Search Results (467)

Cancer metabolic reprogramming plays a critical role in tumor progression and therapeutic resistance, underscoring the need for advanced analytical strategies. Metabolomics, leveraging mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy, offers a comprehensive and functional readout of tumor biochemistry. By enabling both targeted metabolite quantification and untargeted profiling, metabolomics captures the dynamic metabolic alterations associated with cancer. The integration of metabolomics with machine learning (ML) approaches further enhances the interpretation of these complex, high-dimensional datasets, providing powerful insights into cancer biology from biomarker discovery to therapeutic targeting. This review systematically examines the transformative role of ML in cancer metabolomics. We discuss how various ML methodologies—including supervised algorithms (e.g., Support Vector Machine, Random Forest), unsupervised techniques (e.g., Principal Component Analysis, t-SNE), and deep learning frameworks—are advancing cancer research. Specifically, we highlight three major applications of ML–metabolomics integration: (1) cancer subtyping, exemplified by the use of Similarity Network Fusion (SNF) and LASSO regression to classify triple-negative breast cancer into subtypes with distinct survival outcomes; (2) biomarker discovery, where Random Forest and Partial Least Squares Discriminant Analysis (PLS-DA) models have achieved >90% accuracy in detecting breast and colorectal cancers through biofluid metabolomics; and (3) prognostic modeling, demonstrated by the identification of race-specific metabolic signatures in breast cancer and the prediction of clinical outcomes in lung and ovarian cancers. Beyond these areas, we explore applications across prostate, thyroid, and pancreatic cancers, where ML-driven metabolomics is contributing to earlier detection, improved risk stratification, and personalized treatment planning. We also address critical challenges, including issues of data quality (e.g., batch effects, missing values), model interpretability, and barriers to clinical translation. Emerging solutions, such as explainable artificial intelligence (XAI) approaches and standardized multi-omics integration pipelines, are discussed as pathways to overcome these hurdles. By synthesizing recent advances, this review illustrates how ML-enhanced metabolomics bridges the gap between fundamental cancer metabolism research and clinical application, offering new avenues for precision oncology through improved diagnosis, prognosis, and tailored therapeutic strategies. Full article

Legumes are vital sources of protein, dietary fibre and nutrients, making them crucial for global food security and sustainable agriculture. However, their widespread acceptance and consumption are often limited by undesirable sensory characteristics, such as “a beany flavour”, bitterness or variable textures. Addressing these challenges requires a comprehensive understanding of the complex molecular mechanisms governing appearance, aroma, taste, flavour, texture and palatability in legumes, aiming to enhance their sensory appeal. This review highlights the transformative power of multi-omics approaches in dissecting these intricate biological pathways and facilitating the targeted enhancement of legume sensory qualities. By integrating data from genomics, transcriptomics, proteomics and metabolomics, the genetic and biochemical networks that directly dictate sensory perception can be comprehensively unveiled. The insights gained from these integrated multi-omics studies are proving instrumental in developing strategies for sensory enhancement. They enable the identification of key biomarkers for desirable traits, facilitating more efficient marker-assisted selection (MAS) and genomic selection (GS) in breeding programs. Furthermore, a molecular understanding of sensory pathways opens avenues for precise gene editing (e.g., using CRISPR-Cas9) to modify specific genes, reduce off-flavour compounds or optimise texture. Beyond genetic improvements, multi-omics data also inform the optimisation of post-harvest handling and processing methods (e.g., germination and fermentation) to enhance desirable sensory profiles and mitigate undesirable ones. This holistic approach, spanning from the genetic blueprint to the final sensory experience, will accelerate the development of new legume cultivars and products with enhanced palatability, thereby fostering increased consumption and ultimately contributing to healthier diets and more resilient food systems worldwide. Full article

In industrial wireless networks beyond 5G and toward 6G, combining uplink non-orthogonal multiple access (NOMA) with the Kalman filter (KF) effectively reduces interruption risks and transmission delays in remote state estimation. However, the complexity of wireless environments and concurrent multi-sensor transmissions introduce significant interference and latency, impairing the KF’s ability to continuously obtain reliable observations. Meanwhile, existing remote state estimation systems typically rely on oversimplified wireless communication models, unable to adequately handle the dynamics and interference in realistic network scenarios. To address these limitations, this paper formulates a novel dynamic wireless resource allocation problem as a mixed-integer nonlinear programming (MINLP) model. By jointly optimizing sensor grouping and power allocation—considering sensor available power and outage probability constraints—the proposed scheme minimizes both estimation outage and transmission delay. Simulation results demonstrate that, compared to conventional approaches, our method significantly improves transmission reliability and KF estimation performance, thus providing robust technical support for remote state estimation in next-generation industrial wireless networks. Full article

