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25 pages, 28131 KiB  
Article
Landslide Susceptibility Assessment in Ya’an Based on Coupling of GWR and TabNet
by Jiatian Li, Ruirui Wang, Wei Shi, Le Yang, Jiahao Wei, Fei Liu and Kaiwei Xiong
Remote Sens. 2025, 17(15), 2678; https://doi.org/10.3390/rs17152678 (registering DOI) - 2 Aug 2025
Abstract
Landslides are destructive geological hazards, making accurate landslide susceptibility assessment essential for disaster prevention and mitigation. However, existing studies often lack scientific rigor in negative sample construction and have unclear model applicability. This study focuses on Ya’an City, Sichuan Province, China, and proposes [...] Read more.
Landslides are destructive geological hazards, making accurate landslide susceptibility assessment essential for disaster prevention and mitigation. However, existing studies often lack scientific rigor in negative sample construction and have unclear model applicability. This study focuses on Ya’an City, Sichuan Province, China, and proposes an innovative approach to negative sample construction using Geographically Weighted Regression (GWR), which is then integrated with Tabular Network (TabNet), a deep learning architecture tailored to structured tabular data, to assess landslide susceptibility. The performance of TabNet is compared against Random Forest, Light Gradient Boosting Machine, deep neural networks, and Residual Networks. The experimental results indicate that (1) the GWR-based sampling strategy substantially improves model performance across all tested models; (2) TabNet trained using the GWR-based negative samples achieves superior performance over all other evaluated models, with an average AUC of 0.9828, exhibiting both high accuracy and interpretability; and (3) elevation, land cover, and annual Normalized Difference Vegetation Index are identified as dominant predictors through TabNet’s feature importance analysis. The results demonstrate that combining GWR and TabNet substantially enhances landslide susceptibility modeling by improving both accuracy and interpretability, establishing a more scientifically grounded approach to negative sample construction, and providing an interpretable, high-performing modeling framework for geological hazard risk assessment. Full article
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17 pages, 2828 KiB  
Article
Augmented Reality in Cardiovascular Education (HoloHeart): Assessment of Students’ and Lecturers’ Needs and Expectations at Heidelberg University Medical School
by Pascal Philipp Schlegel, Florian Kehrle, Till J. Bugaj, Eberhard Scholz, Alexander Kovacevic, Philippe Grieshaber, Ralph Nawrotzki, Joachim Kirsch, Markus Hecker, Anna L. Meyer, Katharina Seidensaal, Thuy D. Do, Jobst-Hendrik Schultz, Norbert Frey and Ann-Kathrin Rahm
Appl. Sci. 2025, 15(15), 8595; https://doi.org/10.3390/app15158595 (registering DOI) - 2 Aug 2025
Abstract
Background: A detailed understanding of cardiac anatomy and physiology is crucial in cardiovascular medicine. However, traditional learning methods often fall short in addressing this complexity. Augmented reality (AR) offers a promising tool to enhance comprehension. To assess its potential integration into the Heidelberger [...] Read more.
Background: A detailed understanding of cardiac anatomy and physiology is crucial in cardiovascular medicine. However, traditional learning methods often fall short in addressing this complexity. Augmented reality (AR) offers a promising tool to enhance comprehension. To assess its potential integration into the Heidelberger Curriculum Medicinale (HeiCuMed), we conducted a needs assessment among medical students and lecturers at Heidelberg University Medical School. Methods: Our survey aimed to evaluate the perceived benefits of AR-based learning compared to conventional methods and to gather expectations regarding an AR course in cardiovascular medicine. Using LimeSurvey, we developed a questionnaire to assess participants’ prior AR experience, preferred learning methods, and interest in a proposed AR-based, 2 × 90-min in-person course. Results: A total of 101 students and 27 lecturers participated. Support for AR in small-group teaching was strong: 96.3% of students and 90.9% of lecturers saw value in a dedicated AR course. Both groups favored its application in anatomy, cardiac surgery, and internal medicine. Students prioritized congenital heart defects, coronary anomalies, and arrhythmias, while lecturers also emphasized invasive valve interventions. Conclusions: There is significant interest in AR-based teaching in cardiovascular education, suggesting its potential to complement and improve traditional methods in medical curricula. Further studies are needed to assess the potential benefits regarding learning outcomes. Full article
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14 pages, 841 KiB  
Article
Enhanced Deep Learning for Robust Stress Classification in Sows from Facial Images
by Syed U. Yunas, Ajmal Shahbaz, Emma M. Baxter, Mark F. Hansen, Melvyn L. Smith and Lyndon N. Smith
Agriculture 2025, 15(15), 1675; https://doi.org/10.3390/agriculture15151675 (registering DOI) - 2 Aug 2025
Abstract
Stress in pigs poses significant challenges to animal welfare and productivity in modern pig farming, contributing to increased antimicrobial use and the rise of antimicrobial resistance (AMR). This study involves stress classification in pregnant sows by exploring five deep learning models: ConvNeXt, EfficientNet_V2, [...] Read more.
