Search Results (301)

Civil aviation safety remains a critical concern globally, with continuous efforts aimed at reducing accidents and fatalities. This paper focuses on the comprehensive evaluation of civil aviation safety in the Slovak Republic over the past several years, with the main objective of identifying prevailing trends and key risk factors. A comprehensive analysis of 155 accidents and incidents was conducted based on selected operational parameters. Logistic regression was applied to identify potential causal factors influencing various levels of injury severity in aviation accidents. Moreover, the prediction model can also be used to predict the probability of specific injury severity for accidents with given parameter values. The results indicate a clear declining trend in the annual number of aviation safety events; however, the fatality rate has stagnated or slightly increased in recent years. Human error, particularly mistakes and intentional violations of procedures, was identified as the dominant causal factor across all sectors of civil aviation, including flight operations, airport management, maintenance, and air navigation services. Despite technological advancements and regulatory improvements, human-related failures persist as a major safety challenge. The findings highlight the critical need for targeted strategies to mitigate human error and enhance overall aviation safety in the Slovak Republic. Full article

This work focuses on the possibilities of generating synthetic data for machine learning in hazard prediction in area-based speed monitoring systems. The purpose of the research conducted was to develop a methodology for generating realistic synthetic data to support the design of a continuous vehicle speed monitoring system to minimize the risk of traffic accidents caused by speeding. The SUMO traffic simulator was used to model driver behavior in the analyzed area and within a given road network. Data from OpenStreetMap and field measurements from over a dozen speed detectors were integrated. Preliminary tests were carried out to record vehicle speeds. Based on these data, several simulation scenarios were run and compared to real-world observations using average speed, the percentage of speed limit violations, root mean square error (RMSE), and percentage compliance. A new metric, the Combined Speed Accuracy Score (CSAS), has been introduced to assess the consistency of simulation results with real-world data. For this study, a basic hazard prediction model was developed using LoRaWAN sensor network data and environmental contextual variables, including time, weather, location, and accident history. The research results in a method for evaluating and selecting the simulation scenario that best represents reality and drivers’ propensities to exceed speed limits. The results and findings demonstrate that it is possible to produce synthetic data with a level of agreement exceeding 90% with real data. Thus, it was shown that it is possible to generate synthetic data for machine learning in hazard prediction for area-based speed control systems using traffic simulators. Full article

Background/Objectives: Blunt cardiac injury (BCI) is a severe medical condition that may arise as a result of various traumas, including motor vehicle accidents and falls. The main objective of this study was to explore the role and underlying mechanisms of the TRPV4 gene in BCI. Elucidating the function of TRPV4 in BCI may reveal potential novel therapeutic targets for the treatment of this condition. Methods: Rats in each group, including the SD control group (SDCON), the SD blunt-trauma group (SDBT), the TRPV4 gene-knockout control group (KOCON), and the TRPV4 gene-knockout blunt-trauma group (KOBT), were all freely dropped from a fixed height with a weight of 200 g and struck in the left chest with a certain energy, causing BCI. After the experiment, the levels of serum IL-6 and IL-1β were detected to evaluate the inflammatory response. The myocardial tissue structure was observed by HE staining. In addition, cardiac transcriptome analysis was conducted to identify differentially expressed genes, and metabolomics studies were carried out using UHPLC-Q-TOF/MS technology to analyze metabolites. The results of transcriptomics and metabolomics were verified by qRT-PCR and Western blot analysis. Results: Compared with the SDCON group, the levels of serum IL-6 and IL-1β in the SDBT group were significantly increased (p < 0.001), while the levels of serum IL-6 and IL-1β in the KOBT group were significantly decreased (p < 0.001), indicating that the deletion of the TRPV4 gene alleviated the inflammation induced by BCI. HE staining showed that myocardial tissue injury was severe in the SDBT group, while myocardial tissue structure abnormalities were mild in the KOBT group. Transcriptome analysis revealed that there were 1045 upregulated genes and 643 downregulated genes in the KOBT group. These genes were enriched in pathways related to inflammation, apoptosis, and tissue repair, such as p53, apoptosis, AMPK, PPAR, and other signaling pathways. Metabolomics studies have found that TRPV4 regulates nucleotide metabolism, amino-acid metabolism, biotin metabolism, arginine and proline metabolism, pentose phosphate pathway, fructose and mannose metabolism, etc., in myocardial tissue. The combined analysis of metabolic and transcriptional data reveals that tryptophan metabolism and the protein digestion and absorption pathway may be the key mechanisms. The qRT-PCR results corroborated the expression of key genes identified in the transcriptome sequencing, while Western blot analysis validated the protein expression levels of pivotal regulators within the p53 and AMPK signaling pathways. Conclusions: Overall, the deletion of the TRPV4 gene effectively alleviates cardiac injury by reducing inflammation and tissue damage. These findings suggest that TRPV4 may become a new therapeutic target for BCI, providing new insights for future therapeutic strategies. Full article

