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Search Results (221)

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Keywords = data-driven supply chain

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22 pages, 813 KB  
Review
A Narrative Review and Gap Analysis of Blockchain for Transparency, Traceability, and Trust in Data-Driven Supply Chains
by Mitra Madanchian and Hamed Taherdoost
Appl. Sci. 2025, 15(17), 9571; https://doi.org/10.3390/app15179571 (registering DOI) - 30 Aug 2025
Abstract
The increasing complexity and digitization of modern supply chains have created an urgent demand for transparent, traceable, and trustworthy systems of data management. Blockchain, with its core features of immutability, decentralization, and smart contracts, has emerged as a promising solution for strengthening data-driven [...] Read more.
The increasing complexity and digitization of modern supply chains have created an urgent demand for transparent, traceable, and trustworthy systems of data management. Blockchain, with its core features of immutability, decentralization, and smart contracts, has emerged as a promising solution for strengthening data-driven supply chain operations. This paper presents a narrative review synthesizing insights from academic research, industry reports, and regulatory documents to examine blockchain’s role in enhancing transparency, traceability, and trust. References were identified through targeted searches of major databases and gray literature sources, with emphasis on diverse sectors and global perspectives, rather than exhaustive coverage. The review maps how blockchain’s technical capabilities—such as data integrity preservation, access control, automated validation, and provenance tracking—support these outcomes, and assesses the empirical indicators used to evaluate them. A sectoral applicability analysis distinguishes contexts in which blockchain adoption offers clear advantages from those where benefits are limited. The review also identifies critical research gaps, including inconsistent definitions of core concepts, insufficient interoperability standards, overreliance on subjective performance measures, and lack of longitudinal cost–benefit evidence. Finally, it proposes directions for future research, including the development of sector-specific adoption frameworks, integration with complementary technologies, and cross-border regulatory harmonization. Full article
(This article belongs to the Special Issue Data-Driven Supply Chain Management and Logistics Engineering)
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47 pages, 5278 KB  
Article
AI-Enabled Customised Workflows for Smarter Supply Chain Optimisation: A Feasibility Study
by Vahid Javidroozi, Abdel-Rahman Tawil, R. Muhammad Atif Azad, Brian Bishop and Nouh Sabri Elmitwally
Appl. Sci. 2025, 15(17), 9402; https://doi.org/10.3390/app15179402 - 27 Aug 2025
Viewed by 148
Abstract
This study investigates the integration of Large Language Models (LLMs) into supply chain workflow automation, with a focus on their technical, operational, financial, and socio-technical implications. Building on Dynamic Capabilities Theory and Socio-Technical Systems Theory, the research explores how LLMs can enhance logistics [...] Read more.
This study investigates the integration of Large Language Models (LLMs) into supply chain workflow automation, with a focus on their technical, operational, financial, and socio-technical implications. Building on Dynamic Capabilities Theory and Socio-Technical Systems Theory, the research explores how LLMs can enhance logistics operations, increase workflow efficiency, and support strategic agility within supply chain systems. Using two developed prototypes, the Q inventory management assistant and the nodeStream© workflow editor, the paper demonstrates the practical potential of GenAI-driven automation in streamlining complex supply chain activities. A detailed analysis of system architecture and data governance highlights critical implementation considerations, including model reliability, data preparation, and infrastructure integration. The financial feasibility of LLM-based solutions is assessed through cost analyses related to training, deployment, and maintenance. Furthermore, the study evaluates the human and organisational impacts of AI integration, identifying key challenges around workforce adaptation and responsible AI use. The paper culminates in a practical roadmap for deploying LLM technologies in logistics settings and offers strategic recommendations for future research and industry adoption. Full article
(This article belongs to the Special Issue Data-Driven Supply Chain Management and Logistics Engineering)
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22 pages, 4304 KB  
Article
Intelligent Early Warning System for Supplier Delays Using Dynamic IoT-Calibrated Probabilistic Modeling in Smart Engineer-to-Order Supply Chains
by Aicha Alaoua and Mohammed Karim
Appl. Syst. Innov. 2025, 8(5), 124; https://doi.org/10.3390/asi8050124 - 27 Aug 2025
Viewed by 219
Abstract
In increasingly complex Engineer-to-Order (EtO) supply chains, accurately predicting supplier delivery delays is essential for ensuring operational resilience. This study proposes an intelligent Internet of Things (IoT)-enhanced probabilistic framework for early warning and dynamic prediction of supplier lead times in smart manufacturing contexts. [...] Read more.
