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27 pages, 5228 KiB  
Article
Detection of Surface Defects in Steel Based on Dual-Backbone Network: MBDNet-Attention-YOLO
by Xinyu Wang, Shuhui Ma, Shiting Wu, Zhaoye Li, Jinrong Cao and Peiquan Xu
Sensors 2025, 25(15), 4817; https://doi.org/10.3390/s25154817 - 5 Aug 2025
Abstract
Automated surface defect detection in steel manufacturing is pivotal for ensuring product quality, yet it remains an open challenge owing to the extreme heterogeneity of defect morphologies—ranging from hairline cracks and microscopic pores to elongated scratches and shallow dents. Existing approaches, whether classical [...] Read more.
Automated surface defect detection in steel manufacturing is pivotal for ensuring product quality, yet it remains an open challenge owing to the extreme heterogeneity of defect morphologies—ranging from hairline cracks and microscopic pores to elongated scratches and shallow dents. Existing approaches, whether classical vision pipelines or recent deep-learning paradigms, struggle to simultaneously satisfy the stringent demands of industrial scenarios: high accuracy on sub-millimeter flaws, insensitivity to texture-rich backgrounds, and real-time throughput on resource-constrained hardware. Although contemporary detectors have narrowed the gap, they still exhibit pronounced sensitivity–robustness trade-offs, particularly in the presence of scale-varying defects and cluttered surfaces. To address these limitations, we introduce MBY (MBDNet-Attention-YOLO), a lightweight yet powerful framework that synergistically couples the MBDNet backbone with the YOLO detection head. Specifically, the backbone embeds three novel components: (1) HGStem, a hierarchical stem block that enriches low-level representations while suppressing redundant activations; (2) Dynamic Align Fusion (DAF), an adaptive cross-scale fusion mechanism that dynamically re-weights feature contributions according to defect saliency; and (3) C2f-DWR, a depth-wise residual variant that progressively expands receptive fields without incurring prohibitive computational costs. Building upon this enriched feature hierarchy, the neck employs our proposed MultiSEAM module—a cascaded squeeze-and-excitation attention mechanism operating at multiple granularities—to harmonize fine-grained and semantic cues, thereby amplifying weak defect signals against complex textures. Finally, we integrate the Inner-SIoU loss, which refines the geometric alignment between predicted and ground-truth boxes by jointly optimizing center distance, aspect ratio consistency, and IoU overlap, leading to faster convergence and tighter localization. Extensive experiments on two publicly available steel-defect benchmarks—NEU-DET and PVEL-AD—demonstrate the superiority of MBY. Without bells and whistles, our model achieves 85.8% mAP@0.5 on NEU-DET and 75.9% mAP@0.5 on PVEL-AD, surpassing the best-reported results by significant margins while maintaining real-time inference on an NVIDIA Jetson Xavier. Ablation studies corroborate the complementary roles of each component, underscoring MBY’s robustness across defect scales and surface conditions. These results suggest that MBY strikes an appealing balance between accuracy, efficiency, and deployability, offering a pragmatic solution for next-generation industrial quality-control systems. Full article
(This article belongs to the Section Sensing and Imaging)
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29 pages, 1407 KiB  
Article
Symmetry-Driven Two-Population Collaborative Differential Evolution for Parallel Machine Scheduling in Lace Dyeing with Probabilistic Re-Dyeing Operations
by Jing Wang, Jingsheng Lian, Youpeng Deng, Lang Pan, Huan Xue, Yanming Chen, Debiao Li, Xixing Li and Deming Lei
Symmetry 2025, 17(8), 1243; https://doi.org/10.3390/sym17081243 - 5 Aug 2025
Abstract
In lace textile manufacturing, the dyeing process in parallel machine environments faces challenges from sequence-dependent setup times due to color family transitions, machine eligibility constraints based on weight capacities, and probabilistic re-dyeing operations arising from quality inspection failures, which often lead to increased [...] Read more.
