Search Results (55)

By delving into the waste crisis in Western hyperconsumerist societies as an analytical case study, this study advances an actionable theory of minimalism to address systemic overproduction and overconsumption. Drawing on the interdisciplinary literature, the study analyses the structural, cultural, and psychological drivers of waste generation, synthesising critiques of hypercapitalism and hyperhedonism into a unified theoretical framework that exposes systemic lock-ins and the conflation of wants with socially legitimised needs. In response, the study develops a minimalist ethics framework that repositions sufficiency as a guiding principle for systemic transformation. Minimalism is conceptualised not as an individual restraint but as a multidimensional governance strategy capable of informing economic, technical/technological, regulatory, ecological, and cultural interventions to effectively tackle the waste crisis in Western hyperconsumerist societies. Full article

Individuals with serious mental illness (SMI) face profound and largely preventable physical health inequities shaped by social and structural conditions, representing a major public health concern related to avoidable health inequalities. Because many receive everyday support in community mental health (CMH) systems, these services represent a crucial arena for understanding how such inequities are encountered and made sense of in practice. The study examines how physical health is understood within German CMH practice. Five group discussions with 30 CMH workers were analysed using an interpretive qualitative approach. The analysis identified five professional logics through which physical health becomes part of CMH support: trusting relationships that both enable and limit action; psychological stability as a core mandate; physical health positioned between recognition and delegation; fragile motivation combined with an ethics of restraint; and health promotion situated between aspiration and structural constraint. The findings show that helping relationships, everyday environments, and organisational structures create specific conditions for health-related support. Strengthening these interconnected levels may enable CMH to integrate physical health more systematically, offering insights relevant to international CMH contexts facing similar relational and structural challenges. Full article

In climate adaptation plans, national sustainability strategies, and agency-level resilience frameworks, planetary limits are routinely acknowledged, yet proposed responses continue to center on expansion, replication, and scalability. This paper argues that this tension is not merely political or technical but grammatical. It reflects the dominance of the grammar of scale—a patterned way of organizing, evaluating, and legitimizing sustainability action through expansion, metrics, piloting, and exit. While indispensable in many contexts, scale increasingly struggles to secure durable ecological responsibility amid irreversibility, uneven exposure, and intergenerational harm. The paper advances a framework of plural sustainability grammars to diagnose this mismatch. In addition to scale, it identifies six alternative grammars—attachment, settlement, sufficiency, inheritance, exposure, and refusal—that already circulate, often implicitly, within sustainability discourse. Each grammar foregrounds dimensions of responsibility that scalability tends to background, including permanence, restraint, cumulative consequence, and ethical limits. The paper traces these grammars through climate adaptation planning frameworks across governance levels, showing how plural grammars are prominent in problem framing and diagnosis but are progressively narrowed as plans move toward implementation, monitoring, and accountability, where scale becomes dominant. The paper concludes by reflecting on the implications of this grammatical narrowing for practitioners, policymakers, and scholars concerned with adaptation, justice, and the governance of sustainability under planetary limits. Full article

Reliable numerical simulation of concrete-encased steel (CES) composite columns remains challenging, and practical fiber-element modeling can be sensitive to confinement representation and to discretization and integration choices. Although CES columns offer superior structural performance, accurate simulation is difficult due to the complex interaction between steel and concrete under cyclic loading. Current seismic design codes, such as ASCE/SEI 41-17, often simplify modeling parameters by underestimating composite action, which can lead to uneconomical and overly conservative assessments that do not fully reflect the confining effect of the concrete encasement and the buckling restraint of the steel core. This study proposes a practical guideline for constructing an accurate analytical model for CES columns using nonlinear fiber-element analysis, with a specific focus on material constitutive laws. To validate the proposed strategy, nonlinear analyses were conducted and compared against a comprehensive database of 79 experimental specimens compiled from previous studies. The predicted-to-test peak strength ratio shows a mean of 1.02 (standard deviation of 0.058). Sensitivity studies indicate that responses stabilize beyond ~23 fibers (<1.5% error), reducing computation time by ~40% on average (from 52 to 23 fibers) compared with dense discretization while maintaining reliable hysteretic response prediction. Full article

