Search Results (10,232)

The precise measuring and control of fiber tension are critically important for enhancing structural and mechanical properties in spinning processes, as tension directly influences orientation, crystallinity, and mechanical properties. However, current tension measurement methods primarily operate offline and lack real-time measuring capabilities. A non-contact fiber tension detection system is introduced to investigate the effects of draw tension and its uniformity on the structure and mechanical properties of polyester fibers. During experiments conducted at a spinning speed of 1200 m/min across different draw ratios, the non-contact system demonstrated strong agreement with the contact tension detector. The results showed that increasing the tension from 34 cN to 164 cN reduced the monofilament diameter from 39.61 µm to 20.35 µm. Simultaneously, the orientation factor nearly tripled, while crystallinity increased from 55.72% to 77.39%. Mechanical testing revealed a 50.96% improvement in breaking strength, rising from 1.57 to 2.37 cN/dtex, accompanied by a significant decrease in elongation at break from 275.55% to 34.95%. However, tension fluctuations, characterized by an average fluctuation coefficient increase from 4.51% to 18.18%, caused diameter inconsistency. These fluctuations also reduced the orientation factor by 10.78%, lowered crystallinity, and substantially deteriorated mechanical properties. These findings underscore the critical importance of real-time, online tension monitoring for ensuring polyester fiber quality and performance during production. Full article

Locus of control refers to the way in which people perceive whether they have control over situations in their lives or whether these situations are the result of external circumstances. Locus of control subsequently influences individuals’ motivation, decision-making, and ability to accept responsibility. How locus of control manifests itself in the behavior of a particular individual can be influenced by several factors. In this article, we focused on how elements of different dimensions of human resource diversity can influence locus of control. For the research, we chose a quantitative approach using a questionnaire measuring the locus of control, along with additional questions. The main aim of the presented research was to identify the relationship between sociodemographic variables and the locus of control orientation of individual groups of respondents. The research sample consisted of N = 384 participants who completed the reduced standardized Rotter locus of control scale. The results focused on differences in individuals’ locus of control in terms of age, gender, type of work experience, and marital status and to what extent these sociodemographic variables can be a predictor of individuals’ locus of control. Hypotheses testing was performed using IBM SPSS 23 software. Th theoretical application of the research findings lies in the discovery that the locus of control (LoC) is not influenced by simple characteristics but must be understood in a more complex way. The practical application lies in the fact that professional experience can influence how employees perceive their level of control over their ability to affect their work and outcomes. Full article

(1) Background: Data literacy is becoming increasingly important for healthcare professionals in both outpatient care and research. Since healthcare data and the possibilities for its use and misuse are increasing in these areas, healthcare professionals need diverse knowledge regarding the collection, use and evaluation of data. A core component of this is an understanding of the ethical, legal, and social implications (ELSI) of working with health data. (2) Methods: Within the DIM.RUHR project (Data Competence Center for Interprofessional use of Health Data in the Ruhr Metropolis), the challenge of training in data literacy for different healthcare professionals is addressed. Based on a learning objectives matrix for interprofessional data literacy education, an ELSI concept was developed through collaboration with interprofessional project partners. The study was conducted between December 2024 and April 2025. (3) Results: The foundational structure of the ELSI concept was based on the learning objectives matrix and an unstructured literacy search for ELSI concepts in similar contexts. Using an iterative design-based research approach, a group of experts from different fields (didactics, applied ethics, health sciences, law, sociology, informatics, and psychology) developed an ELSI concept for healthcare professionals. The following categories were identified as crucial: 1. philosophy of science: a basic understanding of science and the hurdles and opportunities; 2. ethics: an overview of the biomedical principles and a technological assessment; 3. law: an overview of the reservation of permission and self-determination; 4. social aspects: an overview of health inequalities and different forms of power relations and imbalances. (4) Conclusions: The ELSI concept can be used in the orientation of healthcare professionals in outpatient care and research—regardless of their profession—to develop data competencies, with the aim of providing a holistic view of the challenges and potential in the collection, use, and evaluation of healthcare data. The DIM.RUHR project’s approach is to develop open educational resources that build on the ELSI concept to teach specific skills at different competence levels. Full article