Stress in pigs poses significant challenges to animal welfare and productivity in modern pig farming, contributing to increased antimicrobial use and the rise of antimicrobial resistance (AMR). This study involves stress classification in pregnant sows by exploring five deep learning models: ConvNeXt, EfficientNet_V2, MobileNet_V3, RegNet, and Vision Transformer (ViT). These models are used for stress detection from facial images, leveraging an expanded dataset. A facial image dataset of sows was collected at Scotland’s Rural College (SRUC) and the images were categorized into primiparous Low-Stressed (LS) and High-Stress (HS) groups based on expert behavioural assessments and cortisol level analysis. The selected deep learning models were then trained on this enriched dataset and their performance was evaluated using cross-validation on unseen data. The Vision Transformer (ViT) model outperformed the others across the dataset of annotated facial images, achieving an average accuracy of 0.75, an F1 score of 0.78 for high-stress detection, and consistent batch-level performance (up to 0.88 F1 score). These findings highlight the efficacy of transformer-based models for automated stress detection in sows, supporting early intervention strategies to enhance welfare, optimize productivity, and mitigate AMR risks in livestock production. Full article
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27 pages, 1326 KiB  
Systematic Review
Application of Artificial Intelligence in Pancreatic Cyst Management: A Systematic Review
by Donghyun Lee, Fadel Jesry, John J. Maliekkal, Lewis Goulder, Benjamin Huntly, Andrew M. Smith and Yazan S. Khaled
Cancers 2025, 17(15), 2558; https://doi.org/10.3390/cancers17152558 (registering DOI) - 2 Aug 2025
Abstract
Background: Pancreatic cystic lesions (PCLs), including intraductal papillary mucinous neoplasms (IPMNs) and mucinous cystic neoplasms (MCNs), pose a diagnostic challenge due to their variable malignant potential. Current guidelines, such as Fukuoka and American Gastroenterological Association (AGA), have moderate predictive accuracy and may lead [...] Read more.
Background: Pancreatic cystic lesions (PCLs), including intraductal papillary mucinous neoplasms (IPMNs) and mucinous cystic neoplasms (MCNs), pose a diagnostic challenge due to their variable malignant potential. Current guidelines, such as Fukuoka and American Gastroenterological Association (AGA), have moderate predictive accuracy and may lead to overtreatment or missed malignancies. Artificial intelligence (AI), incorporating machine learning (ML) and deep learning (DL), offers the potential to improve risk stratification, diagnosis, and management of PCLs by integrating clinical, radiological, and molecular data. This is the first systematic review to evaluate the application, performance, and clinical utility of AI models in the diagnosis, classification, prognosis, and management of pancreatic cysts. Methods: A systematic review was conducted in accordance with PRISMA guidelines and registered on PROSPERO (CRD420251008593). Databases searched included PubMed, EMBASE, Scopus, and Cochrane Library up to March 2025. The inclusion criteria encompassed original studies employing AI, ML, or DL in human subjects with pancreatic cysts, evaluating diagnostic, classification, or prognostic outcomes. Data were extracted on the study design, imaging modality, model type, sample size, performance metrics (accuracy, sensitivity, specificity, and area under the curve (AUC)), and validation methods. Study quality and bias were assessed using the PROBAST and adherence to TRIPOD reporting guidelines. Results: From 847 records, 31 studies met the inclusion criteria. Most were retrospective observational (n = 27, 87%) and focused on preoperative diagnostic applications (n = 30, 97%), with only one addressing prognosis. Imaging modalities included Computed Tomography (CT) (48%), endoscopic ultrasound (EUS) (26%), and Magnetic Resonance Imaging (MRI) (9.7%). Neural networks, particularly convolutional neural networks (CNNs), were the most common AI models (n = 16), followed by logistic regression (n = 4) and support vector machines (n = 3). The median reported AUC across studies was 0.912, with 55% of models achieving AUC ≥ 0.80. The models outperformed clinicians or existing guidelines in 11 studies. IPMN