In increasingly complex Engineer-to-Order (EtO) supply chains, accurately predicting supplier delivery delays is essential for ensuring operational resilience. This study proposes an intelligent Internet of Things (IoT)-enhanced probabilistic framework for early warning and dynamic prediction of supplier lead times in smart manufacturing contexts. Within this framework, three novel Early Warning Systems (EWS) are introduced: the Baseline Probabilistic Alert System (BPAS) based on fixed thresholds, the Smart IoT-Calibrated Alert System (SIoT-CAS) leveraging IoT-driven calibration, and the Adaptive IoT-Driven Risk Alert System (AID-RAS) featuring real-time threshold adaptation. Supplier lead times are modeled using statistical distributions and dynamically adjusted with IoT data to capture evolving disruptions. A comprehensive Monte Carlo simulation was conducted across varying levels of lead time uncertainty (σ), alert sensitivity (Pthreshold), and delivery constraints (Lmax), generating over 1000 synthetic scenarios per configuration. The results highlight distinct trade-offs between predictive accuracy, sensitivity, and robustness: BPAS minimizes false alarms in stable environments, SIoT-CAS improves forecasting precision through IoT calibration, and AID-RAS maximizes detection capability and resilience under high-risk conditions. Overall, the findings advance theoretical understanding of adaptive, data-driven risk modeling in EtO supply chains and provide practical guidance for selecting appropriate EWS mechanisms based on operational priorities. Furthermore, they offer actionable insights for integrating predictive EWS into MES (Manufacturing Execution System) and digital control tower platforms, thereby contributing to both academic research and industrial best practices. Full article
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20 pages, 3407 KB  
Review
Application of Digital Twin Technology in Smart Agriculture: A Bibliometric Review
by Rajesh Gund, Chetan M. Badgujar, Sathishkumar Samiappan and Sindhu Jagadamma
Agriculture 2025, 15(17), 1799; https://doi.org/10.3390/agriculture15171799 - 22 Aug 2025
Viewed by 461
Abstract
Digital twin technology is reshaping modern agriculture. Digital twins are the virtual replicas of real-world farming systems, which are continuously updated with real-time data, and are revolutionizing the monitoring, simulation, and optimization of agricultural processes. The literature on agricultural digital twins is multidisciplinary, [...] Read more.
Digital twin technology is reshaping modern agriculture. Digital twins are the virtual replicas of real-world farming systems, which are continuously updated with real-time data, and are revolutionizing the monitoring, simulation, and optimization of agricultural processes. The literature on agricultural digital twins is multidisciplinary, growing rapidly, and often fragmented across disciplines, which lacks well-curated documentation. A bibliometric analysis includes thematic content analysis and science mapping, which provides research trends, gaps, thematic landscape, and key contributors in this continuously evolving and emerging field. Therefore, in this study, we conducted a bibliometric review that included collecting bibliometric data via keyword search strategies on popular scientific databases. The data was further screened, processed, analyzed, and visualized using bibliometric tools to map research trends, landscapes, collaborations, and themes. Key findings show that publications have grown exponentially since 2018, with an annual growth rate of 27.2%. The major contributing countries were China, the USA, the Netherlands, Germany, and India. We observed a collaboration network with distinct geographic clusters, with strong intra-European ties and more localized efforts in China and the USA. The analysis identified seven major research theme clusters revolving around precision farming, Internet of Things integration, artificial intelligence, cyber–physical systems, controlled-environment agriculture, sustainability, and food system applications. We observed that core technologies, such as sensors, artificial intelligence, and data analytics, have been extensively explored, while identifying gaps in research areas. The emerging interests include climate resilience, renewable-energy integration, and supply-chain optimization. The observed transition from task-specific tools to integrated, system-level approaches underline the growing need for adaptive, data-driven decision support. By outlining research trends and identifying strategic research gaps, this review offers insights into leveraging digital twins to improve productivity, sustainability, and resilience in global agriculture. Full article
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20 pages, 474 KB  
Article
Artificial Intelligence Usage and Supply Chain Resilience: An Organizational Information Processing Theory Perspective
by Heng Pan, Ning Zou, Rouyue Wang, Jingchen Ma and Danping Liu
Systems 2025, 13(9), 724; https://doi.org/10.3390/systems13090724 - 22 Aug 2025
Viewed by 640
Abstract
Frequent disruptions to global supply chains, driven by factors such as trade restrictions and geopolitical conflicts, brought supply chain resilience to the forefront of both academic research and industry practice. Concurrently, the rapid advancement of artificial intelligence (AI) technologies in supply chain management [...] Read more.