In lace textile manufacturing, the dyeing process in parallel machine environments faces challenges from sequence-dependent setup times due to color family transitions, machine eligibility constraints based on weight capacities, and probabilistic re-dyeing operations arising from quality inspection failures, which often lead to increased tardiness. To tackle this multi-constrained problem, a stochastic integer programming model is formulated to minimize total estimated tardiness. A novel symmetry-driven two-population collaborative differential evolution (TCDE) algorithm is then proposed. It features two symmetrically complementary subpopulations that achieve a balance between global exploration and local exploitation. One subpopulation employs chaotic parameter adaptation through a logistic map for symmetrically enhanced exploration, while the other adjusts parameters based on population diversity and convergence speed to facilitate symmetry-aware exploitation. Moreover, it also incorporates a symmetrical collaborative mechanism that includes the periodic migration of top individuals between subpopulations, along with elite-set guidance, to enhance both population diversity and convergence efficiency. Extensive computational experiments were conducted on 21 small-scale (optimally validated via CVX) and 15 large-scale synthetic datasets, as well as 21 small-scale (similarly validated) and 20 large-scale industrial datasets. These experiments demonstrate that TCDE significantly outperforms state-of-the-art comparative methods. Ablation studies also further verify the critical role of its symmetry-based components, with computational results confirming its superiority in solving the considered problem. Full article
(This article belongs to the Special Issue Meta-Heuristics for Manufacturing Systems Optimization, 3rd Edition)
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18 pages, 2085 KiB  
Article
Static Analysis of Composite Plates with Periodic Curvatures in Material Using Navier Method
by Ozlem Vardar, Zafer Kutug and Ayse Erdolen
Appl. Sci. 2025, 15(15), 8634; https://doi.org/10.3390/app15158634 (registering DOI) - 4 Aug 2025
Abstract
Fiber-reinforced and laminated composite materials, widely used in engineering applications, may develop periodic curvature during manufacturing due to technological requirements. Given such curvatures in widely used composites, static and dynamic analyses of plates and shells under loads, along with related stability issues, have [...] Read more.
Fiber-reinforced and laminated composite materials, widely used in engineering applications, may develop periodic curvature during manufacturing due to technological requirements. Given such curvatures in widely used composites, static and dynamic analyses of plates and shells under loads, along with related stability issues, have been extensively investigated. However, studies focusing specifically on the static analysis of such materials remain limited. Composite materials with structural curvature exhibit complex mechanical behavior, making their analysis particularly challenging. Predicting their mechanical response is crucial in engineering. In response to this need, the present study conducts a static analysis of plates made of periodically curved composite materials using the Navier method. The plate equations were derived based on the Kirchhoff–Love plate theory within the framework of the Continuum Theory proposed by Akbarov and Guz’. Using the Navier method, deflection, stress, and moment distributions were obtained at every point of the plate. Numerical results were computed using MATLAB. After verifying the convergence and accuracy of the developed MATLAB code by comparing it with existing solutions for rectangular homogeneous isotropic and laminated composite plates, results were obtained for periodically curved plates. This study offers valuable insights that may guide future research, as it employs the Navier method to provide an analytical solution framework. This study contributes to the limited literature with a novel evaluation of the static analysis of composite plates with periodic curvature. Full article
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20 pages, 1773 KiB  
Article
Make Acetylcholine Great Again! Australian Skinks Evolved Multiple Neurotoxin-Proof Nicotinic Acetylcholine Receptors in Defiance of Snake Venom
by Uthpala Chandrasekara, Marco Mancuso, Glenn Shea, Lee Jones, Jacek Kwiatkowski, Dane Trembath, Abhinandan Chowdhury, Terry Bertozzi, Michael G. Gardner, Conrad J. Hoskin, Christina N. Zdenek and Bryan G. Fry
Int. J. Mol. Sci. 2025, 26(15), 7510; https://doi.org/10.3390/ijms26157510 (registering DOI) - 4 Aug 2025
Abstract
Many vertebrates have evolved resistance to snake venom as a result of coevolutionary chemical arms races. In Australian skinks (family Scincidae), who often encounter venomous elapid snakes, the frequency, diversity, and molecular basis of venom resistance have been unexplored. This study investigated the [...] Read more.
