Search Results (7,899)

This research examines the impact of five crucial factors underlying human resource management (HRM), namely, compensation, transformational leadership, motivation, and job satisfaction on sustainable employees’ performance in Lebanese family companies. The research is founded on Social Exchange Theory, Maslow’s Hierarchy of Needs, and Transformational Leadership Theory. Based on a cross-sectional design and quantitative approach, data were collected from 511 full-time employees working for family-owned businesses in Lebanon via structured questionnaires. Structural equation modeling (SEM) using SmartPLS-4 was used to analyze the relationships among the variables. The results point out that job satisfaction, motivation, and the transformational leadership style meaningfully impact employees’ performance. Compensation had a slight yet statistically significant effect. Furthermore, the work environment was found to have both a direct influence on performance and a moderating effect on the relationships between job satisfaction, transformational leadership style, and employees’ outcomes. These outcomes provide theoretical contributions to the literature on HRM in family-owned enterprises and deliver practical insights for improving employees’ performance through targeted HR strategies in emerging economies. The present study concludes by highlighting the role of a supportive environment at work and participative leadership in enhancing performance outcomes, mostly in culturally complex and intergenerational business settings. Full article

Polydopamine (PDA) surface coatings are widely used in biomedical engineering to enhance cell–substrate interactions; however, their effects on cancer-cell behavior remain unclear. In this study, we investigated how PDA-coated two-dimensional (2D) culture surfaces influence oncogenic traits of human prostate cancer (PC) cells in vitro. Using LNCaP, DU145, and PC3 cell lines, we found that PDA-coated substrates markedly increased the adhesion, migration, invasion, proliferation, and colony formation in a dose- and time-dependent manner. PDA exposure also induced epithelial–mesenchymal transition (EMT), upregulated cancer stem cell markers (CD44, CD117, CD133, Sox2, Oct4, and Nanog), and elevated expression of metastasis- and chemoresistance-associated molecules (MMP-2, MMP-9, MDR1, and MRP1). Mechanistically, PDA coatings enhanced integrin α₂β₁-associated cell adhesion, accompanied by increased focal adhesion kinase (FAK) phosphorylation and downstream activation of JNK signaling. Pharmacological inhibition of integrin α₂β₁ (BTT-3033), FAK (PF573228) and JNK (SP600125) effectively abrogated PDA-induced malignant phenotypes and restored chemosensitivity to cabazitaxel, cisplatin, docetaxel, curcumin, and enzalutamide. Collectively, these findings identify PDA-coated surfaces as a simple, efficient, and reductionist in vitro platform for studying adhesion-mediated signaling and phenotypic plasticity in PC cells, while acknowledging that further validation in three-dimensional (3D) and patient-derived models will be required to establish in vivo relevance. Full article

The purpose of this study was to develop and validate an integrated model explaining how AI-enabled knowledge integration and digital ecosystem connectivity influence knowledge innovation capability through the mediating role of knowledge agility and the moderating roles of digital trust and organizational learning culture. Grounded in the Knowledge-Based View (KBV) and Dynamic Capability Theory (DCT), this research seeks to understand how technological and cultural enablers jointly drive exploratory, exploitative, and adaptive innovation. A quantitative cross-sectional research design was employed, and data were collected from 243 professionals working in knowledge-intensive organizations. Measurement scales were adapted from previous studies, and data analysis was conducted through structural equation modeling, using SmartPLS 4. Reliability, validity, and path analyses were performed to test the hypothesized relationships among constructs. The results indicated that AI-enabled knowledge integration and digital ecosystem connectivity significantly enhance knowledge agility, which in turn positively affects knowledge innovation capability. The mediation tests confirmed the role of knowledge agility, while digital trust and organizational learning culture were confirmed to strengthen the relationship between knowledge agility and innovation capability. This study contributes to theory by integrating technological, organizational, and cultural perspectives into a unified model of digital innovation. Practically, it guides organizations in leveraging AI systems, digital connectivity, and learning culture to foster sustainable innovation. Full article