Due to the constraints of early mining conditions in some coal mines in China, a large number of pillar-type coal pillars remain in the mined-out areas. During the upward mining above the underlying pillar-type goaf, it is usually necessary to backfill the underlying goaf to form a backfill–coal pillar synergistic bearing structure, which jointly bears the load during the upward mining process. In this paper, a combination of laboratory mechanical tests and numerical simulations is used to study the failure characteristics of coal pillars, stress–strain curve characteristics, force chain transmission characteristics, and the number and distribution of fractures under the influence of backfill strength and filling ratio. The critical strength and critical filling ratio of coal pillars with different widths under the coordinated action of different backfill strengths and filling ratios are analyzed. The results show that the composite with a backfill filling ratio of 90% exhibits a stepwise change after coal pillar failure, while the composites with filling ratios of 70% and 50% show a cliff-like drop after coal pillar failure. The composite with a filling ratio of 50% completely loses its bearing capacity after coal pillar failure; the backfill is limited by its height and cannot bear the load repeatedly with the failed coal pillar, and the bearing stage lacks the common bearing stage in which the backfill wraps the failed coal pillar. The number of fractures in the coal pillar decreases with the increase in backfill strength. High-strength backfill can provide higher lateral restraint for the coal pillar through its own anti-deformation capacity. Increasing the backfill filling ratio can reduce the propagation rate of internal fractures in the coal pillar, slow down the deformation time of the coal pillar, and prevent the coal pillar from impact failure. When the coal pillar width is 8 m, the critical filling ratio of the backfill decreases from 84% to 70% as the backfill strength increases from 2 MPa to 6 MPa; when the coal pillar width is 11 m, the critical filling ratio decreases from 69% to 62%; when the coal pillar width is 14 m, the critical filling ratio decreases from 58% to 55%. The research results provide important on-site guiding significance for the safe implementation of upward mining. Full article

Major depressive disorder (MDD) is a leading cause of global morbidity and mortality. Although pharmacological treatments are widely used, their effects are often limited, and nearly half of patients show resistance to current antidepressants, including those unresponsive to all available therapies. These challenges highlight the need to better understand the neurobiological mechanisms driving MDD and to develop novel therapeutic strategies, especially those involving natural compounds with multitarget actions. Baicalin, a bioactive flavonoid from Scutellaria baicalensis, exhibits antioxidant, anti-inflammatory, and neuroprotective properties and has recently gained attention for its potential to improve cognitive deficits and mood disorders. In this study, we investigated baicalin’s antidepressant potential and its underlying mechanisms across multiple experimental levels. We found that oral administration of baicalin produced antidepressant-like effects in both naïve mice and those subjected to chronic restraint stress (CRS). CRS impaired hippocampal long-term potentiation (LTP), whereas baicalin restored these synaptic deficits. Importantly, intra-dorsal hippocampal microinjection of the TrkB receptor antagonist ANA-12 abolished baicalin’s antidepressant effects, indicating the involvement of BDNF–TrkB signaling. Baicalin also reduced reactive oxygen species (ROS)/H₂O₂ production in a BDNF-associated manner, demonstrating clear antioxidant activity. Molecular docking further suggested that baicalin binds more effectively to the TrkB receptor than ANA-12, supporting its capacity to activate TrkB-mediated signaling. By integrating in vivo, ex vivo, in vitro, and in silico approaches, our study shows that baicalin exerts robust antioxidant in vitro and antidepressant effects in vivo. These benefits are primarily mediated through activation of BDNF–TrkB signaling, leading to reduced ROS/H₂O₂ accumulation and alleviation of CRS-induced depression-like behaviors. Full article