Many vertebrates have evolved resistance to snake venom as a result of coevolutionary chemical arms races. In Australian skinks (family Scincidae), who often encounter venomous elapid snakes, the frequency, diversity, and molecular basis of venom resistance have been unexplored. This study investigated the evolution of neurotoxin resistance in Australian skinks, focusing on mutations in the muscle nicotinic acetylcholine receptor (nAChR) α1 subunit’s orthosteric site that prevent pathophysiological binding by α-neurotoxins. We sampled a broad taxonomic range of Australian skinks and sequenced the nAChR α1 subunit gene. Key resistance-conferring mutations at the toxin-binding site (N-glycosylation motifs, proline substitutions, arginine insertions, changes in the electrochemical state of the receptor, and novel cysteines) were identified and mapped onto the skink organismal phylogeny. Comparisons with other venom-resistant taxa (amphibians, mammals, and reptiles) were performed, and structural modelling and binding assays were used to evaluate the impact of these mutations. Multiple independent origins of α-neurotoxin resistance were found across diverse skink lineages. Thirteen lineages evolved at least one resistance motif and twelve additional motifs evolved within these lineages, for a total of twenty-five times of α-neurotoxic venoms resistance. These changes sterically or electrostatically inhibit neurotoxin binding. Convergent mutations at the orthosteric site include the introduction of N-linked glycosylation sites previously known from animals as diverse as cobras and mongooses. However, an arginine (R) substitution at position 187 was also shown to have evolved on multiple occasions in Australian skinks, a modification previously shown to be responsible for the Honey Badger’s iconic resistance to cobra venom. Functional testing confirmed this mode of resistance in skinks. Our findings reveal that venom resistance has evolved extensively and convergently in Australian skinks through repeated molecular adaptations of the nAChR in response to the enormous selection pressure exerted by elapid snakes subsequent to their arrival and continent-wide dispersal in Australia. These toxicological findings highlight a remarkable example of convergent evolution across vertebrates and provide insight into the adaptive significance of toxin resistance in snake–lizard ecological interactions. Full article
(This article belongs to the Section Biochemistry)
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23 pages, 4248 KiB  
Article
ASA-PSO-Optimized Elman Neural Network Model for Predicting Mechanical Properties of Coarse-Grained Soils
by Haijuan Wang, Jiang Li, Yufei Zhao and Biao Liu
Processes 2025, 13(8), 2447; https://doi.org/10.3390/pr13082447 - 1 Aug 2025
Viewed by 145
Abstract
Coarse-grained soils serve as essential fill materials in earth–rock dam engineering, where their mechanical properties critically influence dam deformation and stability, directly impacting project safety. Artificial intelligence (AI) techniques are emerging as powerful tools for predicting the mechanical properties of coarse-grained soils. However, [...] Read more.
Coarse-grained soils serve as essential fill materials in earth–rock dam engineering, where their mechanical properties critically influence dam deformation and stability, directly impacting project safety. Artificial intelligence (AI) techniques are emerging as powerful tools for predicting the mechanical properties of coarse-grained soils. However, AI-based prediction models for these properties face persistent challenges, particularly in parameter tuning—a process requiring substantial computational resources, extensive time, and specialized expertise. To address these limitations, this study proposes a novel prediction model that integrates Adaptive Simulated Annealing (ASA) with an improved Particle Swarm Optimization (PSO) algorithm to optimize the Elman Neural Network (ENN). The methodology encompasses three key aspects: First, the standard PSO algorithm is enhanced by dynamically adjusting its inertial weight and learning factors. The ASA algorithm is then employed to optimize the Adaptive PSO (APSO), effectively mitigating premature convergence and local optima entrapment during training, thereby ensuring convergence to the global optimum. Second, the refined PSO algorithm optimizes the ENN, overcoming its inherent limitations of slow convergence and susceptibility to local minima. Finally, validation through real-world engineering case studies demonstrates that the ASA-PSO-optimized ENN model achieves high accuracy in predicting the mechanical properties of coarse-grained soils. This model provides reliable constitutive parameters for stress–strain analysis in earth–rock dam engineering applications. Full article
(This article belongs to the Section Particle Processes)
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21 pages, 670 KiB  
Article
I-fp Convergence in Fuzzy Paranormed Spaces and Its Application to Robust Base-Stock Policies with Triangular Fuzzy Demand
by Muhammed Recai Türkmen and Hasan Öğünmez
Mathematics 2025, 13(15), 2478; https://doi.org/10.3390/math13152478 - 1 Aug 2025
Viewed by 185
Abstract
We introduce I-fp convergence (ideal convergence in fuzzy paranormed spaces) and develop its core theory, including stability results and an equivalence to I*-fp convergence under the AP Property. Building on this foundation, we design an adaptive base-stock policy for a single-echelon [...] Read more.
