and a thorough evaluation of IFC (industry foundation classes), identifying twenty gaps for the automated incorporation of LCA data from construction products into BIM. The identified limitations were assessed using the digital model of a building pilot, applying simplifications to incorporate actual EPD data. This paper presents the identified barriers to the automated incorporation of digital EPDs into BIM, and proposes eleven concrete actions to improve IFC 4.3. While prior studies have analyzed the environmental data in IFC, this research is significant in two key areas. Firstly, it focuses on the direct machine interpretation of environmental information without human intervention. Secondly, it is intended to be directly applicable to a revision of the IFC standards. Full article

Sexual health constitutes a fundamental aspect of overall well-being, with direct implications for individual development and the broader social and economic progress of communities. Promoting environments that ensure sexual experiences free from coercion, discrimination, and violence is a key public health priority. Sexuality, in this regard, should be understood as an inherent dimension of human experience, shaped by biological, cultural, cognitive, and ideological factors. Accordingly, sexual health education requires a holistic and multidimensional approach that integrates sociocultural, biographical, and professional perspectives. This study aims to examine the level of knowledge and training in sexual health among nursing students and healthcare professionals, as well as to assess the extent to which sexual health content is incorporated into nursing curricula at Spanish universities. A scoping review was conducted using the Dialectical Structural Model of Care (DSMC) as the theoretical framework. The findings indicate a significant lack of knowledge regarding sexual health among both nursing students and healthcare professionals, largely due to educational and structural limitations. Furthermore, sexual health education remains underrepresented in nursing curricula and is frequently addressed from a narrow, fragmented biomedical perspective. These results highlight the urgent need for the comprehensive integration of sexual health content into nursing education. Strengthening curricular inclusion is essential to ensure the preparation of competent professionals capable of delivering holistic, inclusive, and empowering care in this critical area of health. Full article

This study investigates the predictive performance of financial indicators in forecasting stock prices within the automotive sector using an adaptive neuro-fuzzy inference system (ANFIS). In light of the growing complexity of global financial markets and the increasing demand for automated, data-driven forecasting models, this research aims to identify those financial ratios that most accurately reflect price dynamics in this specific industry. The model incorporates four widely used financial indicators, return on assets (ROA), return on equity (ROE), earnings per share (EPS), and profit margin (PM), as inputs. The analysis is based on real financial and market data from automotive companies, and model performance was assessed using RMSE, nRMSE, and confidence intervals. The results indicate that the full model, including all four indicators, achieved the highest accuracy and prediction stability, while the exclusion of ROA or ROE significantly deteriorated model performance. These findings challenge the weak-form efficiency hypothesis and underscore the relevance of firm-level fundamentals in stock price formation. This study’s sector-specific approach highlights the importance of tailoring predictive models to industry characteristics, offering implications for both financial modeling and investment strategies. Future research directions include expanding the indicator set, increasing the sample size, and testing the model across additional industry domains. Full article

Hyperspectral image (HSI) denoising is a crucial step in image preprocessing as its effectiveness has a direct impact on the accuracy of subsequent tasks such as land cover classification, target recognition, and change detection. However, existing methods suffer from limitations in effectively integrating multi-scale features and adaptively modeling complex noise distributions, making it difficult to construct effective spatial–spectral joint representations. This often leads to issues like detail loss and spectral distortion, especially when dealing with complex mixed noise. To address these challenges, this paper proposes a multi-scale differentiated denoising network based on spatial–spectral cooperative attention (MDSSANet). The network first constructs a multi-scale image pyramid using three downsampling operations and independently models the features at each scale to better capture noise characteristics at different levels. Additionally, a spatial–spectral cooperative attention module (SSCA) and a differentiated multi-scale feature fusion module (DMF) are introduced. The SSCA module effectively captures cross-spectral dependencies and spatial feature interactions through parallel spectral channel and spatial attention mechanisms. The DMF module adopts a multi-branch parallel structure with differentiated processing to dynamically fuse multi-scale spatial–spectral features and incorporates a cross-scale feature compensation strategy to improve feature representation and mitigate information loss. The experimental results show that the proposed method outperforms state-of-the-art methods across several public datasets, exhibiting greater robustness and superior visual performance in tasks such as handling complex noise and recovering small targets. Full article