This study evaluates leadership uniformity—the degree to which the proposer role is evenly distributed among validator nodes over time—in Quorum-based Byzantine Fault Tolerance (QBFT), a Byzantine Fault-Tolerant (BFT) consensus algorithm used in permissioned blockchain networks. By introducing simulated follower timeouts derived from uniform, normal, lognormal, and Weibull distributions, it models a range of network conditions and latency patterns across nodes. This approach integrates Raft-inspired timeout mechanisms into the QBFT framework, enabling a more detailed analysis of leader selection under different network conditions. Three leader selection strategies are tested: Direct selection of the node with the shortest timeout, and two quorum-based approaches selecting from the top 20% and 30% of nodes with the shortest timeouts. Simulations were conducted over 200 rounds in a 10-node network. Results show that leader selection was most equitable under the Weibull distribution with shape $k=0.5$, which captures delay behavior observed in real-world networks. In contrast, the uniform distribution did not consistently yield the most balanced outcomes. The findings also highlight the effectiveness of quorum-based selection: While choosing the node with the lowest timeout ensures responsiveness in each round, it does not guarantee uniform leadership over time. In low-variability distributions, certain nodes may be repeatedly selected by chance, as similar timeout values increase the likelihood of the same nodes appearing among the fastest. Incorporating controlled randomness through quorum-based voting improves rotation consistency and promotes fairer leader distribution, especially under heavy-tailed latency conditions. However, expanding the candidate pool beyond 30% (e.g., to 40% or 50%) introduced vote fragmentation, which complicated quorum formation in small networks and led to consensus failure. Overall, the study demonstrates the potential of timeout-aware, quorum-based leader selection as a more adaptive and equitable alternative to round-robin approaches, and provides a foundation for developing more sophisticated QBFT variants tailored to latency-sensitive networks. Full article

THz communication stands as a pivotal technology for 6G networks, designed to address the critical challenge of data demands surpassing current microwave and millimeter-wave (mmWave) capabilities. However, realizing Tbps and kilometer-range transmission confronts the “dual attenuation dilemma” comprising severe free-space path loss (FSPL) (>120 dB/km) and atmospheric absorption. This review comprehensively summarizes our group′s advancements in overcoming fundamental challenges of long-distance THz communication. Through systematic photonic–electronic co-optimization, we report key enabling technologies including photonically assisted THz signal generation, polarization-multiplexed multiple-input multiple-output (MIMO) systems with maximal ratio combining (MRC), high-gain antenna–lens configurations, and InP amplifier systems for complex weather resilience. Critical experimental milestones encompass record-breaking 1.0488 Tbps throughput using probabilistically shaped 64QAM (PS-64QAM) in the 330–500 GHz band; 30.2 km D-band transmission (18 Gbps with 543.6 Gbps·km capacity–distance product); a 3 km fog-penetrating link at 312 GHz; and high-sensitivity SIMO-validated 100 Gbps satellite-terrestrial communication beyond 36,000 km. These findings demonstrate THz communication′s viability for 6G networks requiring extreme-capacity backhaul and ultra-long-haul connectivity. Full article

Cell-free massive multiple-input multiple-output (CF M-MIMO) is one of the most promising technologies for future wireless communication such as 5G and beyond fifth-generation (B5G) networks. It is a type of network technology that uses a massive number of distributed antennas to serve a large number of users at the same time. It has the ability to provide high spectral efficiency (SE) as well as improved coverage and interference management, compared to traditional cellular networks. However, estimating the channel with high-performance, low-cost computational methods is still a problem. Different algorithms have been developed to address these challenges in channel estimation. One of the high-performance channel estimators is a phase-aware minimum mean square error (MMSE) estimator. This channel estimator has high computational complexity. To address the shortcomings of the existing estimator, this paper proposed an efficient phase-aware element-wise minimum mean square error (PA-EW-MMSE) channel estimator with QR decomposition and a precoding matrix at the user side. The closed form uplink (UL) SE with the phase MMSE and proposed estimators are evaluated using MMSE combining. The energy efficiency and area throughput are also calculated from the SE. The simulation results show that the proposed estimator achieved the best SE, EE, and area throughput performance with a substantial reduction in the complexity of the computation. Full article