Background/Objectives: Spinal cord injuries (SCIs) are among the most debilitating conditions and are a leading cause of disability in young people. This study aimed to analyze the causes of SCIs, assess injury severity using the AIS scale, and evaluate complications during rehabilitation in a hospital setting. Methods: The study involved 176 individuals with SCI, including 142 with a traumatic SCI (TSCI) and 34 with a non-traumatic SCI (NTSCI), rehabilitated at various times post-injury. The data on injury causes, paresis type, complications, wheelchair use, gender, age, and treatment methods were collected. The injury severity was assessed using the AIS. Results: A significant gender difference was found between the TSCI and NTSCI groups (85.2% male vs. 61.8% male). TSCI individuals were also younger. The causes of TSCI were traffic accidents, falls from height, and diving, while the causes for NTSCI included spinal ischemia, tumors, degenerative disc disease, and inflammation. TSCI individuals had more AIS A lesions (52.8% vs. 26.5%) and more cervical injuries (53.5% vs. 14.7%), whereas NTSCI individuals had more AIS C lesions (38.2% vs. 18.3%) and thoracic damage (58.8% vs. 35.2%). TSCI patients were more often treated surgically (95.7% vs. 61.8%) and used wheelchairs (88% vs. 55.9%). No significant differences were found in terms of complications between the groups, though TSCI individuals underwent more chronic rehabilitation. Conclusions: Our research shows that there are significant differences between TSCI and NTSCI both in terms of the level of damage and the severity of damage to neural structures (AIS scales), and thus significant differences in the patients’ functioning in later life for both groups of individuals. Full article

Traumatic liver injury remains a significant contributor to trauma-related morbidity and mortality worldwide. In Saudi Arabia, motor vehicle accidents (MVAs) are the predominant mechanism of injury, particularly among young adults. This study aimed to evaluate the clinical characteristics, management strategies, and outcomes of patients with liver trauma over a ten-year period at a tertiary academic level-one trauma center. A retrospective cohort study was conducted from January 2015 to December 2024. All adult patients (aged 18–65 years) who sustained blunt or penetrating liver injuries and underwent a pan-CT trauma survey were included. Demographic data, Injury Severity Scores (ISSs), imaging timelines, management approach, and clinical outcomes were analyzed. Statistical analysis was performed using JASP software with a significance threshold set at p < 0.05. A total of 111 patients were included, with a mean age of 33 ± 12.4 years; 78.1% were male. MVAs were the leading cause of injury (75.7%). Most patients (80.2%) had low-grade liver injuries and received non-operative management (NOM), with a high NOM success rate of 94.5%. The median time to CT was 55 ± 64 min, and the mean time to operative or IR intervention was 159.9 ± 78.8 min. Complications occurred in 32.4% of patients, with ventilator-associated pneumonia (19.8%) being most common. The overall mortality was 6.3%. Multivariate analysis revealed that shorter time to CT significantly reduced mortality risk (OR = 0.5, p < 0.05), while a positive e-FAST result was strongly associated with increased mortality (OR = 3.3, p < 0.05). Higher ISSs correlated with longer monitored unit stays (ρ = 0.3, p = 0.0014). Traumatic liver injuries in this cohort were predominantly low-grade and effectively managed conservatively, with favorable outcomes. However, delays in imaging and operative intervention were observed, underscoring the requirement for streamlined trauma workflows. These findings highlight the requirement for continuous trauma system improvement, including protocol optimization and timely access to imaging and surgical intervention. Full article

