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4,749 Results Found

  • Review
  • Open Access
2,683 Views
14 Pages

Factors Determining Ageing Processes and Well-Being of Older Adults Serving Prison Sentences in Germany

  • Andrea Kenkmann,
  • Liane Meyer,
  • Christian Ghanem and
  • Sandra Verhülsdonk

11 December 2024

The well-being of older adults is influenced by their physical and mental health, their opportunities to complete activities of daily living effectively and autonomously, as well as their social connectedness, meaningfulness and positive outlook to t...

  • Review
  • Open Access
26 Citations
21,317 Views
23 Pages

Dermatological Management of Aged Skin

  • Ewelina Rostkowska,
  • Ewa Poleszak,
  • Katarzyna Wojciechowska and
  • Katarzyna Dos Santos Szewczyk

The subject of the work concerns the dermatological management of patients mainly with aged skin. The purpose of the work was to present the basic techniques and preparations which are performed by dermatologists in the treatment of aged skin. There...

  • Article
  • Open Access
10 Citations
3,214 Views
15 Pages

Factors Associated with Body Size Perception and Body Image (Dis)Satisfaction in the Elderly: Results of the ELSA-Brasil Study

  • Maria de Jesus Mendes da Fonseca,
  • Isiyara Taverna Pimenta,
  • Liliane da Silva Albuquerque,
  • Estela M. L. Aquino,
  • Letícia de Oliveira Cardoso,
  • Dóra Chor and
  • Rosane Harter Griep

The study aimed to assess the association between body image perception and (dis)satisfaction and sociodemographic and behavioral factors in the elderly, using multinomial logistic regression. Data were analyzed for 1686 women and 1499 men participat...

  • Systematic Review
  • Open Access
996 Views
21 Pages

21 November 2025

Background: With the global population rapidly aging, resilience has emerged as a critical determinant of healthy aging. While many factors are associated with resilience, a comprehensive synthesis is needed to inform targeted interventions and polic...

  • Article
  • Open Access
17 Citations
4,388 Views
24 Pages

Differential Secretion of Angiopoietic Factors and Expression of MicroRNA in Umbilical Cord Blood from Healthy Appropriate-For-Gestational-Age Preterm and Term Newborns—in Search of Biomarkers of Angiogenesis-Related Processes in Preterm Birth

  • Dorota Gródecka-Szwajkiewicz,
  • Zofia Ulańczyk,
  • Edyta Zagrodnik,
  • Karolina Łuczkowska,
  • Dorota Rogińska,
  • Miłosz P. Kawa,
  • Iwona Stecewicz,
  • Krzysztof Safranow and
  • Bogusław Machaliński

14 February 2020

Objectives: Premature birth, defined as less than 37 weeks gestation, affects approximately 12% of all live births around the world. Advances in neonatal care have resulted in the increased survival of infants born prematurely. Although prematurity i...

  • Article
  • Open Access
7 Citations
2,964 Views
13 Pages

Early Care and Education Center Environmental Factors Associated with Product- and Process-Based Locomotor Outcomes in Preschool-Age Children

  • Jacob Szeszulski,
  • Elizabeth Lorenzo,
  • Michael Todd,
  • Teresia M. O’Connor,
  • Jennie Hill,
  • Gabriel Q. Shaibi,
  • Sonia Vega-López,
  • Matthew P. Buman,
  • Steven P. Hooker and
  • Rebecca E. Lee

Environmental characteristics of early care and education centers (ECECs) are an important context for preschool-aged children’s development, but few studies have examined their relationship with children’s locomotor skills. We examined t...

  • Review
  • Open Access
71 Citations
37,109 Views
8 Pages

Skin ageing is a complex process that is determined by both intrinsic and extrinsic factors, which leads to a progressive loss of structure and function. There is extensive evidence indicating that oxidative stress induced by reactive oxygen species...

  • Review
  • Open Access
14 Citations
8,544 Views
23 Pages

The Role of SOX Transcription Factors in Ageing and Age-Related Diseases

  • Milena Stevanovic,
  • Andrijana Lazic,
  • Marija Schwirtlich and
  • Danijela Stanisavljevic Ninkovic

The quest for eternal youth and immortality is as old as humankind. Ageing is an inevitable physiological process accompanied by many functional declines that are driving factors for age-related diseases. Stem cell exhaustion is one of the major hall...