stratification and subtype classification were common focuses, with CNN-based EUS models achieving accuracies of up to 99.6%. Only 10 studies (32%) performed external validation. The risk of bias was high in 93.5% of studies, and TRIPOD adherence averaged 48%. Conclusions: AI demonstrates strong potential in improving the diagnosis and risk stratification of pancreatic cysts, with several models outperforming current clinical guidelines and human readers. However, widespread clinical adoption is hindered by high risk of bias, lack of external validation, and limited interpretability of complex models. Future work should prioritise multicentre prospective studies, standardised model reporting, and development of interpretable, externally validated tools to support clinical integration. Full article
(This article belongs to the Section Methods and Technologies Development)
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19 pages, 2359 KiB  
Article
Research on Concrete Crack Damage Assessment Method Based on Pseudo-Label Semi-Supervised Learning
by Ming Xie, Zhangdong Wang and Li’e Yin
Buildings 2025, 15(15), 2726; https://doi.org/10.3390/buildings15152726 (registering DOI) - 1 Aug 2025
Abstract
To address the inefficiency of traditional concrete crack detection methods and the heavy reliance of supervised learning on extensive labeled data, in this study, an intelligent assessment method of concrete damage based on pseudo-label semi-supervised learning and fractal geometry theory is proposed to [...] Read more.
To address the inefficiency of traditional concrete crack detection methods and the heavy reliance of supervised learning on extensive labeled data, in this study, an intelligent assessment method of concrete damage based on pseudo-label semi-supervised learning and fractal geometry theory is proposed to solve two core tasks: one is binary classification of pixel-level cracks, and the other is multi-category assessment of damage state based on crack morphology. Using three-channel RGB images as input, a dual-path collaborative training framework based on U-Net encoder–decoder architecture is constructed, and a binary segmentation mask of the same size is output to achieve the accurate segmentation of cracks at the pixel level. By constructing a dual-path collaborative training framework and employing a dynamic pseudo-label refinement mechanism, the model achieves an F1-score of 0.883 using only 50% labeled data—a mere 1.3% decrease compared to the fully supervised benchmark DeepCrack (F1 = 0.896)—while reducing manual annotation costs by over 60%. Furthermore, a quantitative correlation model between crack fractal characteristics and structural damage severity is established by combining a U-Net segmentation network with the differential box-counting algorithm. The experimental results demonstrate that under a cyclic loading of 147.6–221.4 kN, the fractal dimension monotonically increases from 1.073 (moderate damage) to 1.189 (failure), with 100% accuracy in damage state identification, closely aligning with the degradation trend of macroscopic mechanical properties. In complex crack scenarios, the model attains a recall rate (Re = 0.882), surpassing U-Net by 13.9%, with significantly enhanced edge reconstruction precision. Compared with the mainstream models, this method effectively alleviates the problem of data annotation dependence through a semi-supervised strategy while maintaining high accuracy. It provides an efficient structural health monitoring solution for engineering practice, which is of great value to promote the application of intelligent detection technology in infrastructure operation and maintenance. Full article
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26 pages, 1567 KiB  
Article
A CDC–ANFIS-Based Model for Assessing Ship Collision Risk in Autonomous Navigation
by Hee-Jin Lee and Ho Namgung
J. Mar. Sci. Eng. 2025, 13(8), 1492; https://doi.org/10.3390/jmse13081492 (registering DOI) - 1 Aug 2025
Abstract
To improve collision risk prediction in high-traffic coastal waters and support real-time decision-making in maritime navigation, this study proposes a regional collision risk prediction system integrating the Computed Distance at Collision (CDC) method with an Adaptive Neuro-Fuzzy Inference System (ANFIS). Unlike Distance at [...] Read more.