Road traffic accidents remain a critical public health concern worldwide, with Poland consistently experiencing high fatality rates—52 deaths per million inhabitants in 2023, compared to the EU average of 46. To investigate the underlying factors contributing to these accidents, we developed a multifactorial dataset integrating 250,000 accident records from 2015 to 2023 with spatially interpolated weather data and sociodemographic indicators. We employed Kriging interpolation to convert point-based weather station data into continuous surfaces, enabling the attribution of location-specific weather conditions to each accident. Following comprehensive preprocessing and spatial analysis, we generated visualizations—including heatmaps and choropleth maps—that revealed distinct regional patterns at the county level. Our preliminary findings suggest that accident occurrence and severity are driven by different underlying factors: while temperature and vehicle counts strongly correlate with total accident numbers, humidity, precipitation, and road infrastructure quality show stronger associations with fatal outcomes. This integrated dataset provides a robust foundation for Bayesian and time-series modeling, supporting the development of evidence-based road safety strategies. Full article

While traditional risk importance measures in probabilistic risk assessment are effective for ranking safety-significant components, they often overlook critical aspects such as the timing of accident progression and consequences. Dynamic probabilistic risk assessment offers a framework to quantify such risk information, but standardized approaches for estimating risk importance measures remain underdeveloped. This study addresses this gap by: (1) reviewing traditional risk importance measures and their regulatory applications, highlighting their limitations, and introducing newly proposed risk-triplet-based risk importance measures, consisting of timing-based worth, frequency-based worth, and consequence-based worth; (2) conducting a case study of Level 2 dynamic probabilistic risk assessment using the Japan Atomic Energy Agency’s RAPID tool coupled with the severe accident code of MELCOR 2.2 to simulate a station blackout scenario in a boiling water reactor, generating probabilistically sampled sequences with quantified timing, frequency, and consequence of source term release; (3) demonstrating that the new risk importance measures provide differentiated insights into risk significance, enabling multidimensional prioritization of systems and mitigation strategies; for example, the timing-based worth quantifies the delay effect of mitigation systems, and the consequence-based worth evaluates consequence-mitigating potential. This study underscores the potential of dynamic probabilistic risk assessment and risk-triplet-based risk importance measures to support risk-informed and performance-based regulatory decision-making, particularly in contexts where the timing and severity of accident consequences are critical. Full article

Under extreme operating conditions such as high temperatures, strong corrosion, and cyclic thermal shocks, key equipment in solar tower power plants (STPPs) is prone to severe accidents and results in significant losses. To systematically quantify potential failure risks and address the methodological gaps in existing research, this study proposes a risk assessment framework combining a novel scenario propagation model covering triggering factors, precursor events, accident scenarios, and response measures with an interval type-2 fuzzy set (IT2FS) Bayesian network. This framework establishes equipment failure evolution pathways and consequence evaluation criteria. To address data scarcity, the methodology integrates actual case data and expert elicitation to obtain assessment parameters. Specifically, an IT2FS-based similarity aggregation method quantifies expert opinions for prior probability estimation. Additionally, to reduce computational complexity and enhance reliability in conditional probability acquisition, the IT2FS-integrated best–worst method evaluates the relative importance of parent nodes, combined with a leakage-weighted summation algorithm to generate conditional probability tables. The model was applied to a western Chinese STPP and the results show the probabilities of receiver blockage, pipeline blockage, tank leakage, and heat exchanger blockage are 0.061, 0.059, 0.04, and 0.08, respectively. Under normal operating conditions, the occurrence rates of level II accident consequences for all four equipment types remain below 6%, with response measures demonstrating significant suppression effects on accidents. The research results provide critical decision-making support for risk management and mitigation strategies in STPPs. Full article

