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A Promising Intracellular Protein-Degradation Strategy: TRIMbody-Away Technique Based on Nanobody Fragment
- Gang Chen,
- Yu Kong,
- You Li,
- Ailing Huang,
- Chunyu Wang,
- Shanshan Zhou,
- Zhenlin Yang,
- Yanling Wu,
- Jianke Ren and
- Tianlei Ying
Most recently, a technology termed TRIM-Away has allowed acute and rapid destruction of endogenous target proteins in cultured cells using specific antibodies and endogenous/exogenous tripartite motif 21 (TRIM21). However, the relatively large size o...