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Search Results (565)

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Keywords = beyond 5G network

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19 pages, 15647 KB  
Article
Microstructure Evolution and Solute Segregation of Inconel 718 in Laser Additive Manufacturing: A Numerical and Experimental Investigation
by Hang Liu, Wenjia Xiao, Baolin Yan and Hui Xiao
Materials 2026, 19(8), 1642; https://doi.org/10.3390/ma19081642 - 20 Apr 2026
Abstract
The segregation of brittle Laves phases remains a critical bottleneck limiting the performance of additive manufacturing (AM) nickel-based superalloys. While its evolution is governed by complex transient physical fields within the melt pool, a quantitative kinetic correlation between processing parameters and microstructural features [...] Read more.
The segregation of brittle Laves phases remains a critical bottleneck limiting the performance of additive manufacturing (AM) nickel-based superalloys. While its evolution is governed by complex transient physical fields within the melt pool, a quantitative kinetic correlation between processing parameters and microstructural features is currently lacking. In this study, a high-fidelity multiphysics numerical model was developed to establish a cross-scale mapping logic of “Process-Physical Field-Microstructure” by dissecting the global distribution of temperature gradient (G) and solidification rate (R) along the quasi-steady-state melt pool boundary. It is revealed that increasing the scanning speed synergistically enhances R while compressing G. Beyond driving a transition from oriented columnar dendrites to refined mixed-dendritic structures, this shift effectively blocks the continuous enrichment channels of Nb and Mo elements by compressing the “kinetic time window” for solute redistribution. Consequently, the morphology of the Laves phase is forced to evolve from a continuous interconnected chain-like network into dispersed isolated particles. This research clarifies the kinetic essence of microstructural evolution under non-equilibrium solidification, providing critical physical criteria for the precise intervention of deleterious phases and the regulation of microstructural consistency in high-performance AM components. Full article
(This article belongs to the Section Metals and Alloys)
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26 pages, 2277 KB  
Review
EV-Centric Technical Virtual Power Plants in Active Distribution Networks: An Integrative Review of Physical Constraints, Bidding, and Control
by Youzhuo Zheng, Hengrong Zhang, Anjiang Liu, Yue Li, Shuqing Hao, Yu Miao, Chong Han and Siyang Liao
Energies 2026, 19(8), 1945; https://doi.org/10.3390/en19081945 - 17 Apr 2026
Viewed by 214
Abstract
The accelerated low-carbon transition of power systems and the widespread integration of Electric Vehicles (EVs) present both severe operational challenges and substantial flexible regulation potential for Active Distribution Networks (ADNs). This paper provides an integrative review of the coordinated control and multi-market bidding [...] Read more.
The accelerated low-carbon transition of power systems and the widespread integration of Electric Vehicles (EVs) present both severe operational challenges and substantial flexible regulation potential for Active Distribution Networks (ADNs). This paper provides an integrative review of the coordinated control and multi-market bidding mechanisms for EV-centric Technical Virtual Power Plants (TVPPs). Moving beyond descriptive surveys, this review systematically synthesizes the fragmented literature across three critical dimensions: (1) the physical-economic bidirectional mapping, which considers nonlinear power flow constraints and node voltage limits within the TVPP framework; (2) multi-market coupling mechanisms, evolving from unilateral energy bidding to coordinated participation in carbon trading and ancillary services; and (3) real-time control strategies, critically evaluating the trade-offs between optimization techniques (e.g., Model Predictive Control) and cutting-edge artificial intelligence approaches (e.g., Deep Reinforcement Learning) in mitigating battery degradation. Furthermore, a transparent review methodology is adopted to ensure literature rigor. By explicitly outlining the boundaries between TVPPs, Commercial VPPs (CVPPs), and EV aggregators, this paper identifies core unresolved trade-offs among aggregation fidelity, market complexity, and communication latency, providing evidence-backed pathways for future engineering demonstrations and V2G applications. Full article
(This article belongs to the Collection "Electric Vehicles" Section: Review Papers)
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13 pages, 744 KB  
Article
Uplink-Centric DUDe for IoT and Industry 4.0
by Charalampos Chatzigeorgiou, Christos Bouras, Vasileios Kokkinos, Apostolos Gkamas and Philippos Pouyioutas
Electronics 2026, 15(8), 1680; https://doi.org/10.3390/electronics15081680 - 16 Apr 2026
Viewed by 161
Abstract
This study investigates Downlink/Uplink Decoupling (DUDe) in 5G networks, a framework that allows user equipment to select its uplink serving cell independently of the downlink anchor. This approach is designed to alleviate the “macro bias” and pathloss issues that typically degrade performance for [...] Read more.
