Search Results (832)

The landscape of first-line treatment for metastatic non-small cell lung cancer (NSCLC) without actionable driver mutations is rapidly evolving, currently dominated by pembrolizumab-based regimens. This review discusses the unique molecular characteristics of cemiplimab, a newer anti-PD-1 antibody, and defines its optimal positioning against established standards. Cemiplimab is a fully human IgG4 monoclonal antibody distinguished by two key features: an engineered hinge-region mutation that prevents Fab-arm exchange, ensuring exceptional molecular stability which minimizes anti-drug antibody (ADA) risks associated with unstable molecules; and a unique interaction with PD-1 glycosylation sites, potentially enhancing binding efficacy. These structural advantages may be particularly relevant in histologies like squamous NSCLC, where accumulating somatic mutations drive high neoantigen loads and heightened immune responses, creating an environment historically prone to ADA formation. Based on data from the pivotal EMPOWER-Lung program, we highlight cemiplimab’s exceptional promise in specific populations. Firstly, in the EMPOWER-Lung 1 trial, cemiplimab monotherapy demonstrated extraordinary survival benefits in a pre-specified analysis of the distinct “ultra-high” PD-L1 expression subgroup (TPS ≥90%), potentially surpassing historical benchmarks. Secondly, cemiplimab displays consistent, robust efficacy in challenging-to-treat squamous histology, both as monotherapy for patients with high PD-L1 expression and in combination with chemotherapy for patients with PD-L1 < 50%. In conclusion, cemiplimab establishes a unique therapeutic niche for patients with squamous histology and ultra-high PD-L1 expression, likely driven by its distinct structural stability and reduced immunogenicity. Full article

The growing demand for sustainable livestock systems requires efficient methods for monitoring forage biomass. This study evaluated spectral (RGB and multispectral), textural (GLCM), and area attributes derived from unmanned aerial vehicle (UAV) imagery to predict buffelgrass (Cenchrus ciliaris L.) biomass, also testing the effect of soil pixel removal. A comprehensive machine learning pipeline (12 algorithms and 6 feature selection methods) was applied to 14 data combinations. Our results demonstrated that soil removal consistently improved the performance of the applied models. Multispectral (MSI) sensors were the most robust individually, whereas textural (GLCM) attributes did not contribute significantly. Although the MSI and RGB data combination proved complementary, the model with the highest accuracy was obtained with CatBoost using only RGB information after Boruta feature selection, achieving a CCC of 0.83, RMSE of 0.214 kg, and R² of 0.81 in the test set. The most important variable was vegetation cover area (19.94%), surpassing spectral indices. We conclude that integrating RGB UAVs with robust processing can generate accessible and effective tools for forage monitoring. This approach can support pasture management by optimizing stocking rates, enhancing natural resource efficiency, and supporting data-driven decisions in precision silvopastoral systems. Full article

To address the pervasive challenges of resource inefficiency and static management in the hospitality sector, this study proposes a novel management framework that synergistically integrates Model Predictive Control (MPC) with Green Human Resource Management (GHRM). Methodologically, the framework establishes a dynamic closed-loop architecture that cyclically links environmental sensing, predictive optimization, plan execution and organizational learning. The MPC component generates data-driven forecasts and optimal control signals for resource allocation. Crucially, these technical outputs are operationally translated into specific, actionable directives for employees through integrated GHRM practices, including real-time task allocation via management systems, incentives-aligned performance metrics, and structured environmental training. This practical integration ensures that predictive optimization is directly coupled with human behavior. Theoretically, this study redefines hospitality operations as adaptive sociotechnical systems, and advances the hospitality energy-saving management framework by formally incorporating human execution feedback, predictive control theory, and dynamic optimization theory. Empirical validation across a sample of 40 hotels confirms the framework’s effectiveness, demonstrating significant reductions in daily average water consumption by 15.5% and electricity usage by 13.6%. These findings provide a robust, data-driven paradigm for achieving sustainable operational transformations in the hospitality industry. Full article

