Search Results (1,319)

This article presents a comprehensive assessment of mudflow risk in the Talgar River basin through the application of Multi-Criteria Decision Analysis (MCDA) methods and numerical modeling using the Rapid Mass Movement Simulation (RAMMS) environment. The first part of the study involves a spatial assessment of mudflow hazard and susceptibility using GIS technologies and MCDA. The key condition for evaluating mudflow hazard is the identification of factors influencing the formation of mudflows. The susceptibility assessment was based on viewing the area as an object of spatial and functional analysis, enabling determination of its susceptibility to mudflow impacts across geomorphological zones: initiation, transformation, and accumulation. Relevant criteria were selected for analysis, each assigned weights based on expert judgment and the Analytic Hierarchy Process (AHP). The results include maps of potential mudflow hazard and susceptibility, showing areas of hazard occurrence and risk impact zones within the Talgar River basin. According to the mudflow hazard map, more than 50% of the basin area is classified as having a moderate hazard level, while 28.4% is subject to high hazard, and only 1.8% falls under the very high hazard category. The remaining areas are categorized as very low (4.1%) and low (14.7%) hazard zones. In terms of susceptibility to mudflows, 40.1% of the territory is exposed to a high level of susceptibility, 35.6% to a moderate level, and 5.5% to a very high level. The remaining areas are classified as very low (1.8%) and low (15.6%) susceptibility zones. The predictive performance was evaluated through Receiver Operating Characteristic (ROC) curves, and the Area Under the Curve (AUC) value of the mudflow hazard assessment is 0.86, which indicates good adaptability and relatively high accuracy, while the AUC value for assessing the susceptibility of the territory is 0.71, which means that the accuracy of assessing the susceptibility of territories to mudflows is within the acceptable level of model accuracy. To refine the spatial risk assessment, mudflow modeling was conducted under three scenarios of glacial-moraine lake outburst using the RAMMS model. For each scenario, key flow parameters—height and velocity—were identified, forming the basis for classification of zones by impact intensity. The integration of MCDA and RAMMS results produced a final mudflow risk map reflecting both the likelihood of occurrence and the extent of potential damage. The presented approach demonstrates the effectiveness of combining GIS analysis, MCDA, and physically-based modeling for comprehensive natural hazard assessment and can be applied to other mountainous regions with high mudflow activity. Full article

In the earthquakes that occurred in the Pazarcık (Mw = 7.7) and Elbistan (Mw = 7.6) districts of Kahramanmaraş Province on 6 February 2023, many buildings collapsed in the Hayrullah neighborhood of the Onikişubat district. In this study, we investigated whether there was a soil amplification effect on the damage occurring in the Hayrullah neighborhood of the Onikişubat district of Kahramanmaraş Province. Firstly, borehole, SPT, MASW (multi-channel surface wave analysis), microtremor, electrical resistivity tomography (ERT), and vertical electrical sounding (VES) tests were carried out in the field to determine the engineering properties and behavior of soil. Laboratory tests were also conducted using samples obtained from bore holes and field tests. Then, an idealized soil profile was created using the laboratory and field test results, and site dynamic soil behavior analyses were performed on the extracted profile. According to The Turkish Building Code (TBC 2018), the earthquake level DD-2 design spectra of the project site were determined and the average design spectrum was created. Considering the seismicity of the project site and TBC (2018) criteria (according to site-specific faulting, distance, and average shear wave velocity), 11 earthquake ground motion sets were selected and harmonized with DD-2 spectra in short, medium, and long periods. Using scaled motions, the soil profile was excited with 22 different earthquake scenarios and the results were obtained for the equivalent and non-linear models. The analysis showed that the soft soil conditions in the area amplified ground shaking by up to 2.8 times, especially for longer periods (1.0–2.5 s). This level of amplification was consistent with the damage observed in mid- to high-rise buildings, highlighting the important role of local site effects in the structural losses seen during the Kahramanmaraş earthquakes. Full article

