Search Results (201)

This study investigates the predictive performance of financial indicators in forecasting stock prices within the automotive sector using an adaptive neuro-fuzzy inference system (ANFIS). In light of the growing complexity of global financial markets and the increasing demand for automated, data-driven forecasting models, this research aims to identify those financial ratios that most accurately reflect price dynamics in this specific industry. The model incorporates four widely used financial indicators, return on assets (ROA), return on equity (ROE), earnings per share (EPS), and profit margin (PM), as inputs. The analysis is based on real financial and market data from automotive companies, and model performance was assessed using RMSE, nRMSE, and confidence intervals. The results indicate that the full model, including all four indicators, achieved the highest accuracy and prediction stability, while the exclusion of ROA or ROE significantly deteriorated model performance. These findings challenge the weak-form efficiency hypothesis and underscore the relevance of firm-level fundamentals in stock price formation. This study’s sector-specific approach highlights the importance of tailoring predictive models to industry characteristics, offering implications for both financial modeling and investment strategies. Future research directions include expanding the indicator set, increasing the sample size, and testing the model across additional industry domains. Full article

Bioactive glass materials have been used for decades in orthopedic surgery, traumatology, and oral and maxillofacial surgery to repair bone defects. This study aimed to evaluate in vitro the survival and proliferation of MG63 human osteosarcoma-derived cells on S53P4 bioactive glass (BonAlive^® granules). Microscopic visualization was performed to directly observe the interactions between the cells and the material. Osteoblast-like cells were examined on non-adherent test plates, on tissue culture (TC)-treated plates and on the surface of the bioglass to assess the differences. Cell survival and proliferation were monitored using a CCK-8 optical density assay. Comparing the mean OD of MG63 cells in MEM on TC-treated plates with cells on BG, we detected a significant difference (p < 0.05), over each time of observation. The sustained cell proliferation confirmed the non-cytotoxic property of the bioglass, as the cell number increased continuously at 48, 72, 96, and 168 h and even did not plateau after 168 h. Since the properties of bioglasses can vary significantly depending on their composition and environment, a thorough characterization of their biocompatibility is crucial to ensure their effective and appropriate application—for example, during hip and knee prosthesis insertion. Full article

(1) The primary objective was to determine whether, within this taxonomically challenging group, the closely related European species and their subspecies exhibit distinct inflorescence characters that allow for unambiguous differentiation. This study focuses on two closely related species within the genus Hierochloë: Hierochloë hirta (Schrank) Borbás and Hierochloë odorata (L.) Beauv. (2) For four subspecies, data were collected from 15 inflorescences each, while for one subspecies, 10 inflorescences were examined. From each inflorescence, six spikelets were selected. The statistical analyses were non-parametric methods, the Kruskal–Wallis test, and principal component analysis. (3) Morphological traits showed consistent patterns within each subspecies, indicating their suitability for taxonomic differentiation. The most reliable diagnostic traits were the length of the outer glume of the first flower and the lengths of the awns. (4) The study concludes that while some subspecies can be clearly distinguished based on inflorescence morphology, no single trait is sufficient to completely separate all taxa. The authors recommend recognizing Hierochloë odorata subsp. praetermissa as a subspecies rather than a distinct species and affirm the validity of the species names Hierochloë hirta and Hierochloë odorata. Full article

Chronic kidney disease (CKD)-associated anemia is a global health concern and is linked to vascular and ocular complications. Hypoxia-inducible factor (HIF) stabilizers, or HIF prolyl hydroxylase inhibitors (PHIs), are promising candidates for the treatment of CKD-associated anemia. Since hypoxia and angiogenesis are involved in eye diseases, this study examined the effects of HIF-PHIs on metabolism and gene expression in retinal pigment epithelium (RPE) cells. Results revealed that PHIs differentially induced angiogenic (VEGFA, ANG) and glycolytic (PDK1, GLUT1) gene expression, with Roxadustat causing the strongest transcriptional changes. However, Roxadustat-induced angiogenic signals did not promote endothelial tube formation. Moreover, it did not induce oxidative stress, inflammation, or significant antioxidant gene responses in ARPE-19 cells. Roxadustat also reduced the inflammatory cytokine response to tumor necrosis factor-α, including IL-6, IL-8, and MCP-1, and did not exacerbate VEGF expression under high-glucose conditions. Overall, Roxadustat triggered complex gene expression changes without promoting inflammation or oxidative stress in RPE cells. Despite these findings, ophthalmologic monitoring is advised during PHI treatment in CKD patients receiving HIF-PHIs. Full article