  • Review
  • Open Access
66 Citations
8,914 Views
23 Pages

28 February 2021

The World Health Organization estimates that only approximately 25% of diversity in longevity is explained by genetic factors, while the other 75% is largely determined by interactions with the physical and social environments. Indeed, aging is a mul...

  • Review
  • Open Access
103 Citations
10,377 Views
29 Pages

Role of NF-κB in Ageing and Age-Related Diseases: Lessons from Genetically Modified Mouse Models

  • Verónica A. García-García,
  • Josefa P. Alameda,
  • Angustias Page and
  • María Llanos Casanova

27 July 2021

Ageing is a complex process, induced by multifaceted interaction of genetic, epigenetic, and environmental factors. It is manifested by a decline in the physiological functions of organisms and associated to the development of age-related chronic dis...

  • Review
  • Open Access
30 Citations
9,278 Views
33 Pages

Vegetables and Their Bioactive Compounds as Anti-Aging Drugs

  • Hamza Mechchate,
  • Aicha El Allam,
  • Nasreddine El Omari,
  • Naoufal El Hachlafi,
  • Mohammad Ali Shariati,
  • Polrat Wilairatana,
  • Mohammad S. Mubarak and
  • Abdelhakim Bouyahya

Aging is a continuous process over time that is mainly related to natural alterations in mechanical–biological processes. This phenomenon is due to several factors, including the time and energy of biological processes. Aging can be attributed...

  • Review
  • Open Access
56 Citations
12,511 Views
11 Pages

Inflammaging and Immunosenescence as Part of Skin Aging—A Narrative Review

  • Justyna Pająk,
  • Danuta Nowicka and
  • Jacek C. Szepietowski

Inflammaging and immunosenescence are associated with aging of the human body, but there are key differences between them. Immunosenescence aims to adapt the body systems to aging, while inflammaging is considered a consequence of immunosenescence. T...

  • Review
  • Open Access
12 Citations
5,070 Views
12 Pages

Nuclear mRNA Export and Aging

  • Hyun-Sun Park,
  • Jongbok Lee,
  • Hyun-Shik Lee,
  • Seong Hoon Ahn and
  • Hong-Yeoul Ryu

The relationship between transcription and aging is one that has been studied intensively and experimentally with diverse attempts. However, the impact of the nuclear mRNA export on the aging process following its transcription is still poorly unders...

  • Review
  • Open Access
6 Citations
5,307 Views
10 Pages

Impact of Gut Microbiota on Aging and Frailty: A Narrative Review of the Literature

  • Selene Escudero-Bautista,
  • Arianna Omaña-Covarrubias,
  • Ana Teresa Nez-Castro,
  • Lydia López-Pontigo,
  • Maribel Pimentel-Pérez and
  • Alonso Chávez-Mejía

Aging is a natural, complex, and individual process that focuses on the progressive decay of the body and a decrease in cell function that begins in approximately the sixth decade of life and ends with death. Current scientific evidence shows that th...

  • Article
  • Open Access
13 Citations
6,242 Views
10 Pages

Validation of the Lasher and Faulkender Anxiety about Aging Scale (AAS) for the Spanish Context

  • Carolina Fernández-Jiménez,
  • Joaquín F. Álvarez-Hernández,
  • Darío Salguero-García,
  • José M. Aguilar-Parra and
  • Rubén Trigueros

Increased longevity has led to concerns and fears among the population about the inexorable process of ageing. This process causes individuals to become more anxious about the physical and psychosocial changes caused by the passage of time. However,...

  • Review
  • Open Access
19 Citations
5,188 Views
25 Pages

Aging, NRF2, and TAU: A Perfect Match for Neurodegeneration?

  • Mirjam Brackhan,
  • Marina Arribas-Blazquez and
  • Isabel Lastres-Becker

4 August 2023

Although the trigger for the neurodegenerative disease process is unknown, the relevance of aging stands out as a major risk for the development of neurodegeneration. In this review, we highlighted the relationship between the different cellular mech...

