Search Results (46)

The Fernald Feed Materials Production Center (FMPC), located in Fernald, Ohio, USA, released radon (Rn) as a byproduct of the processing of uranium materials during the years from 1951 to 1989. Rn is a colorless, odorless gas that emits charged alpha radiation that interacts with cells in the lung and trachea-bronchial tree, leading to DNA damage, mutations, and tumor initiation. The purpose of this project was to use evidence collected by the Fernald Dosimetry Reconstruction Project and other sources to estimate the outdoor Rn exposure to individuals in the community immediately surrounding the FMPC during the years of plant operation. Using previously tabulated source terms, diffusion and meteorological data, and self-reported detailed residential histories, we estimated radon exposure for approximately 9300 persons who lived at more than 14,000 addresses. The results indicated that a portion of the population cohort experiences mean annual Rn exposure exceeding the U.S. Environmental Protection Agency (EPA) action limit of 4 pCiL⁻¹. These exposure estimates support the analysis of the incidence of lung cancer in the Fernald Community Cohort (FCC). Full article

This paper investigates the cultural, spiritual, and ecological use and value of fish by-products in the material practices of Alaska Native (Indigenous Peoples are the descendants of the populations who inhabited a geographical region at the time of colonisation and who retain some or all of their own social, economic, cultural, and political institutions. In this paper, I use the terms “Indigenous” and “Native” interchangeably. In some countries, one of these terms may be favoured over the other.) and Greenlandic Inuit women. It aims to uncover how fish remnants—skins, bones, bladders, vertebrae, and otoliths—were transformed through tanning, dyeing, and sewing into garments, containers, tools, oils, glues, and adornments, reflecting sustainable systems of knowledge production rooted in Arctic Indigenous lifeways. Drawing on interdisciplinary methods combining Indigenist research, ethnographic records, and sustainability studies, the research contextualises these practices within broader environmental, spiritual, and social frameworks. The findings demonstrate that fish-based technologies were not merely utilitarian but also carried symbolic meanings, linking wearers to ancestral spirits, animal kin, and the marine environment. These traditions persisted even after European contact and the introduction of glass trade beads, reflecting continuity and cultural adaptability. The paper contributes to academic discourse on Indigenous innovation and environmental humanities by offering a culturally grounded model of zero-waste practice and reciprocal ecology. It argues that such ancestral technologies are directly relevant to contemporary sustainability debates in fashion and material design. By documenting these underexamined histories, the study provides valuable insight into Indigenous resilience and offers a critical framework for integrating Indigenous knowledge systems into current sustainability practices. Full article

Pisco is an emblematic spirit in Peru and Chile, made from fermented grapes, gaining growing scientific interest over the last two decades. This study aimed to map 20 years of research on Pisco through a systematic bibliometric review. A search was conducted in the Scopus database covering the period from 2004 to 2024, applying the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology for the transparent selection of scientific articles. The search strategy considered titles, abstracts, and keywords, using the terms “Pisco” and “schnapps”, excluding unrelated fields such as geology (basin, seismic, fossil). The initial search yielded 360 records. After removing non-original articles (books, book chapters, conference papers, and reviews), 101 articles remained. A further screening excluded irrelevant studies (e.g., those referring to the city of Pisco rather than the beverage), resulting in 78 articles included for final analysis. It was observed that 19% of the studies focus on the history, culture, and appellation of origin; 14% on environmental sustainability; 10% on innovation and quality; and 9% on the bioactive properties of by-products. Other areas include extraction technologies (9%), distillation process modeling (8%), and marketing and economics (8%), among others. Recent trends are related to clean production practices. Thus, Pisco by-products and their components can be exploited by applying technologies such as supercritical fluids, drying, and biofilms, while, for waste management, the processes of composting, solar photo-Fenton, and ozonation can be applied. Moreover, it is important to highlight that the valorization of Pisco by-products opens opportunities for translation into the market, particularly in developing cosmetics, nutritional supplements, and bio-packaging materials, contributing to sustainability and innovation in new industries. However, a more holistic view is still needed in Pisco research. These findings suggest that future research should prioritize the integration of consumer-based sensory evaluations and sustainable production innovations to optimize Pisco’s quality, enhance market acceptance, and promote environmentally responsible industry practices. Full article

