Search Results (35)

The mining of relevant association rules from transactional databases is a fundamental process in data mining. Traditional algorithms, however, will typically be based on fixed thresholds and general rule generation, with the result being large and redundant outcomes. This paper presents DERAR (Dynamic Extracting of Relevant Association Rules), a dynamic approach integrating structure pattern mining and dynamic multi-criteria filtering. The process begins with the generation of frequent meta-patterns. Each entity is given a stability score for its consistency across various data projections, then sorted by mutual information in order to preserve the most informative dimensions. The resulting association rules from these models are filtered through a dynamic confidence threshold that is adjusted according to the statistical distribution of the dataset. A final semantic filtering phase identifies rules with high coherence between antecedent and consequent. Experimental results show that DERAR reduces rules by up to 85%, improving interpretability and coherence. It outperforms Apriori, FP-Growth, and H-Apriori in rule quality and computational efficiency. DERAR consistently achieves lower execution times and memory use, especially on large or sparse datasets. These results confirm the benefits of adaptive, semantically guided rule mining for generating concise, high-quality, and actionable knowledge. Full article

Workplace psychological safety (PS) has been recognized as crucial in mitigating organizational stressors and enhancing positive workplace outcomes, particularly in high-risk occupations such as healthcare and public safety. This scoping review aims to synthesize the existing literature on psychological safety in high-risk workplaces to identify key antecedents, workplace enhancements, and research gaps. A systematic search of studies published between 2010 and January 2025 was conducted across multiple databases, including CINAHL, Medline, ERIC, JSTOR, PsycInfo, Business Source Ultimate, and Sociological Abstract. Inclusion criteria focused on adult workers in high-risk workplace environments. Following screening and eligibility assessments, 16 studies from six countries were selected for analysis. Data were extracted and thematically analyzed based on leadership styles, organizational structures, and workplace culture related to psychological safety. The review identified three primary antecedents of psychological safety in high-risk workplaces: (1) inclusive and transformational leadership styles, (2) hierarchical structures and power dynamics, and (3) workplace climate and communication culture. Studies consistently found that inclusive leadership, ethical integrity, and transformational leadership were strongly associated with higher psychological safety levels. While hierarchical structures provided the necessary organization, overly rigid hierarchies often suppressed employee voice and innovation. A workplace culture characterized by trust, transparency, and open communication fosters greater psychological safety and improved teamwork and well-being. Full article

Background: In the United States, approximately 1 in 5 children experience comorbidities with mental illness, including depression and anxiety, which lead to poor general health outcomes. Adolescents with substance use disorders exhibit high rates of co-occurring mental illness, with over 60% meeting diagnostic criteria for another psychiatric condition in community-based treatment programs. Comorbidities are influenced by both genetic (DNA antecedents) and environmental (epigenetic) factors. Given the significant impact of psychiatric comorbidities on individuals’ lives, this study aims to uncover common mechanisms through a Genome-Wide Association Study (GWAS) meta-meta-analysis. Methods: GWAS datasets were obtained for each comorbid phenotype, followed by a GWAS meta-meta-analysis using a significance threshold of p < 5E−8 to validate the rationale behind combining all GWAS phenotypes. The combined and refined dataset was subjected to bioinformatic analyses, including Protein–Protein Interactions and Systems Biology. Pharmacogenomics (PGx) annotations for all potential genes with at least one PGx were tested, and the genes identified were combined with the Genetic Addiction Risk Severity (GARS) test, which included 10 genes and eleven Single Nucleotide Polymorphisms (SNPs). The STRING-MODEL was employed to discover novel networks and Protein–Drug interactions. Results: Autism Spectrum Disorder (ASD) was identified as the top manifestation derived from the known comorbid interaction of anxiety, depression, and attention deficit hyperactivity disorder (ADHD). The STRING-MODEL and Protein–Drug interaction analysis revealed a novel network associated with these psychiatric comorbidities. The findings suggest that these interactions are linked to the need to induce “dopamine homeostasis” as a therapeutic outcome. Conclusions: This study provides a reliable genetic and epigenetic map that could assist healthcare professionals in the therapeutic care of patients presenting with multiple psychiatric manifestations, including anxiety, depression, and ADHD. The results highlight the importance of targeting dopamine homeostasis in managing ASD linked to these comorbidities. These insights may guide future pharmacogenomic interventions to improve clinical outcomes in affected individuals. Full article