High-quality development of agricultural enterprises is essential for China’s rural revitalization, yet the institutional conditions that support it remain poorly understood. Drawing on institutional logics and configuration theory, this study adopts a holistic systems perspective to examine how government, market, and social institutions interact to shape enterprise performance. Using provincial data (2013–2023) matched with firm-level data for 119 listed agricultural enterprises, we estimate total factor productivity as the core outcome and apply dynamic fuzzy-set Qualitative Comparative Analysis (dynamic fsQCA) to identify equifinal institutional pathways. The results reveal that high-quality development is an emergent property of complex institutional systems; instead, high-quality development emerges from several distinct configurations combining policy support, marketization, financial development, Agricultural Infrastructure Index, market stability, and urban–rural integration. Two contrasting configurations are associated with non-high-quality development, characterized by financial scarcity and infrastructure deficits or by fragmented policy support under weak regulation. Dynamic analysis further reveals clear temporal and spatial heterogeneity: some market–finance driven paths lose robustness over time, while policy–urbanization and regulation–infrastructure based configurations become increasingly stable. These findings extend institutional configuration research to the agricultural sector, demonstrate the value of dynamic fsQCA for capturing temporal effects, and offer differentiated policy implications for optimizing institutional environments to foster the high-quality development of agricultural enterprises. Full article

Flooding remains one of the most disruptive and costly natural hazards worldwide. Conventional approaches for estimating flood damage cost rely on empirical loss curves or historical insurance data, which often lack spatial resolution and predictive robustness. This study develops a data-driven framework for estimating flood damage costs across the contiguous United States, where comprehensive hydrologic, climatic, and socioeconomic data are available. A database of 17,407 flood events was compiled, incorporating approximately 38 parameters obtained from the National Oceanic and Atmospheric Administration (NOAA), the National Water Model (NWM), the United States Geological Survey (USGS NED), and the U.S. Census Bureau. Data preprocessing addressed missing values and outliers using the interquartile range and Walsh tests, followed by partitioning into training (70%), testing (15%), and validation (15%) subsets. Four modeling configurations were examined to improve predictive accuracy. The optimal hybrid regression–classification framework achieved correlation coefficients of 0.97 (training), 0.77 (testing), and 0.81 (validation) with minimal bias (−5.85, −107.8, and −274.5 USD, respectively). The findings demonstrate the potential of nationwide, event-based predictive approaches to enhance flood-damage cost assessment, providing a practical tool for risk evaluation and resource planning. Full article

This paper presents a robust data-driven methodology for estimating transmission loss coefficients (B-coefficients) in power systems using linear and quadratic programming (LP and QP), both of which belong to the family of convex optimization models. The first model employs a linear objective function with linear constraints, ensuring computational efficiency for simpler scenarios. The second model utilizes a quadratic objective function, also under linear constraints, to better capture more complex nonlinear relationships. By framing the estimation problem as a parameter identification task, both methodologies minimize the cost functions that quantify the mismatch between measured and modeled power losses. By considering a broad range of operational scenarios, our approach effectively captures the stochastic behavior inherent in power system operations. The effectiveness of both the LP and QP models is validated in terms of their ability to accurately extract physically meaningful B-coefficients from diverse simulation datasets. This study underscores the potential of integrating linear and quadratic programming as powerful and scalable tools for data-driven parameter estimation in modern power systems, especially in environments characterized by uncertainty or incomplete information. Full article

