Search Results (3,006)

Cardiac Ca²⁺ handling is critical for excitation–contraction coupling (ECC), with the ryanodine receptor type 2 (RyR2) serving as the key sarcoplasmic reticulum (SR) Ca²⁺ release channel in cardiomyocytes. The dysfunction of RyR2 is linked to fatal cardiac arrhythmias, including heart failure (HF) and catecholaminergic polymorphic ventricular tachycardia (CPVT). This review aims to elucidate the structural basis of RyR2, its core role in cardiac ECC and Ca²⁺ homeostasis, and the regulatory mechanisms of key modulators on its activity. By integrating recent high-resolution cryo-EM structural analyses with molecular and cellular studies on RyR2 regulation, as well as clinical evidence of RyR2 mutations in arrhythmogenic heart diseases, we provide a comprehensive overview of the field. Cryo-EM has unraveled RyR2’s gating mechanisms, ligand-binding sites, and structural features. Functionally, RyR2 mediates calcium-induced calcium release (CICR) and maintains Ca²⁺ homeostasis through coordination with SERCA2a and NCX. Key modulators (CaM, FKBP12.6, and PKA/CaMKII) and disease-linked mutations regulate RyR2 activity through distinct pathways, with defective RyR2 leading to store-overload-induced Ca²⁺ release (SOICR) and arrhythmias. Furthermore, reactive oxygen species (ROS) can induce RyR2 oxidation, establishing a pathological Ca²⁺ leak-ROS cycle in heart disease. In conclusion, RyR2 is a pivotal sensor of myocardial function, with its structural and regulatory mechanisms now well-characterized by recent studies. However, the effects of numerous RyR2 mutations remain unclear, and deeper mechanistic insights will lay a key foundation for developing novel therapies against RyR2-related cardiac diseases. Full article

As a typical example of a high-density city, Macau’s medical resource allocation system, a key component of the city’s complex socio-technical system, suffers from significant spatial imbalances, which restricts the overall effectiveness of the medical service system. Based on the perspective of systems science theory, regards the allocation of medical resources as a dynamic system with multiple coupled factors. It comprehensively utilizes systems research methods such as POI data mining and space syntax analysis and employs techniques such as kernel density analysis and spatial structure coupling models to systematically evaluate the spatial structure, resource accessibility, and service balance of Macau’s medical service system. It found that (1) the Macau Peninsula has concentrated core medical resources, such as the Conde de São Januário Hospital (CHCSJ) and Kiang Wu Hospital, which form a core subsystem with high service saturation. Excessive concentration of resources has led to high concentration of a certain type of facility. (2) Taipa Island and the Cotai Reclamation Area have created an extended subsystem of medical resources along with urban development. However, the northern area does not have enough facilities, and its internal structure is not balanced. (3) Coloane Island has only basic health stations remaining, forming a marginal subsystem with scarce medical resources, which has a significant hierarchical gap with the core and extended subsystems. This spatial pattern of “saturated Macau peninsula, expanded Taipa Island, and sparse Coloane Island” is essentially a concrete manifestation of the imbalance between the medical resource allocation system and the urban spatial development system. Therefore, based on system optimization theory, it proposes constructing a multi-level, networked spatial system for medical facilities to promote the coordinated operation of various regional medical subsystems and achieve overall functional optimization and a balanced layout for Macau’s medical service system. This research analyzes the imbalance mechanism of high-density urban public service systems using systems science methods, providing not only a scientific basis for the precise optimization of Macau’s medical resource allocation system but also a practical reference for the planning and governance of similar high-density urban public service systems under a systems thinking framework. Full article

