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Article

8 Citations

3,408 Views

20 Pages

Nanoseeded Desupersaturation and Dissolution Tests for Elucidating Supersaturation Maintenance in Amorphous Solid Dispersions

Gulenay Guner,
Ayesha Amjad,
Matthew Berrios,
Manisha Kannan and
Ecevit Bilgili

Pharmaceutics2023, 15(2), 450;https://doi.org/10.3390/pharmaceutics15020450

30 January 2023

The impact of residual drug crystals that are formed during the production and storage of amorphous solid dispersions (ASDs) has been studied using micron-sized seed crystals in solvent-shift (desupersaturation) and dissolution tests. This study exam...

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Article

5 Citations

4,567 Views

18 Pages

Determination of Crystal Growth Rates in Multi-Component Solutions

Christoph Helfenritter and
Matthias Kind

Crystals2022, 12(11), 1568;https://doi.org/10.3390/cryst12111568

3 November 2022

Many solid forming processes involve crystallization from multi-component solutions. In order to predict final phase assemblages, multi-component phase transfer kinetics must be known. It is not sufficient to have the kinetics of only one crystallizi...

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Article

70 Citations

13,654 Views

20 Pages

Agglomeration Control during Ultrasonic Crystallization of an Active Pharmaceutical Ingredient

Bjorn Gielen,
Jeroen Jordens,
Leen C. J. Thomassen,
Leen Braeken and
Tom Van Gerven

Crystals2017, 7(2), 40;https://doi.org/10.3390/cryst7020040

8 February 2017

Application of ultrasound during crystallization can efficiently inhibit agglomeration. However, the mechanism is unclear and sonication is usually enabled throughout the entire process, which increases the energy demand. Additionally, improper opera...

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Article

2 Citations

2,475 Views

16 Pages

Multi-Component Diffusion in the Vicinity of a Growing Crystal

Christoph Helfenritter and
Matthias Kind

Crystals2022, 12(6), 872;https://doi.org/10.3390/cryst12060872

20 June 2022

Co-crystallization from multi-component solutions occurs in many solids formation processes. The measurement or simulative description of concentration courses in the fluid vicinity of a growing crystalline substrate is difficult for such systems. Th...

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