We introduce I-fp convergence (ideal convergence in fuzzy paranormed spaces) and develop its core theory, including stability results and an equivalence to I*-fp convergence under the AP Property. Building on this foundation, we design an adaptive base-stock policy for a single-echelon inventory system in which weekly demand is expressed as triangular fuzzy numbers while holiday or promotion weeks are treated as ideal-small anomalies. The policy is updated by a simple learning rule that can be implemented in any spreadsheet, requires no optimisation software, and remains insensitive to tuning choices. Extensive simulation confirms that the method simultaneously lowers cost, reduces average inventory and raises service level relative to a crisp benchmark, all while filtering sparse demand spikes in a principled way. These findings position I-fp convergence as a lightweight yet rigorous tool for blending linguistic uncertainty with anomaly-aware decision making in supply-chain analytics. Full article
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18 pages, 3114 KiB  
Article
Heavy Rainfall Induced by Typhoon Yagi-2024 at Hainan and Vietnam, and Dynamical Process
by Venkata Subrahmanyam Mantravadi, Chen Wang, Bryce Chen and Guiting Song
Atmosphere 2025, 16(8), 930; https://doi.org/10.3390/atmos16080930 (registering DOI) - 1 Aug 2025
Viewed by 219
Abstract
Typhoon Yagi (2024) was a rapidly moving storm that lasted for eight days and made landfall in three locations, producing heavy rainfall over Hainan and Vietnam. This study aims to investigate the dynamical processes contributing to the heavy rainfall, concentrating on enthalpy flux [...] Read more.
Typhoon Yagi (2024) was a rapidly moving storm that lasted for eight days and made landfall in three locations, producing heavy rainfall over Hainan and Vietnam. This study aims to investigate the dynamical processes contributing to the heavy rainfall, concentrating on enthalpy flux (EF) and moisture flux (MF). The results indicate that both EF and MF increased significantly during the typhoon’s intensification stage and were high at the time of landfall. Before landfalling at Hainan, latent heat flux (LHF) reached 600 W/m2, while sensible heat flux (SHF) was recorded as 80 W/m2. Landfall at Hainan resulted in a decrease in LHF and SHF. LHF and SHF subsequently increased to 700 W/m2 and 100 W/m2, respectively, as noted prior to the landfall in Vietnam. The increased LHF led to higher evaporation, which subsequently elevated moisture flux (MF) following the landfall in Vietnam, while the region’s topography further intensified the rainfall. The mean daily rainfall observed over Philippines is 75 mm on 2 September (landfall and passing through), 100 mm over Hainan (landfall and passing through) on 6 September, and 95 mm at over Vietnam on 7 September (landfall and after), respectively. Heavy rainfall was observed over the land while the typhoon was passing and during the landfall. This research reveals that Typhoon Yagi’s intensity was maintained by a well-organized and extensive circulation system, supported by favorable weather conditions, including high sea surface temperatures (SST) exceeding 30.5 °C, substantial low-level moisture convergence, and elevated EF during the landfall in Vietnam. Full article
(This article belongs to the Section Meteorology)
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21 pages, 2965 KiB  
Article
Inspection Method Enabled by Lightweight Self-Attention for Multi-Fault Detection in Photovoltaic Modules
by Shufeng Meng and Tianxu Xu
Electronics 2025, 14(15), 3019; https://doi.org/10.3390/electronics14153019 - 29 Jul 2025
Viewed by 237
Abstract
Bird-dropping fouling and hotspot anomalies remain the most prevalent and detrimental defects in utility-scale photovoltaic (PV) plants; their co-occurrence on a single module markedly curbs energy yield and accelerates irreversible cell degradation. However, markedly disparate visual–thermal signatures of the two phenomena impede high-fidelity [...] Read more.