Bilirubin, albumin, and uric acid are established endogenous antioxidant biomarkers, whereas the antioxidant role of creatinine has not yet been fully clarified. As a byproduct of creatine metabolism, creatinine may reflect underlying metabolic activity and redox balance, particularly under conditions of oxidative stress such as cigarette smoking. This study aimed to evaluate the associations between serum creatinine and other antioxidant biomarkers and lung cancer risk, stratified by smoking status. We analyzed 83,371 cancer-free men from the Korean Cancer Prevention Study II (KCPS II) cohort. During a mean follow-up of 13.5 years, 533 incident lung cancer cases were identified. Serum creatinine, total bilirubin, albumin, and uric acid were measured. Smoking status classified participants as never-, former, and ever-smokers, with ever-smokers including both current and former smokers. Cox proportional hazards regression models estimated hazard ratios (HRs) and 95% confidence intervals (CIs), stratified by smoking status. Biomarkers were also analyzed by quartiles and linear trends. A single standard deviation increase in serum creatinine was significantly and inversely associated with lung cancer risk among former smokers (HR: 0.774, 95% CI: 0.620 to 0.967) and ever-smokers (HR: 0.823, 95% CI: 0.716 to 0.945). Total bilirubin also showed significant inverse associations in former smokers (HR: 0.826, 95% CI: 0.705 to 0.967) and ever-smokers (HR: 0.785, 95% CI: 0.708 to 0.870). Albumin was inversely associated only with ever-smokers (HR: 0.878, 95% CI: 0.807 to 0.955), while uric acid showed inverse associations with both former smokers (HR: 0.832, 95% CI: 0.699 to 0.989) and ever-smokers (HR: 0.847, 95% CI: 0.760 to 0.944). None of the biomarkers showed significant associations among never-smokers. Serum creatinine and other endogenous antioxidant biomarkers were inversely associated with lung cancer risk, particularly in individuals with a history of smoking exposure. Full article

We explore the diverse roles of reactive oxygen species (ROS) and NADPH oxidases in red algae, focusing on their involvement in fertilization, wound repair, stress adaptation, and development. Once considered mere metabolic byproducts, ROS are now recognized as pivotal signaling molecules in red algae. ROS are actively produced and regulated by NADPH oxidase homologs in red algae. During fertilization, ROS facilitate gamete recognition and post-fertilization cell wall development. NADPH oxidase-produced ROS also play essential roles in wound repair, aiding cellular migration and cytoskeletal reorganization at injury sites. A survey of NADPH oxidase homologs in transcriptomic and genomic datasets shows that NADPH oxidase homologs have a long evolutionary history in red algae, with some orthologs duplicating before the split of the Bangiophyceae–Flordeophyceae, approximately 1.1 billion years ago. Additionally, we discuss modifications in red algal NADPH oxidase genes related to calcium binding compared to plants and hypothesize that independent calcium signaling pathways are involved. These insights reveal the significance of NADPH oxidase at a molecular level in supporting red algae’s physiological processes and adaptive strategies. Full article

Circular economy theorists and advocates typically describe traditional market economies as linear “take, make, use and dispose” systems. Various policy interventions, from green taxes to extended producer responsibility, are therefore deemed essential to ensure the systematic (re)introduction of residuals, secondary materials and components in manufacturing activities. By contrast, many nineteenth- and early twentieth-century writers documented how the profit motive, long-distance trade and actors now largely absent from present-day circularity discussions (e.g., waste dealers and brokers) spontaneously created ever more value out of the recovery of residuals and waste. These opposite assessments and underlying perspectives are perhaps best illustrated in the nineteenth classical liberal and early twenty-first century interventionist writings on circularity of Fellows, members and collaborators of the near tricentennial British Royal Society for the Encouragement of Arts, Manufactures and Commerce. This article summarizes their respective contributions and compares their stance on market institutions, design, intermediaries, extended producer responsibility and long-distance trade. Some hypotheses as to the sources of their analytical discrepancies and current beliefs on resource recovery are then discussed in more detail. A final suggestion is made that, if the analysis offered by early contributors is more correct, then perhaps the most important step towards greater circularity is regulatory reform (or deregulation) that would facilitate the spontaneous recovery of residuals and their processing in the most suitable, if sometimes more distant, locations. Full article

