Search Results (1,703)

Background/Objectives: Oral candidiasis is an infection of the oral cavity caused by Candida albicans. Mucoadhesive buccal films could adhere to the buccal mucosa for prolonged periods, improving the therapeutic outcomes of patients with oral candidiasis. This study aimed to develop and evaluate the properties of fluconazole containing sodium alginate/methylcellulose-based buccal films for potential treatment of oral candidiasis. Methods: Drug-polymer compatibility was investigated using FT-IR spectrophotometry. Three optimised fluconazole films (F1 to F3) containing 1–1.6% sodium alginate and methylcellulose (1.6%) were formulated using the solvent-casting method. Their physicomechanical properties were characterised using standard protocols. Drug content and in vitro drug release profiles were evaluated using UV-visible spectroscopy; in vitro/ex vivo mucoadhesion studies were conducted using the shaking water bath technique, and their antifungal activity against Candida albicans was evaluated using the agar ditch method. Results: FT-IR data analysis revealed that sodium alginate, methylcellulose and fluconazole were compatible in the films. The films were off-white, smooth, peelable, thin, with satisfactory pH values, folding endurance, drug content, excellent zones of inhibition against Candida albicans (40 mm), controlled drug release profile (3.6–4.1 mg/cm² after 6 h), and they displayed Korsmeyer–Peppas drug release kinetics. Film F3 containing 1.6% sodium alginate and 1.6% of methylcellulose exhibited superior swelling index (70 ± 1%), tensile strength (0.68 ± 0.04 MPa) and in vitro/ex vivo mucoadhesion time (5.5 ± 0.3 h; 2.3 ± 0.3 h) relative to other studied films. Conclusions: The sodium alginate content of the films influenced their tensile and mucoadhesive properties. Film F3 was the most promising formulation for potential treatment of oral candidiasis. Full article

Polyhydroxyalkanoates (PHAs) are bio-based, biodegradable polyesters increasingly explored as sustainable biomaterials for regenerative medicine. This review summarizes recent advances in PHA-based bone substitute materials, highlighting their properties, fabrication methods, and biological performance. PHAs combine biocompatibility, tunable mechanical behavior, and degradation into non-toxic metabolites, while copolymerization and monomer selection modulate the stiffness, crystallinity, and resorption rate. Processing techniques such as solvent casting, electrospinning, and additive manufacturing allow the production of porous architectures that mimic bone extracellular matrix. Electrospinning is particularly suitable for nanoscale fibrous matrices, whereas 3D printing enables patient-specific scaffolds with controlled geometry and interconnected porosity. Scaffold performance can be further improved through the incorporation of osteoconductive fillers, including hydroxyapatite, β-tricalcium phosphate, bioactive glasses, graphene oxide, and carbon nanotubes, as well as through drug-delivery and pro-angiogenic functionalization. In vitro and in vivo studies consistently report favorable cytocompatibility, enhanced osteogenic differentiation, vascularization, and effective repair of bone defects in animal models. However, clinical translation remains limited by production costs, variability in polymer quality, thermal processing constraints, and regulatory challenges. Future progress will rely on more efficient biosynthesis, medical-grade purification, multifunctional scaffold design, and stronger collaboration between academia, industry, and clinicians to unlock the full potential of PHAs in regenerative bone therapies. Full article

