Search Results (1,715)

This article introduces an innovative hybrid methodology that integrates deterministic Mixed-Integer Linear Programming optimization with stochastic Agent-Based Simulation to address the PDP-TW. The approach is applied to real-world operational data from a luggage-handling company in Lisbon, covering 158 service requests from January 2025. The MILP model generates optimal routing and task allocation plans, which are subsequently stress-tested under realistic uncertainties, such as variability in travel and service times, using ABS implemented in AnyLogic. The framework is iterative: violations of temporal or capacity constraints identified during the simulation are fed back into the optimization model, enabling successive adjustments until robust and feasible solutions are achieved for real-world scenarios. Additionally, the study incorporates transshipment scenarios, evaluating the impact of using warehouses as temporary hubs for order redistribution. Results include a comparative analysis between deterministic and stochastic models regarding operational efficiency, time window adherence, reduction in travel distances, and potential decreases in CO₂ emissions. This work provides a contribution to the literature by proposing a practical and robust decision-support framework aligned with contemporary demands for sustainability and efficiency in urban logistics, overcoming the limitations of purely deterministic approaches by explicitly reflecting real-world uncertainties. Full article

Background: Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy characterized by impaired differentiation, apoptosis resistance, and metabolic reprogramming, which collectively contribute to therapeutic resistance and poor clinical outcomes. While targeted agents—such as LSD1 inhibitors, the BCL-2 inhibitor venetoclax, and IDH1 inhibitors—have provided clinical benefit, their efficacy is often limited by compensatory signaling and clonal evolution. This study aimed to identify FDA-approved compounds with multitarget potential to simultaneously modulate key epigenetic, apoptotic, and metabolic pathways in AML. Methods: Structure-based virtual screening of 3957 FDA-approved molecules was performed against three AML-relevant targets: lysine-specific demethylase 1 (LSD1), BCL-2, and mutant IDH1 (R132H). Top-ranked hits were evaluated using ADMET prediction and molecular dynamics (MD) simulations to assess pharmacokinetic properties, toxicity, and ligand–protein complex stability over 100 ns trajectories. Results: Three compounds—DB16703, DB08512, and DB16047—exhibited high binding affinities across all three targets with favorable pharmacokinetic and safety profiles. MD simulations confirmed the structural stability of the ligand–protein complexes, revealing persistent hydrogen bonding and minimal conformational deviation. These findings suggest that these repurposed drugs possess a promising multitarget profile capable of addressing AML’s multifactorial pathophysiology. Conclusions: This computational study supports the feasibility of a polypharmacology-based strategy for AML therapy by integrating epigenetic modulation, apoptotic reactivation, and metabolic correction within single molecular scaffolds. However, the identified compounds (Belumosudil, DB08512, and Elraglusib) have not yet demonstrated efficacy in AML models; further preclinical validation is warranted to substantiate these predictions and advance translational development. Full article

In the context of rapid development within the logistics sector and widespread advocacy for sustainable development, this paper proposes enhancements to the task scheduling and path planning components of four-way shuttle systems. The focus lies on refining and innovating modeling approaches and algorithms to address issues in complex environments such as uneven task distribution, poor adaptability to dynamic conditions, and high rates of idle vehicle operation. These improvements aim to enhance system performance, reduce energy consumption, and achieve sustainable development. Therefore, this paper presents an energy-saving and efficiency-enhancing optimization study for a four-way shuttle-based high-density automated warehouse system, utilizing deep reinforcement learning. In terms of task scheduling, a collaborative scheduling algorithm based on an Improved Genetic Algorithm (IGA) and Multi-Agent Deep Deterministic Policy Gradient (MADDPG) has been designed. In terms of path planning, this paper provides the A*-DQN method, which integrates the A* algorithm(A*) with Deep Q-Networks (DQN). Through combining multiple layout scenarios and adjusting various parameters, simulation experiments verified that the system error is within 5% or less. Compared to existing methods, the total task duration, path planning length, and energy consumption per order decreased by approximately 12.84%, 9.05%, and 16.68%, respectively. The four-way shuttle vehicle can complete order tasks with virtually no conflicts. The conclusions of this paper have been validated through simulation experiments. Full article