  • Review
  • Open Access
21 Citations
11,941 Views
25 Pages

Articular Cartilage Aging-Potential Regenerative Capacities of Cell Manipulation and Stem Cell Therapy

  • Magdalena Krajewska-Włodarczyk,
  • Agnieszka Owczarczyk-Saczonek,
  • Waldemar Placek,
  • Adam Osowski and
  • Joanna Wojtkiewicz

22 February 2018

Changes in articular cartilage during the aging process are a stage of natural changes in the human body. Old age is the major risk factor for osteoarthritis but the disease does not have to be an inevitable consequence of aging. Chondrocytes are par...

  • Review
  • Open Access
76 Citations
10,701 Views
19 Pages

The KEAP1-NRF2 System in Healthy Aging and Longevity

  • Daisuke Matsumaru and
  • Hozumi Motohashi

30 November 2021

Aging is inevitable, but the inherently and genetically programmed aging process is markedly influenced by environmental factors. All organisms are constantly exposed to various stresses, either exogenous or endogenous, throughout their lives, and th...

  • Review
  • Open Access
183 Citations
25,797 Views
22 Pages

14 January 2020

Age-related hearing impairment (ARHI), also referred to as presbycusis, is the most common sensory impairment seen in the elderly. As our cochlea, the peripheral organ of hearing, ages, we tend to experience a decline in hearing and are at greater ri...

  • Review
  • Open Access
14 Citations
9,732 Views
19 Pages

27 January 2023

Biological aging is characterized by irreversible cell cycle blockade, a decreased capacity for tissue regeneration, and an increased risk of age-related diseases and mortality. A variety of genetic and epigenetic factors regulate aging, including th...

  • Article
  • Open Access
12 Citations
3,184 Views
12 Pages

23 August 2022

We aim to predict the natural aging life of 8016 ethylene propylene rubber accurately and quickly. Based on the time-temperature equivalent superposition principle, the artificial bee colony algorithm was introduced to calculate the acceleration fact...

  • Article
  • Open Access
10 Citations
2,646 Views
16 Pages

Study on the Aging Behavior of Asphalt Binder Exposed to Different Environmental Factors

  • Shanglin Song,
  • Linbing Wang,
  • Chunping Fu,
  • Meng Guo,
  • Xiaoqiang Jiang,
  • Meichen Liang and
  • Luchun Yan

24 November 2023

Accelerated aging methods commonly used in laboratories struggle to replicate the outdoor aging process of asphalt binder. The aim of this study is to elucidate the impact of different environmental factors on the aging of asphalt binder and recreate...

  • Article
  • Open Access
7 Citations
3,663 Views
11 Pages

29 December 2022

Compared with the constant stress accelerated aging test, the step stress accelerated aging test reduces the accelerated aging test time by increasing the aging temperature step by step to obtain the aging failure life of rubber in a shorter time, bu...

  • Review
  • Open Access
133 Citations
13,881 Views
42 Pages

The Role of Oxidative Stress in Cardiovascular Aging and Cardiovascular Diseases

  • Carmine Izzo,
  • Paolo Vitillo,
  • Paola Di Pietro,
  • Valeria Visco,
  • Andrea Strianese,
  • Nicola Virtuoso,
  • Michele Ciccarelli,
  • Gennaro Galasso,
  • Albino Carrizzo and
  • Carmine Vecchione

15 January 2021

Aging can be seen as process characterized by accumulation of oxidative stress induced damage. Oxidative stress derives from different endogenous and exogenous processes, all of which ultimately lead to progressive loss in tissue and organ structure...

  • Article
  • Open Access
2 Citations
1,367 Views
18 Pages

11 March 2025

The partial discharge (PD) measurement under pulse width modulation (PWM) voltage is a critical measurement of quality assessment for inverter-fed motors, as outlined in IEC 60034-18-41 and IEC 60034-18-42. One of the key parameters in PD measurement...