Background/Objective: Accurate digital recording of implant position is essential for achieving passive fit and predictable outcomes in complete-arch implant-supported prostheses. However, complete-arch cases remain challenging because of increased inter-implant distances, limited anatomical landmarks, soft tissue mobility, scan body-related variables, and cumulative errors during data acquisition and file registration. This narrative review aims to evaluate current intraoral and extraoral digital implant position recording techniques from a clinical decision-making perspective. Methods: A structured narrative literature search was conducted in PubMed from database inception to 15 May 2026 and was supplemented by manual screening of reference lists of key systematic reviews and eligible articles. Systematic reviews, meta-analyses, clinical studies, comparative in vitro studies, dental technique articles, and clinical reports relevant to complete-arch digital implant position recording were considered. Higher-level and clinically relevant evidence was prioritized, whereas technique reports were included primarily for emerging workflows with limited clinical evidence. Results: Intraoral techniques include non-splinted and splinted scan body protocols, calibrated implant scan bodies, calibrated frameworks, and auxiliary reference strategies. These methods may be clinically efficient but remain sensitive to scan path, scanner technology, landmark availability, scan body design, implant distribution, and operator-related factors. Extraoral techniques include stereophotogrammetry, camera- or smartphone-assisted photogrammetric systems, reverse impression workflows, and laboratory scanner-based digitization. These approaches may reduce intraoral stitching errors in complex edentulous arches, but usually require complementary datasets for soft tissue morphology, prosthetic contours, antagonist dentition, and maxillomandibular relationships. Conclusions: Direct intraoral scanner (IOS) protocols may be appropriate in favorable complete-arch situations with accessible scan bodies, limited inter-implant distances, and stable reference geometry. In clinically demanding cases requiring greater cross-arch accuracy, stereophotogrammetry, intraoral photogrammetry, or calibrated scanning approaches may provide more controlled implant position recording. Reverse impression and model-based workflows are particularly useful when a verified interim prosthesis, verification jig, or cast-based reference is available. Regardless of the selected technique, accurate integration of implant coordinates with soft tissue, prosthetic contour, antagonist arch, and occlusal data remains essential. Full article

The microstructure of metal matrix composites is inherently governed by fabrication routes and processing parameters, yet technological and physical constraints often prevent the realization of intended structural designs. In particle-reinforced composites produced via casting, interactions between the solidification front and inclusions frequently lead to agglomeration, segregation, and hence, a non-uniform distribution of the inclusions concentration. To mitigate these effects, post-processing techniques such as Friction Stir Processing offering particular promise for cast materials by refining microstructures and enhancing phase homogeneity. This study addresses these challenges by application of Fourier transform analysis to characterize stochastic inclusion distributions. Building on the Windows Washing method, we extend its application to heterogeneous media with varying inclusion concentrations. Through computer simulations and experimental analysis of real composites, we demonstrate that discrete Fourier transform can reveal hidden stochastic periodicity. The proposed framework provides a pathway toward improved predictive models and optimization strategies for metal matrix composites processing and performance. Full article

The pore-throat structure is a key factor in the exploration and development of tight sandstone reservoirs. In the present study, 14 tight sandstone samples from the Chang 8 member of the Ordos Basin were analyzed using high-pressure mercury intrusion, cast thin section analysis, scanning electron microscopy and cathodoluminescence imaging techniques. Fractal dimensions, obtained from the slopes of log(S_W) versus log(P_c) double-logarithmic plots, were applied to quantitatively characterize pore-throat structures and classify reservoirs through multifractal analysis, and discuss the diagenetic controlling factors affecting the pore-throat structure of different reservoir types. The results showed that the Chang 14 tight sandstones are characterized as two segments fractal features, which indicated that these samples have complex pore-throat structure and consist of two types of spaces: mesopore-throat spaces and micropore-throat spaces. The mesopore-throat system shows a higher fractal dimension (D1: 2.74–2.99), indicating greater heterogeneity and irregularity, while the micropore-throat system exhibits a lower dimension (D2: 2.28–2.61). D1 exhibits a negative correlation with the porosity and permeability of mesopores, while D2 shows a weak positive correlation with the properties of micropores. The total fractal dimension (D) is weakly correlated with overall reservoir properties, confirming that reservoir storage and flow capacity are primarily governed by the mesopore system rather than the micropore system. By analyzing the contribution of pore throats to sample physical properties, the results indicate that the 14 samples can be classified into two types based on 35% porosity contribution and 60% permeability contribution thresholds. Type 1, reservoirs dominated by microporous throat space (D values ranging from 2.603 to 2.644); Type 2, reservoirs dominated by mesoporous throat space (D values ranging from 2.544 to 2.598). Type 1 is characterized by primary intergranular pores, residual intergranular pores and intergranular dissolution pores, which enhance connectivity and reduce network complexity, thereby improving fluid permeability. In contrast, Type 2 consists mainly of intragranular dissolution pores, intergranular gap pores and micro-dissolution pores in clay minerals, which significantly inhibit fluid mobility. Diagenesis, including compaction, dissolution and cementation, exerts a significant control on the fractal characteristics and pore-throat structure evolution. The fractal characteristics exhibited in the pore-throat structure could provide a desirable analytical method, distinguishing from classification based on scale or size, for the evaluation and classification of tight sandstone reservoirs. Full article