Heating, ventilation, and air conditioning (HVAC) systems account for a significant portion of building energy consumption and play a crucial role in maintaining indoor comfort. However, hidden faults in air-handling units (AHUs) often lead to energy waste and degraded performance, highlighting the importance of reliable fault detection and diagnosis (FDD). This study proposes a simulation-driven FDD framework that integrates a standardized prototype dataset and an independent evaluation dataset generated from a calibrated EnergyPlus model representing a target facility, enabling controlled experimentation and transfer evaluation within simulation environments. Training data were generated from the DOE EnergyPlus Medium Office prototype model, while evaluation data were obtained from a calibrated building-specific EnergyPlus model of a research facility operated by Company H in Korea. Three representative fault scenarios—outdoor air damper stuck closed, cooling coil fouling (65% capacity), and air filter fouling (30% pressure drop)—were systematically implemented. A Deep Belief Network (DBN) classifier was developed and optimized through a two-stage hyperparameter tuning strategy, resulting in a three-layer architecture (256–128–64 nodes) with dropout and regularization for robustness. The optimized DBN achieved diagnostic accuracies of 92.4% for the damper fault, 98.7% for coil fouling, and 95.9% for filter fouling. These results confirm the effectiveness of combining simulation-based dataset generation with advanced deep learning methods for HVAC fault diagnosis. The results indicate that a DBN trained on a standardized EnergyPlus prototype can transfer to a second, independently calibrated EnergyPlus building model when AHU topology, control logic, and monitored variables are aligned. This study should be interpreted as a simulation-based proof-of-concept, motivating future validation with field BMS data and more diverse fault scenarios. Full article

High-precision prediction of the crystal diameter during the growth of electronic-grade silicon single crystals is a critical step for the fabrication of high-quality single crystals. However, the process features high-temperature operation, strong nonlinearities, significant time-delay dynamics, and external disturbances, which limit the accuracy of conventional mechanism-based models. In this study, mechanism-based models denote physics-informed heat-transfer and geometric models that relate heater power and pulling rate to diameter evolution. To address this challenge, this paper proposes a hybrid deep learning model combining a convolutional neural network (CNN), a bidirectional long short-term memory network (BiLSTM), and self-attention to improve diameter prediction during the shoulder-formation and constant-diameter stages. The proposed model leverages the CNN to extract localized spatial features from multi-source sensor data, employs the BiLSTM to capture temporal dependencies inherent to the crystal growth process, and utilizes the self-attention mechanism to dynamically highlight critical feature information, thereby substantially enhancing the model’s capacity to represent complex industrial operating conditions. Experiments on operational production data collected from an industrial Czochralski (Cz) furnace, model TDR-180, demonstrate improved prediction accuracy and robustness over mechanism-based and single data-driven baselines, supporting practical process control and production optimization. Full article

This study introduces the Hybrid Hydrological Forecast System (HHFS), a dual-stage, data-driven framework for monthly streamflow forecasting at the Santa Branca outlet in the upper Paraíba do Sul River Basin, Brazil. The system combines two nonlinear regressors, Multi-Layer Perceptron (MLP) and extreme Gradient Boosting (XGB), calibrated through a structured four-step evolutionary procedure in GA₁ (hydrological weighting, dual-regime Ridge fusion, rolling bias correction, and monthly mean–variance adjustment) and a hydro-adaptive probabilistic optimization in GA₂. SHAP-based analysis provides physical interpretability of the learned relations. The regressive stage (GA₁) generates a bias-corrected and climatologically consistent central forecast. After the full four-step optimization, GA₁ achieves robust generalization skill during the independent test period (2020–2023), yielding NSE = 0.77 ± 0.05, KGE = 0.85 ± 0.05, R² = 0.77 ± 0.05, and RMSE = 20.2 ± 3.1 m³ s⁻¹, representing a major improvement over raw MLP/XGB outputs (NSE ≈ 0.5). Time-series, scatter, and seasonal diagnostics confirm accurate reproduction of wet- and dry-season dynamics, absence of low-frequency drift, and preservation of seasonal variance. The probabilistic stage (GA₂) constructs a hydro-adaptive prediction interval whose width (max-min streamflow) and asymmetry evolve with seasonal hydrological regimes. The optimized configuration achieves comparative coverage COV = 0.86 ± 0.00, hit rate p = 0.96 ± 0.04, and relative width r = 2.40 ± 0.15, correctly expanding uncertainty during wet-season peaks and contracting during dry-season recessions. SHAP analysis reveals a coherent predictor hierarchy dominated by streamflow persistence, precipitation structure, temperature extremes, and evapotranspiration, jointly explaining most of the predictive variance. By combining regressive precision, probabilistic realism, and interpretability within a unified evolutionary architecture, the HHFS provides a transparent, physically grounded, and operationally robust tool for reservoir management, drought monitoring, and hydro-climatic early-warning systems in data-limited regions. Full article