This study analyzed the surface layer condition of X5CRNI18-10 stainless austenitic chromium–nickel steel test pieces after burnishing. Among the finishing operations, burnishing is an economical and low-environmental-impact process. In special cases, grinding can be replaced by burnishing, so the same roughness can be achieved with much lower environmental impact. The aim of this study is to analyze the roughness of a surface machined by diamond burnishing using Kraljic matrices. The technological parameters used during the burnishing tests were burnishing speed, feed rate, and burnishing force. The full factorial experimental design method was used to carry out the experiments. Using Kraljic matrices, the optimum burnishing force was determined to select the best value of the surface roughness, and the change in surface roughness was investigated using full factorial experimental design for different technological parameter combinations. A special improvement ratio formula was developed to evaluate the effectiveness of the burnishing process with respect to 2D and 3D roughness parameters. Full article

A previously undescribed cis-clerodane diterpenoid, diangelate solidagoic acid J (1), along with two known cis-clerodane diterpenoids, solidagoic acid C (2) and solidagoic acid D (3), as well as two known unsaturated monoacylglycerols, 1-linoleoyl glycerol (4) and 1-α-linolenoyl glycerol (5), were isolated and characterized from the n-hexane leaf extract of Solidago gigantea (giant goldenrod). Compounds 2–5 were identified first in this species, and compounds 4 and 5 are reported here for the first time in the Solidago genus. The bioassay-guided isolation procedure included thin-layer chromatography (TLC) coupled with a Bacillus subtilis antibacterial assay, preparative flash column chromatography, and TLC–mass spectrometry (MS). Their structures were elucidated via extensive spectroscopic and spectrometric techniques such as one- and two-dimensional nuclear magnetic resonance (NMR) spectroscopy and high-resolution tandem mass spectrometry (HRMS/MS). The antimicrobial activities of the isolated compounds were evaluated by a microdilution assay. All compounds exhibited weak to moderate antibacterial activity against the Gram-positive plant pathogen Clavibacter michiganensis, with MIC values ranging from 17 to 133 µg/mL, with compound 5 being the most potent. Only compound 1 was active against Curtobacterium flaccumfaciens pv. flaccumfaciens, while compound 3 demonstrated a weak antibacterial effect against B. subtilis and Rhodococcus fascians. Additionally, the growth of B. subtilis and R. fascians was moderately inhibited by compounds 1 and 5, respectively. None of the tested compounds showed antibacterial activity against Gram-negative Pseudomonas syringae pv. tomato and Xanthomonas arboricola pv. pruni. No bactericidal activity was observed against the tested microorganisms. Compounds 2 and 3 displayed weak antifungal activity against the crop pathogens Bipolaris sorokiniana and Fusarium graminearum. Our results demonstrate the efficacy of bioassay-guided strategies in facilitating the discovery of novel bioactive compounds. Full article

This study investigates the relationships between entrepreneurial leadership skills (ELSs), ethical entrepreneurial leadership (EEL), corporate sustainable development (CSD), and competitive advantage (CA) in SMEs. Drawing on resource-based view theory, we examine whether entrepreneurial capabilities and ethical practices jointly contribute to sustainability and competitive positioning. Data from 312 SME leaders across manufacturing, services, technology, and trading sectors were analyzed using PLS-SEM. Results reveal that ELSs foster EEL (β = 0.684, p < 0.001) and enhance CSD (β = 0.453, p < 0.001). EEL significantly affects CSD (β = 0.527, p < 0.001) and partially mediates the relationship between entrepreneurial skills and sustainability (indirect effect = 0.361). CSD strongly enhances CA (β = 0.612, p < 0.001). The findings demonstrate that integrating entrepreneurial capabilities with ethical leadership creates foundations for sustainable development and CA in resource-constrained environments. This research extends entrepreneurial leadership theory by showing complementarity between entrepreneurial and ethical orientations, advances sustainability theory by revealing ethical leadership’s mediating role, and enriches RBV by demonstrating how intangible leadership capabilities generate CA when traditional resources are scarce. Practical implications include developing integrated leadership programs and sustainability frameworks for emerging economy SMEs. Full article