Deep tight sandstone reservoirs are characterized by strong microscopic pore structure heterogeneity and commonly exhibit a high-porosity, low-permeability profile, posing significant challenges for effective reservoir evaluation and “sweet spot” prediction. The microscopic pore structure of 209 tight sandstone samples from the deeply buried Huagang Formation in the Xihu Depression, East China Sea Basin, was systematically characterized by integrating multiple analytical techniques, including casting thin sections, scanning electron microscopy (SEM), X-ray diffraction (XRD), nuclear magnetic resonance (NMR), and high-pressure mercury injection (HPMI). The results indicate that the reservoir space is dominated by mesopores (55.48%) and transition pores (32.39%), with macropores (2.09%) and micropores (10.04%) being relatively underdeveloped. A significant vertical heterogeneity in reservoir quality is observed. The H4 member exhibits superior properties, characterized by a higher average movable fluid saturation (averaging 46%) and better pore connectivity. In contrast, the H5 member is more compact, with a notably higher proportion of bound fluid (averaging 47%). The differences in reservoir quality are controlled by a sedimentary–diagenetic coupling mechanism. High-energy, coarse-grained facies underwent a constructive pathway involving chlorite coating protection and dissolution enhancement, forming high-quality pore networks. In contrast, low-energy, fine-grained facies experienced a destructive pathway dominated by intense compaction and cementation, leading to the deterioration of pore structure. The petrophysical properties of the deep reservoirs are primarily governed by the three-dimensional connectivity and spatial distribution of effective “pore-throat assemblages” composed of dominant throats. Accordingly, a “binary” pore structure development pattern is established for the deep tight sandstone reservoirs in the study area. This pattern posits that the reservoir space is heterogeneously composed of a minority of connected “effective percolation assemblages” and a majority of isolated “ineffective assemblages”. Full article

Aluminum alloy A356 (Al-7Si-0.3Mg) is widely employed in automotive structural components due to its favorable strength-to-weight ratio, yet its mechanical performance is highly sensitive to T6 heat-treatment processes. Conventional heat-treatment schedules are typically based on uniform, empirically derived parameters and fail to consider variations in component size, geometry, or thermal mass. Consequently, applying a single schedule across all component sizes often leads to inconsistent microstructural development, energy inefficiency, and elevated scrap rates. Smaller components tend to be over-processed, while larger components may be under-processed, both resulting in suboptimal mechanical properties and increased production costs. To overcome these limitations, this study presents a scalable heat-treatment optimization framework that integrates physics-based thermal simulations with machine learning techniques. The framework combines a transient thermal simulator with Long Short-Term Memory (LSTM) networks to predict sample temperature evolution, Random Forest regressors to estimate mechanical properties such as yield strength, hardness, and modulus of toughness, and Bayesian optimization to generate size-dependent, property-compliant heat-treatment schedules. Unlike traditional methods, this approach dynamically adjusts furnace parameters to individual component characteristics, optimizing both processing time and energy consumption while minimizing scrap. Application of the framework to components ranging from 0.5 to 10 kg demonstrates internally consistent simulation-based predictions of temperature profiles, phase-fraction evolution, and mechanical-property trends within the assumed modelling framework. Optimized schedules achieved 15–25% reductions in cycle time while maintaining properties within T6 specifications. These findings underscore the potential of AI-assisted heat-treatment optimization to enhance energy efficiency, reduce material waste, and improve the consistency of mechanical performance in automotive casting operations. Full article