Bird-dropping fouling and hotspot anomalies remain the most prevalent and detrimental defects in utility-scale photovoltaic (PV) plants; their co-occurrence on a single module markedly curbs energy yield and accelerates irreversible cell degradation. However, markedly disparate visual–thermal signatures of the two phenomena impede high-fidelity concurrent detection in existing robotic inspection systems, while stringent onboard compute budgets also preclude the adoption of bulky detectors. To resolve this accuracy–efficiency trade-off for dual-defect detection, we present YOLOv8-SG, a lightweight yet powerful framework engineered for mobile PV inspectors. First, a rigorously curated multi-modal dataset—RGB for stains and long-wave infrared for hotspots—is assembled to enforce robust cross-domain representation learning. Second, the HSV color space is leveraged to disentangle chromatic and luminance cues, thereby stabilizing appearance variations across sensors. Third, a single-head self-attention (SHSA) block is embedded in the backbone to harvest long-range dependencies at negligible parameter cost, while a global context (GC) module is grafted onto the detection head to amplify fine-grained semantic cues. Finally, an auxiliary bounding box refinement term is appended to the loss to hasten convergence and tighten localization. Extensive field experiments demonstrate that YOLOv8-SG attains 86.8% mAP@0.5, surpassing the vanilla YOLOv8 by 2.7 pp while trimming 12.6% of parameters (18.8 MB). Grad-CAM saliency maps corroborate that the model’s attention consistently coincides with defect regions, underscoring its interpretability. The proposed method, therefore, furnishes PV operators with a practical low-latency solution for concurrent bird-dropping and hotspot surveillance. Full article
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22 pages, 2678 KiB  
Article
Federated Semi-Supervised Learning with Uniform Random and Lattice-Based Client Sampling
by Mei Zhang and Feng Yang
Entropy 2025, 27(8), 804; https://doi.org/10.3390/e27080804 - 28 Jul 2025
Viewed by 204
Abstract
Federated semi-supervised learning (Fed-SSL) has emerged as a powerful framework that leverages both labeled and unlabeled data distributed across clients. To reduce communication overhead, real-world deployments often adopt partial client participation, where only a subset of clients is selected in each round. However, [...] Read more.
Federated semi-supervised learning (Fed-SSL) has emerged as a powerful framework that leverages both labeled and unlabeled data distributed across clients. To reduce communication overhead, real-world deployments often adopt partial client participation, where only a subset of clients is selected in each round. However, under non-i.i.d. data distributions, the choice of client sampling strategy becomes critical, as it significantly affects training stability and final model performance. To address this challenge, we propose a novel federated averaging semi-supervised learning algorithm, called FedAvg-SSL, that considers two sampling approaches, uniform random sampling (standard Monte Carlo) and a structured lattice-based sampling, inspired by quasi-Monte Carlo (QMC) techniques, which ensures more balanced client participation through structured deterministic selection. On the client side, each selected participant alternates between updating the global model and refining the pseudo-label model using local data. We provide a rigorous convergence analysis, showing that FedAvg-SSL achieves a sublinear convergence rate with linear speedup. Extensive experiments not only validate our theoretical findings but also demonstrate the advantages of lattice-based sampling in federated learning, offering insights into the interplay among algorithm performance, client participation rates, local update steps, and sampling strategies. Full article
(This article belongs to the Special Issue Number Theoretic Methods in Statistics: Theory and Applications)
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14 pages, 1576 KiB  
Systematic Review
An Activation Likelihood Estimation Meta-Analysis of How Language Balance Impacts the Neural Basis of Bilingual Language Control
by Tao Wang, Keyi Yin, Qi Zhou, Haibo Hu, Shengdong Chen and Man Wang
Brain Sci. 2025, 15(8), 803; https://doi.org/10.3390/brainsci15080803 - 28 Jul 2025
Viewed by 267
Abstract
Background: Neurological networks involved in bilingual language control have been extensively investigated. Among the factors that influence bilingual language control, language balance has recently been proposed as a critical one. Nevertheless, it remains understudied how the neural basis of bilingual language control is [...] Read more.