Herpes simplex virus type 1 (HSV-1) has been proposed as an environmental risk factor for Alzheimer’s disease (AD). Viral infection of neuronal cells can reproduce hallmark pathological features of AD, including intracellular beta-amyloid (Aβ) accumulation, tau hyperphosphorylation, and lysosomal dysfunction. However, the molecular mechanisms underlying these alterations remain unclear, partly due to limitations of existing experimental models. Here, we established both two-dimensional (2D) and three-dimensional (3D) LUHMES neuronal cultures—a human mesencephalic-derived neural cell line that differentiates rapidly into mature neurons—to investigate HSV-1-induced AD-associated markers. Our results demonstrate that HSV-1 infection induces key features of AD, including intracellular accumulation of Aβ peptides and hyperphosphorylation of tau protein. Moreover, we observed disruptions in the autophagy–lysosome pathway, characterized by increased LC3-II levels, reduced cathepsin activity, and impaired lysosomal burden. Notably, these AD-like alterations were reproduced in 3D LUHMES neuronal aggregates, confirming their susceptibility to productive HSV-1 infection. Collectively, these findings indicate that HSV-1 not only triggers AD-like neuropathological markers but also disrupts cellular clearance mechanisms that may contribute to neuronal dysfunction and degeneration. This study validates the 3D LUHMES system as a useful human neuronal model to study virus-induced neurodegeneration and its mechanistic links to AD pathology. Full article

Indoor positioning systems (IPSs) are increasingly applied in indoor settings where satellite-based GNSS signals are unavailable, including museums and other cultural heritage spaces. Within the META-MUSEUM project, we present a pilot study integrating an Ultra-Wideband (UWB) positioning system and an eye-tracking device to monitor and quantify visitor behavior in a real museum environment. The absence of common timestamps between the two systems, and the presence of UWB signal noise, have been the main challenges to address. A cross-correlation–based synchronization method was developed to align the two independent UWB and eye-tracking datasets. Data were collected from 100 visitors, of whom 7 different clusters were considered based on the characteristics of the visitors. The results demonstrate the system’s feasibility and provide two complementary metrics, Normalized Engagement and Collective Engagement, which are used to quantify the duration and spatial distribution of visitor engagement at specific exhibits. This work establishes a scalable multi-sensor foundation by addressing practical deployment challenges under real-world conditions. These findings form the basis for the project’s broader goal of linking spatial visitor behavior with neurophysiological responses, opening new possibilities for improving visitor engagement and supporting interactive cultural heritage experiences. Full article

Fusion cuisine blends ingredients, cooking techniques, and flavours from different cultures, yet little is known about how it is perceived within the context of gastrodiplomacy. This study explores perceptions of fusion cuisine at a multicultural gastrodiplomacy event held in Kosovo, where the participants first sampled Turkish–Kosovar fusion dishes during tasting sessions and subsequently completed an online questionnaire designed to assess their experience. In this event, participants attended structured tasting activities in Prizren and Pristina, where they sampled dishes combining elements of both culinary traditions, and then completed an online structured questionnaire consisting of 5-point Likert-type items evaluating their fusion cuisine preferences. The study was conducted in Kosovo as part of a unilateral gastrodiplomatic initiative. A total of 451 participants responded to an online questionnaire, which included fusion cuisine preference scores and metaphorical descriptions of their culinary experiences. A key contextual characteristic of this study is that data were collected exclusively during a fusion cuisine event held in Kosovo, with participation from a multinational audience who attended the event. Therefore, the sample reflects diverse cultural backgrounds within a single-location setting. The results indicate that younger, highly educated, and higher-income participants exhibited significantly greater openness to culinary diversity. These findings advance the state of knowledge by demonstrating that public reception of gastrodiplomacy is stratified by socioeconomic factors rather than defined solely by national background. Practically, this implies that effective fusion-based diplomacy requires targeted strategies to bridge demographic gaps and ensure broader social inclusivity, rather than relying on a one-size-fits-all approach. Full article