The recovery of antioxidant compounds from agri-food by-products represents a sustainable strategy for active packaging production. However, the compatibility between natural extracts and film-forming techniques plays a key role in determining film formation and properties. In this work, antioxidant extracts obtained from spent coffee grounds and tomato waste were incorporated into zein-based films produced using two different techniques. The objective was to investigate how extract type and processing technique influence film morphology, wettability, thickness, and mechanical properties. The results demonstrated a strong processing-dependent compatibility between extract composition and production techniques. Spent coffee ground extract was successfully incorporated into compact cast films, while tomato waste extract did not allow the formation of homogeneous cast films and required electrospinning to obtain uniform fibrous structures. The incorporation of spent coffee ground extract significantly increased surface wettability and film stiffness, with Young’s modulus reaching 695 MPa. In contrast, electrospun films containing tomato waste extract exhibited lower tensile strength due to their porous fibrous structure, although uniform fibers were obtained. These findings demonstrate that extract chemistry critically affects the suitability of the processing technique and provide useful guidelines for the design of sustainable zein-based active packaging systems derived from agri-food waste valorization. Full article

Background: Elderly patients often experience difficulty adapting to occlusal reconstruction. Therefore, accurate bite registration is mandatory to ensure precise transfer of the established maxillomandibular relationship to the definitive prosthesis. However, conventional bite registration methods may compromise reproducibility because of deformation of registration materials and instability of mucosa-supported record bases. Methods: A 65-year-old woman with the primary complaints of unstable occlusion and difficulty in mastication underwent occlusal reconstruction. After occlusal stabilization using provisional crowns, bridges, and removable partial dentures, definitive impressions were made with and without the provisional restorations. The casts were scanned, and the digital datasets were superimposed to reproduce the established occlusal morphology of the provisional restorations. This occlusal morphology was used to design a tooth-supported computer-aided design–computer-aided manufacturing (CAD–CAM)-fabricated milled provisional restoration. Following intraoral verification of occlusal stability, the milled provisional restoration served as a mounting guide for the working casts on an articulator. Definitive crowns, bridges, and removable partial dentures were then fabricated. Results: Following comprehensive prosthodontic rehabilitation with definitive prostheses, occlusal stability and masticatory function improved, and the patient was satisfied with the functional outcomes of treatment. Conclusions: A tooth-supported CAD–CAM-fabricated milled provisional restoration used as a bite registration device enables potentially more consistent transfer of the maxillomandibular relationship while avoiding mucosal displacement and material deformation. This technique, which integrates digital and conventional workflows, may provide a new option for addressing adaptation challenges in occlusal reconstruction. Full article

To promote the industrial development of reinforced concrete engineering and enhance the construction quality of prefabricated buildings, an innovative partial prefabricated construction method is proposed in this paper, namely the prefabricated reinforced cage–cast in situ concrete (PRC-CISC) structure with an innovative steel bar connection technology. The connection techniques, including direct thread rolling of steel bars and hot-forged sleeves, are adopted. With the design axial compression ratio and the layout of couplers in the reinforcement cage as the main parameters, quasi-static tests are carried out to investigate the failure mode, seismic behavior, and mechanical mechanism of couplers of PRC-CISC columns. The results indicate that all specimens present typical compression–bending failure with plump hysteretic curves, gradual stiffness degradation, good ductility, and energy dissipation capacity. The new couplers can effectively satisfy the seismic performance requirements of PRC-CISC columns. With the increase in axial compression ratio, the bearing capacity rises while ductility decreases, and the stress of longitudinal bars increases. The layout of couplers exerts a controllable influence on the mechanical and deformation performance of specimens. The steel stress in the core stress region of PRC-CISC columns shows a bilinear distribution with stress concentration at both ends of the sleeves, which is related to the material difference in couplers. Finally, two “non-equal” calculation methods (plastic hinge model and fiber model) are established based on experimental results and finite element analysis, forming a systematic calculation theory for the new material–new technology–new structure system. The research provides important references for the engineering application of such structures. Full article

