Search Results (826)

This study examines the moral agency of French secondary school headteachers through the lens of the theory of conventions. Using qualitative data from interviews with fifteen headteachers involved in professional development, this study explores how these leaders justify their practices within a centralized, bureaucratic, and hierarchical education system. It identifies a variety of conventions—civic, domestic, industrial, project, market, inspired, and fame—that headteachers draw on to navigate institutional constraints, manage professional relationships, and foster pedagogical and organizational change. Particular attention is given to how civic and domestic conventions shape leadership discourse and practices, especially regarding trust building, decision making, and reform implementation. We also compare the French context with international examples from the International Successful School Principalship Project (ISSPP), focusing on Nordic countries, where leadership emphasizes democratic participation, professional trust, and shared responsibility. This study underscores the uniqueness of the French leadership model, which resists managerial and market logics while remaining rooted in republican and egalitarian ideals. It concludes by advocating for a more context-aware, ethically grounded, and dialogical approach to school leadership. Full article

The work Xingli zhenquan tigang (Sing lii jen ciyan bithei hešen) was written in Chinese and Manchu by the French Jesuit Alexandre de la Charme (1695–1767) and published in Beijing in 1753. The first two sections of this paper provide an introduction to de la Charme’s work biography and to further textual and historical contexts, explore the peculiarities of the subsequent early German reception of the work almost 90 years later, and introduce the content from an overview perspective. The third section explores the most essential contents of Book 1 (of 3) of the Manchu version. The investigation is based on Hans Conon von der Gabelentz’s (1807–1874) German translation from 1840. Camouflaged as a Confucian educational dialogue, and by blurring his true identity in his publication, de la Charme criticizes Neo-Confucian positions from an implicitly Cartesian and hidden Christian perspective, tacitly blending Cartesian views with traditional Chinese concepts. In addition, he alludes to Manchu shamanic views in the same regard. De la Charme’s assimilating rhetoric “triangulation” of three different cultural and linguistic horizons of thought and spirituality proves that later Jesuit scholarship reached out into the inherent ethnic and spiritual diversity of the Qing intellectual and political elites. Hidden allusions to Descartes’s dualistic concepts of res cogitans and res extensa implicitly anticipate the beginnings of China’s intellectual modernization period one and a half centuries later. This work also provides an example of how the exchange of intellectual and religious elements persisted despite the Rites Controversy and demonstrates how the fading Jesuit mission influenced early German sinology. I believe that this previously underexplored work is significant in both systematic and historical respects. It is particularly relevant in the context of current comparative research fields, as well as transcultural and interreligious intellectual dialogue in East Asia and around the world. Full article

Background/Objectives: Virtual reality (VR) is becoming an increasingly popular therapeutic tool, with immersion being a key component that provides users with a sense of spatial presence in virtual environments. However, comprehensive research is lacking on the impact of static versus dynamic VR environments on changes in perceived spatial presence. The aim of this study was to assess the experience of spatial presence in virtual environments and to examine the relationship between spatial presence and users’ emotional responses during exposure to static and dynamic VR scenarios. The study also sought to compare the effects of static and dynamic environments on the occurrence of cybersickness symptoms. Methods: The study included 30 participants aged 18 to 26. Each participant was instructed to view two separate films, with each film lasting 20 min (with a 20 min break between them) in virtual reality using Oculus Meta Quest 2 VR goggles, and to share their experiences. Cybersickness was assessed using the Virtual Reality Sickness Questionnaire (VRSQ), emotional responses were evaluated using the International Positive and Negative Affect Schedule—Short Form (I-PANAS-SF), and spatial presence was measured with the Spatial Presence Experience Scale (SPES). Results: In the group of participants who viewed the dynamic film, a significant decrease in stress levels was observed after the projection as compared to the baseline resting state (p = 0.002), along with an increase in experienced relaxation (p < 0.001). In contrast, in the group that viewed the static film, no significant changes were found in stress levels (p = 0.464) or experienced relaxation (p = 0.455) when compared to baseline. The dynamic environment had the greatest impact on the occurrence of cybersickness symptoms, with all responses indicating a progressive increase compared to the static condition. The static environment produced only minor disturbances. Conclusions: These findings confirm that virtual environments can influence users’ emotional states, particularly highlighting the relationship between spatial presence and emotional experience. Full article