This study investigates Downlink/Uplink Decoupling (DUDe) in 5G networks, a framework that allows user equipment to select its uplink serving cell independently of the downlink anchor. This approach is designed to alleviate the “macro bias” and pathloss issues that typically degrade performance for Internet of Things (IoT) traffic. We propose a framework managed by Mobile Edge Computing (MEC) that operates on a per-Transmission Time Interval (TTI) basis, incorporating stability mechanisms such as hysteresis and Time to Trigger to prevent frequent, unnecessary handovers. The performance is evaluated using a system-level simulator across two scenarios: a high-density urban IoT deployment and an Industry 4.0 smart factory environment. Our results demonstrate that the proposed framework significantly improves uplink throughput and reduces tail latency compared to traditional coupled association methods. Furthermore, an ablation study confirms that these performance gains are derived from the structural decoupling of links, providing a scalable path for improving connectivity in 5G and beyond. Full article
(This article belongs to the Special Issue Feature Papers in Networks: 2025–2026 Edition)
15 pages, 854 KB  
Article
Sensor Placement for Contamination Detection in Urban Water Distribution System Based on Multidimensional Resilience
by Albira Acharya, Amrit Babu Ghimire, Binod Ale Magar and Sangmin Shin
Systems 2026, 14(4), 422; https://doi.org/10.3390/systems14040422 - 10 Apr 2026
Viewed by 265
Abstract
Urban water distribution systems (WDSs) face increasing threats from accidental or intentional contaminant intrusion events. While contamination warning systems using water quality sensors enable early detection and rapid response to contamination events, traditional sensor placement approaches often rely on a single or limited [...] Read more.
Urban water distribution systems (WDSs) face increasing threats from accidental or intentional contaminant intrusion events. While contamination warning systems using water quality sensors enable early detection and rapid response to contamination events, traditional sensor placement approaches often rely on a single or limited performance metric, overlooking the multidimensional nature of system resilience. This study presents a multidimensional resilience-based framework for the optimal placement of water quality sensors in urban WDSs, integrating hydraulic and water quality simulations using the EPANET-MATLAB toolkit with a genetic algorithm (GA) optimization process. For Anytown Water Distribution Network, four distinct functionalities were formulated to capture different aspects of system performance during contamination events, and an integrated-multidimensional resilience metric was proposed as a collective measure. Results demonstrated that the optimal sensor configurations varied significantly depending on the selected functionality. However, the integrated multidimensional resilience-based approach yielded more balanced and effective sensor placements, simultaneously enhancing resilience levels for all individual functionalities. Furthermore, the findings indicated that adding more sensors beyond a certain number offers marginal improvements in system resilience, suggesting that sensor deployment should be guided by monitoring objectives (e.g., resilience) rather than simply increasing sensor numbers. The findings and discussion suggest practical insights for utilities to enhance water supply services with safe quality and system security against contamination threats in urban WDSs. Full article
(This article belongs to the Special Issue Management of Water Supply Systems Resilience and Reliability)
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22 pages, 12662 KB  
Article
Geostatistical Reconstruction of Atmospheric Refractivity Fields Using Universal Kriging
by Rubén Nocelo López
Geomatics 2026, 6(2), 37; https://doi.org/10.3390/geomatics6020037 - 9 Apr 2026
Viewed by 202
Abstract
Atmospheric refractivity governs the propagation behavior of electromagnetic waves in the lower troposphere. Accurate spatial characterization of this parameter is essential for optimizing communication, radar, and navigation systems. This study presents a geostatistical framework for generating high-resolution refractivity maps using Universal Kriging (UK) [...] Read more.