Since tires from end-of-life vehicles are not entirely biodegradable and pose a serious environmental problem, their disposal has become a significant global environmental concern. One technique to decrease these environmental issues is incorporating waste rubber to make sustainable green concrete. This study examined the usage of waste supplementary cementitious materials (SCMs) such as fly ash (FA), metakaolin (MK), marble powder (MP), slag (SL), and silica fume (SF) for surface precoating of crumb rubber (CR) to improve the mechanical properties of the produced crumb rubber concrete (CRC) by strengthening the bond between CR and cement paste in the interfacial transition zone (ITZ). The CR replaced (0, 15%, and 25%) of sand by weight in the preparation of CRC mixtures. A total of eleven CRC mixes were cast to investigate the fresh properties, compressive strength, and splitting tensile strength. In addition, the compressive stress-strain curve was investigated, and peak stress, peak strain, energy absorption, toughness, and modulus of elasticity have been evaluated. The outcomes showed that precoating CR using FA, followed by MK, has the strongest effect on increasing CRC compressive performance. The 25% substitution of sand with FA-treated CR increased compressive strength after 28 days, splitting tensile strength, peak stress, toughness, and modulus of elasticity by 34.7%, 23.7%, 34.8%, 26.1%, and 25.2%, respectively, in comparison to the same percentage of untreated CR. The proposed approach demonstrates a viable pathway for integrating waste materials and SCM-based technologies to develop high-performance, sustainable cementitious composites. Full article

Research on edible and biodegradable film packaging (EBFP) has increased significantly to explore sustainable alternatives to synthetic packaging and mitigate its environmental impacts. Biomaterials extracted from agricultural food waste (AFW) may be utilized for the fabrication of EBFP as an alternative packaging for meat and meat products. The focal point of this review is to explore the potential AFW biomaterials and bioactive compounds available in industry, and their utilization techniques for fabricating EBFP with ideal mechanical parameters suitable for use as a packaging material. Moreover, research studies have been summarized related to EBFP’s efficacy on meat shelf life, physicochemical, oxidative, and microbial qualities during storage experiments. EBFP fabricated with AFW biomaterials, such as proteins, carbohydrates, essential oils, and bioactive compounds, exhibits favorable film-forming capacity, mechanical properties, barrier properties, biodegradability, and synergy with meat. Latest advances in the application of AFW biomaterials and bioactive compounds based on EBFP for meat packaging are directed toward novel fabrication processes such as electrospinning, solvent casting, and combination of both to produce a hybrid film, which markedly improves the mechanical and barrier properties. Moreover, including bioactive materials from AFW enhances the antioxidant and antimicrobial properties of EBFP to combat the oxidative rancidity and bacteria, fungi, and molds in meat to prolong shelf life. Incorporation of AFW biomaterials and bioactive compounds has improved the intelligent properties of EBFP, which has been effectively used in meat packaging to detect freshness and spoilage of meat through color and pH changes. Full article