Electromagnetic (EM) metamaterials have a wide range of applications due to their unique properties, but their design is often based on specific topological structures, which come with certain limitations. Designing with stochastic topologies can provide more diverse EM properties. However, this requires experienced designers to search and optimise in a vast design space, which is time-consuming and requires substantial computational resources. In this paper, we employ a deep learning network agent model to replace time-consuming full-wave simulations and quickly establish the mapping relationship between the metamaterial structure and its electromagnetic response. The proposed framework integrates a Convolutional Block Attention Module-enhanced Variational Autoencoder (CBAM-VAE) with a Transformer-based predictor. Incorporating CBAM into the VAE architecture significantly enhances the model’s capacity to extract and reconstruct critical structural features of metamaterials. The Transformer predictor utilises an encoder-only configuration that leverages the sequential data characteristics, enabling accurate prediction of electromagnetic responses from latent variables while significantly enhancing computational efficiency. The dataset is randomly generated based on the filling rate of unit cells, requiring only a small fraction of samples compared to the full design space for training. We employ the trained model for the inverse design of metamaterials, enabling the rapid generation of two cells for 1-bit coding metamaterials. Compared to a similarly sized metallic plate, the designed coding metamaterial radar cross-section (RCS) reduces by over 10 dB from 6 to 18 GHz. Simulation and experimental measurement results validate the reliability of this design approach, providing a novel perspective for the design of EM metamaterials. Full article

This article explores the application of atomic force spectroscopy in in vitro studies of endothelial cells. In this technique, derived from the atomic force microscopy, the AFM probe is employed as a nanoindenter. This review aims to discuss the nanomechanical properties of endothelial cells alongside selected biological parameters used to determine their physiological state. Changes in cellular elasticity are analyzed in the context of an intracellular mechanism involving nitric oxide, prostacyclin, calcium ions and reactive oxygen species levels. The manuscript compiles various articles on endothelial cells, assessing the impact of different agents such as drugs, cytokines and nanostructures. The review article addresses the endothelial dysfunction model, which is based on alteration in the mechanical properties of the cells, and explains how this model is used for potential drug testing. The next part of the study evaluates the toxic effects of nanostructures on endothelial cells. Additionally, the article addresses the finite element method, a promising new approach for modeling and simulating the behavior of cells treated as a multi-layered structure. Full article

This study introduces an autonomous framework for grasping moving objects on a conveyor belt, enabling unsupervised detection, grasping, and categorization. The work focuses on two common object shapes—cylindrical cans and rectangular cartons—transported at a constant speed of 3–7 cm/s on the conveyor, emulating typical scenarios. The proposed framework combines a vision-based neural network for object detection, a target localization algorithm, and a deep reinforcement learning model for robotic control. Specifically, a YOLO-based neural network was employed to detect the 2D position of target objects. These positions are then converted to 3D coordinates, followed by pose estimation and error correction. A Proximal Policy Optimization (PPO) algorithm was then used to provide continuous control decisions for the robotic arm. A tailored reinforcement learning environment was developed using the Gymnasium interface. Training and validation were conducted on a 7-degree-of-freedom (7-DOF) robotic arm model in the PyBullet physics simulation engine. By leveraging transfer learning and curriculum learning strategies, the robotic agent effectively learned to grasp multiple categories of moving objects. Simulation experiments and randomized trials show that the proposed method enables the 7-DOF robotic arm to consistently grasp conveyor belt objects, achieving an approximately 80% success rate at conveyor speeds of 0.03–0.07 m/s. These results demonstrate the potential of the framework for deployment in automated handling applications. Full article