Background/Objectives: Uric acid is a key metabolic byproduct of purine degradation and plays a dual role in human health. At physiological levels, it acts as an antioxidant, protecting against oxidative stress. However, excessive uric acid can lead to hyperuricemia, contributing to conditions like gout, kidney stones, and cardiovascular diseases. Emerging evidence also links elevated uric acid levels with metabolic disorders, including hypertension and insulin resistance. Understanding its regulation is crucial for preventing associated health complications. Methods: This study, part of the Tlalpan 2020 project, aimed to predict uric acid levels using advanced machine learning algorithms. The dataset included clinical, anthropometric, lifestyle, and nutritional characteristics from a cohort in Mexico City. We applied Boosted Decision Trees (Boosted DTR), eXtreme Gradient Boosting (XGBoost), Categorical Boosting (CatBoost), and Shapley Additive Explanations (SHAP) to identify the most relevant variables associated with hyperuricemia. Feature engineering techniques improved model performance, evaluated using Mean Squared Error (MSE), Root-Mean-Square Error (RMSE), and the coefficient of determination (R²). Results: Our study showed that XGBoost had the highest accuracy for anthropometric and clinical predictors, while CatBoost was the most effective at identifying nutritional risk factors. Distinct predictive profiles were observed between men and women. In men, uric acid levels were primarily influenced by renal function markers, lipid profiles, and hereditary predisposition to hyperuricemia, particularly paternal gout and diabetes. Diets rich in processed meats, high-fructose foods, and sugary drinks showed stronger associations with elevated uric acid levels. In women, metabolic and cardiovascular markers, family history of metabolic disorders, and lifestyle factors such as passive smoking and sleep quality were the main contributors. Additionally, while carbohydrate intake was more strongly associated with uric acid levels in women, fructose and sugary beverages had a greater impact in men. To enhance model robustness, a cross-feature selection approach was applied, integrating top features from multiple models, which further improved predictive accuracy, particularly in gender-specific analyses. Conclusions: These findings provide insights into the metabolic, nutritional characteristics, and lifestyle determinants of uric acid levels, supporting targeted public health strategies for hyperuricemia prevention. Full article

By reflecting on the history and environmental impact of conventional biorefining, such as kraft pulping, we aim to explore important questions about how natural polymers can be more sustainably sourced to develop bio-products and reduce reliance on plastics. Since the Industrial Revolution, chemical pulping processes have enabled the mass production of cellulosic products from woody biomass. Kraft pulping, which dominates within modern pulp and paper mills, has significantly contributed to environmental pollution and carbon emissions due to sulfurous byproducts and its high water and energy consumption. While chemical pulping technologies have advanced over time, with improvements aimed at enhancing sustainability and economic feasibility, conventional biorefineries still face challenges related to biomass conversion efficiency and environmental impact. For example, efforts to fully utilize wood resources, such as isolating lignin from black liquor, have made limited progress. This perspective provides a thoughtful examination of the growth of chemical pulping, particularly the kraft process, in the production of consumer goods and its environmental consequences. It also presents key insights into the bottlenecks in developing truly sustainable biomass conversion technologies and explores potential alternatives to traditional chemical pulping. Full article