Atmospheric refractivity governs the propagation behavior of electromagnetic waves in the lower troposphere. Accurate spatial characterization of this parameter is essential for optimizing communication, radar, and navigation systems. This study presents a geostatistical framework for generating high-resolution refractivity maps using Universal Kriging (UK) applied to meteorological observations from a dense network of automatic weather stations in the Galician region (NW Spain). The methodology explicitly models the non-stationary vertical structure of the atmosphere by decomposing the refractivity field into a deterministic altitude-dependent drift and a stochastic residual component characterized by an exponential variogram. Validation, performed using independent test stations bounding the regional vertical profile, demonstrates that the UK approach significantly outperforms Ordinary Kriging (OK). UK not only reduces mean errors and improves linear agreement, but critically minimizes systematic bias and extreme outlier occurrences (P95). Beyond accurate spatial interpolation, the dynamically estimated vertical drift retrieves the macroscopic refractivity gradient, serving as a direct, real-time diagnostic tool to classify anomalous radio-frequency (RF) propagation regimes (e.g., super-refraction and ducting) and supporting robust decision-making in complex topographies. Full article
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23 pages, 3338 KB  
Article
Improving the Energy Efficiency of Radio Access Networks by Using an Adaptive URLLC Slot Structure Within the 5G Advanced Architecture
by Anastasia V. Ermakova and Oleg V. Varlamov
Telecom 2026, 7(2), 36; https://doi.org/10.3390/telecom7020036 - 1 Apr 2026
Viewed by 383
Abstract
As mobile networks evolve toward Beyond 5G and 6G architectures, energy efficiency and sustainability have become increasingly critical due to growing traffic volumes, denser base station deployments, and the rising number of connected devices. Supporting Ultra-Reliable Low-Latency Communication (URLLC) services is particularly challenging, [...] Read more.
As mobile networks evolve toward Beyond 5G and 6G architectures, energy efficiency and sustainability have become increasingly critical due to growing traffic volumes, denser base station deployments, and the rising number of connected devices. Supporting Ultra-Reliable Low-Latency Communication (URLLC) services is particularly challenging, as their stringent requirements for both high reliability and minimal latency can lead to a significant increase in energy consumption within the radio access network. This paper examines slot structure mechanisms for concurrently servicing URLLC and enhanced Mobile Broadband (eMBB) traffic within the 5G Advanced framework, with a focus on improving energy efficiency and optimizing radio resource utilization. We propose an adaptive algorithm for managing radio interface time resources, which dynamically allocates sub-slots based on current network load and radio channel conditions. The system model is implemented in Simulink and incorporates URLLC and eMBB traffic generation, signal-to-noise ratio estimation, and a priority-based scheduling mechanism. Simulation results demonstrate that the proposed approach meets URLLC latency and reliability requirements while reducing redundant transmissions and enhancing the energy efficiency of the radio access network. These findings position the proposed method as a promising solution for the design of energy-efficient, next-generation mobile networks. Full article
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30 pages, 6316 KB  
Article
Transcriptomic Landscape and Regulatory Pathways of Drought Response in Rice (Oryza sativa L.): A Meta-Analysis of Microarray and RNA-Seq Data
by Maria Kampa, Konstantinos Makropoulos, Aikaterini Goule, Ioannis A. Tamposis, Panagiota I. Kontou, Pantelis G. Bagos and Georgia G. Braliou
Int. J. Mol. Sci. 2026, 27(7), 3167; https://doi.org/10.3390/ijms27073167 - 31 Mar 2026
Viewed by 390
Abstract
Drought significantly disrupts rice productivity under increasing climate volatility. Identifying robust molecular determinants for resilience remains a critical priority for crop improvement. Following the PRISMA guidelines, we performed a large-scale, dual-platform meta-analysis of RNA-Seq and microarray datasets to elucidate the robust transcriptomic landscape [...] Read more.