To improve collision risk prediction in high-traffic coastal waters and support real-time decision-making in maritime navigation, this study proposes a regional collision risk prediction system integrating the Computed Distance at Collision (CDC) method with an Adaptive Neuro-Fuzzy Inference System (ANFIS). Unlike Distance at Closest Point of Approach (DCPA), which depends on the position of Global Positioning System (GPS) antennas, Computed Distance at Collision (CDC) directly reflects the actual hull shape and potential collision point. This enables a more realistic assessment of collision risk by accounting for the hull geometry and boundary conditions specific to different ship types. The system was designed and validated using ship motion simulations involving bulk and container ships across varying speeds and crossing angles. The CDC method was used to define collision, almost-collision, and near-collision situations based on geometric and hydrodynamic criteria. Subsequently, the FIS–CDC model was constructed using the ANFIS by learning patterns in collision time and distance under each condition. A total of four input variables—ship speed, crossing angle, remaining time, and remaining distance—were used to infer the collision risk index (CRI), allowing for a more nuanced and vessel-specific assessment than traditional CPA-based indicators. Simulation results show that the time to collision decreases with higher speeds and increases with wider crossing angles. The bulk carrier exhibited a wider collision-prone angle range and a greater sensitivity to speed changes than the container ship, highlighting differences in maneuverability and risk response. The proposed system demonstrated real-time applicability and accurate risk differentiation across scenarios. This research contributes to enhancing situational awareness and proactive risk mitigation in Maritime Autonomous Surface Ship (MASS) and Vessel Traffic System (VTS) environments. Future work will focus on real-time CDC optimization and extending the model to accommodate diverse ship types and encounter geometries. Full article
31 pages, 1370 KiB  
Article
AIM-Net: A Resource-Efficient Self-Supervised Learning Model for Automated Red Spider Mite Severity Classification in Tea Cultivation
by Malathi Kanagarajan, Mohanasundaram Natarajan, Santhosh Rajendran, Parthasarathy Velusamy, Saravana Kumar Ganesan, Manikandan Bose, Ranjithkumar Sakthivel and Baskaran Stephen Inbaraj
AgriEngineering 2025, 7(8), 247; https://doi.org/10.3390/agriengineering7080247 (registering DOI) - 1 Aug 2025
Abstract
Tea cultivation faces significant threats from red spider mite (RSM: Oligonychus coffeae) infestations, which reduce yields and economic viability in major tea-producing regions. Current automated detection methods rely on supervised deep learning models requiring extensive labeled data, limiting scalability for smallholder farmers. [...] Read more.
Tea cultivation faces significant threats from red spider mite (RSM: Oligonychus coffeae) infestations, which reduce yields and economic viability in major tea-producing regions. Current automated detection methods rely on supervised deep learning models requiring extensive labeled data, limiting scalability for smallholder farmers. This article proposes AIM-Net (AI-based Infestation Mapping Network) by evaluating SwAV (Swapping Assignments between Views), a self-supervised learning framework, for classifying RSM infestation severity (Mild, Moderate, Severe) using a geo-referenced, field-acquired dataset of RSM infested tea-leaves, Cam-RSM. The methodology combines SwAV pre-training on unlabeled data with fine-tuning on labeled subsets, employing multi-crop augmentation and online clustering to learn discriminative features without full supervision. Comparative analysis against a fully supervised ResNet-50 baseline utilized 5-fold cross-validation, assessing accuracy, F1-scores, and computational efficiency. Results demonstrate SwAV’s superiority, achieving 98.7% overall accuracy (vs. 92.1% for ResNet-50) and macro-average F1-scores of 98.3% across classes, with a 62% reduction in labeled data requirements. The model showed particular strength in Mild_RSM-class detection (F1-score: 98.5%) and computational efficiency, enabling deployment on edge devices. Statistical validation confirmed significant improvements (p < 0.001) over baseline approaches. These findings establish self-supervised learning as a transformative tool for precision pest management, offering resource-efficient solutions for early infestation detection while maintaining high accuracy. Full article
13 pages, 3776 KiB  
Article
Focused View CT Urography: Towards a Randomized Trial Investigating the Relevance of Incidental Findings in Patients with Hematuria
by Tim E. Sluijter, Christian Roest, Derya Yakar and Thomas C. Kwee
Diseases 2025, 13(8), 242; https://doi.org/10.3390/diseases13080242 (registering DOI) - 1 Aug 2025
Abstract
Background: Computed tomography urography (CTU) is routinely used to evaluate the upper urinary tract in patients with hematuria. CTU may detect incidental findings outside the urinary tract, but it remains unclear if this adds value. This study aimed to develop a deep learning [...] Read more.
