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Article

2,222 Views

11 Pages

Biophysical Studies of Amyloid-Binding Fluorophores to Tau AD Core Fibrils Formed without Cofactors

Daniela P. Freitas,
Joana Saavedra,
Isabel Cardoso and
Cláudio M. Gomes

Int. J. Mol. Sci.2024, 25(18), 9946;https://doi.org/10.3390/ijms25189946

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15 September 2024

Tau is an intrinsically disordered protein involved in several neurodegenerative diseases where a common hallmark is the appearance of tau aggregates in the brain. One common approach to elucidate the mechanisms behind the aggregation of tau has been...

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Article

15 Citations

4,716 Views

25 Pages

Human Serum Albumin Binds Native Insulin and Aggregable Insulin Fragments and Inhibits Their Aggregation

Joanna Wasko,
Marian Wolszczak,
Zbigniew J. Kaminski,
Malgorzata Steblecka and
Beata Kolesinska

Biomolecules2020, 10(10), 1366;https://doi.org/10.3390/biom10101366

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25 September 2020

The purpose of this study was to investigate whether Human Serum Albumin (HSA) can bind native human insulin and its A13–A19 and B12–B17 fragments, which are responsible for the aggregation of the whole hormone. To label the hormone and both hot spot...

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