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Review

22 Citations

9,414 Views

14 Pages

Topical Insulin in Neurotrophic Keratopathy: A Review of Current Understanding of the Mechanism of Action and Therapeutic Approach

Marcin Jaworski,
Anna Lorenc,
Rafał Leszczyński and
Ewa Mrukwa-Kominek

Pharmaceutics2024, 16(1), 15;https://doi.org/10.3390/pharmaceutics16010015

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20 December 2023

Neurotrophic keratopathy is a corneal disease characterized by impaired corneal innervation. It can lead to corneal epithelial defects, ulcerations, and perforations. Topical insulin has been shown to be effective in treating this disorder. Insulin i...

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Article

9 Citations

4,936 Views

24 Pages

IGFBP-3 Regulates Mitochondrial Hyperfusion and Metabolic Activity in Ocular Surface Epithelia during Hyperosmolar Stress

Whitney L. Stuard,
Melis K. Guner and
Danielle M. Robertson

Int. J. Mol. Sci.2022, 23(7), 4066;https://doi.org/10.3390/ijms23074066

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6 April 2022

In the eye, hyperosmolarity of the precorneal tear film triggers inflammation and the development of dry eye disease (DED), a highly prevalent condition that causes depression and disability in severe forms. A member of the insulin-like growth factor...

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Article

21 Citations

4,835 Views

17 Pages

Assessment of a New Nanostructured Microemulsion System for Ocular Delivery of Sorafenib to Posterior Segment of the Eye

Manuela Santonocito,
Cristina Zappulla,
Santa Viola,
Luca Rosario La Rosa,
Elena Solfato,
Ilenia Abbate,
Valeria Tarallo,
Ivana Apicella,
Chiara Bianca Maria Platania and
Francesco Giuliano
+ 5 authors

Int. J. Mol. Sci.2021, 22(9), 4404;https://doi.org/10.3390/ijms22094404

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22 April 2021

Eye drop formulations allowing topical treatment of retinal pathologies have long been sought as alternatives to intravitreal administration. This study aimed to assess whether a novel nanostructured microemulsions system (NaMESys) could be usefully...

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