In recent years, the majority of countries have focused on the development of earth-penetrating weapons and the construction of deep underground fortifications. It is therefore necessary to assess the damage to underground structures under the attacks of earth-penetrating weapons. In this paper, fluid–solid coupling and restarting methods are used to simulate the damage processes of a granite chamber subjected to the combined action of penetration and explosion with the commercial software of LS-DYNA R11. The applicability of the penetration model and the blasting model is verified by the previous penetration and blasting tests. The verified models are used to simulate the complete process of the underground granite chamber attacked by the earth-penetrating weapons. Based on peak particle velocity (PPV) damage criteria, the numerical results show that the hypervelocity impact of the earth penetrating weapons only causes local damage to the granite rock mass, and more serious damage is caused by the subsequent explosion. During the subsequent explosion, part of the detonation products and energy can escape along the penetration trajectory with the blast loading, resulting in the attenuation of blast stress waves. Subsequently, the relationship between the overlay thickness and the vibration attenuation in granite is also studied, which provides a fast method to determine the threshold damage level for an underground chamber to collapse under the attacks of earth-penetrating weapons. Full article

The article presents a new AM (Additive Manufacturing) process development, necessary to repair parts made from Aluminum 6061 material, with T6 treatment. The laser Directed Energy Deposition (DED) and Extreme High-Speed Directed Energy Deposition (EHLA) capabilities are evaluated for repairing Al large components. To optimize the process parameters, single-track depositions were analyzed for both laser-powder DED (feed rate of 2 m/min) and EHLA (feed rate 20 m/min) for AlSi10Mg and Al6061 powders. The cross-sections of single tracks revealed the bonding characteristics and provided laser-powder DED, a suitable parameter selection for the repair. Three damage types were identified on the Al component to define the specification of the repair process and to highlight the capabilities of laser-powder DED and EHLA in repairing intricate surface scratches and dents. Our research is based on variation of the powder mass flow and beam power, studying the influence of these parameters on the weld bead geometry and bonding quality. The evaluation criteria include bonding defects, crack formation, porosity, and dilution zone depth. The bidirectional path planning strategy was applied with a fly-in and fly-out path for the hatching adjustment and acceleration distance. Samples were etched for a qualitative microstructure analysis, and the HV hardness was tested. The novelty of the paper is the new process parameters for laser-powder DED and EHLA deposition strategies to repair large Al components (6061 T6), using AlSi10Mg and Al6061 powder. Our experimental research tested the defect-free deposition and the compatibility of AlSi10Mg on the Al6061 substrate. The readers could replicate the method presented in this article to repair by laser-powder DED/EHLA large Al parts and avoid the replacement of Al components with new ones. Full article

With the rise of carbon capture and storage, liquefied carbon dioxide (LCO₂) has emerged as a promising medium for large-scale marine transport. This study evaluates the structural integrity of an IMO Type C cargo tank for a medium-range LCO₂ carrier under four conditions: ultimate limit state, accidental limit state, hydrostatic pressure test, and fatigue limit state, based on IGC Code and classification rules. Seventeen load cases were analyzed using finite element methods with multi-step loading to ensure stability. The highest stress occurred at the pump dome–shell junction due to geometric discontinuities, but all stress and buckling criteria were satisfied. The fatigue damage from wave-induced loads was negligible, with low-cycle fatigue from loading/unloading operations governing the fatigue life, which exceeded 31,000 years. The findings confirm the tank’s structural robustness and its suitability for safe, efficient medium-pressure LCO₂ transport. Full article

The paper provides an analysis of the causes of accidents in oil and gas pipeline systems. As part of a comprehensive overview of the topic, it also presents the historical development of pipeline systems, from the first commercial oil pipelines in the United States to modern infrastructure projects, with a particular focus on the role of regulatory requirements and measures (prevention, detection, and mitigation) to improve transport efficiency and pipeline safety. The research uses historical accident data from various databases to identify the main causes of accidents and analyse trends. The focus is on factors such as corrosion, third-party interference, and natural disasters that can lead to accidents. A comparison of the various accident databases shows that there are different practises and approaches to operation and reporting. As each database differs in terms of inclusion criteria, the categories are divided into five main groups to allow systematic interpretation of the data and cross-comparison of accident causes. Regional differences in the causes of accidents involving oil and gas pipelines in Europe, the USA, and Canada are visible. However, an integrated analysis shows that the number of accidents is declining in almost all categories. The majority of all recorded accidents are in the “Human factors and Operational disruption” and “Corrosion and Material damage” groups. It is recommended to use the database as required, as each category has its own specifics. Full article