Background: Computed tomography urography (CTU) is routinely used to evaluate the upper urinary tract in patients with hematuria. CTU may detect incidental findings outside the urinary tract, but it remains unclear if this adds value. This study aimed to develop a deep learning algorithm that automatically segments and selectively visualizes the urinary tract on CTU. Methods: The urinary tract (kidneys, ureters, and urinary bladder) was manually segmented on 2 mm dual-phase CTU slices of 111 subjects. With this dataset, a deep learning-based AI was trained to automatically segment and selectively visualize the urinary tract on CTU scans (including accompanying unenhanced CT scans), which we dub “focused view CTU”. Focused view CTU was technically optimized and tested in 39 subjects with hematuria. Results: The technically optimized focused view CTU algorithm provided complete visualization of 97.4% of kidneys, 80.8% of ureters, and 94.9% of urinary bladders. All urinary tract organs were completely visualized in 66.6% of cases. In these cases (excluding 33.3% of cases with incomplete visualization), focused view CTU intrinsically achieved a sensitivity, specificity, positive predictive value, and negative predictive value of 100.0%, 92.3%, 92.9%, and 100.0% for lesions in the urinary tract compared to unmodified CT, although interrater agreement was moderate (κ = 0.528). All incidental findings were successfully hidden by focused view CTU. Conclusions: Focused view CTU provides adequate urinary tract segmentation in most cases, but further research is needed to optimize the technique (segmentation does not succeed in about one-third of cases). It offers selective urinary tract visualization, potentially aiding in assessing relevance and cost-effectiveness of detecting incidental findings in hematuria patients through a prospective randomized trial. Full article
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13 pages, 643 KiB  
Article
Using Artificial Intelligence for Detecting Diabetic Foot Osteomyelitis: Validation of Deep Learning Model for Plain Radiograph Interpretation
by Francisco Javier Álvaro-Afonso, Aroa Tardáguila-García, Mateo López-Moral, Irene Sanz-Corbalán, Esther García-Morales and José Luis Lázaro-Martínez
Appl. Sci. 2025, 15(15), 8583; https://doi.org/10.3390/app15158583 (registering DOI) - 1 Aug 2025
Abstract
Objective: To develop and validate a ResNet-50-based deep learning model for automatic detection of osteomyelitis (DFO) in plain radiographs of patients with diabetic foot ulcers (DFUs). Research Design and Methods: This retrospective study included 168 patients with type one or type two diabetes [...] Read more.
Objective: To develop and validate a ResNet-50-based deep learning model for automatic detection of osteomyelitis (DFO) in plain radiographs of patients with diabetic foot ulcers (DFUs). Research Design and Methods: This retrospective study included 168 patients with type one or type two diabetes and clinical suspicion of DFO confirmed via a surgical bone biopsy. An experienced clinician and a pretrained ResNet-50 model independently interpreted the radiographs. The model was developed using Python-based frameworks with ChatGPT assistance for coding. The diagnostic performance was assessed against the histopathological findings, calculating sensitivity, specificity, the positive predictive value (PPV), the negative predictive value (NPV), and the likelihood ratios. Agreement between the AI model and the clinician was evaluated using Cohen’s kappa coefficient. Results: The AI model demonstrated high sensitivity (92.8%) and PPV (0.97), but low-level specificity (4.4%). The clinician showed 90.2% sensitivity and 37.8% specificity. The Cohen’s kappa coefficient between the AI model and the clinician was −0.105 (p = 0.117), indicating weak agreement. Both the methods tended to classify many cases as DFO-positive, with 81.5% agreement in the positive cases. Conclusions: This study demonstrates the potential of IA to support the radiographic diagnosis of DFO using a ResNet-50-based deep learning model. AI-assisted radiographic interpretation could enhance early DFO detection, particularly in high-prevalence settings. However, further validation is necessary to improve its specificity and assess its utility in primary care. Full article
(This article belongs to the Special Issue Applications of Sensors in Biomechanics and Biomedicine)
22 pages, 6482 KiB  
Article
Surface Damage Detection in Hydraulic Structures from UAV Images Using Lightweight Neural Networks
by Feng Han and Chongshi Gu
Remote Sens. 2025, 17(15), 2668; https://doi.org/10.3390/rs17152668 (registering DOI) - 1 Aug 2025
Abstract
Timely and accurate identification of surface damage in hydraulic structures is essential for maintaining structural integrity and ensuring operational safety. Traditional manual inspections are time-consuming, labor-intensive, and prone to subjectivity, especially for large-scale or inaccessible infrastructure. Leveraging advancements in aerial imaging, unmanned aerial [...] Read more.