Modern industrial ecosystems, particularly those embracing Industry 4.0, increasingly depend on coherent optical networks operating at 400 Gbps and beyond. These high-capacity infrastructures, coupled with advanced digital signal processing and phase-sensitive detection, enable real-time data exchange for automated manufacturing, robotics, and interconnected factory systems. However, they introduce multilayer security challenges—ranging from hardware synchronization gaps to protocol overhead manipulation. Moreover, the rise of large-scale quantum computing intensifies these threats by potentially breaking classical key exchange protocols and enabling the future decryption of stored ciphertext. In this paper, we present a systematic vulnerability analysis of coherent optical networks that use OTU4 framing, Media Access Control Security (MACsec), and 400G ZR+ transceivers. Guided by established risk assessment methodologies, we uncover critical weaknesses affecting management plane interfaces (e.g., MDIO and I²C) and overhead fields (e.g., Trail Trace Identifier, Bit Interleaved Parity). To mitigate these risks while preserving the robust data throughput and low-latency demands of industrial automation, we propose a post-quantum security framework that merges spectral phase masking with multi-homodyne coherent detection, strengthened by quantum key distribution for key management. This layered approach maintains backward compatibility with existing infrastructure and ensures forward secrecy against quantum-enabled adversaries. The evaluation results show a substantial reduction in exposure to timing-based exploits, overhead field abuses, and cryptographic compromise. By integrating quantum-safe measures at the optical layer, our solution provides a future-proof roadmap for network operators, hardware vendors, and Industry 4.0 stakeholders tasked with safeguarding next-generation manufacturing and engineering processes. Full article

In response to the increasing demands for reliable, fast, and secure communications beyond 5G scenarios, the high-capacity networks have become a focal point. Quantum communication is at the forefront of this research, offering unmatched throughput and security. A free space optics (FSO) communication system integrated with fiber-end is designed and investigated using the Bennett–Brassard 1984 quantum key distribution (BB84-QKD) protocol. Simulation results show that reliable transmission can be achieved over a 10–15 km fiber length with a signal power of −19.54 dBm and high optical-to-signal noise of 72.28–95.30 dB over a 550 m FSO range under clear air, haze, fog, and rain conditions at a data rate of 1 Gbps. Also, the system using rectilinearly and circularly polarized signals exhibits a Stokes parameter intensity of −4.69 to −35.65 dBm and −7.7 to −35.66 dBm Stokes parameter intensity, respectively, over 100–700 m FSO range under diverse weather conditions. Likewise, for the same scenario, an FSO range of 100 m incorporating 2.5–4 mrad beam divergence provides the Stokes power intensity of −6.03 to −11.1 dBm and −9.04 to −14.12 dBm for rectilinearly and circularly polarized signals, respectively. Moreover, compared to existing works, this work allows faithful and secure signal transmission in free space, considering FSO–fiber link losses. Full article

The convergence of next-generation wireless communication technologies and modern energy infrastructure presents a promising path toward sustainable and intelligent systems. This survey explores how beyond-5G and 6G communication technologies can support the greening of Industrial Internet of Things (IIoT) systems and smart grids. It highlights the critical challenges in achieving energy efficiency, interoperability, and real-time responsiveness across different domains. The paper reviews key enablers such as LPWAN, wake-up radios, mobile edge computing, and energy harvesting techniques for green IoT, as well as optimization strategies for 5G/6G networks and data center operations. Furthermore, it examines the role of 5G in enabling reliable, ultra-low-latency data communication for advanced smart grid applications, such as distributed generation, precise load control, and intelligent feeder automation. Through a structured analysis of recent advances and open research problems, the paper aims to identify essential directions for future research and development in building energy-efficient, resilient, and scalable smart infrastructures powered by intelligent wireless networks. Full article