The energy transition represents a complex, multi-level system subject to profound uncertainty and recurrent shocks. Current policy design approaches predominantly rely on static optimization frameworks (centralized, calculative models that presume stable conditions and predictable technological trajectories). Yet evidence from the 2021–2023 energy crisis in Europe, coupled with structural challenges in market liberalization and renewable integration, demonstrates persistent challenges in policy implementation. Price interventions affect competitive dynamics; subsidies influence technology selection; capacity mechanisms create coordination tensions; and rigid tariff structures create misalignments with evolving grid needs. This paper argues that these recurrent policy tensions stem not from implementation gaps, but from an inadequate theoretical foundation: the treatment of energy systems as optimizable rather than as complex, adaptive systems operating under Knight–Mises uncertainty and Huerta de Soto dynamic efficiency. This work explores an alternative framework grounded in dynamic efficiency, complex–uncertain systems, decentralized incentives, and adaptive governance (international–domestic, public–private, etc.). This review uses the theoretical and methodological framework of the Heterodox Synthesis, an alternative to the Neoclassical Synthesis. There is a reinterpretation of some insights from Knight and Mises (uncertainty), Hayek (distributed knowledge), Huerta de Soto (dynamic efficiency) and contemporary complexity economics into operational criteria applicable to energy policy design: (1) robustness to deep uncertainty; (2) preservation of price signals and risk-bearing mechanisms; (3) alignment of incentives across distributed actors; (4) institutional adaptability; and (5) minimization of ex post policy corrections. Through illustrative application to four critical policy instruments (price caps, renewable subsidies, capacity mechanisms, and network tariff design), it is shown how this framework identifies systematic tensions and consequences that conventional analysis overlooks. The contribution is exploratory in a bootstrap way: theoretical, by integrating classical and contemporary economics into energy governance; methodological, by operationalizing dynamic efficiency into evaluable criteria distinct from existing adaptive governance frameworks; and sectorial, by providing policymakers and regulators with diagnostic tools for assessing design robustness in conditions of deep uncertainty and rapid transition. According to this review, improved energy policy design under uncertainty is not achieved through more sophisticated optimization (in a calculative way), but through institutional architectures that preserve creative and adaptive learning, maintain distributed decision-making capacity, and remain functional when assumptions prove incorrect or not well-known. Full article

Multi-joint hydraulic robotic arms are core equipment in intelligent mining, yet their performance is often limited by strong dynamic coupling and nonlinear hydraulic effects. Traditional control methods struggle to achieve high-precision trajectory tracking and coordinated motion under high loads and flow-coupling constraints. To address these challenges, this paper establishes a coupled hydraulic–mechanical dynamic model for a multi-joint robotic arm. The mechanical dynamics are derived using the Lagrangian formulation, while the hydraulic dynamics account for flow coupling among cylinders. An improved deviation coupling control (IDCC) strategy is proposed, integrating feedforward–feedback compensation, coupling error regulation, and a flow-limiting correction term. Co-simulation in Simulink (2024b) and Amesim (2020) shows that under flow-saturation conditions, the improved strategy reduces the peak trajectory errors by approximately 47.88%, 28.08%, and 49.89% for Joints 1–3, respectively, and shortens the settling time by 27.93%. Experimental results from a three-joint hydraulic test platform confirm error reductions of 10.20–15.58% and a 31.50% decrease in overall adjustment time. The study demonstrates that the proposed control strategy effectively suppresses multi-joint coupling interferences, enhances trajectory tracking accuracy, and improves the adaptability of hydraulic robotic arms under flow-limited conditions, providing a viable solution for high-precision control in intelligent mining applications. Full article

In large-scale dam construction, the efficiency of concrete transport operations is fundamentally governed by the coordination between horizontal hauling and vertical hoisting capacities. Traditional experience-based scheduling approaches often fail to capture the stochastic, cyclic, and resource-coupled nature of these transport systems. This study developed a closed queuing network-based stochastic simulation framework to model dam concrete transportation as a finite-population cyclic service system. The process was abstracted into sequential service stages with stochastic service times, and a structured state-space representation combined with time-step simulation was constructed to describe dynamic resource occupation and task transitions under varying truck and cable crane configurations. Application to a real large-scale dam project revealed a characteristic multi-stage performance evolution pattern governed by capacity matching mechanisms. As the truck fleet size increased, system performance transitioned from a transport-limited regime to a capacity-coordination regime and ultimately to a hoisting-saturated regime in which further fleet expansion yielded diminishing returns. Sensitivity analysis demonstrated that hoisting capacity imposed an upper bound on system throughput, while adaptive fleet reconfiguration could restore operational equilibrium under constrained equipment availability. The results indicated that dam concrete transport should be treated as a dynamic capacity regulation problem rather than a static allocation task. The proposed framework provides an interpretable and quantitative decision-support tool for equipment configuration, bottleneck identification, and adaptive scheduling in large-scale hydraulic infrastructure projects. Full article