In recent decades, the scientific literature has increasingly linked specific human activities to various environmental issues, with climate change being a prominent concern. Environmental Psychology has thus placed its focus on comprehending the dynamics driving Pro-environmental Behaviors (PEBs). Research spotlights two crucial constructs fueling PEBs: Connectedness to Nature (CTN) and Environmental Attitudes (EAs). In the absence of a well-established model, this systematic review strives to advance the understanding of their compound relationship. Following PRISMA guidelines, a comprehensive literature search across Google Scholar, PsycInfo, PsycArticles, PubMed, Science Direct, Sociological Abstracts, and Academic Search Complete databases produced 2658 records. Of these records, only 19 studies met the eligibility criteria after passing the abstract selection phase and were consequently included in this systematic review. Our analysis revealed that CTN and EAs are distinct constructs but showed moderate-to-high correlations. This review posits two hypotheses: (i) CTN may function as a dimension of identity and serve as an EA antecedent and (ii) CTN could be a combination of both implicit and explicit EAs. Subsequently, an interaction model is devised to comprehensively elucidate PEB dynamics and guide effective interventions for their promotion in the context of sustainability. Full article

Background: Low back pain is one of the most common musculoskeletal complaints in team sports. A screening test can help understand why injuries occur and predict who is at risk for non-contact low back pain. The objectives of the research were (1) to create models using logistic regression analysis of limited lower-extremity ranges of motion to prospectively identify potential factors for in-season non-contact non-contact low back pain and (2) to determine a training threshold (cut-off) for the identified factors in inline hockey players. Methods: A prospective cohort research was performed with 49 male inline hockey players aged 8 to 15 years. Data were collected regarding age, body composition, sports antecedents, competition level, and lower-limb ranges of motion (ROM-SPORT battery, n = 11 tests). A prospective measurement of non-contact low back pain was performed after 1 year (outcome) by asking the players supervised by the medical staff team (questionnaire). Results: Sixteen players (32.7%) experienced non-contact low back pain during the 1-year surveillance period. The model showed a significant relationship (χ²(39) = 43.939; p < 0.001) between the low back pain and the predictor variable hip flexion with the knee extended range of motion (OR = 3.850 [large]; 95% CI = 1.293 to 11.463; p = 0.015). The Bayesian Information Criteria and the Akaike Information Criteria for model fit were 56.885 and 37.967, respectively. The training threshold for hip flexion with the knee extended of ≤67° was set, which has an acceptable (area under the curve ≥ 94.1%) discriminatory ability for the development of non-contact low back pain for the screening test. Conclusions: Hamstring extensibility at 67° or less, as determined by hip flexion with knee extension, is a predictor of non-contact low back pain in youth inline hockey players. Full article

Ice jamming is the primary mechanism that can generate overland flooding and recharge the isolated basins of the Peace–Athabasca Delta (PAD), a valuable ecosystem of international importance and the ancient homeland of the Indigenous Peoples of the region. Focusing on the regulated Peace River and the Peace Sector of the delta, which has been experiencing a drying trend in between rare ice-jam floods over the last ~50 years, this study describes recent notable breakup events, associated observational data, and numerical applications to determine river discharge during the breakup events. Synthesis and interpretation of this material provide a new physical understanding that can inform the ongoing development of a protocol for strategic flow releases toward enhancing basin recharge in years when major ice jams are likely to form near the PAD. Additionally, several recommendations are made for future monitoring activities and improvements in proposed antecedent criteria for early identification of “promising” breakup events. Full article