Artificial intelligence (AI) is rapidly reshaping thoracic surgery, advancing from decision support to the threshold of autonomous intervention. AI-driven technologies—including machine learning (ML), deep learning (DL), and computer vision—have demonstrated significant improvements in diagnostic accuracy, surgical planning, intraoperative navigation, and postoperative outcome prediction. In lung cancer and thoracic oncology, AI enhances imaging analysis, histopathological classification, and risk stratification, supporting multidisciplinary decision-making and personalized therapy. Robotic-assisted and AI-guided systems are optimizing surgical precision and workflow efficiency, while real-time decision-support tools and augmented reality are improving intraoperative safety. Despite these advances, widespread adoption is limited by challenges in algorithmic bias, data integration, regulatory approval, and ethical transparency. The literature emphasizes the need for multicenter validation, explainable AI, and robust governance frameworks to ensure safe and effective clinical integration. Future research should focus on digital twin technology, federated learning, and transparent AI outputs to further enhance reliability and accessibility. AI is poised to transform thoracic surgery, but responsible implementation and ongoing evaluation are essential for realizing its full potential. The aim of this review is to evaluate and synthesize the current landscape of artificial intelligence (AI) applications across the thoracic surgical pathway, from preoperative decision-support to intraoperative guidance and emerging autonomous interventions. Full article

Volatility in the modern world and electricity Day-Ahead Markets (DAMs) usually makes long-term historical data irrelevant or even detrimental for accurate forecasting. This study directly addresses this challenge by proposing a novel forecasting paradigm centered on extremely short training windows, ranging from 7 to 90 days, to maximize responsiveness to recent market dynamics. This volatility-driven approach intentionally creates a data-scarce environment where the suitability of deep learning models is limited. Building on the hypothesis that shallow machine learning models, and more specifically boosting trees, are better adapted to this reality, we evaluate four models, namely LSTM with feed-forward error correction, XGBoost, LightGBM, and CatBoost, across three European energy markets (Greece, Belgium, Ireland) using feature sets derived from ENTSO-E forecast data. Results consistently demonstrate that LightGBM provides superior forecasting accuracy and robustness, particularly when trained on 45–60 day windows, which strike an optimal balance between temporal relevance and learning depth. Furthermore, a stronger capability in detecting seasonal effects and peak price events is exhibited. These findings validate that a short-window training strategy, combined with computationally efficient shallow models, is a highly effective and practical approach for navigating the volatility and data constraints of modern DAM forecasting. Full article

Data uncertainty and limited model generalization remain critical bottlenecks in large-scale remote sensing of soil salinization. Although the integration of multi-source data has improved predictive potential, conventional deterministic feature selection methods often overlook stochastic noise inherent in environmental variables, leading to models that overfit spurious correlations rather than learning stable physical signals. To address this limitation, this study proposes a Bootstrap–Boruta feature stability assessment framework that shifts feature selection from deterministic “feature importance” ranking to probabilistic “feature stability” evaluation, explicitly accounting for uncertainty induced by data perturbations. The proposed framework is evaluated by integrating stability-driven feature sets with multiple machine learning models, including a Back-Propagation Neural Network (BPNN) optimized using the Red-billed Blue Magpie Optimization (RBMO) algorithm as a representative optimization strategy. Using the Minqin Lake region as a case study, the results demonstrate that the stability-based framework effectively filters unstable noise features, reduces systematic estimation bias, and improves predictive robustness across different modeling approaches. Among the tested models, the RBMO-optimized BPNN achieved the highest accuracy. Under a rigorous bootstrap validation framework, the quality-controlled ensemble model yielded a robust mean R² of 0.657 ± 0.05 and an RMSE of 1.957 ± 0.289 dS/m. The framework further identifies eleven physically robust predictors, confirming the dominant diagnostic role of shortwave infrared (SWIR) indices in arid saline environments. Spatial mapping based on these stable features reveals that 30.7% of the study area is affected by varying degrees of soil salinization. Overall, this study provides a mechanism-driven, promising, within-region framework that enhances the reliability of remote-sensing-based soil salinity inversion under heterogeneous environmental conditions. Full article