Frequent disruptions to global supply chains, driven by factors such as trade restrictions and geopolitical conflicts, brought supply chain resilience to the forefront of both academic research and industry practice. Concurrently, the rapid advancement of artificial intelligence (AI) technologies in supply chain management in recent years offers new perspectives for researching resilience. Based on the Organizational Information Processing Theory (OIPT), this study explores the direct and indirect mechanisms through which AI usage impacts supply chain resilience from an information processing perspective. Within the OIPT framework, we develop a theoretical model incorporating AI usage, supply chain resilience, supply chain efficiency, supply chain collaboration, and digital information technology capability. We empirically test the model using survey data collected from 231 Chinese manufacturing senior executives and supply chain managers, employing partial least squares structural equation modeling (PLS-SEM). The findings reveal that AI usage has a significant direct positive effect on supply chain resilience. Additionally, supply chain efficiency and collaboration act as mediators in this relationship. Furthermore, we examined the moderating role of a firm’s digital information technology capability and found that it positively moderates the impact of AI usage on supply chain resilience. Full article
(This article belongs to the Section Supply Chain Management)
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20 pages, 558 KB  
Review
Energy Transition 2024–2025: New Demand Vectors, Technology Oversupply, and Shrinking Net-Zero 2050 Premium
by Henryk Wojtaszek
Energies 2025, 18(16), 4441; https://doi.org/10.3390/en18164441 - 21 Aug 2025
Viewed by 885
Abstract
The global energy transition is accelerating, yet new and underestimated challenges have emerged since 2024. Rising electricity demand—driven by artificial intelligence data centres, extreme heatwaves, and the electrification of transport—has exceeded earlier projections and shifted the system’s pressure point from generation to flexibility. [...] Read more.
The global energy transition is accelerating, yet new and underestimated challenges have emerged since 2024. Rising electricity demand—driven by artificial intelligence data centres, extreme heatwaves, and the electrification of transport—has exceeded earlier projections and shifted the system’s pressure point from generation to flexibility. At the same time, an oversupply of solar PV panels and lithium-ion batteries is lowering costs but increasing the risk of trade conflicts and supply chain concentration. This article presents a meta-analysis of 12 energy scenarios from 2024 to 2025, based on institutional outlooks (IEA, BNEF, and WEF) and peer-reviewed publications selected using transparent quality criteria (TRL thresholds, JRC guidance, and data transparency). A difference-in-differences method is applied to identify changes between editions. Results show a demand increase of over 2200 TWh by 2035, a decline in the “Net-Zero premium” from 19% to 15%, and a pressing need to redirect investment from gas infrastructure to grids, storage, and hydrogen. A case study for Central and Eastern Europe reveals that Poland will require USD 5–6 billion annually, primarily for transmission networks. These findings support a capital shift toward resilient and socially acceptable decarbonisation pathways. Full article
(This article belongs to the Section C: Energy Economics and Policy)
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27 pages, 1393 KB  
Review
A Data-Centric Framework for Implementing Artificial Intelligence in Smart Manufacturing
by Priyanka Mudgal
Electronics 2025, 14(16), 3304; https://doi.org/10.3390/electronics14163304 - 20 Aug 2025
Viewed by 635
Abstract
The manufacturing segment is undergoing a rapid transformation as manufacturers integrate artificial intelligence (AI) and machine learning (ML). These technologies increasingly rely on data-driven architectures, which enable manufacturers to manage large volumes of data from machines, sensors, and other sources. As a result, [...] Read more.