Background: Oxidative stress is a critical factor contributing to male infertility, impairing spermatogonial stem cells (SSCs) and disrupting normal spermatogenesis. This study aimed to isolate and characterize human SSCs and to investigate oxidative stress-related gene expression, protein interaction networks, and developmental trajectories involved in SSC function. Methods: SSCs were enriched from human orchiectomy samples using CD49f-based magnetic-activated cell sorting (MACS) and laminin-binding matrix selection. Enriched cultures were assessed through morphological criteria and immunocytochemistry using VASA and SSEA4. Transcriptomic profiling was performed using microarray and single-cell RNA sequencing (scRNA-seq) to identify oxidative stress-related genes. Bioinformatic analyses included STRING-based protein–protein interaction (PPI) networks, FunRich enrichment, weighted gene co-expression network analysis (WGCNA), and predictive modeling using machine learning algorithms. Results: The enriched SSC populations displayed characteristic morphology, positive germline marker expression, and minimal fibroblast contamination. Microarray analysis revealed six significantly upregulated oxidative stress-related genes in SSCs—including CYB5R3 and NDUFA10—and three downregulated genes, such as TXN and SQLE, compared to fibroblasts. PPI and functional enrichment analyses highlighted tightly clustered gene networks involved in mitochondrial function, redox balance, and spermatogenesis. scRNA-seq data further confirmed stage-specific expression of antioxidant genes during spermatogenic differentiation, particularly in late germ cell stages. Among the machine learning models tested, logistic regression demonstrated the highest predictive accuracy for antioxidant gene expression, with an area under the curve (AUC) of 0.741. Protein oxidation was implicated as a major mechanism of oxidative damage, affecting sperm motility, metabolism, and acrosome integrity. Conclusion: This study identifies key oxidative stress-related genes and pathways in human SSCs that may regulate spermatogenesis and impact sperm function. These findings offer potential targets for future functional validation and therapeutic interventions, including antioxidant-based strategies to improve male fertility outcomes. Full article

Primary aldosteronism (PA), the most common cause of secondary hypertension, is increasingly recognized as an independent driver of adverse cardiac remodeling, mediated through mechanisms beyond elevated blood pressure alone. Chronic aldosterone excess leads to myocardial fibrosis, left ventricular hypertrophy, and diastolic dysfunction via mineralocorticoid receptor activation, oxidative stress, inflammation, and extracellular matrix dysregulation. These changes culminate in a distinct cardiomyopathy phenotype, often underrecognized in early stages. Multimodality cardiac imaging, led primarily by conventional and speckle-tracking echocardiography, and complemented by exploratory cardiac magnetic resonance (CMR) techniques such as T1 mapping and late gadolinium enhancement, enables non-invasive assessment of structural, functional, and tissue-level changes in aldosterone-mediated myocardial damage. While numerous studies have established the diagnostic and prognostic relevance of imaging in PA, several gaps remain. Specifically, the relative sensitivity of different modalities in detecting subclinical myocardial changes, the long-term prognostic significance of imaging biomarkers, and the differential impact of adrenalectomy versus medical therapy on cardiac reverse remodeling require further clarification. Moreover, the lack of standardized imaging-based criteria for defining and monitoring PA-related cardiomyopathy hinders widespread clinical implementation. This narrative review aims to synthesize current knowledge on the pathophysiological mechanisms of aldosterone-induced cardiac remodeling, delineate the strengths and limitations of existing imaging modalities, and critically evaluate the comparative effects of surgical and pharmacologic interventions. Emphasis is placed on early detection strategies, identification of imaging biomarkers with prognostic utility, and integration of multimodal imaging into clinical decision-making pathways. By outlining current evidence and highlighting key unmet needs, this review provides a framework for future research aimed at advancing personalized care and improving cardiovascular outcomes in patients with PA. Full article