This paper experimentally investigates the fretting fatigue behavior of metal additive-manufactured Ti-6Al-4V alloy specimens fabricated using the selective laser melting (SLM) method, focusing on damage characterization and fatigue life assessment. Based on the ASTM E466 standard, the test components were manufactured using metal 3D printing technology. Fretting fatigue tests were conducted under varying axial stress levels and contact loads, followed by microscopic examinations using scanning electron microscopy (SEM) to analyze damage mechanisms. A fretting map was developed based on SEM observations, providing insights into damage evolution under different loading conditions. These findings contribute to a better understanding of the relationship between fretting fatigue parameters and failure mechanisms. The developed fretting map and experimental observations provide a foundation for further studies aimed at enhancing the fretting fatigue life assessment of standard specimens for different test parameters. Finally, this paper includes design-oriented evaluation frameworks that can guide engineers in integrating AM components into safety-critical systems under fretting fatigue conditions. Full article

Uracil−DNA glycosylases (UNGs) are DNA repair enzymes responsible for the removal of uracil, a canonical RNA nucleobase, from DNA, where it appears through cytosine deamination or incorporation from the cellular dUTP pool. While human and Escherichia coli UNGs have been extensively investigated, much less is known about their plant counterparts, of which UNGs from Arabidopsis thaliana are the only studied examples. Here, we show that in sugar beet (Beta vulgaris L.), an important crop species, cold and salt stress induce the expression of the UNG gene (BvUNG) and modulate the level of the uracil-excising activity in the roots. Purified recombinant BvUNG efficiently removes uracil from DNA both in vitro and in an E. coli reporter strain but does not excise 5-hydroxyuracil, 5,6-dihydrouracil, or 5-hydroxymethyluracil. The activity is abolished by Ugi, a protein UNG inhibitor from PBS1 bacteriophage, and by a mutation of a conserved active site His residue. Structural modeling shows the presence of a disordered N-tail prone to undergo phase separation, followed by a long α helix oriented differently from its counterpart in human UNG. Overall, BvUNG is a functional uracil–DNA glycosylase that might participate in the response to abiotic stress. Full article

Developments in agriculture is reshaping the agribusiness landscape, altering farms’ bargaining power and strategic positioning within supply chains. These dynamics raise important questions about how financial strength influences farmers’ preferences for different components of business relationships with input suppliers. The primary objective of this study is to examine the relationship between a farm’s financial power and the importance it assigns to the behavioral dimension in such relationships. To address this objective, we employ a two-stage research design. In the first stage, qualitative interviews with farmers were conducted to identify the key attributes contributing to relationship value, encompassing economic, strategic, and behavioral dimensions. In the second stage, a quantitative survey was administered to 249 farmers, supplemented with financial data from the Farm Accountancy Data Network (FADN). The Maximum Difference Scaling (MaxDiff) method was applied to assess the relative importance of these attributes, followed by statistical analysis linking the observed preferences to a composite indicator of financial power. The results indicate that financially stronger farms place greater emphasis on economic factors while attaching less importance to behavioral aspects. Among less financially powerful farms, two distinct patterns emerge: one characterized by opportunistic, price-oriented behavior, and another reflecting a relational orientation that values trust, communication, and long-term cooperation alongside economic conditions. These findings contribute to a better understanding of business relationships in agribusiness by explaining how financial power shapes the trade-off between economic and behavioral components. Full article

Inattention and hyperactivity/impulsivity that feature Attention-Deficit/Hyperactivity Disorder (ADHD) may be challenging in the classroom setting. However, little is known about language teachers’ self-efficacy and the approaches they would employ to deal with context-specific ADHD-like behaviours. Therefore, this mixed-method study used the vignette methodology to investigate the self-reported efficacy and teaching approaches of 62 pre-service English language teachers from Japan, Poland, Turkey, and Ukraine in managing ADHD-like behaviours in six hypothetical classroom scenarios. By comparing diverse educational and cultural contexts, the study aimed to identify convergences and divergences in coping with these behaviours to promote evidence-based approaches in inclusive language teaching. Data were gathered using an online questionnaire with both open- and closed-ended questions on a Likert-type scale. The findings indicate that participants feel moderately confident in managing ADHD-like behaviours; however, some statistically significant country-related differences were observed. A number of similar teaching approaches were identified across the sample, but prominent country-specific differences in approaching specific ADHD-like behaviours were present. The approaches used by participants align with evidence-based recommendations for teaching students with ADHD to some extent. The discussed implications of the study inform pre-service teachers’ education and call for approaches that are more universal in design and language-skill-development-oriented. Full article