The integration of intangible cultural heritage (ICH) and tourism development (TD) is regarded as a crucial national strategy for China’s sustainable development, as their synergistic relationship is considered pivotal for regional progress. A coupling coordination evaluation system was constructed. Kernel density estimation, entropy method, coupling coordination degree (CCD) and relative development degree (RDD) models, and a tobit model were employed to examine the spatiotemporal characteristics and influencing factors of ICH–TD integration in Sichuan Province. Key findings are as follows: (1) Sichuan is endowed with abundant ICH resources characterized by high heritage value and diverse typologies. However, the distribution is skewed toward traditional skills, exhibiting notable regional disparities. ICH demonstrates a “single-core, belt-shaped and multi-cluster” pattern, which is centered on Chengdu, extends along a north–south high-density belt, and forms several secondary high-density clusters. (2) Temporally, the CCD demonstrates a sustained upward trend, whereas the RDD transitions from ICH-lagged to TD-lagged. Spatially, the number of high coordinated cities increases annually, expanding radially from regional centers, while central-eastern regions consistently outperform the west. (3) Regarding influencing factors, comprehensive economic strength, distribution of industrial structure, overall level of urbanization, and transportation accessibility exert significant positive effects on the CCD, with comprehensive economic strength demonstrating the strongest influence. This study contributes to the theoretical understanding of ICH–TD synergy and provides policy-relevant guidance for integration. Full article

Travel time prediction (TTP) is a fundamental pillar of intelligent transportation systems (ITS). However, deploying highly parameterized deep learning models in data-scarce environments—referred to as the “cold-start” problem—remains a critical bottleneck, frequently leading to overfitting and severe error accumulation on ultra-long trajectories. To surmount these limitations, this study proposes the Dual-Attentional Gated Residual Network (DAGRN), a data-efficient forecasting framework driven by a novel topology-temporal coordination mechanism. Specifically, the framework introduces three integrated innovations: (1) transforming the primal network into a physics-aware Line Graph to explicitly filter out illegal movements and dynamically modulating topological propagation via Feature-wise Linear Modulation (FiLM); (2) coupling a Bidirectional GRU backbone with a Multi-Head Attention module to simultaneously capture global trends and localized intersection delays; (3) employing a Gated Residual Fusion mechanism that preserves dimensional consistency and facilitates gradient flow in extensive sequences. To rigorously validate the model’s robustness, we conduct evaluations on a highly constrained, stratified dataset comprising merely 2000 trajectories. Experimental results demonstrate that DAGRN achieves state-of-the-art predictive precision with an RMSE of 415.485 s and an R² of 0.848, significantly outperforming 12 advanced baseline models and reducing error by up to 13.8% against the strongest graph baseline. Comprehensive ablation studies confirm the absolute necessity of the Multi-Head Attention module, whose removal causes the most severe performance degradation (RMSE surging to 521.495 s). Ultimately, DAGRN presents a readily deployable solution for sparse-data ITS regimes, actively paving the way for future hybrid integrations with microscopic traffic simulations and evolutionary road network optimization algorithms. Full article

Against the backdrop of a gradual shift in the focus of cultural heritage (CH) conservation and utilization toward the integrated system formed by CH and its surrounding environment as well as regional systems, research on the coordinated protection of nature and culture to promote regional high-quality development has become a new trend. However, systematic summaries of the spatial–temporal distribution of CH in cross-regional typical geomorphic units at the river basin scale and their correlation with the natural environment remain insufficient. This study takes 387 Cultural Relics Protection Units in the Three Gorges of the Yangtze River (the Three Gorges region) as the research objects, utilizing GIS spatial analysis technology to examine the impact of the natural environment on CH across different periods and types. The theory of time-depth is introduced to reveal the layering mechanisms and underlying cultural logics. Coupled with the Minimum Cumulative Resistance (MCR) model, this study constructs a cultural corridor network and proposes spatial planning strategies. The findings are as follows: (1) The absolute core area for the distribution of CH across all periods remains the gentle slope zone near the river, characterized by elevations below 500 m, slopes within 25°, and distances from water systems within 1 km. However, the adaptive scope exhibits a diachronic evolution from core accumulation to peripheral expansion. (2) Different types of CH exhibited distinct natural adaptation strategies and vertical accumulation. Settlement Sites in the Before Qin Dynasty Period formed the foundational layer of survival rationality, while Ordinary Tombs in the Qin–Yuan Dynasty Period reinforced sedentism. Ancient Architecture in the Ming–Qing Dynasty Period underwent a transformation from “adapting to nature” to “reconstructing nature” as a product of environmental construction. Modern and Contemporary Significant Historical Sites and Representative Buildings in the After Qing Dynasty Period are characterized by a ruptured insertion on steep slopes, inscribing revolutionary memory onto space. The main stream of the Yangtze River serves as the core area of continuous deposition, while the extremely steep slopes form a distinctive stratigraphic accumulation of precipitous terrain. (3) Based on these distribution patterns, the study further proposes a spatial framework for CH called “One Corridor, Three Wings.” This framework uses the main stream of the Yangtze River as the spatial–temporal axis, linking the four core overlapping nodes of Fengjie, Wushan, Badong, and Xiling, supplemented by three secondary cultural clusters of the red heritage sites in southern Badong, the ancient town along the Daning River in Wushan, and the fortress sites in the Xiling–Yiling area. This research not only reveals the evolutionary path of CH in the Three Gorges region, but also provides a scientific basis for the systematic conservation and differentiated utilization of regional CH. Furthermore, it serves as a planning foundation and strategic reference for planning the Yangtze River National Cultural Park, as well as for the integrated preservation and utilization of river basin CH and linear CH with the aim of coordinated natural and cultural conservation. Full article

