Search Results (1,353)

Sustainable xanthan gum (XG) production is increasingly prioritized as global demand rises, and conventional processes face economic and environmental constraints. Traditional manufacturing depends heavily on refined sugars, intensive fermentation control, and solvent-based purification, which elevate production costs and ecological impact. This review highlights recent advancements designed to improve sustainability across the XG value chain, focusing on alternative substrates, optimized fermentation, and greener extraction methods. Agricultural residues, food-processing waste, lignocellulosic biomass, and industrial effluents have emerged as promising low-cost substrates that reduce reliance on refined sugar sources while supporting waste valorization. Pretreatment strategies, such as acid hydrolysis, enzymatic processing, and integrated biological–chemical methods, significantly enhance the accessibility of complex biomass for microbial fermentation. Concurrently, improvements in strain selection, metabolic engineering, and process control have increased XG yield, molecular weight, and rheological performance. Environmentally friendly extraction technologies, including ultrasound-assisted extraction, pulsed electric fields, membrane filtration, and electro-dewatering, further reduce solvent consumption and energy demand in downstream processing. However, challenges persist, including substrate variability, formation of inhibitory compounds, strain instability, and regulatory considerations for waste-derived substrates or genetically modified strains. Future progress will rely on integrating bioprocess intensification, genetic engineering, and techno-economic assessment to build scalable, low-impact, and circular XG production systems. Full article

The electric vehicle revolution has created an urgent need for lithium-ion battery (LIB) recycling, with projections exceeding 11 million tons of end-of-life batteries annually by 2030. However, progress toward a circular economy remains fragmented. This perspective article introduces the concept of a ‘Recycling Trilemma,’ arguing that technological advancements in material separation are systematically undermined by economic volatility and regulatory fragmentation. While current literature focuses on isolated domains—chemistry, business models, or policy—this work provides a systems-level synthesis. By analyzing the friction points between material science (e.g., binder removal, impurity sensitivity), economic realities (e.g., logistics costs, LFP profitability), and regulatory frameworks (e.g., EU vs. US divergence), we propose that true circularity requires synchronized design-for-recycling, market stabilization mechanisms, and harmonized digital product passports. The paper concludes that overcoming the trilemma demands a shift from isolated fixes to integrated, cross-sectoral coordination. Full article

To address the mounting environmental burden caused by solid waste from the food supply chain—specifically agricultural residues and plastic packaging—this study systematically investigated the synergistic mechanisms and product regulation pathways in the co-pyrolysis of four representative food processing by-products—rice husk, pine wood, corn stover, and chestnut shell—with polypropylene, a common food packaging material. A comprehensive methodology integrating thermogravimetric analysis, kinetic modeling, and product characterization was employed. The results demonstrate that incorporating polypropylene into co-pyrolysis systems, such as those involving waste oil, significantly reduces the average activation energy, indicating a catalytic effect that enhances reaction kinetics. Notably, the co-catalytic interaction between corn stover and PP led to a substantial 54.90% reduction in oxygen content, underscoring PP’s role as an effective hydrogen donor that promotes deoxygenation and free radical reactions, thereby increasing hydrocarbon production. At an optimal pyrolysis temperature of 600 °C, product distribution was effectively regulated: the hydrocarbon yield in the CP (corn stover/PP) system increased from 39.8% to a maximum of 65.6%, reflecting a targeted conversion of oxygenated compounds into high-value hydrocarbons. Furthermore, greenhouse gas (GHG) emission calculation and techno-economic analyses indicate that a natural gas-assisted co-pyrolysis process (Scenario C) can generate a net daily profit of 1835 RMB while reducing annual CO₂ emissions by 6515 tons, demonstrating both economic feasibility and environmental benefits. This study provides a theoretical foundation for the circular economy in the food industry, offering a viable technical pathway for the simultaneous treatment of organic food waste and packaging plastics, thereby supporting the sustainable development of the agri-food sector. Full article