The manufacturing segment is undergoing a rapid transformation as manufacturers integrate artificial intelligence (AI) and machine learning (ML). These technologies increasingly rely on data-driven architectures, which enable manufacturers to manage large volumes of data from machines, sensors, and other sources. As a result, they optimize operations, increase productivity, and reduce costs. This paper examines the role of AI in manufacturing through the lens of data-driven architecture. It focuses on the key components, challenges, and opportunities involved in implementing these systems. The paper explores various data types and architecture models that support AI-driven manufacturing, with an emphasis on real-time analytics. It highlights key use cases in manufacturing, including predictive maintenance, quality control, and supply chain optimization, and identifies the essential components required to implement AI successfully in smart manufacturing. The paper emphasizes the critical importance of data governance, security, and scalability in developing resilient and future-proof AI systems. Finally, it reviews a data-centric framework with essential components for manufacturers aiming to leverage these technologies to drive sustained growth and innovation. Full article
(This article belongs to the Section Artificial Intelligence)
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28 pages, 1878 KB  
Article
Introducing the Manufacturing Digital Passport (MDP): A New Concept for Realising Digital Thread Data Sharing in Aerospace and Complex Manufacturing
by Mohammed M. Mabkhot, Roy S. Kalawsky and Amer Liaqat
Systems 2025, 13(8), 700; https://doi.org/10.3390/systems13080700 - 15 Aug 2025
Viewed by 535
Abstract
In the current data-driven era, effective data sharing is set to unlock billions in value for aerospace and complex manufacturing and their supply chains by enhancing product quality, boosting manufacturing and operational efficiency, and generating new value streams. However, current practices are hindered [...] Read more.
In the current data-driven era, effective data sharing is set to unlock billions in value for aerospace and complex manufacturing and their supply chains by enhancing product quality, boosting manufacturing and operational efficiency, and generating new value streams. However, current practices are hindered by fragmented data ecosystems, isolated silos, and reliance on paper-based documentation. Although the Digital Thread (DTh) initiative holds promise, its implementation remains impractical due to interoperability challenges, security and intellectual property risks, and the inherent difficulty of capturing and managing the overwhelming volume of data in such complex products as a holistic thread. This paper introduces the Manufacturing Digital Passport (MDP), a novel industry-driven concept that employs a product-centric, system-independent digital carrier to facilitate targeted, structured sharing of technical product data across the supply chain. The conceptual contribution of this work is the analytical formalisation of the MDP as a value-oriented carrier that shifts DTh thinking from costly, system-wide interoperability toward an incremental, ROI-driven record of lifecycle data. Rooted in real-world challenges and built on foundational principles of modularity, value creation, and model-based structures, the MDP, by design, enhances traceability, security, and trust through a bottom-up, incremental, use case-driven approach. The paper outlines its benefits through core design principles, definition, practical features, and integration strategies with legacy systems, laying the groundwork for a structured adoption roadmap in high-value manufacturing ecosystems. Full article
(This article belongs to the Special Issue Management and Simulation of Digitalized Smart Manufacturing Systems)
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15 pages, 2401 KB  
Article
Evaluation of Nutrient Loss and Greenhouse Gas Emissions Caused by Food Loss and Waste in China
by Chun Chen, Yiman Fang and Xiaozhong Wang
Sustainability 2025, 17(16), 7341; https://doi.org/10.3390/su17167341 - 14 Aug 2025
Viewed by 345
Abstract
Food loss and waste (FLW) impose major nutritional and environmental costs globally. This comprehensive China-wide study quantifies FLW-driven nutrient depletion and greenhouse gas (GHG) emissions across the entire supply chain. Using national-scale modeling with China-specific data, we found that FLW in 2022 reached [...] Read more.
Food loss and waste (FLW) impose major nutritional and environmental costs globally. This comprehensive China-wide study quantifies FLW-driven nutrient depletion and greenhouse gas (GHG) emissions across the entire supply chain. Using national-scale modeling with China-specific data, we found that FLW in 2022 reached 415 million tons (i.e., 21.4% of total production was lost/wasted), generating 281 Mt CO2-eq. Daily per capita FLW at 757 kcal (29.7% of recommended intake lost/wasted), 28.4 g protein (43.7%), and 114 mg vitamin C (14%) dissipated significant nutrients. Using the Wasted Nutrient Days metric, 72–416 days of varying nutrient adult needs were lost, worsening malnutrition burdens. The key node along the supply chain leading to high FLW is postharvest handling and storage (responsible for 49% of FLW mass and emissions), while vegetables/cereals (mass loss quantities) and meat-based foods (high emission intensity) were the most lost/wasted food types. Scenario analysis shows that combining optimized diets and supply chain improvements could reduce FLW by 503 g/capita/day and emissions by 62.2%, closing nutritional gaps and supporting carbon neutrality. Full article
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49 pages, 2632 KB  
Review
A Review of Digital Twin Integration in Circular Manufacturing for Sustainable Industry Transition
by Seyed Mohammad Mehdi Sajadieh and Sang Do Noh
Sustainability 2025, 17(16), 7316; https://doi.org/10.3390/su17167316 - 13 Aug 2025
Viewed by 1060
Abstract
The integration of digital twin (DT) technology into circular economy (CE) frameworks has emerged as a critical pathway for achieving sustainable and intelligent manufacturing under the Industry 4.0 paradigm. This study addresses the lack of structured guidance for DT adoption in CE strategies [...] Read more.