The high salt content, low permeability, and fragile structure of saline–alkali land severely constrain the construction and development of irrigation channels. Compaction is an effective means of improving the soil’s engineering performance. Previous studies in this field have mostly been limited to two-dimensional numerical simulations and generally lack systematic physical experiments to support their findings, resulting in an insufficient understanding of the three-dimensional deformation mechanism and macroscopic mechanical response of soil during compaction. In view of the above limitations, this study adopts a comprehensive research framework of “physical experiment–numerical simulation”. Conducting indoor rolling model tests of control variables and simultaneously constructing the corresponding 2D and 3D discrete element models based on the MatDEM platform revealed the influence of curing agent dosage (10% and 25%), loosely laid sample thickness (10 cm and 30 cm), and number of rolling passes on the compaction effect. The test results show that the degree of compaction increases in a typical three-stage pattern of “rapid rise–slow growth–gradual stabilization” with the number of rolling passes, and the number of economic rolling passes is from 4 to 6. Increasing the dosage of the curing agent and reducing the thickness of application both significantly improve the uniformity of compaction and the final density. Numerical simulation further reveals that the 3D model can more accurately reflect the three-dimensional stress state of the soil and the spatial movement of particles, and that the simulation results are in higher agreement with the experimental data. The 2D model has greater computational efficiency and can capture the main compaction trends under specific simplified conditions, but it has deficiencies in quantitative accuracy. This study verified the effectiveness and advantages of MatDEM in simulating complex geotechnical compaction processes, providing theoretical support for an in-depth understanding of compaction mechanisms and the optimization of construction parameters using discrete element methods. Full article

The low stability and bioaccessibility of polyphenols limit their application in functional foods. To address this, chlorogenic acid (CGA) and curcumin (CU) were selected as model compounds and co-encapsulated in spray-dried linseed oil (LO) multiple emulsions (MEs), using octenyl succinic anhydride-modified waxy maize starch as encapsulating agent. Water-in-oil-in-water MEs were prepared by two-step high-pressure homogenization and spray-dried under optimized conditions determined by response surface methodology to minimize surface oil. The resulting microparticles were characterized for encapsulation efficiency (EE), morphology, oxidative stability, and performance under simulated gastrointestinal digestion (INFOGEST protocol). Both CGA and CU exhibited high EE in microparticles (~88–90%), with spray drying significantly improving CGA retention compared to liquid emulsions. Microparticles also showed improved oxidative stability due to the presence of antioxidants. During digestion, CU bioaccessibility decreased (62.7%) relative to liquid MEs (83.6%), consistent with reduced lipid digestion. Conversely, CGA bioaccessibility was higher in microparticles (47.6%) than in MEs (29.2%), indicating a protective effect of the encapsulating agent under intestinal conditions. Overall, spray drying stabilized linseed oil-based MEs and enabled effective co-encapsulation of hydrophilic and lipophilic compounds, supporting their potential as multifunctional delivery systems for functional foods. Full article

Prefabricated building projects represent industrialized and intelligent construction through factory production, standardized design, and mechanized assembly. This study presents a multi-agent simulation approach to model the prefabricated construction process, allowing for the concurrent optimization of the prefabricated component (PC) splitting design and the construction organization plan through iterative simulation. (1) Employing a questionnaire survey, it identifies critical factors affecting schedule and cost from a design–construction coordination perspective. (2) Based on these findings, an agent-based model was developed incorporating PC installation, crane operations, and storage yard spatial constraints, along with interaction rules governing these agents. (3) Data interoperability was achieved among Revit, NetLogo3D and Navisworks. This integrated environment offers project managers digital management of design and construction plans, simulation support, and visualization tools. Simulation results confirm that a hybrid resource allocation strategy utilizing both tower cranes and mobile cranes enhances resource leveling, accelerates schedule performance, and improves cost efficiency. Full article