Background: Neurological networks involved in bilingual language control have been extensively investigated. Among the factors that influence bilingual language control, language balance has recently been proposed as a critical one. Nevertheless, it remains understudied how the neural basis of bilingual language control is affected by language balance. Methods: To address this gap, we conducted a meta-analysis of functional magnetic resonance imaging (fMRI) studies on bilingual language control using Ginger ALE, with language balance as a moderating factor. Results: Conjunction analyses revealed a domain-general pattern of neural activities shared by balanced and unbalanced bilinguals, with convergent activation observed in the left precentral gyrus and left medial frontal gyrus. Regarding domain-specificity, contrast analyses did not identify stronger activation convergence in balanced bilinguals compared to unbalanced bilinguals. However, unbalanced bilinguals exhibited significantly stronger convergence of activation in the left middle frontal gyrus, left inferior frontal gyrus, and left precuneus. Conclusions: These findings suggest that language balance can modify the neural mechanisms of bilingual language control, with unbalanced bilinguals relying on more domain-general cognitive control resources during bilingual language control. Full article
(This article belongs to the Section Neurolinguistics)
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31 pages, 2944 KiB  
Systematic Review
Mapping the Landscape of Sustainability Reporting: A Bibliometric Analysis Across ESG, Circular Economy, and Integrated Reporting with Sectoral Perspectives
by Radosveta Krasteva-Hristova, Diana Papradanova and Ventsislav Vechev
J. Risk Financial Manag. 2025, 18(8), 416; https://doi.org/10.3390/jrfm18080416 - 28 Jul 2025
Viewed by 408
Abstract
Sustainability reporting has evolved into a multidimensional field encompassing Environmental, Social, and Governance (ESG) disclosure, integrated reporting (IR), and circular economy (CE) practices. This study aims to map the intellectual and thematic landscape of sustainability reporting research over the past decade, with a [...] Read more.
Sustainability reporting has evolved into a multidimensional field encompassing Environmental, Social, and Governance (ESG) disclosure, integrated reporting (IR), and circular economy (CE) practices. This study aims to map the intellectual and thematic landscape of sustainability reporting research over the past decade, with a focus on sectoral differentiation. Drawing on bibliometric analysis of 1611 scientific articles indexed in Scopus, this research applies co-word analysis, thematic mapping, and bibliographic coupling to identify prevailing trends, conceptual clusters, and knowledge gaps. The results reveal a clear progression from fragmented debates toward a more integrated discourse combining ESG, IR, and CE frameworks. In the real economy, sustainability reporting demonstrates a mature operational focus, supported by standardized frameworks and extensive empirical evidence. In contrast, the banking sector exhibits emerging engagement with sustainability disclosure, while the public sector remains at an earlier stage of conceptual and practical development. Despite the increasing convergence of research streams, gaps persist in linking reporting practices to tangible sustainability outcomes, integrating digital innovations, and addressing social dimensions of circularity. This study concludes that further interdisciplinary and sector-specific research is essential to advance credible, comparable, and decision-useful reporting practices capable of supporting the transition toward sustainable and circular business models. Full article
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33 pages, 1777 KiB  
Review
Immunomodulatory Natural Products in Cancer Organoid-Immune Co-Cultures: Bridging the Research Gap for Precision Immunotherapy
by Chang-Eui Hong and Su-Yun Lyu
Int. J. Mol. Sci. 2025, 26(15), 7247; https://doi.org/10.3390/ijms26157247 - 26 Jul 2025
Viewed by 587
Abstract
Natural products demonstrate potent immunomodulatory properties through checkpoint modulation, macrophage polarization, and T cell/natural killer (NK) cell activation. While cancer organoid-immune co-culture platforms enable physiologically relevant modeling of tumor–immune interactions, systematic investigation of natural product immunomodulation in these systems remains entirely unexplored. We [...] Read more.