Background/Objectives: In recent years, research has increasingly highlighted the significance of nursing practice environments, linking positive settings with enhanced job satisfaction, professional autonomy, and care quality. Such environments can decrease turnover, stress, and costs while improving patient safety. Despite this extensive literature, there is limited consensus on defining a ‘positive nursing practice environment’, highlighting the need for a systematic analysis to advance understanding and application. This study aims to explore and clarify the concept of a ‘Positive Nursing Practice Environment’. Methods: This study applied Walker and Avant’s approach for concept analysis, conducting a comprehensive database search to gather relevant evidence. To review the available evidence on the concept of nursing practice environments, we followed the methodology proposed by JBI for scoping reviews. Results: The inclusion of 166 studies meeting the criteria provided a broad understanding of the topic, revealing 10 key attributes of a ‘positive nursing practice environment’ and identifying various antecedents and consequences affecting clients, nurses, and institutions. Conclusions: The concept analysis of a ‘Positive Nursing Practice Environment’ offers valuable insights into nurses’ working conditions, systematically identifying characteristics that impact professionals, patients, and institutions. This analysis lays the groundwork for future research and practical improvements in nursing practice environments. This study was not registered. Full article

Acute Erythroid Leukemia (AEL) is a rare and aggressive subtype of Acute Myeloid Leukemia (AML). In 2022, the World Health Organization (WHO) defined AEL as a biopsy with ≥30% proerythroblasts and erythroid precursors that account for ≥80% of cellularity. The International Consensus Classification refers to this neoplasm as “AML with mutated TP53”. Classification entails ≥20% blasts in blood or bone marrow biopsy and a somatic TP53 mutation (VAF > 10%). This type of leukemia is typically associated with biallelic TP53 mutations and a complex karyotype, specifically 5q and 7q deletions. Transgenic mouse models have implicated several molecules in the pathogenesis of AEL, including transcriptional master regulator GATA1 (involved in erythroid differentiation), master oncogenes, and CDX4. Recent studies have also characterized AEL by epigenetic regulator mutations and transcriptome subgroups. AEL patients have overall poor clinical outcomes, mostly related to their poor response to the standard therapies, which include hypomethylating agents and intensive chemotherapy. Allogeneic bone marrow transplantation (AlloBMT) is the only potentially curative approach but requires deep remission, which is very challenging for these patients. Age, AlloBMT, and a history of antecedent myeloid neoplasms further affect the outcomes of these patients. In this review, we will summarize the diagnostic criteria of AEL, review the current insights into the biology of AEL, and describe the treatment options and outcomes of patients with this disease. Full article

Neighborhoods have been the focus of health researchers seeking to develop upstream strategies to mitigate downstream disease development. In recent years, neighborhoods have become a primary target in efforts to promote health and resilience following deleterious social conditions such as the climate crisis, extreme weather events, the global pandemic, and supply chain disruptions. Children are often the most vulnerable populations after experiencing unexpected shocks. To examine and describe conceptually the construct of Neighborhood Resilience, we conducted a comprehensive scoping review using the terms (“resilience” or “resiliency” or “resilient”) AND (“neighborhood”), utilizing MEDLINE (through PubMed) and CINAHL (through EBSCOhost) databases, to assess overall neighborhood themes that impact resilience. A total of 57 articles were extracted that met inclusion criteria. Extracted characteristics included study purpose, country of origin, key findings, environmental protective/risk factors. The analysis revealed a positive relationship between neighborhood resource density, neighborhood resiliency, and individual resiliency. This study reports the finding for studies with a population focus of pre-school age and school age children (1.5–18 years of age). Broadly, we identified that the primary goals regarding neighborhood resilience for childhood can be conceptualized as all activities and resources that (a) prevent trauma during childhood development and/or (b) mitigate or heal childhood trauma once it has occurred. This goal conceptually encompasses antecedents that increase protective factors and reduces risk factors for children and their families. This comprehensive look at the literature showed that a neighborhood’s ability to build, promote, and maintain resiliency is often largely dependent on the flexible resources (i.e., knowledge, money, power, prestige, and beneficial social connections) that are available. Full article