The gut microbiota plays an essential role in maintaining immune homeostasis and influencing the immune landscape within the tumor microenvironment. This review aims to elucidate the interactions between gut microbiota and tumor immune dynamics, with a focus on colorectal cancer (CRC). The review spans foundational concepts of immuno-microbial interplay, factors influencing microbiome composition, and evidence linking gut microbiota to cancer immunotherapy outcomes. Gut microbiota modulates anti-cancer immunity through several mechanisms, including enhancement of immune surveillance and modulation of inflammatory responses. Specific microbial species and their metabolic byproducts can significantly influence the efficacy of cancer immunotherapies. Furthermore, microbial diversity within the gut microbiota correlates with clinical outcomes in CRC, suggesting potential as a valuable biomarker for predicting response to immunotherapy. Conclusions: Understanding the relationship between gut microbiota and tumor immune responses offers potential for novel therapeutic strategies and biomarker development. The gut microbiota not only influences the natural history and treatment response of CRC but also serves as a critical modulator of immune homeostasis and anti-cancer activity. Further exploration into the microbiome’s role could enhance the effectiveness of existing treatments and guide the development of new therapeutic modalities. Full article

The need for innovative catalysts and catalytic support materials is continually growing due to demanding requirements, stricter environmental demands, and the ongoing development of new chemical processes. Since about 80% of all industrial processes involve catalysts, there is a continuing need to develop new catalyst materials and supports with suitable qualities to meet ongoing industrial demands. Not only must new catalysts have tailored properties, but they must also be suitable for large-scale production through environmentally friendly and cost-effective processes. Clay minerals, with their rich history in medicine and ceramics, are now emerging as potential catalysts. Their transformative potential is exemplified in applications such as hydrogenating the greenhouse gas CO₂ into carbohydrate fuel, a crucial step in meeting the rising electrical demand. Moreover, advanced materials derived from clay minerals are proving their mettle in diverse photocatalytic reactions, from organic dye removal to pharmaceutical pollutant elimination and photocatalytic energy conversion through water splitting. Clay minerals in their natural state show a low catalytic activity, so to increase their reactivity, they must be activated. Depending on the requirements of a particular application, selecting an appropriate activation method for modifying a natural clay mineral is a critical consideration. Traditional clay mineral processing methods such as acid or alkaline treatment are used. Still, these have drawbacks such as high costs, long processing times, and the formation of hazardous by-products. Other activation processes, such as ultrasonication and mechanical activation routes, have been proposed to reduce the production of hazardous by-products. The main advantage of ultrasonication and microwave-assisted procedures is that they save time, whereas mechanochemical processing is simple and efficient. This short review focuses on modifying clay minerals using various new methods to create sophisticated and innovative new materials. Recent advances in catalytic reactions are specifically covered, including organic biogeochemical processes, photocatalytic processes, carbon nanotube synthesis, and energy conversion processes such as CO₂ hydrogenation and dry reforming of methane. Full article

Growing attention has been directed towards affects and emotions in the New Testament texts within recent scholarship over the course of the past two decades. Although biblical exegesis of the 20th century suspected psychological interpretations of New Testament texts of being highly subjective and hence frail, recent research has developed a number of approaches that allow for addressing the subject in a methodologically controlled way. The aim of the present article is to review important monographs from the field of New Testament emotion research with special attention to their particular focuses and research methods. Despite some degree of overlap between these perspectives, six major areas of scholarly work can be identified: (1) “text psychology” that explains New Testament findings against the backdrop of modern psychological theories; (2) historical psychology that explores ancient notions of the affects; (3) narratology that observes recurring a narrative pattern in ancient descriptions of the affects; (4) rhetorical criticism that traces the rhetorical presentation of affects as well as the capability of rhetorical language to evoke affects in the addressees; (5) philosophy of the body that examines the bodily aspects of psychological dynamics; and finally (6) social history that identifies social functions of collective affects, e.g., in the formation and stabilization of social groups. After introducing each of these approaches briefly, the affect of desire (gr. ἐπιθυμία) will serve as a test case to demonstrate the possibilities and usefulness that the different perspectives offer. This way, it becomes clear that affects are by no means a by-product of theological teaching in the New Testament, but in fact indicators of true relevance. Full article