Millimeter-wave (mmWave) antennas and antenna arrays have gained significant attention due to their pivotal role in emerging wireless communication, sensing, and imaging technologies. With the rapid deployment of 5G and the transition toward 6G networks, the demand for compact, high-gain, and reconfigurable mmWave antennas has intensified. This article highlights recent advancements in mmWave antenna technologies, including hybrid beamforming using phased arrays, dynamic beam-steering enabled by liquid crystal and MEMS-based structures, and high-capacity MIMO architectures. We also examine the integration of metamaterials and metasurfaces for miniaturization and gain enhancement. Applications covered include wearable antennas with low-SAR textile substrates, conformal antennas for UAV-based mmWave relays, and high-resolution radar arrays for autonomous vehicles. The study further analyzes innovative fabrication methods such as inkjet and aerosol jet printing, micromachining, and laser direct structuring, along with advanced materials like Kapton, PDMS, and graphene. Numerical modeling techniques such as full-wave EM simulation and machine learning-based optimization are discussed alongside experimental validation approaches. Beyond communications, we assess mmWave systems for biomedical imaging, security screening, and industrial sensing. Key challenges addressed include efficiency degradation at high frequencies, interference mitigation in dense environments, and system-level integration. Finally, future directions, including AI-driven design automation, intelligent reconfigurable surfaces, and integration with quantum and terahertz technologies, are outlined. This comprehensive synthesis aims to serve as a valuable reference for advancing next-generation mmWave antenna systems. Full article

This paper presents an intelligent predictive system designed to support real-time decision making in the control of rubber blend mixing processes. The core of the system is a General Regression Neural Network (GRNN), which accurately predicts key process parameters, such as viscosity (expressed as torque), temperature, and energy consumption across varying masses of the processed material. The model can evaluate the mixing progress based on the initial 10% of input data, allowing early intervention and process optimisation. Experimental validation was conducted using a Brabender Plastograph EC Plus with a natural rubber-based blend in the mass range of 60–75 g. The GRNN kernel width parameter (σ) was optimised through a 10-fold cross-validation. High predictive accuracy was confirmed by values of the coefficient of determination (R²) approaching 1, and consistently low values of the root mean square error (RMSE). This system offers a robust and scalable solution for intelligent process control, productivity enhancement, and quality assurance across diverse industrial applications, beyond rubber blending. Full article

USP (usual temperature pitch)-modified asphalt optimizes its rheological properties through reactions between the modifier and the asphalt. This significantly enhances the high- and low-temperature adaptability and environmental friendliness of asphalt. It has now become an important research direction in the field of highway engineering. This article systematically investigates the impact of different dosages of USP warm mix modifier on asphalt binders through rheological and microstructural analysis. Base asphalt and SBS-modified asphalt were blended with USP at varying ratios. Conventional tests (penetration, softening point, ductility) were combined with dynamic shear rheometry (DSR, AASHTO T315) and bending beam rheometry (BBR, AASHTO T313) to characterize temperature/frequency-dependent viscoelasticity. High-temperature performance was quantified via multiple stress creep recovery (MSCR, ASTM D7405), while fluorescence microscopy and FTIR spectroscopy elucidated modification mechanisms. Key findings reveal that (1) optimal USP thresholds exist at 4.0% for base asphalt and 4.5% for SBS modified asphalt, beyond which the rutting resistance factor (G*/sin δ) decreases by 20–31% due to plasticization effects; (2) USP significantly improves low-temperature flexibility, reducing creep stiffness at −12 °C by 38% (USP-modified) and 35% (USP/SBS composite) versus controls; (3) infrared spectroscopy displays that no new characteristic peaks appeared in the functional group region of 4000–1300 cm⁻¹ for the two types of modified asphalt after the incorporation of USP, indicating that no chemical changes occurred in the asphalt; and (4) fluorescence imaging confirmed that the incorporation of USP led to disintegration of the spatial network structure of the control asphalt, explaining the reason for the deterioration of high-temperature performance. Full article