Originating from the practical demands of digital irrigation district construction, this study aims to provide support for precise irrigation management. This study developed a reinforcement learning-based intelligent irrigation decision-making model for districts employing traditional surface flood irrigation methods. Grounded in the theoretical framework of water cycle processes within the Soil–Crop–Atmosphere Continuum (SPAC) system and incorporating district-specific irrigation management experience, the model achieves intelligent and precise irrigation decision-making through agent–environment interactive learning. Simulation results show that in the selected typical area of the irrigation district, during the 10-year validation period from 2014 to 2023, the model triggered a total of 22 irrigation events with an average annual irrigation volume of 251 mm. Among these, the model triggered irrigation 18 times during the winter wheat growing season and 4 times during the corn growing season. The intelligent irrigation decision-making model effectively captures the coupling relationship between crop water requirements during critical periods and the temporal distribution of precipitation, and achieves preset objectives through adaptive decisions such as peak-shifting preemptive irrigation in spring, limited irrigation under low-temperature conditions, no irrigation during non-irrigation periods, delayed irrigation during the rainy season, and timely irrigation during crop planting periods. These outcomes validate the model’s scientific rigor and operational adaptability, providing both a scientific water management tool for irrigation districts and a new technical pathway for the intelligent development of irrigation decision-making systems. Full article

This paper presents the development and evaluation of an autonomous solar dryer designed to enhance the drying efficiency of bee bread granules. In contrast to natural open-air drying, the proposed system utilizes solar energy in an oscillating operational mode to achieve a controlled and accelerated drying process. The dryer comprises a solar collector integrated into the base of the drying chamber, which facilitates convective heating of the drying agent (air). The system is further equipped with a photovoltaic panel to generate electricity for powering and controlling the operation of air extraction fans. The methodology combines numerical modeling with experimental studies, structured by an experimental design framework. The modeling component simulates variations in temperature (288–315 K) and relative humidity within a layer of bee bread granules subjected to a convective air flow. The numerical simulation enabled the determination of the following: the time required to achieve a stationary operating mode in the dryer chamber (20 min); and the rate of change in moisture content within the granule layer during conventional drying (18 h) and solar drying treatment (6 h). The experimental investigations focused on determining the effects of granule mass, air flow rate, and drying time on the moisture content and temperature of the granular layer of Bee Bread. A statistically grounded analysis, based on the design of experiments (DoE), demonstrated a reduction in moisture content from an initial 16.2–18.26% to a final 11.1–12.1% under optimized conditions. Linear regression models were developed to describe the dependencies for both natural and forced convection drying. A comparative evaluation using enthalpy–humidity (I-d) diagrams revealed a notable improvement in the drying efficiency of the proposed method compared to natural drying. This enhanced performance is attributed to the system’s intermittent operational mode and its ability to actively remove moist air. The results confirm the potential of the developed system for sustainable and energy-efficient drying of bee bread granules in remote areas with limited access to a conventional power grid. Full article

With the rapid development of edge-intelligence systems, multi-UAV platforms have become vital for large-scale 3D reconstruction. However, efficient task scheduling remains a critical challenge due to constraints on UAV energy, communication range, and the need for balanced workload distribution. To address these issues, this paper presents a novel, centralized two-stage task scheduling framework. In the first stage, the framework partitions the target area into communication-feasible subregions by applying cell decomposition that accounts for no-fly zones and workload. It then models the subregion allocation as a Capacitated Vehicle Routing Problem (CVRP) with an added balancing constraint to optimize the traversal sequence for each operational sortie. In the second stage, a time-efficient, scan-based heuristic algorithm allocates viewpoints among UAVs to ensure workload balance, minimizing the mission completion time. Extensive simulations demonstrate that our proposed approach achieves superior performance in workload balance, path efficiency, and reconstruction quality. Overall, this work provides a scalable and energy-aware solution for centralized multi-UAV 3D reconstruction, highlighting an effective approach to ensure cooperation and efficiency in complex multi-agent systems. Full article