The objective of this study is to detect the locations of submarine groundwater discharge (SGD) in the coastal area of the El Jebha region, located in northwestern Morocco. It is hypothesized that this zone is fed by one of the most rain-rich karstic aquifers in Morocco (the Dorsale Calcaire). The region’s geology is complex, characterized by multiple faults and fractures. Thermal remote sensing is used in this study to locate potential SGD zones, as groundwater emerging from karst systems is typically cooler than surrounding ocean water. Landsat satellite imagery was used to assess temperature variations and detect anomalies associated with the presence of freshwater in the marine environment. El Jebha’s geographical location, with a direct interface between limestone and sea, makes it an ideal site for the appearance of submarine groundwater discharges. This study constitutes the first use of Landsat-8/9 thermal-infrared imagery, processed with a multi-temporal fuzzy-overlay method, to detect SGD. Out of 107 Landsat scenes reviewed, 16 cloud-free images were selected. The workflow identified 18 persistent cold anomalies, of which three were classified as high-probability SGD zones based on recurrence and spatial consistency. The results highlight several potential SGD zones, confirming the cost-effectiveness of thermal remote sensing in mapping thermal anomalies and opening up new perspectives for the study of SGD in Morocco, where these phenomena remain rarely documented. Full article

Background: Female sex workers (FSWs) in sub-Saharan Africa bear a disproportionate burden of sexually transmitted infections, including HIV, high-risk HPV (HR-HPV), and herpes simplex virus type 2 (HSV-2). This study evaluated possible association between HR-HPV, HIV, and HSV-2 among FSWs in the Democratic Republic of the Congo. Methods: A cross-sectional study was conducted among 432 FSWs (mean age, 28.1 years) recruited via respondent-driven sampling. Genital self-sampling using the V-Veil UP2™ device was performed, followed by HPV genotyping and quantification by multiplex PCR, and HSV-2 DNA detection by PCR. Results: Among 415 participants, HR-HPV prevalence was 36.9%, with HPV-52 (14.9%), HPV-58 (10.1%), and HPV-16 (6.5%) as leading genotypes. Overall, 89% of HR-HPV-positive women harbored genotypes covered by Gardasil-9^®. Co-infection with HIV and HSV-2 significantly increased HPV prevalence, genotype diversity, and viral load. Notably, HSV-2 positivity was the sole independent predictor of elevated replication of HR-HPV (p < 0.001), vaccine HR-HPV (p < 0.001), and non-vaccine HR-HPV (p < 0.021). Conclusions: FSWs exhibit a high burden of HR-HPV, shaped by co-infections with HIV and HSV-2. HSV-2 independently drives HR-HPV replication, highlighting its role in HPV persistence and cervical cancer risk. Integrated HSV-2 detection and Gardasil-9^® vaccination should be prioritized in cervical cancer elimination strategies targeting high-risk populations in sub-Saharan Africa. Full article

Personalized Federated Learning (PFL) seeks to train client-specific models across distributed data silos with heterogeneous distributions. We introduce Sign-Entropy Regularization (SER), a novel entropy-based regularization technique that penalizes excessive directional variability in client-local optimization. Motivated by Descartes’ Rule of Signs, we hypothesize that frequent sign changes in gradient trajectories reflect complexity in the local loss landscape. By minimizing the entropy of gradient sign patterns during local updates, SER encourages smoother optimization paths, improves convergence stability, and enhances personalization. We formally define a differentiable sign-entropy objective over the gradient sign distribution and integrate it into standard federated optimization frameworks, including FedAvg and FedProx. The regularizer is computed efficiently and applied post hoc per local round. Extensive experiments on three benchmark datasets (FEMNIST, Shakespeare, and CIFAR-10) show that SER improves both average and worst-case client accuracy, reduces variance across clients, accelerates convergence, and smooths the local loss surface as measured by Hessian trace and spectral norm. We also present a sensitivity analysis of the regularization strength $\rho$ and discuss the potential for client-adaptive variants. Comparative evaluations against state-of-the-art methods (e.g., Ditto, pFedMe, momentum-based variants, Entropy-SGD) highlight that SER introduces an orthogonal and scalable mechanism for personalization. Theoretically, we frame SER as an information-theoretic and geometric regularizer that stabilizes learning dynamics without requiring dual-model structures or communication modifications. This work opens avenues for trajectory-based regularization and hybrid entropy-guided optimization in federated and resource-constrained learning settings. Full article