Timely and accurate identification of surface damage in hydraulic structures is essential for maintaining structural integrity and ensuring operational safety. Traditional manual inspections are time-consuming, labor-intensive, and prone to subjectivity, especially for large-scale or inaccessible infrastructure. Leveraging advancements in aerial imaging, unmanned aerial vehicles (UAVs) enable efficient acquisition of high-resolution visual data across expansive hydraulic environments. However, existing deep learning (DL) models often lack architectural adaptations for the visual complexities of UAV imagery, including low-texture contrast, noise interference, and irregular crack patterns. To address these challenges, this study proposes a lightweight, robust, and high-precision segmentation framework, called LFPA-EAM-Fast-SCNN, specifically designed for pixel-level damage detection in UAV-captured images of hydraulic concrete surfaces. The developed DL-based model integrates an enhanced Fast-SCNN backbone for efficient feature extraction, a Lightweight Feature Pyramid Attention (LFPA) module for multi-scale context enhancement, and an Edge Attention Module (EAM) for refined boundary localization. The experimental results on a custom UAV-based dataset show that the proposed damage detection method achieves superior performance, with a precision of 0.949, a recall of 0.892, an F1 score of 0.906, and an IoU of 87.92%, outperforming U-Net, Attention U-Net, SegNet, DeepLab v3+, I-ST-UNet, and SegFormer. Additionally, it reaches a real-time inference speed of 56.31 FPS, significantly surpassing other models. The experimental results demonstrate the proposed framework’s strong generalization capability and robustness under varying noise levels and damage scenarios, underscoring its suitability for scalable, automated surface damage assessment in UAV-based remote sensing of civil infrastructure. Full article
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27 pages, 6085 KiB  
Article
Assessing Model Trade-Offs in Agricultural Remote Sensing: A Review of Machine Learning and Deep Learning Approaches Using Almond Crop Mapping
by Mashoukur Rahaman, Jane Southworth, Yixin Wen and David Keellings
Remote Sens. 2025, 17(15), 2670; https://doi.org/10.3390/rs17152670 (registering DOI) - 1 Aug 2025
Abstract
This study presents a comprehensive review and comparative analysis of traditional machine learning (ML) and deep learning (DL) models for land cover classification in agricultural remote sensing. We evaluate the reported successes, trade-offs, and performance metrics of ML and DL models across diverse [...] Read more.
This study presents a comprehensive review and comparative analysis of traditional machine learning (ML) and deep learning (DL) models for land cover classification in agricultural remote sensing. We evaluate the reported successes, trade-offs, and performance metrics of ML and DL models across diverse agricultural contexts. Building on this foundation, we apply both model types to the specific case of almond crop field identification in California’s Central Valley using Landsat data. DL models, including U-Net, MANet, and DeepLabv3+, achieve high accuracy rates of 97.3% to 97.5%, yet our findings demonstrate that conventional ML models—such as Decision Tree, K-Nearest Neighbor, and Random Forest—can reach comparable accuracies of 96.6% to 96.8%. Importantly, the ML models were developed using data from a single year, while DL models required extensive training data spanning 2008 to 2022. Our results highlight that traditional ML models offer robust classification performance with substantially lower computational demands, making them especially valuable in resource-constrained settings. This paper underscores the need for a balanced approach in model selection—one that weighs accuracy alongside efficiency. The findings contribute actionable insights for agricultural land cover mapping and inform ongoing model development in the geospatial sciences. Full article
12 pages, 277 KiB  
Article
Exploring the Implementation of Gamification as a Treatment Modality for Adults with Depression in Malaysia
by Muhammad Akmal bin Zakaria, Koh Ong Hui, Hema Subramaniam, Maziah Binti Mat Rosly, Jesjeet Singh Gill, Lim Yee En, Yong Zhi Sheng, Julian Wong Joon Ip, Hemavathi Shanmugam, Chow Soon Ken and Benedict Francis
Medicina 2025, 61(8), 1404; https://doi.org/10.3390/medicina61081404 (registering DOI) - 1 Aug 2025
Abstract
Background and Objectives: Depression is a leading cause of disability globally, with treatment challenges including limited access, stigma, and poor adherence. Gamification, which applies game elements such as points, levels, and storytelling into non-game contexts, offers a promising strategy to enhance engagement [...] Read more.