Anterior cruciate ligament reconstruction (ACLR) results in prolonged muscle weakness, impaired neuromuscular control, and delayed return to sport. Cross-education (CE), unilateral training of the uninjured limb, has been proposed as an adjunct therapy to promote bilateral adaptations. This scoping review evaluated the functional and neuroplastic effects of CE rehabilitation post-ACLR. Following PRISMA-ScR and JBI guidelines, PubMed, Scopus, Web of Science, and PEDro were searched up to February 2025. A bibliometric analysis was also conducted to report keyword co-occurrence and identify trends in this line of research. Of 333 screened references, 14 studies (price index: 43% and low-to-moderate risk of bias) involving 721 participants (aged 17–45 years) met inclusion criteria. CE protocols (6–12 weeks; 2–5 sessions/week) incorporating isometric, concentric, and eccentric exercises demonstrated strength gains (10–31%) and strength preservation, alongside improved limb symmetry (5–14%) and dynamic balance (7–18%). There is growing interest in neuroplasticity and corticospinal excitability, although neuroplastic changes were assessed heterogeneously across studies. Findings support CE as a feasible and low-cost strategy to complement early-stage ACLR rehabilitation, especially when direct loading of the affected limb is limited. Standardized protocols for clinical intervention and neurophysiological assessment are needed. Full article

Background: Bipolar disorder (BD) is a chronic and disabling psychiatric condition characterized by recurring episodes of mania, hypomania, and depression. Despite the availability of mood stabilizers, antipsychotics, and antidepressants, long-term management remains challenging due to incomplete symptom control, adverse effects, and high relapse rates. Methods: This paper is a narrative review aimed at synthesizing emerging trends and future directions in the pharmacological treatment of BD. Results: Future pharmacotherapy for BD is likely to shift toward precision medicine, leveraging advances in genetics, biomarkers, and neuroimaging to guide personalized treatment strategies. Novel drug development will also target previously underexplored mechanisms, such as inflammation, mitochondrial dysfunction, circadian rhythm disturbances, and glutamatergic dysregulation. Physiological endophenotypes, such as immune-metabolic profiles, circadian rhythms, and stress reactivity, are emerging as promising translational tools for tailoring treatment and reducing associated somatic comorbidity and mortality. Recognition of the heterogeneous longitudinal trajectories of BD, including chronic mixed states, long depressive episodes, or intermittent manic phases, has underscored the value of clinical staging models to inform both pharmacological strategies and biomarker research. Disrupted circadian rhythms and associated chronotypes further support the development of individualized chronotherapeutic interventions. Emerging chronotherapeutic approaches based on individual biological rhythms, along with innovative monitoring strategies such as saliva-based lithium sensors, are reshaping the future landscape. Anti-inflammatory agents, neurosteroids, and compounds modulating oxidative stress are emerging as promising candidates. Additionally, medications targeting specific biological pathways implicated in bipolar pathophysiology, such as N-methyl-D-aspartate (NMDA) receptor modulators, phosphodiesterase inhibitors, and neuropeptides, are under investigation. Conclusions: Advances in pharmacogenomics will enable clinicians to predict individual responses and tolerability, minimizing trial-and-error prescribing. The future landscape may also incorporate digital therapeutics, combining pharmacotherapy with remote monitoring and data-driven adjustments. Ultimately, integrating innovative drug therapies with personalized approaches has the potential to enhance efficacy, reduce adverse effects, and improve long-term outcomes for individuals with bipolar disorder, ushering in a new era of precision psychiatry. Full article

Traditional path planning algorithms often fail to simultaneously ensure operational efficiency, energy constraint compliance, and environmental adaptability in agricultural scenarios, thereby hindering the advancement of precision agriculture. To address these challenges, this study proposes a deep reinforcement learning algorithm, MoE-D3QN, which integrates a Mixture-of-Experts mechanism with a Bi-directional Long Short-Term Memory model. This design enhances the efficiency and robustness of UAV path planning in agricultural environments. Building upon this algorithm, a hierarchical coverage path planning framework is developed. Multi-level task maps are constructed using crop information extracted from Sentinel-2 remote sensing imagery. Additionally, a dynamic energy consumption model and a progressive composite reward function are incorporated to further optimize UAV path planning in complex farmland conditions. Simulation experiments reveal that in the two-level scenario, the MoE-D3QN algorithm achieves a coverage efficiency of 0.8378, representing an improvement of 37.84–63.38% over traditional algorithms and 19.19–63.38% over conventional reinforcement learning methods. The redundancy rate is reduced to 3.23%, which is 38.71–41.94% lower than traditional methods and 4.46–42.77% lower than reinforcement learning counterparts. In the three-level scenario, MoE-D3QN achieves a coverage efficiency of 0.8261, exceeding traditional algorithms by 52.13–71.45% and reinforcement learning approaches by 10.15–50.2%. The redundancy rate is further reduced to 5.26%, which is significantly lower than the 57.89–92.11% observed with traditional methods and the 15.57–18.98% reported for reinforcement learning algorithms. These findings demonstrate that the MoE-D3QN algorithm exhibits high-quality planning performance in complex farmland environments, indicating its strong potential for widespread application in precision agriculture. Full article