This study investigated the cage size preferences of juvenile chinchillas using enclosures that allowed free choice between different dimensions. Three comparisons were tested: (1) small floor area (0.15 m²) vs. double floor area (0.30 m²) at constant height; (2) low height (0.4 m) vs. high height (1.0 m) at constant floor area (0.15 m²); and (3) small–low cage (0.15 m² × 0.4 m) vs. large–high cage (0.30 m² × 1.0 m). The juveniles consistently preferred the smaller or lower enclosures across all trials. In the floor area tests, chinchillas spent about 66–75% of their time in the small cage compartments (p < 0.001). In the height comparison, the low cage was preferred by 70% (p < 0.001). When both floor area and height were increased, the small–low cage was preferred by 79% (p < 0.001). Differences in preference were most evident during the daytime period. At night, however, cage utilization was more even. These results indicate that young chinchillas strongly prefer smaller, lower spaces. Based on these preference tests alone, simply providing larger cages (without other modifications) did not result in greater use by juvenile chinchillas. These unexpected results suggest that factors such as safety or familiarity drive juveniles to choose smaller enclosures. Further research is needed to clarify the motivation behind these preferences and to determine how best to incorporate them into improved welfare-oriented housing designs. Full article

Against the backdrop of global commitments to sustainable development and carbon neutrality objectives, the agricultural sector faces compelling imperatives to transition toward environmentally sustainable and resource-efficient production systems. Focusing on the critical role of agricultural inputs, this study investigates how China’s Zero Growth Policy for Fertilizer and Pesticide Use (ZGP), implemented in 2015, influences green transformation in the agricultural inputs sector through a quasi-natural experiment framework. Employing a staggered difference-in-differences (DID) design with comprehensive nationwide firm registration data from 2013 to 2020, we provide novel micro-level evidence on environmental regulation’s market-shaping effects. Our findings demonstrate that the ZGP significantly enhances green market selection, stimulating entry of environmentally certified firms, with effect heterogeneity revealing policy impacts are attenuated in manufacturing-intensive regions due to green entry barriers, while being amplified in major grain-producing areas and more market-oriented regions. Mechanism analyses identify three key transmission channels: intensified regulatory oversight, heightened public environmental awareness, and growing market demand for sustainable inputs. Furthermore, the policy has induced structural transformation within the industry, progressively increasing green enterprises’ market share. These results offer valuable insights for designing targeted environmental governance mechanisms to facilitate sustainable transitions in agricultural input markets. Full article

Despite increasing evidence that cigarette smoke is a significant source of indoor fine particulate matter (PM_2.5), quantitative emission factors (EFs) for PM_2.5 and its toxic chemical composition in mainstream (MS) and sidestream (SS) smoke are still not well defined. In this study, we employed a custom-designed chamber to separately collect MS (intermittent puff) and SS (continuous sampling) smoke from eleven cigarette models, representing six brands and two product types, under controlled conditions. PM_2.5 was collected on quartz-fiber filters and analyzed for carbon fractions (using the thermal–optical IMPROVE-A protocol), nine water-soluble inorganic ions (by ion chromatography), and twelve trace elements (via ICP-MS). SS smoke exhibited significantly higher mass fractions of total analyzed species (84.7% vs. 65.9%), carbon components (50.6% vs. 44.2%), water-soluble ions (17.1% vs. 13.7%), and elements (17.0% vs. 7.0%) compared to MS smoke. MS smoke is characterized by a high proportion of pyrolytic organic carbon fractions (OC₁–OC₃) and specific elements such as vanadium (V) and arsenic (As), while SS smoke shows elevated levels of elemental carbon (EC1), water-soluble ions (NH₄⁺, NO₃⁻), and certain elements like zinc (Zn) and cadmium (Cd). The toxicity-weighted distribution indicates that MS smoke primarily induces membrane disruption and pulmonary inflammation through semi-volatile organics and elements, whereas SS smoke enhances oxidative stress and cardiopulmonary impairment via EC-mediated reactions and secondary aerosol formation. The mean OC/EC ratio of 132.4 in SS smoke is an order of magnitude higher than values reported for biomass or fossil-fuel combustion, indicative of extensive incomplete combustion unique to cigarettes and suggesting a high potential for oxidative stress generation. Emission factors (µg/g cigarette) revealed marked differences: MS delivered higher absolute EFs for PM_2.5 (422.1), OC (8.8), EC (5.0), Na⁺ (32.6), and V (29.2), while SS emitted greater proportions of NH₄⁺, NO₃⁻, Cl⁻, and carcinogenic metals (As, Cd, Zn). These findings provide quantitative source profiles suitable for receptor-oriented indoor source-apportionment models and offer toxicological evidence to support the prioritization of comprehensive smoke-free regulations. Full article