Cystinosis is a rare systemic disease characterized by the accumulation of cystine in tissues, leading to multi-organ damage. Infantile nephropathic cystinosis is the dominant and severe form of cystinosis with critical renal manifestations that require kidney transplantation at an early age if left untreated. Cysteamine, the lifelong cystine-depleting therapy, is the mainstay treatment of nephropathic cystinosis. Cysteamine prevents cystine crystal formation and delays disease progression. While the initially introduced cysteamine consists of an immediate-release (IR) formulation, a delayed-release (DR) formulation has been developed with a simplified dosing regimen (Q12H instead of Q6H) and an improved quality of life while maintaining comparable efficacy. Due to the rare incidence of the disease and lack of international guidelines, diagnosis and treatment initiation are oftentimes delayed, leading to a poor prognosis. Pediatric and adult nephrologists from Kuwait, Saudi Arabia, the United Arab Emirates (UAE), and Qatar, in addition to one international expert from Amsterdam, convened to share their clinical experience, reflecting on the challenges encountered and therapeutic approaches followed in the management of nephropathic cystinosis in the Gulf Cooperation Council (GCC) region. Experts completed a multiple-choice questionnaire and engaged in structured discussions, where they shed light on gaps and limitations with regard to diagnostic tests and criteria to ensure early diagnosis and timely treatment initiation. Based on available literature, experts suggested an algorithm to help guide nephropathic cystinosis management in the GCC. It is highly recommended for patients who do not tolerate IR-cysteamine and do not adhere to IR-cysteamine treatment to switch to DR-cysteamine. Given the systemic nature of the disease, a multi-disciplinary approach is required for optimal disease management. Full article

Consumers are increasingly exposed to environmental claims on food products. These claims often lack scientific validation and there are different methodologies that can be used for grounding these claims, which can lead to misleading results. The European Union’s (EU) Environmental Footprint methodology excludes the aggregation of environmental impacts, including damage to human health. This fact reduces transparency and limits the consumers’ ability to make information-based sustainable choices. This study aims to address this issue by calculating aggregated impacts on human health via life cycle assessment (LCA) in the agriculture and food-production sectors. In the study the IMPACT World+ method was used, including trustworthy databases and proper functional unit definition. The assessment encompassed three types of vegetables, four types of fruit, and four types of ready meals. The study also attempts to assess the impact of different farming systems (organic and conventional) on human health. Two standardised functional units, i.e., the unit based on product weight and product energy value were considered for each group of products. Our findings showed significant differences in results when different functional units were used. Additionally, no conclusion could be drawn regarding which farming system is more sustainable. Therefore, it is essential that the regulator clearly defines the criteria for selecting the appropriate functional unit in LCA within the agriculture and food-production sectors. In the absence of these criteria, results should be presented for all alternatives. Although not required by EU regulation, the authors suggest that companies should nevertheless disclose information regarding the environmental impact of agriculture and food production on human health, as this is important for consumers. Full article

Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by venous and arterial thrombosis and obstetric complications, driven by antiphospholipid antibodies (APLAs). This review synthesizes the latest advancements and current understanding, diagnosis, and treatment of APS. APLAs, including lupus anticoagulant (LAC), anticardiolipin (aCL), and anti-β2-glycoprotein I (aβ2-GPI), interfere with coagulation and endothelial function, as well as with placental health. APS can be primary or secondary; it is often associated with systemic autoimmune diseases like lupus. The pathogenesis of APS remains only partially understood. APLAs promote thrombosis through endothelial damage, platelet activation, and inflammatory signaling pathways. Laboratory diagnosis relies on persistent positivity for APLAs and LAC through tests like ELISA and clotting assays, following a three-step confirmation process. New integrated test systems have been introduced to improve standardization. Classification criteria have evolved, with the 2023 EULAR-ACR criteria providing a weighted, domain-based scoring system, enhancing diagnostic precision. Catastrophic APS (CAPS) is a severe, rare manifestation of APS, characterized by multi-organ failure due to rapid, widespread microthrombosis and systemic inflammation, which requires urgent anticoagulation. Seronegative APS is proposed for patients with clinical features of APS but negative standard antibody tests, possibly due to non-criteria antibodies or transient immunosuppression. Treatment primarily involves long-term anticoagulation with vitamin K antagonists; direct oral anticoagulants are generally not recommended. APS diagnosis and management remain complex due to clinical heterogeneity and laboratory challenges. Continued refinement of diagnostic tools and criteria is essential for improving outcomes in this life-threatening condition. Full article

This study investigates the fire dynamics and structural response of steel-framed warehouse racking systems under various fire scenarios, emphasizing the critical importance of fire safety measures in mitigating structural damage. Through advanced computational simulations (Fire Dynamics Simulator) and thermomechanical analysis, this research reveals that fire intensity and progression are highly influenced by the ignition point and the stored material types, with maximum recorded temperatures reaching 720 °C and 970 °C in different scenarios. The results highlight the localization of significant strain and drift ratios in structural elements near the ignition zone, underscoring their vulnerability. This study demonstrates the rapid loss of load-bearing capacity in steel elements at elevated temperatures, leading to severe deformations and increased collapse risks. Key findings emphasize the necessity of strategically positioned sprinkler systems and the integration of passive fire protection measures, such as fire-resistant coatings, to enhance structural resilience. Performance-based fire design approaches, aligning with FEMA-356 criteria, offer realistic frameworks for improving the fire safety of warehouse structures. Full article