  • Review
  • Open Access
29 Citations
8,998 Views
22 Pages

Potential Anti-Aging Substances Derived from Seaweeds

  • Lei Cao,
  • Sang Gil Lee,
  • Kwon Taek Lim and
  • Hyeung-Rak Kim

18 November 2020

Aging is a major risk factor for many chronic diseases, such as cancer, cardiovascular disease, and diabetes. The exact mechanisms underlying the aging process are not fully elucidated. However, a growing body of evidence suggests that several pathwa...

  • Perspective
  • Open Access
8 Citations
3,542 Views
19 Pages

Two Old Wild-Type Strains of Drosophila melanogaster Can Serve as an Animal Model of Faster and Slower Aging Processes

  • Lyudmila P. Zakharenko,
  • Margarita A. Bobrovskikh,
  • Nataly E. Gruntenko,
  • Dmitrii V. Petrovskii,
  • Evgeniy G. Verevkin and
  • Arcady A. Putilov

Background: Drosophila melanogaster provides a powerful platform to study the physiology and genetics of aging, i.e., the mechanisms underpinnings healthy aging, age-associated disorders, and acceleration of the aging process under adverse environmen...

  • Article
  • Open Access
7 Citations
5,483 Views
14 Pages

Consumption Patterns of Processed Foods in Singapore—A Cross-Sectional Study

  • Patrick Gan,
  • Jun Cheng Er,
  • Kenneth Chow,
  • Benjamin Er,
  • Joanne Sheot Harn Chan,
  • Angela Li and
  • Kyaw Thu Aung

9 September 2022

The consumption of processed foods is increasingly widespread and could have an impact on diet quality and health. Understanding the factors influencing people’s eating habits is useful for assessing such impact. There are limited data on the c...

  • Review
  • Open Access
80 Citations
7,481 Views
18 Pages

The Role of Oxidative Stress in the Aging Heart

  • Luana U Pagan,
  • Mariana J Gomes,
  • Mariana Gatto,
  • Gustavo A F Mota,
  • Katashi Okoshi and
  • Marina P Okoshi

9 February 2022

Medical advances and the availability of diagnostic tools have considerably increased life expectancy and, consequently, the elderly segment of the world population. As age is a major risk factor in cardiovascular disease (CVD), it is critical to und...

  • Article
  • Open Access
27 Citations
1,570 Views
6 Pages

Factors determining age-related macular degeneration: a current view

  • Rasa Liutkevičienė,
  • Vaiva Lesauskaitė,
  • Virginija Ašmonienė,
  • Dalia Žaliūnienė and
  • Vytautas Jašinskas

10 February 2010

Age-related macular degeneration affects the macula and is the leading cause of significant and irreversible central visual loss. It is the most common cause of visual loss in people older than 60 years. The pathogenesis of age-related macular degene...

  • Article
  • Open Access
13 Citations
7,203 Views
13 Pages

Effects of Eggshell Membrane on Keratinocyte Differentiation and Skin Aging In Vitro and In Vivo

  • Kyohei Furukawa,
  • Masaya Kono,
  • Tetsuro Kataoka,
  • Yukio Hasebe,
  • Huijuan Jia and
  • Hisanori Kato

22 June 2021

Skin aging is one of the hallmarks of the aging process that causes physiological and morphological changes. Recently, several nutritional studies were conducted to delay or suppress the aging process. This study investigated whether nutritional supp...

  • Article
  • Open Access
29 Citations
12,440 Views
17 Pages

Aging in China: An International and Domestic Comparative Study

  • Jie Feng,
  • Ganlin Hong,
  • Wenrong Qian,
  • Ruifa Hu and
  • Guanming Shi

22 June 2020

This study investigates the age structure and aging process in China over the last two decades. Comparing internationally, we find that China’s aging status is currently moderate. However, its aging process is accelerating at a rate faster than...

  • Review
  • Open Access
1 Citations
4,096 Views
33 Pages

An Update on Neuroaging on Earth and in Spaceflight

  • Nik V. Kuznetsov,
  • Yauhen Statsenko and
  • Milos Ljubisavljevic

18 February 2025

Over 400 articles on the pathophysiology of brain aging, neuroaging, and neurodegeneration were reviewed, with a focus on epigenetic mechanisms and numerous non-coding RNAs. In particular, this review the accent is on microRNAs, the discovery of whos...