Background: Trastuzumab is a blockbuster monoclonal antibody that has revolutionized the treatment of HER2-positive breast and gastric cancers. With the increasing availability of biosimilar monoclonal antibodies in clinical practice, independent verification of biosimilarity using products sampled from a real-world supply chain is important to assure clinicians and the patients to use these products confidently. Objective: The aim of this study is to assess the biosimilarity of AryoTrust, a trastuzumab biosimilar, in comparison with the reference product Herceptin. AryoTrust and Herceptin products were randomly withdrawn from Iraqi hospitals to reflect medicines administered in real clinical settings. Methods: AryoTrust and Herceptin were compared using an extensive set of orthogonal analytical techniques which included SDS-PAGE, ion-exchange chromatography, capillary isoelectric focusing, peptide mapping, N-glycan profiling, circular dichroism, differential scanning calorimetry, and surface plasmon resonance. In addition to these teste, functional comparability was also tested using an HER2-dependent cell-based proliferation inhibition bioassay. Results: The results showed that both products have highly comparable profiles in all assessed attributes. The analysis showed similar molecular integrity and purity, identical primary structure, comparable charge heterogeneity, similar isoelectric points (pI) of the main isoform, close glycosylation patterns (mainly, by core-fucosylated complex-type glycans), similar higher-order structural features, and thermal stability. The receptor binding studies exhibited comparable binding affinities with Fcγ receptors and FcRn. Finally, the cell-based bioassay revealed comparable dose–response curves with similar EC₅₀ values and relative potency. Conclusions: The integrated analytical and functional data support the biosimilarity of AryoTrust to the reference product Herceptin, which has been marketed and used in Iraq. This study provides real-world scientific evidence supporting confidence in the quality and comparability of this trastuzumab biosimilar and reduces any doubt in the product and at the same time emphasizes the value of independent post-marketing biosimilarity assessments. Full article

The agri-food sector is undergoing a profound transformation driven by the combined pressures of climate change, resource scarcity, policy frameworks, and evolving consumer expectations. In this context, digital and green technologies have emerged as key enablers of more sustainable, transparent, and resilient food systems. This review provides a comprehensive overview of the conceptual foundations, technological drivers, and policy frameworks shaping the digital and green transition of the agri-food sector. Digital technologies—including precision agriculture, sensing and data acquisition systems, artificial intelligence, blockchain, and data platforms—are examined in relation to their role in improving resource-use efficiency, traceability, and decision-making across the food value chain. In parallel, green technologies and sustainable practices in food production, processing, and waste management are discussed, with emphasis on resource optimization, circular economy approaches, and environmental impact reduction. This review further highlights the role of European and global policy frameworks, such as the European Green Deal and the Farm to Fork strategy, in steering technological adoption and aligning innovation with sustainability objectives. By synthesizing technological, environmental, and policy perspectives, this work underscores the importance of integrated digital–green strategies for achieving long-term sustainability, competitiveness, and resilience in agri-food systems. Full article

To mitigate environmental plastic accumulation and close the loop on plastic, the development of biodegradable plastics has presented a promising prospect for overcoming the global plastic pollution issue. However, it is critical to examine not only their benefits but also their unintended ecological consequences, especially for smaller-sized biodegradable nanoplastics. Our work highlights the often-overlooked risks associated with biodegradable nanoplastics. Due to the lack of environmental in situ monitoring data, the global occurrence, fate, and ecological risk of biodegradable nanoplastics remain poorly understood. Likewise, it remains unclear and questionable whether nanoplastics are eco-friendly as a promising alternative to the circular and sustainable plastic economy. We, therefore, call for a coordinated global effort to proactively mitigate the potential risks of biodegradable nanoplastics, including establishing a full-chain risk assessment system, developing key detection and simulation technologies, designing and optimizing bioplastic structures, and improving the legal supervision mechanism. These holistic efforts will facilitate the development of a sustainable practice for the closed-loop recycling of biodegradable plastics, which simultaneously helps establish a sustainable biodegradable plastic circular economy. Full article

Indonesia, as a major global textile exporter, faces substantial sustainability challenges due to its linear production model, which generates massive volumes of post-industrial polyester waste (PIPW). However, reliable data and recycling pathways remain critically lacking. This study quantifies the volume, composition, and textile-to-textile (T2T) recyclability potential of PIPW across Indonesia’s national textile and clothing production chain, employing a mixed-methods approach that integrates material flow analysis (MFA), site visits, and stakeholder interviews. The results indicate that 572 kilotonnes of PIPW were generated in 2023, with garment manufacturing identified as the most waste-intensive. Nineteen waste types were identified; 61% comprise fibre blends, which significantly constrain closed-loop recycling. A novel five-tier waste typology was developed to classify waste streams based on material characteristics, technological availability, and economic feasibility. The circularity map reveals that Indonesia is trapped in pseudo-circularity. Scenario analysis suggests that up to 184 kilotonnes of PIPW could be feasibly redirected towards higher-value chemical recycling. The research recommends mandatory source segregation, fiscal incentives, investment in chemical recycling infrastructure, and the integration of circular design into national standards. The study provides the first national-level MFA of PIPW in Indonesia and establishes an empirical baseline to advance T2T recycling in emerging economies. Full article