Objectives: Despite the relatively high incidence of vulvar cancer, there is a noticeable lack of studies in Romania and other Eastern European countries focused on evaluating the long-term oncological outcomes and Quality of Life (QoL) for patients with this condition. Methods: A total of 91 patients were included in the study. The first objective was to evaluate the 5-year overall survival (OS) in patients with vulvar cancer at International Federation of Gynecology and Obstetrics (FIGO) stages IA-IVA who underwent surgery, ±adjuvant radiotherapy (RT). Additionally, the study aimed to identify prognostic factors that could either positively or negatively influence survival outcomes in these patients. The second objective was to assess the QoL, conducted using validated questionnaires issued by the European Organization for Research and Treatment of Cancer, specifically the QLQ-CX30 and QLQ-VU34. Results: The patients had an average age of 67.7 years (38–91). At the time of assessment, 51.6% of the patients were alive. Additionally, the 5-year OS was reported at 45%. The multivariate analysis indicated that age ≤ 50 years (p < 0.03), FIGO stage IB (p < 0.007), and tumor differentiation grade I (p < 0.01) were associated with improved survival rates. Conversely, age > 80 years (p < 0.05), FIGO stages IIIB (p < 0.01) and IIIC (p < 0.06), tumor size > 5 cm (p < 0.02), positive resection margins (p < 0.03), lymph node metastasis (p < 0.06), and pelvic exenteration (p < 0.002) were identified as independent negative prognostic factors. Of the 47 living patients, 32 completed the QoL questionnaires. The respondents reported a decent overall QoL score of 65.3. However, treatment-specific symptoms, such as vulvar scarring, vulvar swelling, groin lymphedema, and leg lymphedema, had a negative impact on QoL. Consequently, functional symptoms like fatigue, pain, and sleep disturbances persisted, leading to a body image perception score of 33.7 on a scale from 0 to 100. Conclusions: This study highlights decent OS and QoL outcomes. It is important to note that vulvar cancer primarily affects older women. In this study, 51.6% of patients were over 70 years old at the time of surgery. Consequently, the 5-year OS of 45% could not be attributed solely to oncological factors, as most of these patients did not die from recurrences but rather from associated comorbidities. The findings of this study provide a foundation for future randomized controlled trials aimed at further enhancing vulvar cancer patients’ care and outcomes. Full article

Background: Acromioclavicular (AC) joint dislocations are frequent, especially kocsisamong young male athletes. While over 150 surgical techniques exist, consensus on optimal treatment—particularly for Rockwood type III injuries—remains elusive. This study evaluates the Lockdown procedure’s efficacy, safety, and patient satisfaction, a synthetic ligament technique for AC joint stabilization. Methods: A multicenter prospective study was conducted on 39 patients across three Hungarian hospitals (2018–2023). Outcomes included shoulder function, pain levels, and complication rates, with subgroup analysis of acute (≤3 weeks) versus chronic (>3 weeks) cases. A systematic review of nine studies (205 cases) was also performed to assess broader outcomes and complications. Results: Significant improvements were observed in functional scores (OSS, Constant, DASH, SST, ASES, Nottingham, Imitani) and pain reduction, especially in acute cases with no prior shoulder surgery. The mean patient age was 38.9 ± 12.68 years, with a 24.5-month average follow-up. OSS improvement between acute and chronic cases was 14.96 (95% CI: 6.45–23.47; p = 0.0017). Complications (30.8%) occurred in eleven patients, mainly minor infections; implant failure necessitated revision in 5.1%. The systematic review reported a 34.6% complication rate (predominantly minor complications, like asymptomatic subluxation −16%) and 5.4% implant removal due to failure. A meta-analysis was not feasible due to data heterogeneity. Conclusions: The Lockdown procedure significantly enhances shoulder function and reduces pain, particularly in acute dislocations. However, the procedure showed a moderate complication rate, underscoring the need for careful patient selection and postoperative management. Full article

Honey is increasingly recognized not only as a functional food but also as a potential bioindicator of environmental pollution. This study assessed the concentrations of four potentially toxic elements (PTEs)—lead (Pb), cadmium (Cd), copper (Cu), and zinc (Zn)—in 48 multifloral honey samples collected in 2023 from seven locations across a historically polluted agro-industrial region in Romania. Samples were analyzed using Flame Atomic Absorption Spectrometry (FAAS) and Graphite Furnace AAS (GFAAS), with quality control ensured through certified reference materials. Results revealed that Pb (0.72–1.69 mg/kg) and Cd (0.02–0.37 mg/kg) levels consistently exceeded international safety thresholds, while Cu (0.62–2.22 mg/kg) and Zn (0.91–1.93 mg/kg), although essential nutrients, were found in elevated concentrations. Spatial analysis indicated a general trend of higher contamination in sites located closer to former industrial facilities, influenced by factors such as altitude and atmospheric transport. These findings confirm the persistent environmental burden in post-industrial landscapes and support the use of honey as a cost-effective tool for pollution monitoring. The study underscores the need for targeted environmental policies, sustainable apicultural practices, and continued surveillance to protect ecosystem health and food safety. Full article

I dispute the conventional claim that the second law of thermodynamics is saved from a “Maxwell’s demon” by the entropy cost of information erasure and show that instead it is measurement that incurs the entropy cost. Thus, Brillouin, who identified measurement as savior of the second law, was essentially correct, and putative refutations of his view, such as Bennett’s claim to measure without entropy cost, are seen to fail when the applicable physics is taken into account. I argue that the tradition of attributing the defeat of Maxwell’s demon to erasure rather than to measurement arose from unphysical classical idealizations that do not hold for real gas molecules, as well as a physically ungrounded recasting of physical thermodynamical processes into computational and information-theoretic conceptualizations. I argue that the fundamental principle that saves the second law is the quantum uncertainty principle applying to the need to localize physical states to precise values of observables in order to effect the desired disequilibria aimed at violating the second law. I obtain the specific entropy cost for localizing a molecule in the Szilard engine and show that it coincides with the quantity attributed to Landauer’s principle. I also note that an experiment characterized as upholding an entropy cost of erasure in a “quantum Maxwell’s demon” actually demonstrates an entropy cost of measurement. Full article