In the European Union (EU), the labeling of coffee and coffee by-products adheres to comprehensive regulations aimed at ensuring product transparency and consumer safety. According to Regulation (EU) 1169/2011, the mandatory particulars that must appear on coffee labels include the name of the food, the net quantity, the date of minimum durability, and the name and address of the food business operator. For coffee by-products classified as novel foods—those not recognized within the EU prior to 1997—additional stipulations under Regulation (EU) 2015/2283 require a rigorous approval process. This process involves a safety assessment and the possibility of a simplified notification procedure if the product has a history of safe use outside the EU. The already approved novel coffee by-product ingredients such as coffee leaves and cascara (dried coffee cherry pulp) must also adhere to specific labeling requirements, which dictate precise naming conventions and usage categories that align with safety standards and consumer information needs. These detailed labeling requirements are pivotal for maintaining the integrity of coffee products sold within the EU, ensuring that all items, from traditional coffee to innovative coffee by-product-based ingredients, meet the highest standards of safety and consumer information. This article describes from a practical perspective the labeling standards for coffee and coffee by-products, and points out challenges in the implementation of the regulations. Full article

This paper addresses the problem of hydrogen generation from hydrocarbon gases using Steam Methane Reforming (SMR) with byproduct CO₂ injected into and stored in a partially depleted oil reservoir. It focuses on the reservoir aspects of the problem using numerical simulation of the processes. To this aim, a numerical model of a real oil reservoir was constructed and calibrated based on its 30-year production history. An algorithm was developed to quantify the CO₂ amount from the SMR process as well as from the produced fluids, and optionally, from external sources. Multiple simulation forecasts were performed for oil and gas production from the reservoir, hydrogen generation, and concomitant injection of the byproduct CO₂ back to the same reservoir. EOR from miscible oil displacement was found to occur in the reservoir. Various scenarios of the forecasts confirmed the effectiveness of the adopted strategy for the same source of hydrocarbons and CO₂ sink. Detailed simulation results are discussed, and both the advantages and drawbacks of the proposed approach for blue hydrogen generation are concluded. In particular, the question of reservoir fluid balance was emphasized, and its consequences were presented. The presented technology, using CO₂ from hydrogen production and other sources to increase oil production, also has a significant impact on the protection of the natural environment via the elimination of CO₂ emission to the atmosphere with concomitant production of H₂. Full article

In the first half of the twentieth century, scientific communities worldwide endeavored to diminish dependence on expensive and scarce animal fibers like wool and silk. Their efforts focused on developing regenerated protein fibers, including soy, zein, and casein, to provide comparable benefits to natural protein fibers, such as lustrous appearance, warmth, and a soft feel. The popularity and cost-effectiveness of mass-produced petroleum-based synthetic polymer fibers during World War II diminished interest in developing soy protein fiber. Realizing the ecological degradation caused by fossil fuels and their derived products, a renewed drive exists to explore bio-based waste materials like soy protein. As a fast-growing crop, soy provides abundant byproducts with opportunities for waste valorization. The soybean oil extraction process produces soy protein as a byproduct, which is a highly tunable biopolymer. Various functional groups within the soy protein structure enable it to acquire different valuable properties. This review critically examines scholarly publications addressing soy protein fiber developmental history, soy protein microstructure modification methods, and soy protein fiber spinning technologies. Additionally, we provide our scientific-based views relevant to overcoming the limitations of previous work and share prospects to make soy protein byproducts viable textile fibers. Full article

The primary goal of this scoping review is to collect, analyze, and critically describe information regarding the role of the main compounds (reuterin, phenyllactic acid, and exopolysaccharides) produced by LAB that possess antifungal properties and provide some suggestions for further research. The use of lactic acid bacteria (LAB) to mitigate spoilage and extend the shelf life of foodstuffs has a long history. Recently, there has been a growing interest in the unique properties of these additions to the foodstuffs in which they are applied. In recent studies regarding biopreservation, significant attention has been given to the role of these microorganisms and their metabolites. This fascinating recent discipline aims not only to replace traditional preservation systems, but also to improve the overall quality of the final product. The biologically active by-products produced by lactic acid bacteria are synthesized under certain conditions (time, temperature, aerobiosis, acidity, water activity, etc.), which can be enacted through one of the oldest approaches to food processing: fermentation (commonly used in the dairy and bakery sectors). This study also delves into the biosynthetic pathways through which they are synthesized, with a particular emphasis on what is known about the mechanisms of action against molds in relation to the type of food. Full article