Background: Oxytocin (OT) is a nonapeptide hormone produced in the hypothalamus, released into the brain and peripheral circulation, and plays a key role in social behavior. Recent studies indicate that complement component C4a is an OT-binding protein, which modulates plasma OT concentrations in mice. However, the role of C4a is unclear as to whether it contributes to consolation behavior. Methods: Social behavior, especially allogrooming, which is a form of empathy that depends on detecting the emotional states of others, was measured in wild-type or C4a/Slp knockout (Slp^−/−) male mice. Results: Observer mice of both genotypes exhibited comforting (allogrooming) behavior toward a cage-mate demonstrator during reunion after brief isolation of the demonstrator mice. When demonstrator mice experienced body restraint stress during isolation, the allogrooming behavior was significantly increased in both genotypes, with a markedly greater increase in Slp^−/− than in Slp^+/+ mice. Allogrooming behavior in observer Slp^−/− mice was significantly suppressed by an OT receptor antagonist. Furthermore, immunohistochemical analysis revealed that activation was significantly elevated in OT-positive hypothalamic neurons in observer Slp^−/− mice that interacted with stressed demonstrator mice. OT release from the isolated hypothalamus, stimulated via CD38 and TRPM2 channel activation, was greater in Slp^−/− mice than in Slp^+/+ mice. Conclusions: Our results highlight that the data are consistent with a potential role for C4a in modulating neural circuits, possibly via its peripheral action on OT bioavailability. Direct evidence for C4a’s action within the brain remains a hypothesis for future investigation, for example, via site-specific manipulations. Full article

Genotypic characteristics may determine the body’s response to stressful conditions as well as its susceptibility to cardiovascular diseases and stroke. Old age worsens the course of these diseases, and often concomitant hypertension can negatively affect brain function, especially in cases of social isolation. In this work, we studied how social isolation and hypertension affect the transcription activity of genes associated with glucocorticoid signaling in the rat brain. The study was performed on 10-month-old rats of the outbred Wistar stock (n = 48) and the inbred spontaneously hypertensive (SHR) strain (n = 28). The animals of each genotype were divided into groups, one of which was kept in home cages in groups of 3–4 individuals, and the other in single cages for 3 months. Physiological parameters and plasma corticosterone were controlled before the start and after 3 months of isolation. Each group was additionally divided into two subgroups: one subjected to 1 h of restraint stress, and changes in blood glucose and corticosterone levels were assessed. At the end, the levels of Nr3c1, Nr3c2, Hsd11b1, and Fkbp5 mRNAs were measured in the hippocampus and frontal cortex using the Q-PCR technique. After isolation, weight gain stopped in SHRs, although blood pressure did not change, and heart rate increased in rats of both genotypes. In response to restraint, there was practically no increase in corticosterone in isolated Wistar rats, whereas in SHRs, there were significant glucose and corticosterone responses. Significant disruptions in the system responsible for corticosterone-activated signaling cascades were found in the brains of SHR rats. The transcriptional activity of genes encoding corticosterone receptors and proteins regulating their action was reduced in the hippocampus and frontal cortex in SHRs compared to Wistar rats. However, neither isolation nor acute stress significantly affected the contents of transcripts studied. Meanwhile, after isolation, the relationships between the expression of these genes changed significantly, in different directions, in rats of the studied genotypes, both within and between brain structures. Thus, the SHR genotype is associated with persistent changes in the brain that affect the expression of glucocorticoid-associated genes. This indicates a more complex regulation of the stress response, not limited only by the feedback system within the hypothalamic–pituitary–adrenocortical or sympatho-adrenomedullary systems, but operated at the level of the limbic system and the cerebral cortex. Full article

This paper explores methods of simulating the behaviour of building structures under progressive collapse conditions through alternative models of different levels of structural idealization. Such models have been applied in many previous studies, but there is insufficient information regarding their reliability and their ability to represent actual structural behaviour as the level of idealization is reduced. To address this, the study adopts the alternative load path method through the well-established concept of notional column removal, performed via nonlinear static analyses of models with different levels of structural idealization. The focus is on the interaction between the directly affected structural members and the surrounding structure, which is shown to significantly influence the overall response under progressive collapse. The results demonstrate that this interaction depends on multiple factors and cannot be reliably captured when the surrounding structure is not explicitly modelled. Building on this finding, the study systematically evaluates how reduced models can be enhanced to better represent these interactions and proposes strategies for defining boundary conditions that preserve global structural behaviour. Overall, the study advances understanding of model idealization effects and provides practical guidance for developing efficient reduced models for progressive collapse simulations without compromising essential aspects of structural response. Full article