The Latin (De Homine, 1662, 1664) and French (L’Homme, 1664) editions of René Descartes’ Treatise on Man present different iconographic traditions, but the iconography of the Latin editions is little known. Dutch physician and botanist Florentius Schuyl edited De Homine and illustrated it himself with a mix of woodcut and copperplate illustrations. This paper examines Schuyl’s innovative depictions of purported dynamic aspects of the pineal gland as claimed by Descartes: (1) repeatedly illustrating the pineal gland as the corporeal–spiritual linkage of the brain and soul; and (2) using a movable flap anatomy to illustrate the pineal gland as a motile structure that both responds to and directs animal spirits. None of the canonical illustrations in the later French edition attempted to depict the corporeal–spiritual linkage of the brain and soul, and the modest attempts in the French edition to depict the motility of the pineal gland relied simply on superimposition of two purported positions of the gland, a technique also employed by Schuyl. This paper also reviews how Schuyl’s illustration of a corporeal–spiritual linkage of the brain and soul in a goat sharply contrasts with his written defense of Descartes’ bête-machine doctrine in the extended preface to De Homine. Full article

In this paper, an experimental and theoretical study was undertaken to assess the impact of rare-earth co-doping of silica glasses on the light emission under X-rays. To this aim, radioluminescence (RL), phosphorescence (PP), and thermoluminescence (TL) signals of Ce³⁺/Gd³⁺ co-doped silica glasses have been successively measured and combined at different dose rates and irradiation temperatures. The RL response of the weakly co-doped sample was found to be temperature-independent between 273 K and 353 K. This result suggests that, based on this RL response, it is possible to design ionizing radiation sensors independent of the irradiation temperature in the corresponding range. Moreover, a model that considers the electron–hole pair generation, the charge carrier trapping–detrapping, and the electron–hole recombination in the localized and delocalized bands has been developed to reproduce these optical signals. The theoretical model also explains the temperature independence of the RL response between 273 K and 353 K for the weakly co-doped sample and, therefore, the operating principle of an X-ray sensor independent of the irradiation temperature. Full article

Background/Objectives: The surveillance of viral strain evolution is needed during prophylactic HPV vaccination programs against cervical cancer and necessitates safely archiving and storing cervical samples while maintaining the long-term stability of HPV DNA to carry out molecular diagnosis. The present proof-of-concept study aimed to assess DNA stability for HPV molecular detection from veils resuspended in a universal transport medium (UTM) and conserved at different temperatures after long-term storage. Methods: The detection and quantification of HPV DNA were evaluated in female genital secretions self-collected using veils and conserved in Cyt-All^® UTM at −30 °C, +4 °C, and +25 °C after long-term 27-month storage. Results: A slight degradation of the ubiquitous single-copy cellular DNA TOP3 gene was assessed using multiplex real-time PCR (BMRT Human Papillomavirus Genotyping Real Time PCR Kit, Bioperfectus Technologies Co., Ltd., Taizhou, Jiangsu, China) at positive temperatures (+4 °C and +25 °C) but not at a frozen temperature (−30 °C) after 27 months of storage. Nevertheless, HPV DNA preservation was sufficient at the three storage temperatures to detect and quantify HPV DNA, with a similar rate of HPV detection, a similar level of cumulative HPV viral loads, high sensitivity and specificity, and perfect concordance in HPV genotype detection after the long period of 27 months of storage. Finally, the conservation of genital samples for a prolonged period in the Cyt-All^® medium, even at room temperature, allows for the detection and quantification of any HPV and HR-HPV with high accuracy. Conclusions: The combination of veil-based self-sampling of female genital secretions and their elution and conservation in UTM may be used in the field to carry out longitudinal molecular epidemiology surveys of circulating HPV. Full article