This paper tackles the challenge of disassembly sequence planning (DSP) in energy-efficient remanufacturing by introducing an innovative hybrid optimization framework. The proposed model integrates a Dynamic Time-Varying CRITIC–Entropy (DTVCE) decision-making framework with an Improved Honey Badger Algorithm (IHBA) to optimize disassembly sequences under key operational criteria, including idle rate, line smoothness, and energy consumption. The DTVCE framework constructs a dynamic composite score by normalizing evaluation criteria across time slices and incorporating temporal discounting to capture the evolving importance of each factor. Meanwhile, by establishing a symmetric disassembly constraint matrix to restrict the disassembly sequence and integrating exploration and exploitation mechanisms to enhance the IHBA, the solution process is empowered to efficiently generate feasible disassembly sequences and fulfill task allocation across workstations while satisfying takt time constraints. Experimental validation demonstrates that the proposed framework significantly outperforms traditional disassembly optimization approaches in both energy efficiency and line balance performance. In a case study involving an automotive drive axle, the method achieved a near-optimal configuration using only eight workstations, leading to a marked reduction in both energy consumption and idle times. Sensitivity analysis further verifies the model’s robustness, showing stable convergence and consistent performance under varying takt times and energy parameters. Overall, this study contributes to the advancement of green remanufacturing by offering a scalable, data-driven, and adaptive solution to disassembly optimization—paving the way toward sustainable and energy-aware production environments. Full article

Accurate short-term forecasting of photovoltaic (PV) output is critical to managing the variability of PV generation and ensuring reliable grid operation with high renewable integration. We propose an enhanced hybrid deep learning framework that combines Temporal Convolutional Networks (TCNs), Gated Recurrent Units (GRUs), and Random Forests (RFs) in an optimized weighted ensemble strategy. This approach leverages the complementary strengths of each component: TCNs capture long-range temporal dependencies via dilated causal convolutions; GRUs model sequential weather-driven dynamics; and RFs enhance robustness to outliers and nonlinear relationships. The model was evaluated on high-resolution operational data from the Yulara solar plant in Australia, forecasting horizons from 5 min to 1 h. Results show that the TCN-GRU-RF model consistently outperforms conventional benchmarks, achieving R² = 0.9807 (MAE = 0.0136; RMSE = 0.0300) at 5 min and R² = 0.9047 (RMSE = 0.0652) at 1 h horizons. Notably, the degradation in R² across forecasting horizons was limited to 7.7%, significantly lower than the typical 10–15% range observed in the literature, highlighting the model’s scalability and resilience. These validated results indicate that the proposed approach provides a robust, scalable forecasting solution that enhances grid reliability and supports the integration of distributed renewable energy sources. Full article

Modern processes to produce rare-earth elements, strategic metals, and nuclear fuel reprocessing require highly efficient liquid–liquid extraction in systems characterized by high viscosity, elevated interfacial tension, and small density differences. Traditional gravity-driven extractors exhibit low performance under these conditions, whereas centrifugal extractors enable rapid mass transfer and nearly complete phase separation. Differential-contact annular centrifugal contactors offer the highest flexibility and efficiency, but their optimization is limited by the lack of experimental data on the hydrodynamics of liquid flow through perforated nozzles in a rotating field. This limitation hinders the development of accurate computational fluid dynamics (CFD) models (e.g., ANSYS Fluent), reliable equipment scale-up, and the design of optimized contactor configurations. The present study addresses this gap by experimentally determining the flow velocity of liquids through nozzles of various geometries across a wide range of centrifugal accelerations. From these data, a universal power-law correlation was derived, linking the flow rate to rotor speed, nozzle geometry, and the physicochemical properties of the phases. The proposed correlation provides a robust experimental basis for numerical model validation, computational design, and optimization of next-generation differential-contact centrifugal extractors. Full article