Cardiovascular disease and type 2 diabetes mellitus are leading contributors to the health inequity experienced by Aboriginal and Torres Strait Islander peoples, and their antecedents can be identified from early childhood. We aimed to establish the quality of available data and the prevalence of cardiometabolic risk markers among Aboriginal and Torres Strait Islander children and youths (0–24-year-olds) to inform public health approaches. A systematic review of the peer-reviewed and grey literature was conducted between 1 January 2000–28 February 2021. Included studies reported population prevalence of cardiometabolic risks, including elevated blood pressure, obesity, central adiposity, dyslipidaemia, hyperglycaemia, and ‘metabolic syndrome’ for Aboriginal and Torres Strait Islander people aged 0–24 years. Fifteen studies provided population estimates. Data quality was limited by low response rates (10/15 studies) and suboptimal outcome measurements. Obesity is the most reported risk (13/15 studies). Aboriginal and Torres Strait Islander children have an excess risk of obesity from early childhood and prevalence increases with age: 32.1% of Aboriginal and Torres Strait Islander 18–24-year-olds had obesity and 50.8% had central adiposity. In a cohort of 486 9–14-year-olds in Darwin, 70% had ≥1 component of metabolic syndrome; 14% met the full criteria for the syndrome. The prevalence of cardiometabolic risk in Aboriginal and Torres Strait Islander young people is difficult to estimate due to limitations in measurement quality and sampling representativeness. Available data suggest that cardiometabolic risk markers are evident from early childhood. The establishment of national and state-level datasets and a core outcome set for cardiometabolic screening would provide opportunities for preventative action. Full article

Healthcare workers have been under a great deal of stress and have been experiencing burnout throughout the COVID-19 pandemic. Among these, healthcare workers are pharmacists who have been instrumental in the fight against the pandemic. This scoping review examined the impact of the pandemic on pharmacists’ mental health and their antecedents using three databases (CINAHL, MEDLINE, and PsycINFO). Eligible studies included primary research articles that examined the mental health antecedents and outcomes among pharmacists during the first two years of the pandemic. We used the Social Ecological Model to categorize antecedents per outcome. The initial search yielded 4165 articles, and 23 met the criteria. The scoping review identified pharmacists experiencing poor mental health during the pandemic, including anxiety, burnout, depression, and job stress. In addition, several individual, interpersonal, organizational, community, and policy-level antecedents were identified. As this review revealed a general decline in pharmacists’ mental health during the pandemic, further research is required to understand the long-term impacts of the pandemic on pharmacists. Furthermore, we recommend practical mitigation strategies to improve pharmacists’ mental health, such as implementing crisis/pandemic preparedness protocols and leadership training to foster a better workplace culture. Full article

The present study is an attempt to model the stormwater quality of a stream located in Pune, India. The city is split up into twenty-three basins (named A to W) by the Pune Municipal Corporation. The selected stream lies in the haphazardly expanded peri-urban G basin. The G basin has constructed stormwater drains which open up in this selected open stream. The runoff over the regions picks up the non-point source pollutants which are also added to the selected stream. The study becomes more complex as the stream is misused to dump trash materials, garbage and roadside litter, which adds to the stormwater pollution. Experimental investigations include eleven distinct locations on a naturally occurring stream in the G basin. Stormwater samples were collected for twenty-two storm events, for the monsoon season over four years from 2018–2021, during and after rainfall. The physicochemical characteristics were analyzed for twelve water quality parameters, including pH, Conductivity, Turbidity, Total solids (TS), Total Suspended Solids (TSS), Total Dissolved Solids (TDS), Bio-chemical Oxygen Demand (BOD5), Chemical Oxygen Demand (COD), Dissolved Oxygen (DO), Phosphate, Ammonia and Nitrate. The Water Quality Index (WQI) ranged from 46.9 to 153.9 and from 41.20 to 87.70 for samples collected during and immediately after the rainfall, respectively. Principal Component Analysis was used to extract the most significant stormwater quality parameters. To understand the non-linear complex relationship of rainfall characteristics with significant stormwater pollutant parameters, a Support Vector Regression (SVR) model with Radial Basis Kernel Function (RBF) was developed. The Support Vector Machine is a powerful supervised algorithm that works best on smaller datasets but on complex ones with the help of kernel tricks. The accuracy of the model was evaluated based on normalized root-mean-square error (NRMSE), coefficient of determination (R²) and the ratio of performance to the interquartile range (RPIQ). The SVR model depicted the best performance for parameter TS with NRMSE (0.17), R² (0.82) and RPIQ (2.91). The unit increase or decrease in the coefficients of rainfall characteristics displays the weighted deviation in the values of pollutant parameters. Non-linear Support Vector Regression models confirmed that both antecedent dry days and rainfall are correlated with significant stormwater quality parameters. The conclusions drawn can provide effective information to decision-makers to employ an appropriate treatment train approach of varied source control measures (SCM) to be proposed to treat and mitigate runoff in an open stream. This holistic approach serves the stakeholder’s objectives to manage stormwater efficiently. The research can be further extended by selecting a multi-criteria decision-making tool to adopt the best SCM and its multiple potential combinations. Full article