The integration of digital twin (DT) technology into circular economy (CE) frameworks has emerged as a critical pathway for achieving sustainable and intelligent manufacturing under the Industry 4.0 paradigm. This study addresses the lack of structured guidance for DT adoption in CE strategies by proposing two interrelated frameworks: the Sustainable Digital Twin Maturity Path (SDT-MP) and the Digital Twin Nexus. The SDT-MP outlines progressive stages of DT deployment—from data acquisition and real-time monitoring to AI-enabled decision-making—aligned with CE principles and Industry 4.0 capabilities. The DT Nexus complements this maturity model by structuring the integration of enabling technologies such as AI, IoT, and edge/cloud computing to support closed-loop control, resource optimization, and predictive analytics. Through a mixed-methods approach combining literature analysis and real-world case validation, this research demonstrates how DTs can facilitate lifecycle intelligence, enhance operational efficiency, and drive sustainable transformation in manufacturing. The proposed frameworks offer a scalable roadmap for intelligent circular systems, addressing implementation challenges while supporting Sustainable Development Goal 9 (Industry, Innovation, and Infrastructure) by promoting digital infrastructure, innovation-driven manufacturing, and environmentally responsible industrial growth. This study contributes to the advancement of digital infrastructure and sustainable circular supply chains in the context of smart, connected industrial ecosystems. Full article
(This article belongs to the Special Issue Sustainable Circular Economy in Industry 4.0)
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26 pages, 10493 KB  
Article
Assessing the Climate and Land Use Impacts on Water Yield in the Upper Yellow River Basin: A Forest-Urbanizing Ecological Hotspot
by Li Gong and Kang Liang
Forests 2025, 16(8), 1304; https://doi.org/10.3390/f16081304 - 11 Aug 2025
Viewed by 392
Abstract
Understanding the drivers of water yield (WY) changes in ecologically sensitive, data-scarce watersheds is crucial for sustainable management, particularly in the context of accelerating forest expansion and urbanization. This study focuses on the upper Yellow River Basin (UYRB), a critical headwater region that [...] Read more.
Understanding the drivers of water yield (WY) changes in ecologically sensitive, data-scarce watersheds is crucial for sustainable management, particularly in the context of accelerating forest expansion and urbanization. This study focuses on the upper Yellow River Basin (UYRB), a critical headwater region that supplies 60% of the Yellow River’s flow and is undergoing rapid land use transitions from 1990 to 2100. Using the Integrated Valuation of Ecosystem Services and Tradeoffs (InVEST) model and the Future Land-Use Simulation (FLUS) model, we quantify historical (1990–2020) and projected (2025–2100) WY dynamics under three SSP scenarios (SSP126, SSP370, and SSP585). InVEST, a spatially explicit ecohydrological model based on the Budyko framework, estimates WY by balancing precipitation and evapotranspiration. The FLUS model combines cellular automata (CA) with an artificial neural network (ANN)-based suitability evaluation and Markov chain-derived transition probabilities to simulate land-use change under multiple scenarios. Results show that WY increased significantly during the historical period (1990–2020), primarily driven by increased precipitation, with climate change accounting for 94% and land-use change for 6% of the total variation in WY. Under future scenarios (SSP126, SSP370, and SSP585), WY is projected to increase to 217 mm, 206 mm, and 201 mm, respectively. Meanwhile, the influence of land-use change is expected to diminish, with its contribution decreasing to 9.1%, 5.7%, and 3.1% under SSP126, SSP370, and SSP585, respectively. This decrease reflects the increasing strength of climate signals (especially extreme precipitation and evaporative demand), which masks the hydrological impacts of land-use transitions. These findings highlight the dominant role of climate change, the scenario-dependent effects of land-use change, and the urgent need for integrated climate–land management strategies in forest-urbanizing watersheds. Full article
(This article belongs to the Section Forest Hydrology)
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27 pages, 1062 KB  
Article
Dynamic Supply Chain Decision-Making of Live E-Commerce Considering Netflix Marketing Under Different Power Structures
by Yawen Liu, Mohammed Gadafi Tamimu and Junwu Chai
J. Theor. Appl. Electron. Commer. Res. 2025, 20(3), 202; https://doi.org/10.3390/jtaer20030202 - 6 Aug 2025
Viewed by 448
Abstract
The rapid growth of live e-commerce, a sector valued at over USD 100 billion worldwide, demonstrates its transformative impact on the retail industry, especially in markets like China, where platforms such as Taobao Live and TikTok Shop have markedly altered consumer interaction. This [...] Read more.