Studies of complex natural environments often focus on either biodiversity or on isolating organisms with specific properties. In this study, we sought to widen this perspective and achieve both. In particular, hypersaline ecosystems, such as the Sečovlje salt pans (Slovenia), are particularly promising sources of novel bioactive compounds, as their microorganisms have evolved adaptations to desiccation and high light intensity stress. We applied shotgun metagenomics to assess microbial biodiversity under low- and high-salinity conditions, complemented by isolation and cultivation of photosynthetic microorganisms. Metagenomic analyses revealed major shifts in community composition with increasing salinity: halophilic Archaea became dominant, while bacterial abundance decreased. Eukaryotic assemblages also changed, with greater representation of salt-tolerant genera such as Dunaliella sp. Numerous additional microorganisms with biotechnological potential were identified. Samples from both petola and brine led to the isolation and cultivation of Dunaliella sp., Tetradesmus obliquus, Tetraselmis sp. and cyanobacteria Phormidium sp./Sodalinema stali, Leptolyngbya sp., and Capilliphycus guerandensis. The newly established cultures are the first collection from this hypersaline environment and provide a foundation for future biodiscovery, production optimization, and sustainable bioprocess development. The methods developed in this study constitute a Toolbox Solution that can be easily replicated in other habitats. Full article

This study examines a seven-week informal familycentric rocketry pilot program designed for Latina girls in grades 5 and 6 and their parents. Grounded in Community Cultural Wealth and Culturally Sustaining Pedagogy, the program integrated Family Problem-Based Learning to position families as co-educators in science learning. Through activities such as designing NASA-style mission patches, constructing egg-drop devices, and launching rockets, the program sought to center family knowledge, bilingual practices, and cultural values within physical science experiences. Data reported here were collected through mid- and post-program surveys with both parents and daughters. Responses indicate strong engagement from families, with parents reporting increased high confidence in supporting their daughters’ science learning and daughters expressing enjoyment and strong interest in science learning. Both groups valued the use of English and Spanish and the program’s emphasis on collaborative, family-centered participation. Responses highlight the potential of culturally sustaining, familycentric approaches to address the underrepresentation of Latina women in Science, Technology, Engineering, and Math (STEM) by fostering a sense of belonging. This study contributes to informal science education by demonstrating how families can be centered in a program focused on physical science. School-based outreach of this kind may also strengthen families and parent–child relationships. Full article

The olive tree hosts diverse endophytic fungi that may contribute to plant protection and growth. In this study, a preliminary screening of olive-associated fungal endophytes was conducted. A total of 67 fungal endophytes were isolated from the leaves and roots of the Greek cultivars Amfissa and Kalamon and identified using morphological and molecular approaches; 28 representative strains were selected for functional evaluation. Dual culture assays revealed substantial antagonistic activity against major phytopathogens, with growth inhibition ranging from 19.05% to 100%. Notably, strains F.KALl.8 and F.AMFr.15 showed the strongest suppression across pathogens. Interaction phenotyping revealed all major interaction types (A, B, C) and subtype C1/C2, with several strains producing pigmentation zone lines or hyphal ridges at contact sites. The assessment of plant growth-related effects using Arabidopsis thaliana as a model system showed that three strains (F.AMFr.15, F.KALr.4, F.KALr.38A) significantly increased seedling biomass (up to ~16% above the control), whereas nine strains caused severe growth reduction and disease symptoms. Beneficial strains also altered root architecture, inhibiting primary root elongation while inducing extensive lateral root formation. Collectively, these findings highlight the functional diversity of olive-associated fungal endophytes and identify promising candidate strains, particularly F.AMFr.15 (identified as Clonostachys sp.), for further host-specific validation as potential biological control and plant growth-promoting agents. Full article