The rapid proliferation of electric vehicles (EVs) has introduced significant challenges to the efficient operation of hydrogen-containing integrated energy systems (H-IESs). To cope with these challenges, this paper develops a bi-level optimal scheduling strategy for H-IESs that simultaneously incorporates a ladder-type carbon emission trading mechanism, demand response, and the operational characteristics of EVs. A demand response model is formulated by considering the coupling characteristics of electric and thermal loads. Price-based incentive signals are further designed to coordinate the interactions between the H-IES operator and EV users, enabling flexible resources to actively participate in system scheduling. In the proposed bi-level framework, the upper-level problem aims to minimize the total operating cost of the H-IES, while the lower-level problem seeks to reduce the charging cost of EV users. The resulting bi-level optimization problem is reformulated and solved using the Karush–Kuhn–Tucker (KKT) conditions. Case study results demonstrate that, compared with the single-level benchmark, the proposed bi-level strategy reduces the total operating cost by 34.79% and lowers the EV charging cost by 4.50%. Full article

The coupling of electricity, heat, and hydrogen subsystems together with carbon capture technologies introduces complex operational interactions in modern multi-energy systems. Existing game-based scheduling studies mainly focus on electricity–heat or electricity–heat–gas coupling, often neglecting hydrogen blending, carbon capture integration, and strategic coordination among heterogeneous stakeholders. To address these gaps, this study develops a game-theoretic hierarchical optimization framework for electricity–heat–hydrogen integrated energy systems incorporating carbon capture. Compared with conventional multi-energy game models, the proposed framework integrates hydrogen blending and carbon capture into a unified electricity–heat–hydrogen–carbon coupling structure, enabling coordinated low-carbon operation. A Stackelberg leader–follower structure is adopted, where the upper-level operator determines electricity and heat prices, and lower-level participants optimize generation dispatch and demand response accordingly. The bi-level model is transformed into an equivalent single-level formulation using Karush–Kuhn–Tucker conditions and solved through a hybrid particle swarm optimization–mathematical programming approach. Simulation results based on an extended IEEE 30-bus system demonstrate improved coordination, enhanced scheduling flexibility, and reduced operating costs and carbon emissions. Compared with centralized optimization, the proposed framework enables the integrated energy operator and energy supplier to achieve revenues of 3.18 × 10⁵ CNY and 3.95 × 10⁵ CNY, respectively, while reducing the load aggregator’s cost by 41.71%, confirming its effectiveness for coordinated low-carbon IES scheduling. Full article

This study develops and optimizes a hybrid plant that couples a recompression sCO₂ Brayton cycle to a central-tower particle receiver with a bottoming Organic Rankine Cycle (ORC), including environmental and exergy balances. The two scenarios revealed Pareto points that raised the exergy efficiency to 0.65 in winter and reduced the fuel flow to 15 kg/s. Scenario number two achieves an overall thermal efficiency of 0.50 with total daily emissions of 2520 t CO₂ and 2850 kg NO_x, enabling nearly constant net power. Exergy destruction is concentrated in the high-temperature recuperator (HTR) and ORC turbines (27% each) and the ORC condenser (25%). Compared to a non-optimized baseline, the best solutions increased the ORC and Brayton efficiencies by 6.8–12.66% and 33.4–33.5%, respectively; cut gas-turbine power by 34% and ORC power to 10%; and lowered daily CO₂ and NO_x emissions by 52%. The gains stem from the coordinated adjustments of key levers: lower gas-turbine inlet temperature (about 10%), reduced Brayton mass flow (23%), and tuned ORC turbine inlet pressure. Full article

