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The Natural Janus Kinase Inhibitor Agerarin Downregulates Interleukin-4-Induced PER2 Expression in HaCaT Keratinocytes
- Jeong Yeon Lee,
- Euitaek Jung,
- Hyunjin Yeo,
- Sung Shin Ahn,
- Yoongho Lim and
- Young Han Lee
The circadian clock system is closely associated with inflammatory responses. Dysregulation of the circadian clock genes in the skin impairs the skin barrier function and affects the pathophysiology of atopic dermatitis. Interleukin 4 (IL-4) is a pro...