Natural products demonstrate potent immunomodulatory properties through checkpoint modulation, macrophage polarization, and T cell/natural killer (NK) cell activation. While cancer organoid-immune co-culture platforms enable physiologically relevant modeling of tumor–immune interactions, systematic investigation of natural product immunomodulation in these systems remains entirely unexplored. We conducted a comprehensive literature analysis examining natural products tested in cancer organoids, immunomodulatory mechanisms from traditional models, technical advances in organoid-immune co-cultures, and standardization requirements for clinical translation. Our analysis reveals a critical research gap: no published studies have investigated natural product-mediated immunomodulation using organoid-immune co-culture systems. Even though compounds like curcumin, resveratrol, and medicinal mushroom polysaccharides show extensive immunomodulatory effects in two-dimensional (2D) cultures, and organoid technology achieves high clinical correlation for drug response prediction, all existing organoid studies focus exclusively on direct cytotoxicity. Technical challenges include compound stability, limited matrix penetration requiring substantially higher concentrations than 2D cultures, and maintaining functional immune populations in three-dimensional (3D) systems. The convergence of validated organoid-immune co-culture platforms, Food and Drug Administration (FDA) regulatory support through the Modernization Act 2.0, and extensive natural product knowledge creates unprecedented opportunities. Priority research directions include systematic screening of immunomodulatory natural products in organoid-immune co-cultures, development of 3D-optimized delivery systems, and clinical validation trials. Success requires moving beyond cytotoxicity-focused studies to investigate immunomodulatory mechanisms in physiologically relevant 3D systems, potentially unlocking new precision cancer immunotherapy approaches. Full article
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35 pages, 1334 KiB  
Article
Advanced Optimization of Flowshop Scheduling with Maintenance, Learning and Deteriorating Effects Leveraging Surrogate Modeling Approaches
by Nesrine Touafek, Fatima Benbouzid-Si Tayeb, Asma Ladj and Riyadh Baghdadi
Mathematics 2025, 13(15), 2381; https://doi.org/10.3390/math13152381 - 24 Jul 2025
Viewed by 240
Abstract
Metaheuristics are powerful optimization techniques that are well-suited for addressing complex combinatorial problems across diverse scientific and industrial domains. However, their application to computationally expensive problems remains challenging due to the high cost and significant number of fitness evaluations required during the search [...] Read more.
Metaheuristics are powerful optimization techniques that are well-suited for addressing complex combinatorial problems across diverse scientific and industrial domains. However, their application to computationally expensive problems remains challenging due to the high cost and significant number of fitness evaluations required during the search process. Surrogate modeling has recently emerged as an effective solution to reduce these computational demands by approximating the true, time-intensive fitness function. While surrogate-assisted metaheuristics have gained attention in recent years, their application to complex scheduling problems such as the Permutation Flowshop Scheduling Problem (PFSP) under learning, deterioration, and maintenance effects remains largely unexplored. To the best of our knowledge, this study is the first to investigate the integration of surrogate modeling within the artificial bee colony (ABC) framework specifically tailored to this problem context. We develop and evaluate two distinct strategies for integrating surrogate modeling into the optimization process, leveraging the ABC algorithm. The first strategy uses a Kriging model to dynamically guide the selection of the most effective search operator at each stage of the employed bee phase. The second strategy introduces three variants, each incorporating a Q-learning-based operator in the selection mechanism and a different evolution control mechanism, where the Kriging model is employed to approximate the fitness of generated offspring. Through extensive computational experiments and performance analysis, using Taillard’s well-known standard benchmarks, we assess solution quality, convergence, and the number of exact fitness evaluations, demonstrating that these approaches achieve competitive results. Full article
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25 pages, 1169 KiB  
Article
DPAO-PFL: Dynamic Parameter-Aware Optimization via Continual Learning for Personalized Federated Learning
by Jialu Tang, Yali Gao, Xiaoyong Li and Jia Jia
Electronics 2025, 14(15), 2945; https://doi.org/10.3390/electronics14152945 - 23 Jul 2025
Viewed by 214
Abstract
Federated learning (FL) enables multiple participants to collaboratively train models while efficiently mitigating the issue of data silos. However, large-scale heterogeneous data distributions result in inconsistent client objectives and catastrophic forgetting, leading to model bias and slow convergence. To address the challenges under [...] Read more.