Oxidative stress (OS) occurs when there is an imbalance between oxidants and antioxidants, leading to disruptions in cellular signaling and causing damage to molecules. Glutathione S-transferase (GST) enzymes are crucial for maintaining redox balance by facilitating glutathione conjugation. Increased oxidative damage has been noted during the COVID-19 pandemic, and its persistence may be linked to the onset of long COVID. This systematic review aimed to assess the relationship between GST gene polymorphisms and the prognosis of COVID-19, including long COVID. Adhering to the PRISMA guidelines, a thorough search was carried out in MEDLINE, CENTRAL, PubMed, and EMBASE for studies published from September 2020 to February 2025. Out of an initial selection of 462 articles, ten studies (four concerning COVID-19 severity and six related to long COVID) satisfied the inclusion criteria. The findings regarding GST polymorphisms were not consistent, especially concerning the GSTM1 and GSTT1 isoforms. Nevertheless, evidence indicates a sustained state of oxidative stress in patients with long COVID. The majority of research has focused on cytosolic GSTs, while the functions of microsomal and mitochondrial GST families remain largely unexplored. These findings suggest that further research into the various GST subfamilies and their genetic variants is necessary to enhance our understanding of their impact on COVID-19 severity and the pathophysiology of long COVID. Full article

Photobiomodulation (PBM) has been widely studied for its regenerative and anti-inflammatory properties. Its application, combined with biomaterials, is emerging as a promising strategy for promoting tissue regeneration. Considering the diversity of available evidence, this study conducted an integrative literature review, aiming to critically analyze and synthesize the effects of PBM on bone tissue, particularly its potential role as an adjunct in guided bone regeneration (GBR) procedures. To ensure an integrative approach, studies with different methodological designs were included, encompassing both preclinical and clinical research. The article search was performed in the digital databases PubMed/MEDLINE, Scopus, and Web of Science, using the following search terms: “Photobiomodulation therapy” AND “guided bone regeneration”. The search was conducted from November 2024 to January 2025. A total of 85 articles were found using the presented terms; after checking the results, 11 articles were selected for this study. The remaining articles were excluded because they did not fit the proposed inclusion and exclusion criteria. Studies to date have shown preclinical models that demonstrated increased bone-volume fraction and accelerating healing. Although it has exciting potential in bone regeneration, offering a non-invasive and promising approach to promote healing and repair of damaged bone tissue, the clinical application of PBM faces challenges, such as the lack of consensus on the ideal treatment parameters. Calcium phosphate ceramics were one of the most used biomaterials in the studied associations. Further well-designed studies are necessary to clarify the effectiveness, optimal parameters, and clinical relevance of PBM in bone regeneration, in order to strengthen the current evidence base and guide its potential future use in clinical practice. Full article

Background/Objectives: The inferior thyroid artery (ITA) is an essential component of the thyroid gland’s vasculature, with significant clinical and surgical implications due to its anatomical variability. This systematic review aimed to describe the prevalence of ITA anatomical variants and their association with clinical conditions or surgical implications. Methods: A comprehensive search was conducted in MEDLINE, Web of Science, Google Scholar, CINAHL, Scopus, and EMBASE on 20 November 2025. Eligibility criteria included studies reporting on the presence of ITA variants and their correlation with pathologies. Two authors independently screened the literature, extracted data, and assessed methodological quality using the AQUA and JBI tools. Results: Of the 2647 articles identified, 19 studies involving 1118 subjects/cadavers were included. Variations in ITA origin, absence, and additional arteries were reported, with the most common variant being direct origin from the subclavian artery. Clinically, these variations were associated with increased risk of intraoperative hemorrhage, potential nerve damage, and challenges in preoperative planning, particularly during thyroidectomy and other neck procedures. Conclusions: Understanding the anatomical diversity of the ITA is crucial for reducing surgical risks and improving patient outcomes. The review highlighted the need for more standardized research protocols and comprehensive data reporting to enhance the quality of evidence in this domain. Preoperative imaging and thorough anatomical assessments tailored to individual patient profiles, considering ethnic and gender-related differences, are essential for safe surgical interventions in the thyroid region. Full article