The circular economy (CE) has emerged as a central policy framework for advancing sustainable urban development; however, empirical evidence regarding the role of micro, small, and medium-sized enterprises (MSMEs) in metropolitan CE transitions remains limited, particularly in arid regions. This study examines how private sector firms and MSMEs engage with CE practices within an arid metropolitan context, using the Dammam Metropolitan Area (Saudi Arabia) as an illustrative case study. Adopting a place-based and governance-sensitive analytical perspective grounded in urban studies scholarship, the research employs a structured quantitative survey of 180 firms across key urban–industrial sectors. The analysis investigates levels of CE awareness, adoption patterns, perceived barriers, support needs, and future expectations. The findings indicate that MSMEs primarily engage in resource-based and efficiency-oriented circular practices, while more systemic models, such as supply-chain integration and platform-based circular solutions, remain limited. Moreover, capability-related factors, particularly skills and technological capacity, exert a stronger influence on adoption than awareness alone. Importantly, the study identifies a high level of latent willingness among MSMEs to invest in circular practices under supportive policy and institutional conditions. The discussion reframes CE transitions as governance-mediated urban development processes, emphasizing the importance of metropolitan coordination, institutional capacity-building, and shared spatial infrastructure. By grounding the analysis in the case of the Dammam Metropolitan Area, the study contributes to urban studies and CE scholarship by positioning MSMEs as conditionally willing system-building actors whose engagement is essential for advancing inclusive and place-sensitive circular transitions in arid metropolitan regions. Full article

The transition towards a circular bioeconomy in developing regions is frequently hindered by operational failures caused by feedstock discontinuity. Whilst biochemical potential is traditionally the primary selection criterion, this study postulates that logistic reliability serves as the governing constraint. To validate this strategic reorientation, a decision-making framework was developed and applied to a representative tropical agro-industrial region. A sensitivity analysis comparing objective, subjective and neutral weighting scenarios identified annual residue production as the dominant factor. Results established cattle manure as the universal baseload substrate essential for mitigating seasonality, outweighing higher-yielding but intermittent agricultural residues. Spatial analysis revealed distinct territorial vocations, identifying a high-availability rice–livestock cluster in the south suitable for centralised industrial plants and dispersed cassava–livestock nodes in the centre favourable for decentralised digestion. Furthermore, the assessment of energy autonomy demonstrated that the prioritised co-digestion scenarios could cover local residential electricity demand between 1.5 times and 81 times. Crucially, residues favoured by expert judgement proved logistically unfeasible despite superior theoretical yields. This data-driven approach demonstrates that successful substrate selection must transcend theoretical yield maximisation to prioritise supply chain reliability, providing a robust roadmap for de-risking bioenergy investments and ensuring regional energy autonomy. Full article

The widespread use of synthetic pesticides has ensured crop productivity but has also raised serious environmental and human health concerns, including water contamination, biodiversity loss, and intoxication risks. In this context, global strategies for sustainable agriculture, safer alternatives are urgently needed. This systematic review, conducted in accordance with PRISMA guidelines, examines the potential of agri-food by-products as sources of bioactive compounds for biopesticide development within a circular economy framework. Residues from major agri-food chains, including the olive, potato, banana, citrus, and winery industries, were systematically analyzed with respect to their phytochemical composition, such as phenolics, flavonoids, terpenoids, fatty acids, and essential oils, and their reported bioactivity against insects, weeds, fungi, bacteria, and nematodes. The mechanisms of action, technological recovery strategies, and formulation challenges are critically discussed. Additionally, regulatory challenges and opportunities in the European and U.S. markets are described together with the role of Industry 4.0 technologies in optimizing recovery processes and product development. By promoting biopesticides from agri-food biowaste, this approach contributes to sustainable production (SDG 12), innovation in industrial processes (SDG 9), and the protection of terrestrial and aquatic ecosystems (SDGs 14 and 15), positioning food industry residues as a strategic resource for green crop protection. Full article

Lithium is a critical mineral for traction batteries and a cornerstone of the sustainable transition toward low-carbon transportation. Understanding the supply–demand dynamics and resource-saving potential of lithium is essential for advancing circular economy goals and ensuring the long-term stability of the electric vehicle (EV) industry. This study develops an integrated lithium forecast framework by coupling a System Dynamics (SD) model with dynamic Material Flow Analysis (MFA) and multi-scenario pathways. To ensure robust conclusions, the model is validated against historical data, and a multi-level sensitivity analysis is conducted to address the inherent uncertainties of evolving socio-technical assumptions over a ten-year horizon. The simulation results reveal that under the baseline scenario, China’s EV stocks and annual lithium demand will grow by 8.3 and 4.7 times from 2024 to 2035, respectively. This rapid expansion poses a significant sustainability challenge, as cumulative demand will deplete 50–71% of China’s domestic lithium reserves by 2035. Despite a projected supply–demand gap of 110–120 kt/yr, the study identifies critical pathways for resource decoupling and circularity. Technology-driven interventions, such as enhancing energy density and extending battery lifespan, can reduce primary lithium demand by up to 18.9%. Furthermore, optimizing the closed-loop recycling system can contract the supply–demand gap by 31–39%, demonstrating the pivotal role of secondary resource recovery in building a resilient supply chain. Despite this reduction, a persistent reliance on international markets remains inevitable. These findings provide a quantified scientific foundation for policymakers, emphasizing that lithium security requires a synergistic transition from volume-based subsidies to resource efficiency mandates and standardized, formal closed-loop recycling systems. Full article