Drought significantly disrupts rice productivity under increasing climate volatility. Identifying robust molecular determinants for resilience remains a critical priority for crop improvement. Following the PRISMA guidelines, we performed a large-scale, dual-platform meta-analysis of RNA-Seq and microarray datasets to elucidate the robust transcriptomic landscape of Oryza sativa underwater deficit. Tissue-specific regulatory pathways were identified using STRING, g:Profiler, and PANTHER. Our analysis resolved distinct functional divergence, where shoots prioritize photosynthetic adjustment while roots emphasize transcriptional and chromatin reprogramming. Beyond validating core ABA signaling, we uncover a novel metabolic pivot: the activation of glyoxylate and dicarboxylate metabolism to mitigate drought-induced carbon starvation. We further identify specialized transport systems for ions and electrons across organelle membranes, alongside cellular reorganization driven by autophagy and actin-dependent cytoskeleton remodeling. These findings highlight a sophisticated network of survival strategies governing energy conservation and structural adaptation. By synthesizing heterogeneous transcriptomics, this study reveals robust pathways that are overlooked in single-platform investigations. This work provides a prioritized roadmap for utilizing functional validation and precision breeding to accelerate the development of climate-resilient rice cultivars. Full article
(This article belongs to the Special Issue New Insights into Plant Stress)
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20 pages, 3392 KB  
Article
AI-Driven Reliability in 6G Networks: Enhancing QoE of Real-World Video Streaming
by Christos Betzelos, Dimitrios Uzunidis, Anastasios Vetsos and Panagiotis A. Karkazis
Telecom 2026, 7(2), 35; https://doi.org/10.3390/telecom7020035 - 30 Mar 2026
Viewed by 496
Abstract
This paper advances user-centric Artificial Intelligence (AI) frameworks for reliability in fifth-generation and beyond (B5G) networks by examining their use in high-demand services such as video streaming. The proposed framework can leverage multi-layer monitoring across the edge–cloud continuum, application-layer metrics, and 5G core [...] Read more.
This paper advances user-centric Artificial Intelligence (AI) frameworks for reliability in fifth-generation and beyond (B5G) networks by examining their use in high-demand services such as video streaming. The proposed framework can leverage multi-layer monitoring across the edge–cloud continuum, application-layer metrics, and 5G core performance data to evaluate reliability through Quality of Experience (QoE) optimization. Results demonstrate that improved frame delivery can be achieved via dynamic resource prediction and proactive resource allocation. The study validates the framework’s scalability in dynamic workload conditions, emphasizing its role in mission-critical video services. Full article
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27 pages, 5252 KB  
Article
Beyond Sociodemographics: Attitudinal and Personality Predictors of Lexical Change
by Adrian Leemann, Simon Kistler and Fabian Tomaschek
Languages 2026, 11(3), 61; https://doi.org/10.3390/languages11030061 - 23 Mar 2026
Viewed by 610
Abstract
Moving beyond traditional sociodemographic models, this study investigates the psychometric drivers of lexical change. Using Swiss German as a case study, we compare historical data from the Sprachatlas der deutschen Schweiz (1939–1958) with a recent large-scale app-based survey (N = 1013) to quantify [...] Read more.