The present study aimed to examine the role of character virtues in the quality of romantic relationships and friendships during emerging adulthood. The sample included 505 individuals, comprising 269 single and 236 partnered emerging adults. Participants completed three self-report instruments: the Values in Action-114GR (VIA-114GR), Sternberg’s Triangular Love Scale (STLS), and the Friendship Network Satisfaction scale (FNS). Latent Profile Analysis (LPA) applying ipsatization identified three distinct virtue profiles, which were not significantly associated with participants’ relationship status. Concerning friendships, analyses of variance revealed that emerging adults characterized by a balanced virtue profile reported significantly greater perceived closeness than those classified within profiles defined by lower levels of restraint and transcendence virtues. However, no significant differences were observed in the frequency of socializing. Regarding romantic relationships, it was found that different virtue profiles support different love dynamics. Specifically, the results showed that profiles differing in endorsing the knowledge virtue were overrepresented in love profiles characterized by low passion or low commitment. These findings offer significant theoretical contributions and practical implications for strengths-based interventions designed to enhance emerging adults’ social and emotional well-being. Full article

Preventing progressive collapse induced by accidental events poses a critical challenge in the design and construction of resilient structures. While substantial progress has been made in planar structures, the progressive collapse mechanisms of precast concrete spatial structures—particularly regarding the effects of precast slabs—remain inadequately explored. This study develops a refined finite element modeling approach to investigate progressive collapse mechanisms in fully bonded prestressed precast concrete (FB-PPC) spatial frames, both with and without precast slabs. The modeling approach was validated against available test data from related sub-assemblies, and applied to assess the collapse performance. A series of pushdown analyses were conducted on the spatial frames under various column removal scenarios. The load–displacement curves, slab contribution, and failure modes under different conditions were compared and analyzed. A simplified energy-based dynamic assessment was additionally employed to offer a rapid estimation of the dynamic collapse capacity. The results show that when interior or side columns fail, the progressive collapse process can be divided into the beam action stage and the catenary action (CA) stage. During the beam action stage, the compressive membrane action (CMA) of the slabs and the compressive arch action (CAA) of the beams work in coordination. Additionally, the tensile membrane action (TMA) of the slabs strengthens the CA in the beams. When the corner columns fail, the collapse stages comprise the beam action stage followed by the collapse stage. Due to insufficient lateral restraints around the failed column, the development of CA is limited. The membrane action of the slabs cannot be fully mobilized. The contribution of the slabs is significant, as it can substantially enhance the vertical resistance and restrain the lateral displacement of the columns. The energy-based dynamic assessment further reveals that FB-PPC spatial frames exhibit high ductility and residual strength following sudden column removal, with dynamic load–displacement curves showing sustained plateaus or gentle slopes across all scenarios. The inclusion of precast slabs consistently enhances both the peak load capacity and the residual resistance in dynamic collapse curves. Full article

Urban transport is a key driver of greenhouse gas emissions in Europe, making its decarbonization essential to achieving EU climate neutrality targets. This study examines how European strategies, such as the Green Deal, the Sustainable and Smart Mobility Strategy, and the Fit for 55 package, are reflected in Romania’s transport policies, with a focus on implementation challenges and urban outcomes in Bucharest. By combining policy analysis, stakeholder mapping, and comparative mobility indicators, the paper critically assesses Bucharest’s current reliance on private vehicles, underperforming public transport satisfaction, and limited progress on active mobility. The study develops a context-sensitive reform framework for the Romanian capital, grounded in transferable lessons from Western and Central European cities. It emphasizes coordinated metropolitan governance, public trust-building, phased car-restraint measures, and investment alignment as key levers. Rather than merely cataloguing policy intentions, the paper offers practical recommendations informed by systemic governance barriers and public attitudes. The findings will contribute to academic debates on urban mobility transitions in post-socialist cities and provide actionable insights for policymakers seeking to operationalize EU decarbonization goals at the metropolitan scale. Full article