The artisanal harvesting of Anadara mazatlanica is of fundamental importance to the sociocultural identity and economic livelihood of the coastal communities located in the San Ignacio–Navachiste–Macapule (SINM) lagoon system in Mexico; its conservation depends on the sustainable use of the species and its habitat, which is considered vulnerable to multiple socioeconomic and environmental pressures. The circular economy (CE) emerges as a potential approach to integrate resource exploitation, waste reduction, and community-oriented conservation management. This study analyzed the perceptions of A. mazatlanica harvesters, covering social, economic, environmental, and recycling dimensions (theoretical approach) and corroborated by exploratory factor analysis, thereby identifying the main challenges and areas of opportunity for the transition to sustainable development models. A quantitative (exploratory–descriptive) approach was used, employing a structured questionnaire that included a sociodemographic section and 23 items on a Likert scale. The findings revealed a high sociocultural appreciation of artisanal fishing and community cohesion ($\overline{\mathrm{x}}$ = 4.55). In contrast, economic perceptions showed a moderately negative level ($\overline{\mathrm{x}}$ = 2.48), indicating a dependence on intermediaries, limited added value, and institutional support. The CE dimension ($\overline{\mathrm{x}}$ = 1.55) suggested an underutilization of shells. In addition, the mean value of 3.44 for environmental perceptions highlighted awareness of ecosystem deterioration and regulatory deficiencies. These results highlight the need to enhance fisheries governance, diversify value chains, and integrate circular innovations to ensure the sustainability of this fishery. Full article

With the rapid and exponential expansion of the lithium-ion battery (LIB) market, a new regulatory framework has been introduced, centered on the implementation of a Battery Passport (BP) to enhance transparency, traceability, and sustainability across the battery value chain. This review aims to provide the context in which the BP is being implemented by discussing the reliance of LIBs on critical raw materials (CRMs), as well as the related economic and regulatory aspects of the BP system. Furthermore, it examines ongoing BP initiatives and pilot projects and discusses the challenges and opportunities associated with this tool, highlighting its central role in enabling a circular LIB economy in Europe. A critical analysis from a research-oriented perspective is also provided. Full article

This paper presents a mathematical programming model to optimize the design and sustainability performance of the urban food–energy–water (FEW) nexus. The model incorporates a micro supply chain and addresses the supply-demand balance within existing and future FEW systems using performance indicators such as cost and carbon footprint. The problem allows for optimal discrete choices, such as investment in new assets, as well as continuous choices, including capacity of different units and produce exchange among urban farms. The model is applied to an urban agriculture network in South Florida that integrates renewable energy technologies (solar, wind, biomass), combined heat and power (CHP) units, reclaimed wastewater and stormwater for irrigation, and electric vehicles for produce transport. The optimization process identifies the most effective infrastructure investment decisions, resource allocation, and technology configurations to support circular economy practices and long-term sustainability objectives. The proposed framework enables reductions in carbon footprints, food waste, and improves food accessibility in food deserts and strengthens collaboration among urban farms. It supports the planning of resilient urban FEW systems by aligning resource use with social, economic and environmental sustainability objectives. The results provide a decision-support tool for urban planners and policymakers, offering practical insights to guide infrastructure investment and sustainability planning in other geographic regions. Full article

The transition to a circular economy is a strategic direction of the European Union, and the agri-food sector is essential in this transformation through resource consumption, climate impact and an economic role in the food chain. This study analyses the relationship between the circularity of the economy and the sustainable performance of agri-food systems in the EU-27, using Eurostat data for the period of 2014–2023. Circularity is operationalised through a composite index built from the circularity of materials and resource productivity, aggregated through principal component analysis and complemented by an alternative measure based on the average of the standardised components. Sustainable performance is assessed through economic indicators (value added and output in agriculture, value added in the food industry), environmental indicators (greenhouse gas emissions from agriculture) and, complementary, energy indicators (energy intensity in the food industry), the latter being analysed separately on the available observations. The results do not indicate clear aggregate differences in sustainable performance associated with circularity measured at the macro level over the analysed period, underlining the importance of connecting circularity objectives with interventions and indications specific to the agri-food chain for monitoring and policy design at the EU level. Full article