Intracranial tumors such as gliomas, meningiomas, and brain metastases induce complex alterations in brain function beyond their focal presence. Modern connectomic and neuroimaging approaches, including resting-state functional MRI (rs-fMRI) and diffusion MRI, have revealed that these tumors disrupt and reorganize large-scale brain networks in heterogeneous ways. In adult patients, diffuse gliomas infiltrate neural circuits, causing both local disconnections and widespread functional changes that often extend into structurally intact regions. Meningiomas and metastases, though typically well-circumscribed, can perturb networks via mass effect, edema, and diaschisis, sometimes provoking global “dysconnectivity” related to cognitive deficits. Therefore, this review synthesizes interdisciplinary evidence from neuroscience, oncology, and neuroimaging on how intracranial tumors disrupt functional brain connectivity pre- and post-surgery. We discuss how functional heterogeneity (i.e., differences in network involvement due to tumor type, location, and histo-molecular profile) manifests in connectomic analyses, from altered default mode and salience network activity to changes in structural–functional coupling. The clinical relevance of these network effects is examined, highlighting implications for pre-surgical planning, prognostication of neurocognitive outcomes, and post-operative recovery. Gliomas demonstrate remarkable functional plasticity, with network remodeling that may correlate with tumor genotype (e.g., IDH mutation), while meningioma-related edema and metastasis location modulate the extent of network disturbance. Finally, we explore future directions, including imaging-guided therapies and “network-aware” neurosurgical strategies that aim to preserve and restore brain connectivity. Understanding functional heterogeneity in brain tumors through a connectomic lens not only provides insights into the neuroscience of cancer but also informs more effective, personalized approaches to neuro-oncologic care. Full article

This study presents a new intelligent aquatic farming surveillance system that tackles real-time monitoring challenges in the industry. The main technical break-throughs of this system are evident in four key aspects: First, it achieves the smooth integration of remotely operated vehicles (ROVs), sensors, and real-time data transmission. Second, it uses a mobile communication architecture with buoy relay stations for distributed edge computing. This design supports future upgrades to Beyond 5G and satellite networks for deep-sea applications. Third, it features a multi-terminal control system that supports computers, smartphones, smartwatches, and centralized hubs, effectively enabling monitoring anytime, anywhere. Fourth, it incorporates a cost-effective modular design, utilizing commercial hardware and innovative system integration solutions, making it particularly suitable for farms with limited resources. The data indicates that the system’s 4G connection is both stable and reliable, demonstrating excellent performance in terms of data transmission success rates, control command response delays, and endurance. It has successfully processed 324,800 data transmission events, thoroughly validating its reliability in real-world production environments. This system integrates advanced technologies such as the Internet of Things, mobile communications, and multi-access control, which not only significantly enhance the precision oversight capabilities of marine farming but also feature a modular design that allows for future expansion into satellite communications. Notably, the system reduces operating costs while simultaneously improving aquaculture efficiency, offering a practical and intelligent solution for small farmers in resource-limited areas. Full article

Sparse borehole sampling at contaminated sites results in sparse and unevenly distributed data on soil pollutants. Traditional interpolation methods may obscure local variations in soil contamination when applied to such sparse data, thus reducing the interpolation accuracy. We propose an adaptive graph convolutional network with spatial autocorrelation (ASI-GCN) model to overcome this challenge. The ASI-GCN model effectively constrains pollutant concentration transfer while capturing subtle spatial variations, improving soil pollution characterization accuracy. We tested our model at a coking plant using 215 soil samples from 15 boreholes, evaluating its robustness with three pollutants of varying volatility: arsenic (As, non-volatile), benzo(a)pyrene (BaP, semi-volatile), and benzene (Ben, volatile). Leave-one-out cross-validation demonstrates that the ASI-GCN_RC_G model (ASI-GCN with residual connections) achieves the highest prediction accuracy. Specifically, the R for As, BaP, and Ben are 0.728, 0.825, and 0.781, respectively, outperforming traditional models by 58.8% (vs. IDW), 45.82% (vs. OK), and 53.78% (vs. IDW). Meanwhile, their RMSE drop by 36.56% (vs. Bayesian_K), 38.02% (vs. Bayesian_K), and 35.96% (vs. IDW), further confirming the model’s superior precision. Beyond accuracy, Monte Carlo uncertainty analysis reveals that most predicted areas exhibit low uncertainty, with only a few high-pollution hotspots exhibiting relatively high uncertainty. Further analysis revealed the significant influence of pollutant volatility on vertical migration patterns. Non-volatile As was primarily distributed in the fill and silty sand layers, and semi-volatile BaP concentrated in the silty sand layer. At the same time, volatile Ben was predominantly found in the clay and fine sand layers. By integrating spatial autocorrelation with deep graph representation, ASI-GCN redefines sparse data 3D mapping, offering a transformative tool for precise environmental governance and human health assessment. Full article