Moving beyond traditional sociodemographic models, this study investigates the psychometric drivers of lexical change. Using Swiss German as a case study, we compare historical data from the Sprachatlas der deutschen Schweiz (1939–1958) with a recent large-scale app-based survey (N = 1013) to quantify trajectories over the past century. We identify four distinct mechanisms: exogenous convergence (Schmetterling), endo-normative leveling (Rande), endogenous innovation and divergence (schlittschuhlaufen), and diachronic persistence (Stäge). For the locally rooted speakers in our dataset, structural analysis indicates that traditional variables carry less weight than expected. While age remains the primary vertical predictor, psychological factors outperform traditional variables (e.g., gender, social networks) in this environment of ubiquitous exposure. Multivariate models demonstrate that lexical choices are strongly influenced by individual disposition: traits such as agreeableness accelerate the adoption of supraregional forms, whereas a strong local identity functions as a “brake” against standardization. Ultimately, while macro-factors create the pressure for change, individual micro-factors determine whether it takes hold. A speaker’s attitude acts as a “filter” and their personality as a “gate,” deciding whether they accept or resist new forms. These findings challenge purely structural accounts, suggesting that for these locally rooter speakers, even without high physical mobility, lexical change is shaped by a psychometric architecture. Full article
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45 pages, 2643 KB  
Article
From Complexity Theory to Computational Wisdom: Enhancing EEG–Neurotransmitter Models Through Sophimatics for Brain Data Analysis
by Gerardo Iovane and Giovanni Iovane
Algorithms 2026, 19(3), 237; https://doi.org/10.3390/a19030237 - 22 Mar 2026
Cited by 1 | Viewed by 374
Abstract
The analysis of brain data through electroencephalography (EEG) has become essential in neuroscience, affective computing, and brain–computer interfaces. Recent work associates EEG features with artificial neurotransmitter models, simulating emotions and rational–emotional decision-making using complexity theory. However, current methods face limitations: (1) linear temporal [...] Read more.
The analysis of brain data through electroencephalography (EEG) has become essential in neuroscience, affective computing, and brain–computer interfaces. Recent work associates EEG features with artificial neurotransmitter models, simulating emotions and rational–emotional decision-making using complexity theory. However, current methods face limitations: (1) linear temporal representations lacking memory and anticipation, (2) limited contextual adaptation, (3) difficulty with paradoxical affective states, and (4) absence of ethical reasoning in decision-making. We present a framework based on Sophimatics, using complex time (t=treal+itimagC) where treal represents chronology and timag encodes experiential dimensions including memory depth and anticipatory imagination. The Super Time Cognitive Neural Network (STCNN) architecture enables the parallel processing of objective time sequences and subjective cognitive experiences. Our Sophimatics-assisted EEG analysis achieves: (1) two-dimensional temporal coherence integrating past experiences and future projections, (2) context-sensitive adaptation via ontological knowledge graphs, (3) interpretable symbolic reasoning compatible with clinical psychology, (4) mechanisms for resolving affective paradoxes, and (5) ethical constraints ensuring value-based decision-making. Across three case studies (emotion recognition, meditation-induced transitions, and brain–computer interface decision support), integrated Sophimatics models outperform traditional machine learning (15–22% accuracy improvement) and complexity theory models (8–14% improvement), while offering greater cognitive richness and immunity to incomplete data. Results establish a post-generative AI framework with computational wisdom: relationally interactive, ethically informed, and temporally consistent with human cognitive and affective life. The framework outlines paths toward next-generation neuromorphic systems achieving genuine understanding beyond pattern recognition. Full article
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30 pages, 1713 KB  
Article
Safe-Calibrated TCN–Transformer Transfer Learning for Reliable Battery SoH Estimation Under Lab-to-Field Domain Shift
by Kumbirayi Nyachionjeka and Ehab H. E. Bayoumi
World Electr. Veh. J. 2026, 17(3), 149; https://doi.org/10.3390/wevj17030149 - 17 Mar 2026
Viewed by 624
Abstract
Battery state-of-health (SoH) estimation is central to transportation electrification because it conditions safety limits, warranty accounting, power capability management, and long-horizon fleet optimization. Although deep temporal architectures can achieve high laboratory accuracy, field deployment is frequently limited by laboratory (Lab)-to-field (L2F) domain shift [...] Read more.