Renewable hydrogen is increasingly promoted as a key component of sustainable low-emission energy systems; however, its realistic role remains highly dependent on national system conditions. This review examines under what circumstances renewable hydrogen can effectively contribute to Poland’s low-emission energy transition, given its coal-dominated electricity mix, energy-intensive industrial structure, and evolving regulatory environment. The article adopts a system-oriented review approach that integrates recent European Union and national policy developments, including RED III and related delegated acts, with technological pathways, infrastructure readiness, safety considerations, and sectoral demand. Particular attention is given to electricity–hydrogen–industry coupling and the system-level conditions that determine the technical feasibility, efficiency losses, and economic viability of renewable hydrogen deployment. The review demonstrates that renewable hydrogen in Poland is unlikely to become a universal decarbonization solution. Its effective deployment is conditional on accelerated renewable electricity expansion, coordinated development of hydrogen transport and storage infrastructure, and regulatory alignment with EU frameworks. In the short and medium term, the highest system value lies in substituting fossil-based hydrogen in existing industrial applications, while in the longer-term hydrogen may support system flexibility and the decarbonization of hard-to-electrify sectors. Technology-neutral policy approaches may facilitate early market formation but risk reinforcing technology lock-in effects if maintained in the long term. These findings suggest that renewable hydrogen should be positioned as a complementary element of Poland’s low-emission energy system, requiring targeted, system-integrated policy and investment strategies rather than broad, technology-neutral deployment. Full article

In this work, we investigate the shadow properties of the Kerr–Newman–Anti-de Sitter black hole coupled to nonlinear electrodynamics. The shadow is constructed by employing the celestial coordinate approach for an observer located at a finite distance, which is required due to the non-asymptotically flat structure of the spacetime. The size, distortion, area, and oblateness of the shadow are analyzed in terms of the black hole parameters, namely, the spin, the effective charge, and the nonlinearity parameter. We show that the nonlinear electrodynamics significantly modifies the photon region and therefore changes the shadow observables, while the rotation mainly controls the deformation of the silhouette. We further confront the theoretical results with the Event Horizon Telescope observations of M87* and Sgr A* in order to constrain the parameter space of the model. The allowed ranges of the effective charge depend sensitively on the nonlinearity parameter, and the combination of both sources leads to tighter and physically more consistent bounds. In addition, we study the energy emission rate derived from the shadow radius and the Hawking temperature and discuss how it is affected by the rotation and the nonlinear electromagnetic field. Our analysis shows that the considered black hole solution provides a consistent extension of the Kerr geometry in a non-asymptotically flat background and that the shadow observables can be used as an efficient tool to test the effects of nonlinear electrodynamics in strong gravity. Full article

Distributed hydrogen refueling stations enable the coupling of renewable generation, storage, and demand fulfillment; however, their performance depends on coordinated control under strict physical safety limits. Centralized controllers are often impractical due to privacy constraints and unreliable communication links, while unconstrained learning can reduce operating costs at the expense of unsafe pressure excursions. Therefore, this study evaluates safety-constrained coordination across multiple stations using federated learning-based distributed scheduling and benchmarks a non-federated Local Control baseline (local-only, no coordination). Using a feasibility-first rule with an acceptance threshold of $\tau =0.2$ on the pressure violation metric ($V_p\le 0.2$), the best feasible overall controller (Local Control) achieved a cost of 2131.83 with pressure violation $V_p=0.172$, representing a 37.22% reduction relative to a centralized reference cost of 3396.25. Federated training with Federated Averaging and a solar–wind mixing scheme produced the best feasible federated policy (cost 2423.72, $V_p=0.163$) with 866,688 transmitted bytes. Extensive simulations report cost, unmet demand, safety violations, and communication overhead, demonstrating that feasibility-first selection is essential because lower-cost policies can be unsafe (e.g., cost 1952.27 with $V_p=2.63$). Full article

With the increasing penetration of distributed energy resources in power systems, the coupling between transmission and distribution networks has become increasingly complex. How to ensure short-term voltage stability (STVS) and maintain the supply–demand flexibility balance under complex transmission–distribution interactions and uncertain renewable generation has become a key challenge that must be addressed for coordinated transmission–distribution operation. To this end, this paper proposes a transmission–distribution coordinated optimal scheduling strategy that accounts for STVS and the supply–demand flexibility balance. First, the causes of short-term voltage instability were analyzed, and a time-domain simulation model of the power system was developed that incorporates the active voltage support capability of distribution networks. Second, an improved flexibility demand model was established based on the probability-box (p-box) method. Then, economic models for the transmission network and the distribution network were formulated, and a coordinated transmission–distribution operation model was constructed by considering both the short-term voltage instability risk and the supply–demand flexibility imbalance risk. Finally, a test system was built by connecting two modified IEEE 13-node feeders to buses 14 and 13 of the IEEE 14-bus system, and simulation studies were conducted. The results demonstrate that the proposed coordinated scheduling strategy can effectively reduce the risk of short-term voltage instability and ensure flexibility balance across the transmission and distribution networks. Full article