This article explores the sustainable management of construction and demolition waste (CDW) as part of a circular economy in Europe. It provides an overview of current European practices, identifies the main challenges associated with collecting, sorting and recycling waste, and highlights the need to design buildings and construction that encourage the reuse of materials. The study also draws on best practice from internationally recognised examples such as Japan, Singapore, California, the Netherlands and China, which highlights the effectiveness of a combination of strict regulations, economic incentives and advanced recycling technologies. These international cases provide valuable lessons that can be adapted to the European context to improve the situation and fill gaps in policy, innovation and education. This article recommends targeted measures to strengthen circular practices, such as harmonising European standards, promoting eco-design principles in public procurement, investing in research and development (R&D) and establishing green administrative practices. By adopting these strategies, Europe can significantly improve the management of CDW, fostering a more resilient, sustainable and integrated circular economy. Full article

Background/Objectives: To assess the spatial presence and impact of an immersive virtual reality (VR) walk on symptoms of cybersickness, emotions, and participant engagement, with the aim of providing insights applicable to future therapeutic VR interventions for individuals with limited mobility. Methods: The experiment involved 30 healthy individuals who used VR headsets while seated on chairs to experience a 360° virtual tour of the Venice Canals in Los Angeles. The effect of immersion was evaluated using the Virtual Reality Sickness Questionnaire (VRSQ) to measure cybersickness symptoms, the International Positive and Negative Affect Schedule-Short Form (I-PANAS-SF) to assess emotions, the Spatial Presence Experience Scale (SPES) to evaluate spatial presence, and the Flow State Scale (FSS) to quantify the flow state. Results: The results indicated that the virtual walk elicited both positive and negative reactions. The increase in eye strain (+0.66), general discomfort (+0.6), and headache (+0.43) was achieved in the VRSQ scale. Despite experiencing nausea and oculomotor symptoms, participants reported a high level of flow (range of scale items from 3.47 to 3.70), suggesting a beneficial impact of immersion on their well-being. Furthermore, the analysis of the I-PANAS-SF results revealed a predominance of positive emotions, indicating a favorable perception of the experience. However, the SPES scores exhibited variability in the perception of spatial presence (mean spatial presence score 3.74, SD 2.06), likely influenced by the characteristics of the visual material used. Conclusions: Overall, the immersive VR walk, despite the potential risk of cybersickness symptoms, as a seated passive exploration still promoted feelings of satisfaction and fulfillment, allowing the participants to actively engage with the virtual environment. These findings suggest that seated VR experiences hold promise as a tool for promoting well-being, but further research is needed to address cybersickness and optimize VR content for therapeutic use in populations with limited mobility. Full article

Background: Childhood, adolescent, and young adult cancer survivors (CAYACS) face significant long-term health risks, yet adherence to long-term follow-up (LTFU) care remains inconsistent. This study explores the concept of akrasia (i.e., acting against one’s better judgment by engaging in behaviors known to be harmful or counterproductive) to understand the psychological, cognitive, and systemic barriers influencing survivor engagement in LTFU. Method: Using an ethical reflection approach based on a literature review, we discussed survivor experiences, behavioral science insights, and ethical principles to identify solutions that balance patient autonomy with supportive interventions. A narrative approach was used to summarize the key points discussed during the ethics reflection group meetings. Results: Our findings highlight key barriers such as trauma, avoidance behaviors, and cognitive constraints that contribute to non-adherence. Strategies such as shared decision-making, digital health tools, and nudge-based interventions are proposed to enhance survivor engagement. Ethical considerations emphasize the need for personalized and flexible care approaches that respect survivor agency while mitigating obstacles to adherence. Conclusions: Addressing akrasia through ethical and behavioral frameworks could improve LTFU adherence, ultimately enhancing survivorship care and long-term health outcomes. Full article