The rapid growth of live e-commerce, a sector valued at over USD 100 billion worldwide, demonstrates its transformative impact on the retail industry, especially in markets like China, where platforms such as Taobao Live and TikTok Shop have markedly altered consumer interaction. This transition is further expedited by Netflix-like entertainment marketing methods, which have demonstrated the capacity to enhance consumer retention by as much as 40%. As organizations adjust to this evolving landscape, it is essential to optimize supply chain strategies to align with these dynamic, consumer-centric environments. This paper examines the complexity of decision-making in live e-commerce supply chains, specifically regarding Netflix-inspired marketing strategies. The primary aim of this study is to design a game-theoretic framework that examines the interactions between producers and online celebrity retailers (OCRs) across different power dynamics. As live commerce integrates digital retail with immersive experiences, businesses must optimize pricing, quality, and marketing strategies in real-time. We present engagement-driven marketing as a strategic variable and incorporate consumer regret and switching costs into the demand function. To illustrate practical trade-offs in strategy, we incorporate a multi-criteria decision-making (MCDM) layer with AHP-TOPSIS, assessing profit, consumer surplus, engagement score, and channel efficiency. The experiment results indicate that Netflix-style marketing markedly increases demand and profit in retailer-led frameworks, whereas centralized tactics enhance overall channel performance. TOPSIS analysis prioritizes high-effort, high-engagement methods, whereas the Stackelberg experiment underscores the influence of power dynamics on profit distribution. This study presents an innovative integrative decision-making methodology for enhancing live-streaming commerce tactics in data-driven and consumer-focused markets. Full article
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25 pages, 5349 KB  
Review
A Comprehensive Survey of Artificial Intelligence and Robotics for Reducing Carbon Emissions in Supply Chain Management
by Mariem Mrad, Mohamed Amine Frikha and Younes Boujelbene
Logistics 2025, 9(3), 104; https://doi.org/10.3390/logistics9030104 - 4 Aug 2025
Viewed by 842
Abstract
Background: Artificial intelligence (AI) and robotics are increasingly pivotal for reducing carbon emissions in supply chain management (SCM); however, research exploring their combined potential from a sustainability perspective remains fragmented. This study aims to systematically map the research landscape and synthesize evidence [...] Read more.
Background: Artificial intelligence (AI) and robotics are increasingly pivotal for reducing carbon emissions in supply chain management (SCM); however, research exploring their combined potential from a sustainability perspective remains fragmented. This study aims to systematically map the research landscape and synthesize evidence on the applications, benefits, and challenges. Methods: A systematic scoping review was conducted on 23 peer-reviewed studies from the Scopus database, published between 2013 and 2024. Data were systematically extracted and analyzed for publication trends, application domains (e.g., transportation, warehousing), specific AI and robotic technologies, emissions reduction strategies, and implementation challenges. Results: The analysis reveals that AI-driven logistics optimization is the most frequently reported strategy for reducing transportation emissions. At the same time, robotic automation is commonly associated with improved energy efficiency in warehousing. Despite these benefits, the reviewed literature consistently identifies significant barriers, including the high energy demands of AI computation and complexities in data integration. Conclusions: This review confirms the transformative potential of AI and robotics for developing low-carbon supply chains. An evidence-based framework is proposed to guide practical implementation and identify critical gaps, such as the need for standardized validation benchmarks, to direct future research and accelerate the transition to sustainable SCM. Full article
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32 pages, 944 KB  
Review
Continuous Manufacturing of Recombinant Drugs: Comprehensive Analysis of Cost Reduction Strategies, Regulatory Pathways, and Global Implementation
by Sarfaraz K. Niazi
Pharmaceuticals 2025, 18(8), 1157; https://doi.org/10.3390/ph18081157 - 4 Aug 2025
Viewed by 1374
Abstract
The biopharmaceutical industry is undergoing a fundamental transformation from traditional batch manufacturing to continuous manufacturing (CM) for recombinant drugs and biosimilars, driven by regulatory support through the International Council for Harmonization (ICH) Q13 guidance and compelling economic advantages. This comprehensive review examines the [...] Read more.