Battery state-of-health (SoH) estimation is central to transportation electrification because it conditions safety limits, warranty accounting, power capability management, and long-horizon fleet optimization. Although deep temporal architectures can achieve high laboratory accuracy, field deployment is frequently limited by laboratory (Lab)-to-field (L2F) domain shift that alters input statistics, feature definitions, and noise regimes. Under such a shift, predictors may remain strongly monotonic, preserving degradation ordering and become operationally unreliable due to systematic output distortion (e.g., compression/warping of the SoH scale). A deployment-complete L2F transfer learning pipeline is presented, built around a gated Temporal Convolutional Network (TCN)–Transformer fusion backbone, domain-specific adapters and heads, alignment-regularized fine-tuning, and row-level inference via sliding-window overlap averaging. To address the dominant deployment failure mode, a Safe Calibration stage robustly filters calibration pairs and selects among candidate calibrators under a strict do-no-harm criterion. On an unseen deployment stream (2154 labeled rows), overlap-averaged raw inference achieves MAE = 0.0439, RMSE = 0.0501, and R2 = 0.7451, consistent with mid-to-high SoH range compression, while Safe Calibration (Isotonic-Balanced selected) corrects nonlinear scaling without violating monotonic structure, improving to MAE = 0.0188, RMSE = 0.0252, and R2 = 0.9357 to obtain a complete understanding of the challenges due to domain shifts, evaluation is extended to include other architecture baselines such as TCN-only, Transformer-only, Gated Recurrent Unit (GRU), and Long Short-Term Memory (LSTM), and a Ridge regression baseline. Also added is explicit alignment and calibration ablations that include CORAL off/on, that is, none vs. Safe-Global vs. Context-Aware under identical leakage-safe splits and the same overlap-averaged deployment inference operator. This work goes beyond peak-score reporting and looks at the robustness of a pipeline under domain shift, which is quantified across four random seeds and multiple deployment streams, with uncertainty summarized via mean ± std and bootstrap confidence intervals for Mean of Absolute value of Errors (MAE)/Root of the Mean of the Square of Errors (RMSE) computed from per-example absolute errors. Full article
(This article belongs to the Section Storage Systems)
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19 pages, 970 KB  
Review
Photo-Oxidative Stress in Plants: ROS Signaling, Damage Propagation, and Systems-Level Resilience
by Xinguo Li, Sha Yang, Jialei Zhang and Shubo Wan
Antioxidants 2026, 15(3), 371; https://doi.org/10.3390/antiox15030371 - 15 Mar 2026
Viewed by 717
Abstract
Photo-oxidative stress, resulting from an imbalance between light absorption and photosynthetic carbon utilization, poses a fundamental challenge to plant survival and productivity. This review synthesizes recent advances to present an integrated framework connecting reactive oxygen species (ROS) signaling, damage propagation, and systems-level resilience. [...] Read more.
Photo-oxidative stress, resulting from an imbalance between light absorption and photosynthetic carbon utilization, poses a fundamental challenge to plant survival and productivity. This review synthesizes recent advances to present an integrated framework connecting reactive oxygen species (ROS) signaling, damage propagation, and systems-level resilience. We move beyond describing ROS as mere toxic byproducts to position them as central hubs in a complex, interconnected network. We integrate the specific sites of ROS generation, particularly 1O2 at PSII and H2O2 at PSI, with their distinct retrograde signaling pathways (e.g., EXECUTER, β-cyclocitral, and RES/RCS pathways) that reprogram nuclear gene expression. A systems perspective is then applied to reveal how initial photochemical damage propagates through a self-amplifying “vicious cycle” of impaired photosystem repair, lipid peroxidation, and protein oxidation, ultimately threatening cellular integrity. Counteracting this cycle is a multi-layered photoprotective arsenal including NPQ, alternative electron sinks (CEF, WWC), and an integrated antioxidant network, which we re-evaluate not as independent modules but as a coordinated, evolutionary-tuned defense system. We synthesize this knowledge to highlight a central paradigm for crop improvement: the pervasive growth–defense trade-off. Investment in photoprotection, while crucial for survival, diverts resources from yield, explaining why single-gene modifications often fail in the field. Therefore, we argue that future strategies must move beyond simply enhancing single components and instead focus on “optimizing the network”. We conclude by outlining how synthetic biology, multi-omics integration, and genomics-assisted breeding can be leveraged to fine-tune this integrated system, aiming to develop climate-resilient crops that balance productivity with survival in an increasingly volatile climate. Full article
(This article belongs to the Special Issue Advances in Plant Redox Biology Research)
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34 pages, 501 KB  
Review
An Overview of Existing Applications of Artificial Intelligence in Histopathological Diagnostics of Lymphoma: A Scoping Review
by Mieszko Czaplinski, Grzegorz Redlarski, Mateusz Wieczorek, Paweł Kowalski, Piotr Mateusz Tojza, Adam Sikorski and Arkadiusz Żak
Appl. Sci. 2026, 16(6), 2803; https://doi.org/10.3390/app16062803 - 14 Mar 2026
Viewed by 336
Abstract
Background: Artificial intelligence (AI) shows promising results in lymphoma detection, prediction, and classification. However, translating these findings into practice requires a rigorous assessment of potential biases, clinical utility, and further validation of research models. Objective: The goal of this study was to summarize [...] Read more.