Background/Objectives: Different strategies were proposed to enhance dyslexic children’s performance. This study aimed to investigate the effect of combined cognitive and motor training on reading, writing, and motor coordination in dyslexic children. Methods: Twenty-four children with dyslexia (9.33 ± 0.48 years) were randomly allocated to either a Control (CG, 9.25 ± 0.45 years, n = 12) or a Trained Group (TG, 9.42 ± 0.51 years, n = 12). The intervention lasted eight weeks with a pre/post measurement (Δ) design in each group. It consisted of a combined cognitive and motor program composed of two 45 min sessions per week in TG. Reading and writing capabilities were measured using the word reading task based on the French battery (BALE) and the word dictation task, inspired by the ODÉDYS-2 French battery, respectively. The visuospatial orientation and the upper limb coordination parameters were evaluated using the Judgment of Line Orientation Test and Bruininks–Oseretsky test of motor proficiency, second edition, short form test, respectively. Results: Two-way ANOVA for repeated measures showed no significant difference between CG and TG in pre-intervention in all tests. Reading (p < 0.001, d = 1.19, Δ% = 15.07) and writing (p < 0.001, d = 1.13, Δ% = 19.69) scores increased significantly at post-compared to preintervention in the TG group. Comparable results were obtained in the visuospatial orientation (p < 0.001, d = 0.97, Δ% = 63.50) and the upper limb coordination (p < 0.001, d = 0.69, Δ% = 110.42) scores. No significant change was observed in CG comparing pre/post-intervention. Conclusions: A combined cognitive and motor training program could allow better cerebellar integration, leading to the improvement in reading, writing, and motor abilities in children with dyslexia. Further studies on a larger number of dyslexic children will be necessary to explore such issues. Full article

Neuropilin-1 is henceforth a relevant target in cancer treatment; however, its way of action remains partly elusive, and the development of small inhibitory molecules is therefore required for its study. Here, we report that two small-sized neuropilin antagonists (NRPa-47 and NRPa-48), VEGF-A₁₆₅/NRP-1 binding inhibitors, are able to decrease VEGF-Rs phosphorylation and to modulate their downstream cascades in the triple-negative breast cancer cell line (MDA-MB-231). Nevertheless, NRPas exert a divergent pathway regulation of MAPK phosphorylation, such as JNK-1/-2/-3, ERK-1/-2, and p38β/γ/δ-kinases, as well as their respective downstream targets. However, NRPa-47 and NRPa-48 apply a common down-regulation of the p38α-kinase phosphorylation and their downstream targets, emphasising its central regulating role. More importantly, none of the 40 selected kinases, including SAPK2a/p38α, are affected in vitro by NRPas, strengthening their specificity. Taken together, NRPas induced cell death by the down-modulation of pro-apoptotic and anti-apoptotic proteins, cell death receptors and adaptors, heat shock proteins (HSP-27/-60/-70), cell cycle proteins (p21, p27, phospho-RAD17), and transcription factors (p53, HIF-1α). In conclusion, we showed for the first time how NRPas may alter tumour cell signalling and contribute to the down-modulation of the cancer therapeutic key factor p38α-kinase phosphorylation. Thus, the efficient association of NRPas and p38α-kinase inhibitor strengthened this hypothesis. Full article

The fifth generation (5G) of mobile communications promotes human exposure to electromagnetic fields exploiting the 3.5 GHz frequency band. We analyzed behaviors, cognitive functions, and gene expression in mice submitted to asymmetrical head exposure to a 5G-modulated 3.5 GHz signal. The exposures were applied for 1 h daily, 5 days per week over a six-week period, at a specific absorption rate (SAR) averaging 0.19 W/kg over the brain. Locomotor activities in an open field, object location, and object recognition memories were assessed repeatedly after four weeks of exposure and did not reveal any significant effect on the locomotion/exploration, anxiety level, or memory processes. mRNA profiling was performed at the end of the exposure period in two symmetrical areas of the right and left cerebral cortex, in which the SAR values were 0.43 and 0.14 W/kg, respectively. We found significant changes in the expression of less than 1% of the expressed genes, with over-representations of genes related to glutamatergic synapses. The right cortical area differed from the left one by an over-representation of responsive genes encoded by the mitochondrial genome. Our data show that repeated head exposures to a 5G-3.5 GHz signal can trigger mild transcriptome alterations without changes in memory capacities or emotional state. Full article