  • Review
  • Open Access
22 Citations
5,322 Views
14 Pages

Present Status and Future Challenges of New Therapeutic Targets in Preclinical Models of Stroke in Aged Animals with/without Comorbidities

  • Aurel Popa-Wagner,
  • Daniela-Gabriela Glavan,
  • Andrei Olaru,
  • Denissa-Greta Olaru,
  • Otilia Margaritescu,
  • Oana Tica,
  • Roxana Surugiu and
  • Raluca Elena Sandu

The aging process, comorbidities, and age-associated diseases are closely dependent on each other. Cerebral ischemia impacts a wide range of systems in an age-dependent manner. However, the aging process has many facets which are influenced by the ge...

  • Review
  • Open Access
14 Citations
7,563 Views
14 Pages

Caenorhabditis elegans as a Model to Study Aging and Photoaging

  • Saowanee Jeayeng,
  • Jirapan Thongsroy and
  • Sirithip Chuaijit

30 September 2024

Caenorhabditis elegans (C. elegans) has emerged as an outstanding model organism for investigating the aging process due to its shortened lifespan, well-defined genome, and accessibility of potent genetic tools. This review presents the current findi...

  • Article
  • Open Access
1 Citations
623 Views
17 Pages

Study on the Influence and Contribution Rates of Field Aging Factors on Rheological Performance of Bitumen

  • Shanglin Song,
  • Yunding Zhu,
  • Zhen Wang,
  • Ziyang Gao,
  • Meng Guo,
  • Jing Huang and
  • Xiaoqiang Jiang

13 April 2025

Laboratory simulation of aging cannot restore the complex aging behavior of bitumen well. The objective of study is to reveal the role of various field aging factors on the aging process of virgin bitumen and SBS(Styrene–Butadiene–Styrene...

  • Review
  • Open Access
27 Citations
7,377 Views
16 Pages

Premature Aging in Chronic Kidney Disease: The Outcome of Persistent Inflammation beyond the Bounds

  • Andrea Figuer,
  • Guillermo Bodega,
  • Patricia Tato,
  • Gemma Valera,
  • Nadia Serroukh,
  • Noemi Ceprian,
  • Patricia de Sequera,
  • Enrique Morales,
  • Julia Carracedo and
  • Matilde Alique
  • + 1 author

Over the last hundred years, life expectancy in developed countries has increased because of healthier living habits and the treatment of chronic pathologies causing premature aging. Aging is an inexorable, time-dependent, multifactorial process char...

  • Article
  • Open Access
6 Citations
2,569 Views
17 Pages

2 November 2023

In this research, the degradation behavior and failure mechanism of silicone rubber seal rings under the synergistic effects of multiple factors in the marine atmosphere are fully investigated. Firstly, four aging factors of air, temperature, compres...

  • Article
  • Open Access
5 Citations
2,724 Views
11 Pages

Evidence of Validity and Reliability of the Lasher and Faulkender Anxiety about Aging Scale in Mexican Older Adults

  • María del Carmen Zueck-Enríquez,
  • Ma. Concepción Soto,
  • Susana Ivonne Aguirre,
  • Martha Ornelas,
  • Humberto Blanco,
  • Jesús Enrique Peinado,
  • Juan Cristóbal Barrón-Luján and
  • Juan Francisco Aguirre

23 November 2021

Anxiety about aging is an important mediating factor in attitudes and behavior toward elderly individuals as well as a mediating factor in the adjustment to one’s own aging processes. The aim of this study was to analyze the factor structure, i...

  • Review
  • Open Access
192 Citations
28,923 Views
17 Pages

19 November 2021

Skin aging is a complex process influenced by intrinsic and extrinsic factors. Together, these factors affect the structure and function of the epidermis and dermis. Histologically, aging skin typically shows epidermal atrophy due to decreased cell n...

  • Review
  • Open Access
27 Citations
7,928 Views
31 Pages

Can Blood-Circulating Factors Unveil and Delay Your Biological Aging?

  • Natalia Rybtsova,
  • Tatiana Berezina,
  • Alexander Kagansky and
  • Stanislav Rybtsov

According to the World Health Organization, the population of over 60 will double in the next 30 years in the developed countries, which will enforce a further raise of the retirement age and increase the burden on the healthcare system. Therefore, t...