Porous Ti₂AlC, a member of the MAX phase family of nanolaminated ternary carbides and nitrides, has attracted increasing attention due to its unique combination of metallic and ceramic properties. This review summarizes recent advances in the fabrication, structure–property relationships, and applications of porous Ti₂AlC. Various processing routes, including incomplete sintering, sacrificial templating, replica techniques, gel casting, extrusion, and direct ink writing, are compared in terms of achievable porosity, pore morphology, and structural control. Particular emphasis is placed on the role of porosity in tailoring mechanical performance, thermal conductivity, and high-temperature oxidation resistance, based on available literature data. Recent progress in applications of porous Ti₂AlC and related MAX phases is also discussed, including their use in filtration, membrane supports, heat exchangers, electrochemical systems for hydrogen evolution, and as preforms for lightweight interpenetrating metal/MAX phase composites. Finally, current challenges and future research directions are identified, highlighting the need for improved control of porosity and a deeper understanding of structure–property relationships. Full article

The growing penetration of renewable energy sources has intensified the demand for safe, sustainable, and cost-effective energy-storage technologies. Aqueous lithium-ion batteries are promising candidates because of their intrinsic safety and high ionic conductivity, though their deployment is limited by narrow electrochemical stability window of water. Lithium titanate oxide (LTO) has emerged as an ideal anode material for aqueous systems because of its exceptional structural stability, negligible volume change during lithiation/delithiation, and relatively high operating potential that suppresses hydrogen evolution. This review examines the peer-reviewed literature (2010–2026) on LTO-based aqueous lithium-ion batteries, focusing on the interdependence between material synthesis, electrode fabrication, electrolyte engineering, and electrochemical performance. Scalable fabrication techniques, such as spray deposition and tape casting, are discussed alongside their pact on electrode quality. Attention is given to water-in-salt, gel-polymer, and localized high-concentration electrolytes that expand the stability window and improve interfacial behavior. Overall, the review highlights how electrolyte design, electrode architecture, and processing methods can be jointly tailored to support stable and scalable LTO-based aqueous lithium-ion batteries systems. Full article

Background/Objectives: The A-Palp enables a calibrated anatomical systems technique (CAST) approach. Previous studies have demonstrated repeatability and concurrent validity for selected spinal curvature angles in patients with scoliosis. However, the inter-operator reproducibility, temporal repeatability, and reliability of sagittal spinal curvature measurements and spinopelvic parameters remain to be established. Methods: Eighteen healthy adults without spinal pathology were assessed. Two operators sampled sagittal spinal profiles with the A-Palp in a 14-camera optoelectronic setup, applying reflective markers and palpating spinous processes. One operator repeated measurements after seven days. Marker data were processed in MATLAB (R2019b) to smooth trajectories, fit curvature arcs, and compute extracorporeal kyphosis, lordosis, and pelvic parameters. Reliability and repeatability were evaluated using Bland & Altman analysis, intraclass correlations (ICCs), standard error of measurement (SEM), mean detectable change (MDC₉₅), root-mean-squared errors (RMSEs), and Statistical Parametric Mapping (SPM). Results: Reliability and repeatability were strong. For global spinal angles, ICCs exceeded 0.90 across operators and sessions. The tangent method yielded low SEM (1–2°) and MDC₉₅ (3–6°) values, whereas the circle-fit/trigonometric methods showed larger errors. Most spinopelvic angles had moderate-to-excellent ICCs (0.65–0.98) with SEM/MDC₉₅ values ≈2.1–4.5°/5.9–12.4°. Ground reaction force-referenced distances showed good ICCs and small intra-operator error (SEM: 3.8–4.8 mm; MDC₉₅: 10.7–13.4 mm) but wider inter-session thresholds (SEM: 10.3–11.6 mm; MDC₉₅: 28.6–32.8 mm). Bland & Altman biases were ~0, with narrower limits for the tangent (≈±5°) than circle-fit/trigonometric (≈±8–12°) methods. Curve tracking was consistent (RMSE: 2.7–3.7 mm, <5% amplitude), and SPM detected no point-wise differences. Conclusions: The A-Palp method demonstrated high reliability and repeatability for extracorporeal sagittal spinal and sacro-spinal evaluation. Variability was low across operators and sessions, supporting its use as a robust, non-invasive clinical and research tool. Full article