The goal of this study was to analyse the influence of the antecedents of patient experience, namely staff appearance, laboratory staff attitude, information clarity, staff responsiveness, laboratory ambience, phlebotomy process, laboratory technology, and report results, which furtherly generate customer delight and drive favourable intentions such as revisit intentions to the laboratory and willingness to share and post on social media. By extending earlier studies and using data from a leading private clinical laboratory service, this study suggests a new insight. A quantitative study with a survey is used with a cross-sectional data approach. The sample was taken purposively from customers who have had laboratory services at the laboratory, particularly from customers who have undergone the phlebotomy process. The 186 samples that complied with the criteria were examined using the PLS-SEM method. The findings demonstrated that the eight antecedents show a high probability of influencing the patient experience, with the phlebotomy process found as the predominant antecedent, followed by laboratory staff attitude and patient perception of laboratory technology. Further, this study found strong evidence that patient experience could generate customer delight, which drives the revisit intention and willingness to share and post positive things on social media. Openness is found to strengthen that process. The results of this study revealed that the higher the patient’s experience through their journey, the higher the probability of delight could exist in the context of service provided in the private clinical laboratory. Thus, it is worth considering by the clinic management to develop a more effective business. Full article

Peer Victimization (PV) or being bullied in childhood/adolescence has been associated with several negative outcomes in mental health conditions beyond the time of its occurrence. However, its possible association with personality disorders has been slightly explored. In the present study we have compared the frequency of DSM IV personality disorders among adult patients with (N = 28) or without (N = 418) a reported history of PV. For this purpose, axis II was evaluated with the Self-Report Checklist for Preliminary Items for Major Categories, whereas self-esteem and self-assessment of functioning were evaluated with single questions. Patients with PV history have met the diagnostic criteria of the avoidant (60.7% vs. 12.2%), depressive (28.5% vs. 5.2%) and paranoid (17.9% vs. 5%) personality disorders more frequently than patients without history of PV. Moreover, these patients with antecedents of being bullied have also reported lower self-esteem (2 vs. 3) and in the assessment of social functioning (4 vs. 5). Our study indicated that there is a clear association between PV and avoidant, depressive and paranoid personality patterns. These results suggest that the stress related with the experience of PV threatens a basic psychobiological need such as social acceptance with implications for the beginning of long-term dysfunctional personality trajectories. Full article

This research focused on establishing a hierarchy concerning the influence of various biological markers and body composition parameters on preventing, diagnosing and managing Metabolic Syndrome (MetS). Our cross-sectional cohort study included 104 subjects without any atherosclerotic antecedent pathology, organized in two groups (with and without MetS). All participants underwent clinical and anthropometric measurements, DEXA investigation and blood tests for all MetS criteria, together with adiponectin, leptin, insulin, uric acid and CRP. Based on mathematical logic, we calculated a normalized sensitivity score to compare the predictive power of biomarkers and parameters associated with MetS, upon the prevalence of MetS. Patients with MetS report higher levels of uric acid (p = 0.02), CRP (p = 0.012) and lower levels of adiponectin (p = 0.025) than patients without MetS. The top three biological markers with the highest predictive power of the prevalence of the disease are HDL, insulin, and adiponectin:leptin ratio, and the top three body composition parameters are trunk fat-free percentage, waist-height ratio and trunk fat percentage. Their high sensitivity scores differentiate them from all the other markers analysed in the study. Our findings report relevant scores for estimating the importance of cardiometabolic risks in the prevalence of MetS. The high rank of protective markers, HDL and trunk fat-free percentage, suggest that positive effects have a stronger association with the prevalence of MetS, than negative ones do. Therefore, this risk stratification study provides important support for prevention and management programs regarding MetS. Full article