Federated learning (FL) enables multiple participants to collaboratively train models while efficiently mitigating the issue of data silos. However, large-scale heterogeneous data distributions result in inconsistent client objectives and catastrophic forgetting, leading to model bias and slow convergence. To address the challenges under non-independent and identically distributed (non-IID) data, we propose DPAO-PFL, a Dynamic Parameter-Aware Optimization framework that leverages continual learning principles to improve Personalized Federated Learning under non-IID conditions. We decomposed the parameters into two components: local personalized parameters tailored to client characteristics, and global shared parameters that capture the accumulated marginal effects of parameter updates over historical rounds. Specifically, we leverage the Fisher information matrix to estimate parameter importance online, integrate the path sensitivity scores within a time-series sliding window to construct a dynamic regularization term, and adaptively adjust the constraint strength to mitigate the conflict overall tasks. We evaluate the effectiveness of DPAO-PFL through extensive experiments on several benchmarks under IID and non-IID data distributions. Comprehensive experimental results indicate that DPAO-PFL outperforms baselines with improvements from 5.41% to 30.42% in average classification accuracy. By decoupling model parameters and incorporating an adaptive regularization mechanism, DPAO-PFL effectively balances generalization and personalization. Furthermore, DPAO-PFL exhibits superior performance in convergence and collaborative optimization compared to state-of-the-art FL methods. Full article
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14 pages, 4599 KiB  
Article
Predictive Flood Uncertainty Associated with the Overtopping Rates of Vertical Seawall on Coral Reef Topography
by Hongqian Zhang, Bin Lu, Yumei Geng and Ye Liu
Water 2025, 17(15), 2186; https://doi.org/10.3390/w17152186 - 22 Jul 2025
Viewed by 210
Abstract
Accurate prediction of wave overtopping rates is essential for flood risk assessment along coral reef coastlines. This study quantifies the uncertainty sources affecting overtopping rates for vertical seawalls on reef flats, using ensemble simulations with a validated non-hydrostatic SWASH model. By generating extensive [...] Read more.
Accurate prediction of wave overtopping rates is essential for flood risk assessment along coral reef coastlines. This study quantifies the uncertainty sources affecting overtopping rates for vertical seawalls on reef flats, using ensemble simulations with a validated non-hydrostatic SWASH model. By generating extensive random wave sequences, we identify spectral resolution, wave spectral width, and wave groupiness as the dominant controls on the uncertainty. Statistical metrics, including the Coefficient of Variation (CV) and Range Uncertainty Level (RUL), demonstrate that overtopping rates exhibit substantial variability under randomized wave conditions, with CV exceeding 40% for low spectral resolutions (50–100 bins), while achieving statistical convergence (CV around 20%) requires at least 700 frequency bins, far surpassing conventional standards. The RUL, which describes the ratio of extreme to minimal overtopping rates, also decreases markedly as the number of frequency bins increases from 50 to 700. It is found that the overtopping rate follows a normal distribution with 700 frequency bins in wave generation. Simulations further demonstrate that overtopping rates increase by a factor of 2–4 as the JONSWAP spectrum peak enhancement factor (γ) increases from 1 to 7. The wave groupiness factor (GF) emerges as a predictor of overtopping variability, enabling a more efficient experimental design through reduction in groupiness-guided replication. These findings establish practical thresholds for experimental design and highlight the critical role of spectral parameters in hazard assessment. Full article
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