Background and Objectives: Depression is a leading cause of disability globally, with treatment challenges including limited access, stigma, and poor adherence. Gamification, which applies game elements such as points, levels, and storytelling into non-game contexts, offers a promising strategy to enhance engagement and augment traditional treatments. Our research is the first study designed to explore the implementation of gamification within the Malaysian context. The objective was to explore the feasibility of implementation of gamification as an adjunctive treatment for adults with depression. Materials and Methods: Focus group discussions were held with five mental health professionals and ten patients diagnosed with moderate depression. The qualitative component assessed perceptions of gamified interventions, while quantitative measures evaluated participants’ depressive and anxiety symptomatology. Results: Three key themes were identified: (1) understanding of gamification as a treatment option, (2) factors influencing its acceptance, and (3) characteristics of a practical and feasible intervention. Clinicians saw potential in gamification to boost motivation, support psychoeducation, and encourage self-paced learning, but they expressed concerns about possible addiction, stigma, and the complexity of gameplay for some patients. Patients spoke of gaming as a source of comfort, escapism, and social connection. Acceptance was shaped by engaging storylines, intuitive design, balanced difficulty, therapist guidance, and clear safety measures. Both groups agreed that gamification should be used in conjunction with standard treatments, be culturally sensitive, and be presented as a meaningful therapeutic approach rather than merely as entertainment. Conclusions: Gamification emerges as an acceptable and feasible supplementary approach for managing depression in Malaysia. Its success depends on culturally sensitive design, robust clinical oversight, and seamless integration with existing care pathways. Future studies should investigate long-term outcomes and establish guidelines for the safe and effective implementation of this approach. We recommend targeted investment into culturally adapted gamified tools, including training, policy development, and collaboration with key stakeholders to realistically implement gamification as a mental health intervention in Malaysia. Full article
(This article belongs to the Section Psychiatry)
34 pages, 2929 KiB  
Review
Recent Advances in PET and Radioligand Therapy for Lung Cancer: FDG and FAP
by Eun Jeong Lee, Hyun Woo Chung, Young So, In Ae Kim, Hee Joung Kim and Kye Young Lee
Cancers 2025, 17(15), 2549; https://doi.org/10.3390/cancers17152549 (registering DOI) - 1 Aug 2025
Abstract
Lung cancer is one of the most common cancers and the leading cause of cancer-related death worldwide. Despite advancements, the overall survival rate for lung cancer remains between 10% and 20% in most countries. However, recent progress in diagnostic tools and therapeutic strategies [...] Read more.
Lung cancer is one of the most common cancers and the leading cause of cancer-related death worldwide. Despite advancements, the overall survival rate for lung cancer remains between 10% and 20% in most countries. However, recent progress in diagnostic tools and therapeutic strategies has led to meaningful improvements in survival outcomes, highlighting the growing importance of personalized management based on accurate disease assessment. 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) has become essential in the management of lung cancer, serving as a key imaging modality for initial diagnosis, staging, treatment response assessment, and follow-up evaluation. Recent developments in radiomics and artificial intelligence (AI), including machine learning and deep learning, have revolutionized the analysis of complex imaging data, enhancing the diagnostic and predictive capabilities of FDG PET/CT in lung cancer. However, the limitations of FDG, including its low specificity for malignancy, have driven the development of novel oncologic radiotracers. One such target is fibroblast activation protein (FAP), a type II transmembrane glycoprotein that is overexpressed in activated cancer-associated fibroblasts within the tumor microenvironment of various epithelial cancers. As a result, FAP-targeted radiopharmaceuticals represent a novel theranostic approach, offering the potential to integrate PET imaging with radioligand therapy (RLT). In this review, we provide a comprehensive overview of FDG PET/CT in lung cancer, along with recent advances in AI. Additionally, we discuss FAP-targeted radiopharmaceuticals for PET imaging and their potential application in RLT for the personalized management of lung cancer. Full article
(This article belongs to the Special Issue Molecular PET Imaging in Cancer Metabolic Studies)
29 pages, 1477 KiB  
Review
Bioinformation and Monitoring Technology for Environmental DNA Analysis: A Review
by Hyo Jik Yoon, Joo Hyeong Seo, Seung Hoon Shin, Mohamed A. A. Abedlhamid and Seung Pil Pack
Biosensors 2025, 15(8), 494; https://doi.org/10.3390/bios15080494 (registering DOI) - 1 Aug 2025
Abstract
Environmental DNA (eDNA) analysis has emerged as a transformative tool in environmental monitoring, enabling non-invasive detection of species and microbial communities across diverse ecosystems. This study systematically reviews the role of bioinformation technology in eDNA analysis, focusing on methodologies and applications across air, [...] Read more.