This study addresses a critical gap in blast-resistant design by investigating the influence of axial compression ratio—a previously underexplored parameter—on the dynamic response of reinforced concrete (RC) shear walls under close-in explosions. While existing research has focused on conventional loading scenarios, the interplay between axial compression and blast effects remains poorly understood, despite its practical significance for structural safety in high-risk environments. Through a combined experimental and numerical approach, three half-scale RC shear walls were tested under blast loading, complemented by simulations analyzing key parameters (aspect ratio, axial compression ratio, boundary conditions, and charge weight). The results demonstrate that a moderate axial compression ratio (around 0.3) enhances structural stiffness and reduces displacement, effectively helping to control wall damage. Boundary conditions were also found to affect failure modes: walls with stiffer end restraints exhibited reduced deformation but more brittle cracking. Lower aspect ratios (i.e., wider walls) improved blast resistance, and peak displacement progressively increased with the charge weight. These findings provide actionable insights for optimizing RC shear wall design in blast-prone infrastructures, balancing ductility and load capacity. By linking theoretical analysis to practical design criteria, this study advances blast-resistant engineering solutions. Full article

Fire safety is one of the critical concerns for the design and construction of modular structures. The lack of understanding of cavity fire spread in modular construction could create variations in the fire performance of structural members. This study aimed to assess the impact of cavity fire spread in modular buildings initiated by a room fire using validated fire dynamics and structural numerical models. A comprehensive parametric study was conducted to identify critical thermal conditions affecting adjacent structural members under plausible cavity fire scenarios. The identified critical cavity fire thermal conditions were used to examine the structural performance of cold-formed steel intermediate column specimens while varying geometric configurations, material properties, and boundary conditions. The results highlighted two distinct phases of restrained thermal expansion and lateral deformations under material yielding and buckling, resulting in the loss of structural integrity. The restrained thermal expansion significantly increased axial/restraint forces, reaching up to 155% of the initial load. This behavior decreased axial load capacity by 2.4% to 35% of the ambient capacity. Further, the study identifies a requirement for designing the intermediate columns and the connected intermodular connections for increased design action equivalent to 56% of the service load. Full article

Background: Agitation is a frequent and challenging symptom in schizophrenia and bipolar disorder, characterized by heightened motor activity, emotional distress, and potential aggression. This symptom is most observed during acute episodes, representing a significant burden on patients, caregivers, and healthcare systems. Agitation is a leading cause of emergency department visits and psychiatric hospitalizations, necessitating prompt and effective interventions to ensure safety and mitigate its far-reaching impact. Traditional treatments, including high-potency antipsychotics and benzodiazepines, remain first-line options but are associated with significant drawbacks such as sedation, extrapyramidal symptoms, tolerance, and limited applicability in certain patient populations, especially those with respiratory or cardiac depression and the elderly. Non-pharmacologic strategies like de-escalation techniques and environmental modifications are invaluable but may be impractical in acute care settings, as speed and efficiency are critical in emergent settings. These limitations, including the onset of extrapyramidal symptoms with high-dose antipsychotics and the development of tolerance with benzodiazepines, highlight gaps in care, including the need for faster-acting, safer, and more patient-friendly alternatives that reduce reliance on physical restraints and invasive interventions. Methods: This review explores the evolution of treatments for agitation, focusing on alternative and innovative approaches. To highlight these treatments, an extensive review of the literature was conducted utilizing PubMed, Google Scholar, Embase.com, and other search engines. Results: Key developments include sublingual dexmedetomidine, recently FDA-approved, which offers sedation without respiratory depression and a non-invasive administration route. Similarly, subcutaneous olanzapine provides a more convenient alternative to intramuscular injections, reducing injection-related complications. Other emerging treatments such as gabapentin, pregabalin, and ketamine show promise in addressing agitation in specific contexts, including comorbid conditions and treatment-resistant cases. A comparative analysis of these therapies highlights their mechanisms of action, clinical evidence, and practical challenges. Conclusions: Future directions emphasize intranasal delivery systems, novel pharmacologic agents, and potential roles for cannabinoids in managing agitation. These innovations aim to balance rapid symptom control with improved patient safety and experience. The set back with these emerging techniques is a lack of standardized dosing and protocols. They also face ethical concerns, including the chance of misuse or abuse, as well as regulatory barriers, as they lack FDA approval and their legality changes between states. This review underscores the clinical, practical, and ethical considerations in advancing care for agitated patients, paving the way for more effective and compassionate management strategies in psychiatric settings. Full article