Background: Artificial intelligence (AI) shows promising results in lymphoma detection, prediction, and classification. However, translating these findings into practice requires a rigorous assessment of potential biases, clinical utility, and further validation of research models. Objective: The goal of this study was to summarize existing studies on artificial intelligence models for the histopathological detection of lymphoma. Design: This study adhered to the PRISMA Extension for Scoping Reviews (PRISMA-ScR) guidelines. A systematic search was conducted across three major databases (Scopus, PubMed, Web of Science) for English-language articles and reviews published between 2016 and 2025. Seven precise search queries were applied to identify relevant publications, accounting for variations in study modality, algorithmic architectures, and disease-specific terminology. Results: The search identified 612 records, of which 36 articles met the inclusion criteria. These studies presented 36 AI models, comprising 30 diagnostic and six prognostic applications, with Convolutional Neural Networks (CNNs) being the predominant architecture. Regarding data sources, 83% (30/36) of datasets utilized Hematoxylin and Eosin (H&E)-stained images, while the remainder relied on diverse modalities, including IHC-stained slides, bone marrow smears, and other tissue preparations. Studies predominantly utilized retrospective, private cohorts with sample sizes typically ranging from 50 to 400 patients; only a minority leveraged open-access repositories (e.g., Kaggle, TCGA). The primary application was slide-level multi-class classification, distinguishing between specific lymphoma subtypes and non-neoplastic controls. Beyond diagnosis, a subset of studies explored advanced prognostic tasks, such as predicting chemotherapy response and disease progression (e.g., in CLL), as well as automated biomarker quantification (c-MYC, BCL2, PD-L1). Reported diagnostic performance was generally high, with accuracy ranging from 60% to 100% (clustering around 90%) and AUC values spanning 0.70 to 0.99 (predominantly >0.90). Conclusions: While AI models demonstrate high diagnostic accuracy, their translation into practice is limited by unstandardized protocols, morphological complexity, and the “black box” nature of algorithms. Critical issues regarding data provenance, image noise, and lack of representativeness raise risks of systematic bias, hence the need for rigorous validation in diverse clinical environments. Full article
(This article belongs to the Special Issue Advances and Applications of Machine Learning for Bioinformatics)
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30 pages, 3618 KB  
Review
The Structure, Classification, Functional Diversity and Regulatory Mechanism of Plant C2H2 Transcription Factors
by Junbai Ma, Xinyi Zhang, Shan Jiang, Shuoyao Fei, Lingyang Kong, Meitong Pan, Wei Ma and Weichao Ren
Biology 2026, 15(6), 471; https://doi.org/10.3390/biology15060471 - 14 Mar 2026
Viewed by 517
Abstract
Cys2/His2-type zinc finger transcription factors (C2H2 TFs) constitute one of the largest and most functionally diverse transcription factor families in plants, playing core regulatory roles in multiple aspects of plant growth, development, and stress adaptation. Based on literature data from databases including PubMed [...] Read more.