Environmental DNA (eDNA) analysis has emerged as a transformative tool in environmental monitoring, enabling non-invasive detection of species and microbial communities across diverse ecosystems. This study systematically reviews the role of bioinformation technology in eDNA analysis, focusing on methodologies and applications across air, soil, groundwater, sediment, and aquatic environments. Advances in molecular biology, high-throughput sequencing, bioinformatics tools, and field-deployable detection systems have significantly improved eDNA detection sensitivity, allowing for early identification of invasive species, monitoring ecosystem health, and tracking pollutant degradation processes. Airborne eDNA monitoring has demonstrated potential for assessing microbial shifts due to air pollution and tracking pathogen transmission. In terrestrial environments, eDNA facilitates soil and groundwater pollution assessments and enhances understanding of biodegradation processes. In aquatic ecosystems, eDNA serves as a powerful tool for biodiversity assessment, invasive species monitoring, and wastewater-based epidemiology. Despite its growing applicability, challenges remain, including DNA degradation, contamination risks, and standardization of sampling protocols. Future research should focus on integrating eDNA data with remote sensing, machine learning, and ecological modeling to enhance predictive environmental monitoring frameworks. As technological advancements continue, eDNA-based approaches are poised to revolutionize environmental assessment, conservation strategies, and public health surveillance. Full article
(This article belongs to the Section Environmental Biosensors and Biosensing)
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25 pages, 953 KiB  
Article
Command Redefined: Neural-Adaptive Leadership in the Age of Autonomous Intelligence
by Raul Ionuț Riti, Claudiu Ioan Abrudan, Laura Bacali and Nicolae Bâlc
AI 2025, 6(8), 176; https://doi.org/10.3390/ai6080176 (registering DOI) - 1 Aug 2025
Abstract
Artificial intelligence has taken a seat at the executive table and is threatening the fact that human beings are the only ones who should be in a position of power. This article gives conjectures on the future of leadership in which managers will [...] Read more.
Artificial intelligence has taken a seat at the executive table and is threatening the fact that human beings are the only ones who should be in a position of power. This article gives conjectures on the future of leadership in which managers will collaborate with learning algorithms in the Neural Adaptive Artificial Intelligence Leadership Model, which is informed by the transformational literature on leadership and socio-technical systems, as well as the literature on algorithmic governance. We assessed the model with thirty in-depth interviews, system-level traces of behavior, and a verified survey, and we explored six hypotheses that relate to algorithmic delegation and ethical oversight, as well as human judgment versus machine insight in terms of agility and performance. We discovered that decisions are made quicker, change is more effective, and interaction is more vivid where agile practices and good digital understanding exist, and statistical tests propose that human flexibility and definite governance augment those benefits as well. It is single-industry research that contains self-reported measures, which causes research to be limited to other industries that contain more objective measures. Practitioners are provided with a practical playbook on how to make algorithmic jobs meaningful, introduce moral fail-safes, and build learning feedback to ensure people and machines are kept in line. Socially, the practice is capable of minimizing bias and establishing inclusion by visualizing accountability in the code and practice. Filling the gap between the theory of leadership and the reality of algorithms, the study provides a model of intelligent systems leading in organizations that can be reproduced. Full article
(This article belongs to the Section AI Systems: Theory and Applications)
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