Nuclear energy is a cornerstone of the global energy mix, delivering reliable, low-carbon power essential for sustainable energy systems. However, the safety of nuclear reactors is critical to maintaining operational reliability and public trust, particularly during accidents like a Loss of Coolant Accident (LOCA) or a Steam Line Break Inside Containment (SLBIC). This study introduces a Bayesian Network (BN) framework used to enhance nuclear energy safety by predicting accident severity and identifying key factors that ensure energy production stability. With the integration of simulation data and physical knowledge, the BN enables dynamic inference and remains robust under missing-data conditions—common in real-time energy monitoring. Its hierarchical structure organizes variables across layers, capturing initial conditions, intermediate dynamics, and system responses vital to energy safety management. Conditional Probability Tables (CPTs), trained via Maximum Likelihood Estimation, ensure accurate modeling of relationships. The model’s resilience to missing data, achieved through marginalization, sustains predictive reliability when critical energy system variables are unavailable. Achieving R² values of 0.98 and 0.96 for the LOCA and SLBIC, respectively, the BN demonstrates high accuracy, directly supporting safer nuclear energy production. Sensitivity analysis using mutual information pinpointed critical variables—such as high-pressure injection flow (WHPI) and pressurizer level (LVPZ)—that influence accident outcomes and energy system resilience. These findings offer actionable insights for the optimization of monitoring and intervention in nuclear power plants. This study positions Bayesian Networks as a robust tool for real-time energy safety assessment, advancing the reliability and sustainability of nuclear energy production. Full article

Background: Electric motorized rental scooters (ES) were introduced in Italy in 2019 as an alternative form of urban transportation, aiming to reduce traffic congestion and air pollution. As their popularity has grown, a parallel increase in ES-related injuries has been observed. This study aims to investigate the types and patterns of ES-related injuries and to identify potentially modifiable risk factors. Methods: We conducted a retrospective analysis of all consecutive patients admitted to the Emergency Department of Policlinico Umberto I in Rome between January 2020 and December 2022 following ES-related trauma. Collected data included demographics, injury mechanisms and types, helmet use, Injury Severity Score (ISS), blood alcohol levels, and patient outcomes. Results: A total of 411 individuals presented to the Emergency Department due to ES-related injuries, either as riders or pedestrians. The mean age was 31 years (range: 2–93); 38 patients (9%) were under 18 years of age. Fifty-six accidents (14%) occurred during work-related commutes. Only three riders (0.7%) wore helmets, and nine patients (2%) had blood alcohol levels > 0.50 g/L. Cranial injuries (134 cases, 32%) and upper limb fractures (93 cases, 23%) were the most frequently reported serious injuries. The mean ISS was 4.5; 17 patients (4%) had an ISS ≥ 16. A total of 270 orthopedic injuries and 118 (29%) maxillofacial injuries were documented. Head trauma was reported in 115 patients (28%), with 19 cases classified as severe traumatic brain injuries. Twenty-three patients (5.5%) were hospitalized, three (0.7%) required intensive care, and one patient (0.2%) died. Conclusions: ES-related injuries are becoming increasingly common and present a significant public health concern. A nationwide effort is warranted to improve rider safety through mandatory helmet use, protective equipment, alcohol consumption control, and stricter enforcement of speed regulations. Full article

Vehicle accidents, particularly PV-PV collisions, result in significant property damage and driver injuries, causing substantial economic losses and health risks. Most existing studies focus on macro-level predictions, such as accident frequency, but lack detailed collision-level analysis, which limits the precision of severity prediction. This study investigates various accident-related factors, including environmental conditions, vehicle attributes, driver characteristics, pre-crash scenarios, and collision dynamics. Data from NHTSA’s CRSS and FARS datasets were integrated and balanced using random over-sampling and under-sampling techniques to address severity-level data imbalances. The mRMR algorithm was employed for feature selection to minimize redundancy and identify key features. Five advanced machine learning models were evaluated for severity prediction, with XGBoost achieving the best performance: 84.9% accuracy, 84.85% precision, 84.90% recall, and an F1-score of 84.87%. SHAP analysis was utilized to interpret the model and conduct a comprehensive analysis of accident features, including their importance, dependencies, and combined effects on severity prediction. This study achieved high accuracy in predicting accident severity across all levels in PV-PV collisions. Moreover, by integrating the SHAP model interpretation method, we conducted detailed feature analysis at global, local, and individual case levels, thereby filling the gap in PV-PV accident severity prediction and feature analysis. Full article

This investigation analyses driving behaviors that lead to accidents on overly sharp mountain road curves in Nanjing Province, China. We collected information through field observations and driving simulations while analyzing key indicators like the mean speed of vehicles and spacing between vehicles. The FP-Growth algorithm was used to identify frequent behavioral patterns and measure their relationship with traffic conflicts. The findings showed that unsafe driver behavior on sharp turns was common, while the combination of “speeding–tailgating–frequent lane changing” behavior increased conflict risk by 3.7 times. A predictive LSTM neural network model was developed with driver, vehicle, road, and environmental factors. Testing on 4795 samples achieved 83.7% accuracy in foreseeing conflict risk levels. The model, which distinguishes between safety conditions and three severity levels of potential conflict, can provide the most fundamental level of safety needed. The research provides quantitative tools for improved road safety management aimed at supporting real evidence-based “safe roads” approaches. Full article

