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Genetic Incorporation of Dansylalanine in Human Ferroportin to Probe the Alternating Access Mechanism of Iron Transport
- Matteo Amadei,
- Antonella Niro,
- Maria Rosaria Fullone,
- Rossella Miele,
- Fabio Polticelli,
- Giovanni Musci and
- Maria Carmela Bonaccorsi di Patti
Ferroportin (Fpn), a member of the major facilitator superfamily (MFS) of transporters, is the only known iron exporter found in mammals and plays a crucial role in regulating cellular and systemic iron levels. MFSs take on different conformational s...