Background and Objectives: Inflammatory bowel diseases (IBDs) are chronic conditions of the digestive tract, often requiring life-long treatments in order to achieve and maintain remission. However, treatment adherence among patients with IBD can frequently be suboptimal, which can compromise disease control and long-term outcomes. The aim of this study was to analyze the adherence rate and to identify factors that significantly influence treatment adherence in patients with IBD. Materials and Methods: The study employed a cross-sectional design and was conducted at the Fundeni Clinical Institute, a tertiary medical center in Bucharest, Romania. The treatment adherence was assessed using the Medication Adherence Report Scale-5 (MARS-5), with patients scoring greater than 23 considered adherent. Anxiety, depression and perceived stress were assessed using the Depression, Anxiety and Stress Scale-21 (DASS-21). Perceived social support was measured with the Multidimensional Scale of Perceived Social Support (MSPSS), and coping strategies were assessed using the Brief Coping Orientation to Problems Experienced Inventory (Brief COPE Inventory). Results: A total of 188 patients were included in the final analysis. Of these, 99 patients (52.7%) were male and 109 (58.0%) had a diagnosis of Crohn’s disease. The majority of patients (81.9%) were receiving treatment with advanced therapies, including biologics or small molecules. Forty patients were receiving their therapy through more than one route of administration. Optimal adherence was noted in 160 patients (85.1%). Patients treated with advanced therapies (biologics and small molecules) had significantly higher odds of optimal adherence (OR 10.52, 95% CI: 4.3–25.74, p < 0.001), with a rate of adherence of 92.2%. Significantly lower odds of adherence were found for the oral (OR 0.35, 95% CI: 0.14–0.83, p = 0.01) and rectal (OR 0.09, 95% CI: 0.03–0.29, p < 0.001) routes of administration, while the intravenous administration had higher odds of adherence (OR 4.85, 95% CI: 1.02–22.9, p = 0.04) compared to the subcutaneous route. Other factors associated with an improved adherence were being retired (OR 3.5, 95% CI: 1.13–10.8, p = 0.029) and using positive reframing (p = 0.04), planning (p = 0.01) and venting (p = 0.02) as coping strategies; active smoking (OR 0.26, 95% CI: 0.11–0.6, p = 0.002), active disease (OR 0.36, 95% CI: 0.16–0.81, p = 0.014) and behavioral disengagement (p = 0.04) were associated with impaired treatment adherence. No significant differences in adherence were observed between disease phenotypes. Conclusions: The route of administration, smoking status and psychosocial factors, such as perceived stress of social support and coping strategies, may play an important role in influencing treatment adherence in patients with IBD. While the disease phenotype was not associated with differences in adherence, patients with active disease had significantly lower odds of optimal adherence. Full article

Rapid population aging in developing countries has intensified demand for accessible nursing home services, yet spatial disparities in service distribution remain insufficiently examined in secondary cities. This study investigates spatial distribution and multi-dimensional accessibility of nursing homes in Kunming, China, using comprehensive spatial analytical methods to inform sustainable urban development. We analyzed 205 nursing homes with 47,600 beds, evaluating spatial distribution patterns, economic accessibility, and spatial accessibility across different transportation modes. Our analysis reveals a pronounced monocentric pattern with nursing resources concentrated within central urban districts, creating a “primary core-multiple satellite” structure and spatial mismatch between service supply and older adult population needs. A distinct institutional dichotomy exists between publicly and privately operated facilities, establishing a dual-track system with different accessibility implications for social equity. Economic accessibility analysis demonstrates significant barriers in central urban and tourism-oriented districts dominated by higher-priced private facilities, where minimum prices frequently exceed average monthly pension. Spatial accessibility remains inadequate across all transportation modes, with only 24.3% of communities achieving normal or higher accessibility via private car, 21.5% via public bus, and merely 13.9% via walking. These limitations primarily stem from insufficient service capacity (34 beds per 1000 older adults) relative to demographic needs rather than transportation constraints. We recommend three sustainable interventions: implementing demand-based planning mechanisms, establishing progressive pricing policies, and developing older adult-friendly transportation networks. This framework supports sustainable urbanization by promoting spatial equity and efficient resource allocation, providing valuable insights for secondary cities pursuing sustainable development goals. Full article