The manufacturing process contributes significantly to the proliferation, metabolic state, and functional persistence of chimeric antigen receptor (CAR)-T cells. However, how different culture systems regulate CAR-T cell metabolism and thereby influence their long-term antitumor activity remains poorly understood. In this study, we compared dynamic cultivation using a wave bioreactor with static expansion systems (gas-permeable and conventional T-flasks) for the production of CD99-specific CAR-T cells. CAR-T cells expanded by the wave bioreactor exhibited faster proliferation and stronger cytotoxicity during culture. Upon repeated antigen stimulation, they retained these enhanced functional properties and showed the reduced expression of immune checkpoint molecules, preferentially preserved memory-like subsets, and displayed transcriptional features consistent with memory maintenance and exhaustion resistance. Targeted metabolomic profiling revealed enhanced Tricarboxylic Acid (TCA) cycle activity and features consistent with sustained oxidative phosphorylation, supporting mitochondrial-centered metabolic reprogramming. In a Ewing sarcoma xenograft model, wave bioreactor-cultured CAR-T cells showed a greater percentage of memory-like tumor-infiltrating lymphocytes. Collectively, these results indicate that wave bioreactor-based dynamic cultivation promotes mitochondrial metabolic reprogramming, which is characterized by an enhanced TCA cycle and sustained oxidative phosphorylation, thereby sustaining CAR-T cell functionality and providing a robust platform for the manufacturing of potent and durable cellular therapeutics. Full article

The overall knowledge structure, developmental context, and research frontiers in the field of bronze cultural relic corrosion and protection are lacking. This study employs bibliometric methods to comprehensively analyze 2614 relevant publications from 1906 to 2025 in the Web of Science Core Collection, utilizing the software Citespace 6.2.R3 to construct a knowledge map. The research results based on the number of publications and keyword statistics indicate that the research in this field has undergone a temporal evolution of research trends. Since 2010, the annual number of publications has grown rapidly, peaking in 2024, which reflects the continuously increasing academic attention given to the subject. Globally, China, Italy, and the United States are the leading contributors, forming a closely knit international cooperation network. Among these, China leads in total publications, though there remains room for improvement in its centrality within the collaborative network. Major research institutions are primarily large scientific organizations, such as the National Research Council of Italy and the Chinese Academy of Sciences. Keyword analysis demonstrates that research hotspots have long centered on “corrosion mechanisms and control” and “innovative protection materials and technologies”. Temporal evolution analysis further indicates that the research paradigm is shifting: from the early investigations of mechanisms, through a middle phase focused on material development, to the current emphasis on the development of preventative and intelligent protection systems via multidisciplinary integration. This study systematically reviews the field’s evolutionary trajectory, collaboration networks, and thematic dynamics, providing a comprehensive reference for research planning and future development. Full article

This study explores the role of Applied Theatre as a form of cultural mediation in addressing issues of environmental justice within higher education. Eight university professors participated in the study, providing qualitative data through semi-structured interviews that focused on their perceptions of environmental inequalities, their teaching practices, and the potential of theatrical approaches to foster critical engagement with sustainability issues, drawing on their prior use of drama-based methods in university teaching. Using a directed content analysis framework, the study highlights that environmental inequalities are not only material or ecological but are closely intertwined with social relations, access to resources, and collective experiences. The findings indicate that Applied Theatre can create an intermediate learning space where knowledge, emotion, and action intersect, enabling students to engage critically and experientially with social and environmental injustices. Essential conditions for successful integration include targeted professional development of faculty, institutional support, and interdisciplinary collaborations, while challenges such as limited resources, time constraints, and lack of curricular recognition remain significant. The study contributes to the development of a theoretical framework that positions Applied Theatre as cultural mediation in higher education, framing it not only as an artistic methodology but also as a social and educational practice. This framework provides directions for future research and policy, particularly in the design of sustainable teaching practices that connect higher education with social justice and ecological responsibility. Full article