Cys2/His2-type zinc finger transcription factors (C2H2 TFs) constitute one of the largest and most functionally diverse transcription factor families in plants, playing core regulatory roles in multiple aspects of plant growth, development, and stress adaptation. Based on literature data from databases including PubMed (1995–April 2026) and integrated with bioinformatics analyses, this review provides a comprehensive overview of this family. We first summarize the structural characteristics and classification systems of C2H2 TFs, and elucidate their evolutionary dynamics from lower plants to angiosperms. Regarding their impact on plant organ development, beyond key biological processes, this review details the molecular mechanisms of C2H2 TFs in floral organ morphogenesis (e.g., petal, sepal, stamen, and ovule development), pollen fertility maintenance, and flowering time regulation. Concurrently, we systematically analyze their functional pathways in responses to abiotic stresses (drought, high salinity, low temperature, aluminum toxicity, etc.) and biotic stresses (pathogens, pests), clarifying the molecular networks through which they coordinate reactive oxygen species (ROS) homeostasis, stomatal movement, and osmotic regulation by modulating hormone signaling pathways such as ABA, SA, and JA. Furthermore, this review discusses major limitations of current research, including knowledge gaps concerning functional redundancy, pseudogenization phenomena, and cell type-specific regulation. We also provide perspectives on future research directions leveraging cutting-edge technologies such as CRISPR gene editing, single-cell sequencing, and multi-omics integration, as well as their application prospects in crop stress resistance breeding and quality improvement. This review provides ideas for in-depth research on the regulatory network and related functions of C2H2 TFs, and offers reference value for improving plant traits, enhancing plant resistance, and increasing the production of plant secondary metabolites. Full article
(This article belongs to the Special Issue Genetic and Epigenetic Regulation of Gene Expression)
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16 pages, 625 KB  
Article
Benchmarking Training Emissions of Regression Models for Vehicle CO2 Prediction
by Mahmut Turhan, Murat Emeç and Muzaffer Ertürk
Sustainability 2026, 18(6), 2830; https://doi.org/10.3390/su18062830 - 13 Mar 2026
Viewed by 307
Abstract
The urgency of climate action has intensified the use of machine learning (ML) to predict vehicular CO2 emissions; however, the training of machine learning models also generates computational emissions that are seldom reported. This study addresses a paradox central to Green AI: [...] Read more.
The urgency of climate action has intensified the use of machine learning (ML) to predict vehicular CO2 emissions; however, the training of machine learning models also generates computational emissions that are seldom reported. This study addresses a paradox central to Green AI: can carbon-intensive algorithms be justified for predicting carbon emissions? Using a public dataset of 7385 light-duty vehicles, we trained nine widely used regression models spanning simple linear baselines, polynomial and regularised linear methods, tree-based learners, ensembles, and a neural network. All experiments were instrumented with CodeCarbon to quantify real-time training footprints under a grid carbon intensity of 450 g CO2/kWh. Across models, test performance ranged from R2 = 0.72 to 0.99, yet training emissions varied by four orders of magnitude, from 0.001 g CO2 (simple linear regression) to 2.3 g CO2 (XGBoost). Although XGBoost achieved the highest accuracy (R2 = 0.9947), it emitted approximately 2300× more CO2 than regularised polynomial linear models for only a 0.39-point gain in R2. Pareto analysis identifies Lasso and Ridge regression with degree-4 polynomial features as sustainability-optimal, reaching R2 = 0.9908 at ~0.004 g CO2. To unify predictive and environmental efficiency, we introduce Accuracy-per-Gram (APG = R2/CO2) and Marginal Emissions Cost (MEC = ΔCO2/ΔR2), demonstrating a steep efficiency cliff beyond regularised linear models. At the fleet scale (100 million vehicles with daily retraining), algorithm choice implies ~84 t CO2/year for XGBoost versus ~0.15 t for Lasso, highlighting the potential climate cost of marginal accuracy gains. We provide a reproducible carbon-tracking pipeline, Green-AI evaluation metrics, and deployment guidance, arguing that computational sustainability must co-determine model selection for emissions-related ML systems. Most critically, we identify a clear accuracy–carbon emission Pareto frontier, demonstrating that regularised polynomial linear models lie on the sustainability-optimal boundary, while widely used ensemble methods such as XGBoost sit beyond an “efficiency cliff,” where marginal accuracy improvements incur disproportionately high carbon costs. Full article
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