This paper presents a novel speed controller design for a brushless DC motor (BLDCM) operating under field-oriented control (FOC). The proposed speed controller is developed by integrating the zebra optimization algorithm (ZOA) with sliding mode theory (SMT). In this approach, the parameter ranges of the sliding mode dynamic trajectory control gain, exponential reaching gain, and constant speed reaching gain—three key components of the exponential reaching law-based sliding mode controller (ERLSMC)—are defined as the research space for the ZOA. The feedback speed error and its rate of change are used as features to calculate the fitness value. Subsequently, the fitness value computed by the algorithm is compared with the current best fitness value to determine the optimal position coordinates. These coordinates correspond to the optimal set of gain parameters for the sliding mode speed controller. During the operation of the BLDCM, these optimized parameters are applied to the controller in real time. This enables the system to adjust the three gain parameters dynamically under different operating conditions, thereby reducing the overshoot commonly induced by the ERLSMC. As a result, the speed response of the BLDCM drive system can more accurately and rapidly track the speed command. Therefore, the proposed control strategy is not only characterized by a small number of parameters and ease of tuning, but also does not require large datasets for training, making it highly practical and easy to implement. Finally, the proposed control strategy is simulated using Matlab/Simulink (2024b version) and applied to the BLDCM drive system for experimental testing. Its performance is compared against three types of sliding mode controllers employing different reaching laws: the constant speed reaching law, the exponential reaching law, and the exponential reaching law combined with extension theory (ET). Simulation and experimental results confirm that the proposed novel speed controller outperforms the other three sliding mode controllers based on different reaching laws, both in terms of speed command tracking and load regulation response. Full article

Background: Magnolia alejandrae is a tree endemic to Tamaulipas, Mexico, distributed in the forests of the Sierra Madre Oriental. Objective: Our objective was to analyze the secondary metabolite profile of different parts of M. alejandrae and evaluate their antiproliferative activity in vitro. Methods: Different extracts of leaf, bark, and fruit were obtained using conventional and unconventional extraction methods with solvents of different polarity. The extracts were analyzed by Ultra-Performance Liquid Chromatography-Mass Spectra (UPLC-MS), and their antiproliferative activity against cancer cell lines was determined. Results: The primary yields of the extracts obtained from M. alejandrae ranged from 8.32% to 36.19%. Three hundred and twelve secondary metabolites previously reported from the Magnolia genus were detected. The most frequent were magnone A, pinoresinol, and yangambin. Honokiol and magnolol were not detected. Two of the extracts (FSW and BSW) had antiproliferative activity (IC₅₀ < 140 µg/mL) against HeLa, MCF-7, A549, U373, and PC3 cancer cell lines. The higher activity was against the A549 cell line. Conclusions: M. alejandre extracts showed secondary metabolites previously reported and unreported in other species. Interestingly, some extracts had antiproliferative activity against cancer cell lines. Therefore, M. alejandrae is a source of molecules that could be explored to develop new drugs. Full article

Dry powder inhalers (DPIs) are the mainstay in the treatment of obstructive pulmonary diseases. However, the performance of DPI formulations is highly dependent on the used inhaler device and the patient’s inspiratory effort. This study aimed to evaluate and compare the aerosolization behavior of three commercially available capsule-based DPI medications—formoterol (Foradil^®), glycopyrronium (Seebri^® Breezhaler), and tiotropium (Spiriva^®)—delivered using three different capsule-based inhalers (Aerolizer, Breezhaler, and Handihaler), under varying flow conditions. Methods: The aerodynamic performance of each formulation–inhaler combination was assessed using the Next-Generation Impactor (NGI) and Dosage Unit Sampling Apparatus (DUSA) methodology. Fine particle dose (FPD) and aerodynamic particle size distribution (APSD) were determined at fixed flow rates of 15, 30, 60, and 100 L/min, as well as at inhaler-specific flow rates corresponding to a 4 kPa pressure drop. Chromatographic quantification of active ingredients was performed using validated HPLC methods specific to each drug. Results: The FPD values increased consistently with higher flow rates across all tested formulations and inhalers. At a 4 kPa pressure drop, Aerolizer and Breezhaler achieved significantly higher FPDs compared to Handihaler. Notably, in some instances, non-dedicated inhalers produced greater respirable fractions than the originally intended devices. APSD profiles revealed that drug deposition shifted toward smaller NGI stages at higher inspiratory flows, supporting enhanced deep lung delivery potential under optimal conditions. Conclusions: Device resistance, capsule orientation, and piercing mechanics substantially influence drug aerosolization. Although non-dedicated inhalers may offer improved FPDs in vitro, clinical use should adhere to approved drug–device combinations, as these have been validated for efficacy and safety under real-world conditions. Full article