This article examines how the Ahiska Turks—deported from Georgia’s Meskheti region to Central Asia in 1944—sustained their religious belonging under shifting Soviet and post-Soviet political and social conditions, and how this religious continuity became intertwined with processes of collective memory formation. Drawing on published archival materials, existing scholarship, and a long-term ethnographic corpus composed of fourteen life-history oral interviews conducted between 2006 and 2025 in Turkey and Kazakhstan, the study traces the multigenerational trajectories of ritual practice. The findings show that funeral ceremonies, mevlid gatherings, Ramadan practices, and domestic prayer circles function as “sites of memory” through which the trauma of displacement is reinterpreted and intergenerational belonging is continually reconstituted. These ritual forms generate a meaningful sense of continuity and communal resilience in the face of prolonged experiences of loss, uncertainty, and “placelessness.” Situated at the intersection of the anthropology of religion, cultural trauma theory, and Soviet/post-Soviet diaspora studies, the article conceptualizes Islam as more than a realm of belief: for the Ahiska Turks, it operates as a core cultural infrastructure that anchors post-displacement resilience, social organization, and collective memory. The study contributes to the literature by offering an integrated analytical framework that places the Ahiska community within broader debates on religion, memory, and forced migration; by examining rituals not only as emotional practices but also as institutional and cultural scaffolding; and by foregrounding the understudied post-traumatic religious experiences of Muslim diasporas. Full article

Objectives/Background: In this study, we aimed to examine the associations of participation in leisure dance activity with perceived health status, happiness level, and perceptions of leisure, and the relevance of demographic characteristics to these associations. Moreover, we sought to explore ways of revitalizing leisure dance activity. Methods: We used data from the 2022 Korea National Leisure Activity Survey organized by the Korean Ministry of Culture, Sports, and Tourism. The 2022 Korea National Leisure Activity Survey was conducted from September to November 2022. The survey was conducted among 10,046 Koreans aged ≥15 who lived in 17 cities and provinces across the country. The participants were informed about the survey schedule in advance, and interviews were conducted at the participants’ homes using tablet PCs. Random telephone verification was performed on the recovered questionnaires to ensure the accuracy of responses. Questionnaires that passed the first verification were subjected to secondary verification by a computerized program, and questionnaires that did not pass the verification were supplemented and re-examined. The collected data were entered electronically through an encoding process, and only the data that passed the final test were compiled in the multi-stage verification process. The data were analyzed using frequency analysis, chi-squared tests, and multivariate logistic regression analysis. Results: Of the 1004 participants, 655 (6.5%) participated in leisure dance activity. Women, individuals in their twenties and thirties, college graduates or those with lower-level educational qualifications, and unmarried individuals were more likely to participate in leisure dance activities. In addition, leisure dance activities were found to be likely to increase happiness levels and leisure life satisfaction, and leisure expenses were likely to be low. Conclusions: Schools should provide high-quality dance education and enhance the professionalism of physical education teachers in the management of dance classes. This is because dance-related experiences in childhood can increase the likelihood of engaging in dancing in adulthood. Efforts are also needed to increase men’s awareness of and participation in leisure dance activities and to lower barriers to entry. The convergence of dance, games, and technology can make this possible. Full article

The production of fats and oils represents a task that is in demand in a variety of industries, including the food industry. Presently, the predominant method of acquiring them is through the processing of plant and animal products, a process that substantially increases the cost of production at all stages. Oleaginous yeasts can serve as an alternative source for obtaining edible oils, as demonstrated by yeast strains employed in the development of palm oil analogues. In this study, we created and characterized a collection of oil-producing yeast species obtained from various natural sources. These species were identified using MALDI-TOF and Sanger sequencing. The isolates were qualitatively and quantitatively tested for their ability to grow on various culture media compositions. The oil-producing strains were characterized by their fatty acid profile and lipidome composition. In addition, we evaluated the biotechnological potential of these organisms as producers of fatty acid- and fat-related products. As a result, the collection contains 100 strains, 31 of which are oleaginous yeasts, and three strains show potential as promising producers of edible oil analogues. Our research demonstrates the benefits of searching for and studying natural yeast strains, both from a fundamental science perspective and for the creation of future innovative biotechnological solutions in the food industry. Full article