  • Review
  • Open Access
2 Citations
2,686 Views
13 Pages

13 February 2025

As the world’s population continues to age, social patterns are changing, making aging a notable public health challenge. With aging as the major risk factor for cognitive decline, the global prevalence of dementia is projected to triple in the...

  • Review
  • Open Access
14 Citations
9,630 Views
23 Pages

Mechanisms of Senescence and Anti-Senescence Strategies in the Skin

  • Evangelia Konstantinou,
  • Eliane Longange and
  • Gürkan Kaya

23 August 2024

The skin is the layer of tissue that covers the largest part of the body in vertebrates, and its main function is to act as a protective barrier against external environmental factors, such as microorganisms, ultraviolet light and mechanical damage....

  • Review
  • Open Access
37 Citations
4,400 Views
16 Pages

27 February 2023

The world population is aging rapidly, and increasing lifespan exacerbates the burden of age-related health issues. On the other hand, premature aging has begun to be a problem, with increasing numbers of younger people suffering aging-related sympto...

  • Review
  • Open Access
3 Citations
1,678 Views
16 Pages

Essential Pieces of the Puzzle: The Roles of VEGF and Dopamine in Aging

  • Melanie B. Thompson,
  • Sanjay P. Tirupattur,
  • Nandini Vishwakarma and
  • Laxmansa C. Katwa

31 July 2025

Aging is a well-known, complex physiological process characterized by progressive functional decline and increased susceptibility to disease, particularly in the cardiovascular and nervous systems. While genetic and environmental factors can shape it...

  • Review
  • Open Access
32 Citations
4,916 Views
22 Pages

Role of the Nrf2 Signaling Pathway in Ovarian Aging: Potential Mechanism and Protective Strategies

  • Xiaofan Gao,
  • Bo Wang,
  • Yibao Huang,
  • Meng Wu,
  • Yuting Li,
  • Yinuo Li,
  • Xiaoran Zhu and
  • Mingfu Wu

28 August 2023

The ovary holds a significant role as a reproductive endocrine organ in women, and its aging process bears implications such as menopause, decreased fertility, and long-term health risks including osteoporosis, cardiovascular disorders, and cognitive...

  • Article
  • Open Access
23 Citations
4,247 Views
25 Pages

Analytical and Chemometric Characterization of Fino and Amontillado Sherries during Aging in Criaderas y Solera System

  • Manuel J. Valcárcel-Muñoz,
  • María Guerrero-Chanivet,
  • María del Carmen Rodríguez-Dodero,
  • María de Valme García-Moreno and
  • Dominico A. Guillén-Sánchez

7 January 2022

Fino and Amontillado are Sherry wines, produced in Marco de Jerez area (southern Spain), and aged in Criaderas y Solera system. Fino Sherry wine follows a biological aging process, under a veil of flor yeasts, while Amontillado Sherry wine shares the...

  • Review
  • Open Access
14 Citations
4,850 Views
14 Pages

The Cross Talk between Cellular Senescence and Melanoma: From Molecular Pathogenesis to Target Therapies

  • Jiahua Liu,
  • Runzi Zheng,
  • Yanghuan Zhang,
  • Shuting Jia,
  • Yonghan He and
  • Jing Liu

6 May 2023

Melanoma is a malignant skin tumor that originates from melanocytes. The pathogenesis of melanoma involves a complex interaction that occurs between environmental factors, ultraviolet (UV)-light damage, and genetic alterations. UV light is the primar...

  • Article
  • Open Access
36 Citations
8,093 Views
17 Pages

The Effects of Muscle Cell Aging on Myogenesis

  • Athanasios Moustogiannis,
  • Anastassios Philippou,
  • Orjona Taso,
  • Evangelos Zevolis,
  • Maria Pappa,
  • Antonios Chatzigeorgiou and
  • Michael Koutsilieris

The process of myogenesis gradually deteriorates as the skeletal muscle ages, contributing to muscle mass loss. The aim of this study is to investigate the effect of senescence/aging on skeletal myogenesis, in vitro. A model of multiple cell division...

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