The biopharmaceutical industry is undergoing a fundamental transformation from traditional batch manufacturing to continuous manufacturing (CM) for recombinant drugs and biosimilars, driven by regulatory support through the International Council for Harmonization (ICH) Q13 guidance and compelling economic advantages. This comprehensive review examines the technical, economic, and regulatory aspects of implementing continuous manufacturing specifically for recombinant protein production and biosimilar development, synthesizing validated data from peer-reviewed research, regulatory sources, and global implementation case studies. The analysis demonstrates that continuous manufacturing offers substantial benefits, including a reduced equipment footprint of up to 70%, a 3- to 5-fold increase in volumetric productivity, enhanced product quality consistency, and facility cost reductions of 30–50% compared to traditional batch processes. Leading biomanufacturers across North America, Europe, and the Asia–Pacific region are successfully integrating perfusion upstream processes with connected downstream bioprocesses, enabling the fully end-to-end continuous manufacture of biopharmaceuticals with demonstrated commercial viability. The regulatory framework has been comprehensively established through ICH Q13 guidance and region-specific implementations across the FDA, EMA, PMDA, and emerging market authorities. This review provides a critical analysis of advanced technologies, including single-use perfusion bioreactors, continuous chromatography systems, real-time process analytical technology, and Industry 4.0 integration strategies. The economic modeling presents favorable return-on-investment profiles, accompanied by a detailed analysis of global market dynamics, regional implementation patterns, and supply chain integration opportunities. Full article
(This article belongs to the Section Pharmaceutical Technology)
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32 pages, 3202 KB  
Article
An Integrated Framework for Urban Water Infrastructure Planning and Management: A Case Study for Gauteng Province, South Africa
by Khathutshelo Godfrey Maumela, Tebello Ntsiki Don Mathaba and Mahalieo Kao
Water 2025, 17(15), 2290; https://doi.org/10.3390/w17152290 - 1 Aug 2025
Viewed by 613
Abstract
Effective water infrastructure planning and management is key to sustainable water supply globally. This research assesses water infrastructure planning and management in Gauteng, South Africa, amid growing challenges from rapid urbanisation, high water demand, climate change, and resource scarcity. These challenges threaten the [...] Read more.
Effective water infrastructure planning and management is key to sustainable water supply globally. This research assesses water infrastructure planning and management in Gauteng, South Africa, amid growing challenges from rapid urbanisation, high water demand, climate change, and resource scarcity. These challenges threaten the achievement of Sustainable Development Goals 6 and 11; hence, an integrated approach is required for water sustainability. The study responds to a gap in the literature, which often treats planning and management separately, by adopting an integrated, multi-institutional approach across the water value chain. A mixed-methods triangulation strategy was employed for data collection whereby surveys provided quantitative data, while two sets of structured interviews were conducted: the first round to determine causal relationships among the critical success factors and the second round to validate the proposed framework. The findings reveal a misalignment between infrastructure planning and implementation, contributing to infrastructure backlogs and a short- to medium-term focus. Infrastructure management is further constrained by inadequate system redundancy, leading to ineffective maintenance. External factors such as delayed adoption of 4IR technologies, lack of climate resilient strategies, and fragmented institutional coordination exacerbate these issues. Using Decision-Making Trial and Evaluation Laboratory (DEMATEL) analysis, the study identified Strategic Alignment and a Value-Driven Approach as the most influential critical success factors in water asset management. The research concludes by proposing an integrated water infrastructure and planning framework that supports sustainable water supply. Full article
(This article belongs to the Section Urban Water Management)
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