This study involved the simulation of five real-world head impact events in rugby, to assess the level of protection provided by a novel foam headguard, the N-Pro. The University College Dublin Brain Trauma Model (UCDBTM) was used to estimate the peak resultant head accelerations and brain tissue responses in different head impact scenarios. The input kinematics were obtained from two sources: video analysis of impact events, and real-time data obtained through instrumented mouthguards. The impact events were simulated under both unprotected and protected conditions. All simulations were performed against a rigid, non-compliant surface model. The results obtained in this study demonstrate the significant potential of the N-Pro in reducing peak head accelerations and brain tissue stress/strain responses by up to c. 70% compared to unprotected head impacts. This study highlights the headguard’s promising potential to reduce the severity of impact-related injuries by effectively attenuating stresses and strains, as well as linear and rotational kinematics. Additionally, the study supports the recommendation in the literature that kinematic data collected from wearable sensors should be supplemented by video analysis to improve accident reconstructions. Full article

Ionizing radiation (IR) is widely present in the environment, with ¹³⁷Cesium (Cs) radiation having particularly severe impacts during nuclear accidents. The objective of our study was to assess the radiation protection or repair effect of one year (WT-1Y) or seven years (WT-7Y) of storage on white teas, as well as to investigate the mechanism of radioprotection. HGC-27 cells exposed to ¹³⁷Cs γ-rays (30 Gy) exhibited significant changes in cell structure, apoptosis, ROS, LDH, and their expression of p53 and Caspase-3. The results showed that WT-1Y and WT-7Y acted as antioxidants, showed reduced ROS and LDH levels, and had increased CAT and SOD activities as well as cell survival rate. The WT treatments significantly inhibited apoptosis in both the pre- and post-radiation groups, with WT-1 showing stronger effects in pretreatment by reducing LDH, p53, and Caspase-3 levels and enhancing ROS scavenging and enzyme activities. Post-treatment analysis revealed WT-7 had greater effects on cell viability and SOD activity. Overall, both WT-1 and WT-7 mitigated radiation damage, likely by inhibiting the p53/Caspase-3 apoptosis pathway. A Spearman analysis of the differential metabolites in WT-1Y and WT-7Y with cellular radioprotective indicators revealed that metabolites, such as EGC, procyanidin B4, and phenolic acids (abundant in WT-1Y), quercetin-3-glucosylrutinoside, and caffeine (enriched in WT-7Y) contributed to their distinct effects in the pre- and post-treatment of ¹³⁷Cs γ-rays. Full article

As an emerging strategic industry, drone delivery operation has demonstrated significant potential in urban environments due to its efficiency and adaptability to complex scenarios. However, critical bottlenecks persist during the take-off and landing phases, where accident rates account for over 52% of total flight risks, severely limiting operational safety and throughput. While existing droneport designs and sequencing strategies draw inspiration from traditional aviation methods, they inadequately address the separation of take-off/landing flows and lack tailored solutions for logistics drones’ unique characteristics. To overcome these limitations, this paper presents an integrated framework combining innovative airspace design with dynamic sequencing optimization. First, a novel terminal airspace structure is proposed to enable simultaneous multi-drone operations through spatially segregated routes and dedicated zones, fundamentally resolving collision risks between ascending and descending drones. Second, a real-time sequencing model based on the Hungarian algorithm is developed, incorporating drone-specific factors such as battery levels and task priorities to formulate a cost matrix for optimal scheduling. Experimental results demonstrate that the proposed airspace design reduces take-off/landing time by 34.8% compared to conventional funnel-shaped configurations. The sequencing algorithm prioritizes high-value missions while reducing the average waiting time for low-battery drones by 47.3%, effectively alleviating endurance pressures. Notably, the sequencing algorithm prevents low-battery drones from crashing in the experiments. In comparison, under the sequencing of the comparison method, numerous drones crash due to low battery levels. Full article