Robot navigation in confined spaces has gained popularity in recent years, but offline planning assumes static obstacles, which limits its application to online path-planning. Several methods have been introduced to perform an efficient robot navigation process. However, various existing methods mainly depend on pre-defined maps and struggle in a dynamic environment. Also, diminishing the moving costs and detour percentages is important for real-world scenarios of robot navigation systems. Thus, this study proposes a novel perceptron-Q learning fusion (PQLF) model for Robot Navigation to address the aforementioned difficulties. The proposed model is a combination of perceptron learning and Q-learning for enhancing the robot navigation process. The robot uses the sensors to dynamically determine the distances of nearby, intermediate, and distant obstacles during local path-planning. These details are sent to the robot’s PQLF Model-based navigation controller, which acts as an agent in a Markov Decision Process (MDP) and makes effective decisions making. Thus, it is possible to express the Dynamic Robot Navigation in a Confined Indoor Environment as an MDP. The simulation results show that the proposed work outperforms other existing methods by attaining a reduced moving cost of 1.1 and a detour percentage of 7.8%. This demonstrates the superiority of the proposed model in robot navigation systems. Full article

Following the stablecoin legislation (GENIUS Act) enacted under the second Trump administration in 2025, blockchain has become core digital economy infrastructure. However, privacy risks from decentralization and transparency constrain adoption in regulated industries, requiring solutions that harmonize blockchain architecture with regulatory compliance. Existing research relies on reactive auditing or post-execution rule checking, which wastes computational resources or provides only basic encryption or access controls without comprehensive privacy compliance. The proposed Artificial Intelligence-enhanced Regulatory Proof-of-Compliance (AIRPoC) framework addresses this gap through a two-phase consensus mechanism that integrates AI legal agents with semantic web technologies for autonomous regulatory compliance enforcement. Unlike existing research, AIRPoC implements a dual-layer architecture where AI-powered regulatory validation precedes consensus execution, ensuring that only compliant transactions proceed to blockchain finalization. The system employs AI legal agents that automatically construct and update regulatory databases via multi-oracle networks, using SPARQL-based inference engines for real-time General Data Protection Regulation (GDPR) compliance validation. A simulation-based experimental evaluation conducted across 24 tests with 116,200 transactions in a controlled environment demonstrates 88.9% compliance accuracy, with 9502 transactions per second (TPS) versus 11,192 TPS for basic Proof-of-Stake (PoS) (4.5% overhead). This research represents a paradigm shift to dynamic, transaction-based regulatory models that preserve blockchain efficiency. Full article

The rapid expansion of electric vehicles in high-altitude Andean cities, such as the Metropolitan District of Quito, Ecuador’s capital, presents unique challenges for electrical infrastructure planning, necessitating advanced methodologies that capture behavioral heterogeneity and mass synchronization effects in high-penetration scenarios. This study introduces a hybrid approach that combines agent-based modelling with Monte Carlo simulation and a TimescaleDB architecture project charging demand with quarter-hour resolution through 2040. The model calibration deployed real-world data from 764 charging points collected over 30 months, which generated 2.1 million charging sessions. A dynamic coincidence factor ($F_C=0.222+0.036\ast e^{(-0.0003n)}$) was incorporated, resulting in a 52% reduction in demand overestimation compared to traditional models. The results for the 2040 project show a peak demand of 255 MW (95% CI: 240–270 MW) and an annual consumption of 800 GWh. These findings reveal that non-optimized time-of-use tariffs can generate a critical “cliff effect,” increasing peak demand by 32%, whereas smart charging management with randomization reduces it by 18 ± 2.5%. Model validation yields a MAPE of 4.2 ± 0.8% and an RMSE of 12.3 MW. The TimescaleDB architecture demonstrated processing speeds of 2398.7 records/second and achieved 91% data compression. This methodology offers robust tools for urban energy planning and demand-side management policy optimization in high-altitude contexts, with the source code available to ensure reproducibility. Full article