Changes in land use and agricultural practices have altered the resilience of plant communities and can lead to the emergence of invasive species. One of these is the perennial grass species Bothriochloa ischaemum (L.) Kleng., whose diversity-reducing effects are known from several studies. Our exploratory questions were as follows: How does the presence of B. ischaemum affect the diversity and ratio of the species of sandy grasslands? To what extent does this diversity change depend on site characteristics? The supporting studies were carried out in five low-lying sand dune slacks and six relatively higher areas in the upper-intermediate part of the dunes and on an abandoned old field located in the Hungarian Great Plain in the Carpathian Basin. The cover of vascular plant species was recorded in all sampling sites in twelve 2 by 2 m plots, and the dataset was analysed using agglomerative cluster analyses and a non-parametric Kruskal–Wallis test. Five significantly different groups were identified, separating the vegetation types of the sides of the sand dunes, the vegetation types of the dune slack and the old field, and a Stipa borysthenica Kolkov ex Prokudin-dominated vegetation type. Our results suggest that B. ischaemum is only present as small tussocks on the drier, more exposed sides of dunes, with 3.9–24.2% average coverage; is less able to outcompete Festuca vaginata Waldst. et Kit. ex Willd. and S. borysthenica; and is only able to form large tussocks mainly in the lower dune slacks, with 45.6–79.5% average coverage. Here, in the wetter areas, it achieves high cover with a considerable accumulation of litter, and it becomes a dominant species in this association. The diversity-reducing effect of B. ischaemum on old-field grasslands depends on the age of the site and on the stability of the vegetation. Full article

Although a myocardial infarction occurs roughly every minute in the U.S. alone, medical research has yet to unlock the key to fully enabling post-hypoxic myocardial regeneration. Thymosin beta-4 (TB4), a short, secreted peptide, was shown to possess a beneficial impact regarding myocardial cell survival, coronary re-growth and progenitor cell activation following myocardial infarction in adult mammals. It equally reduces scarring, however, the precise mechanisms through which the peptide assists this phenomenon have not been properly elucidated. Accordingly, the primary aim of our study was to identify novel molecular contributors responsible for the positive impact of TB4 during the remodeling processes of the infarcted heart. We performed miRNA profiling on adult mice hearts following permanent coronary ligation with or without systemic TB4 injection and searched for targets and novel mechanisms through which TB4 may mitigate pathological scarring in the heart. Our results revealed a significant increase in miR139-5p expression and identified ROCK1 as a potential target protein aligned. Real-time PCR, Western blot and immunostaining on adult mouse hearts and human cardiac cells revealed the peptide indirectly or directly modulates ROCK1 protein levels both in vivo and in vitro. We equally discovered TB4 may reverse or inhibit fibroblast/myofibroblast transformation and the potential downstream mechanisms by which TB4 alters cellular responses through ROCK1 are cell type specific. Given the beneficial effects of ROCK1 inhibition in various cardiac pathologies, we propose a potential utilization for TB4 as a ROCK1 inhibitor in the future. Full article

Background: The early recognition of systemic hemodynamic changes resulting from uteroplacental circulation disturbance in preeclampsia (PE) is of great importance for its appropriate treatment and prevention. The aim of the present study was to assess the hemodynamic changes during a roll-over test in healthy normotensive and preeclamptic pregnant women using applanation tonometry. Patients and methods: Healthy pregnant and PE women in their third trimester were studied. First, applanation tonometry was performed in a resting state on the right radial artery of each subject. In the second phase, the measurements were repeated in the left-lateral position and 5 min after turning each patient into a supine position (roll-over test = ROT). The systolic and diastolic central and peripheral blood pressures, pulse pressures, and augmentation index (AIx₇₅) values were registered for all phases. Results: A total of 21 PE and 14 healthy pregnant women entered this study. At rest, the PE patients had higher systolic, diastolic, and mean blood pressures; the preeclamptic patients had higher peripheral and central blood pressure and pulse pressure values compared to the healthy controls. A statistically significant difference was found between the augmentation index (AIX-75) values for the preeclamptic and healthy pregnant women (healthy pregnant: 9.0 ± 2.4 vs. preeclamptic: 18.9 ± 6.0; p = 0.019). During the ROT, no significant differences could be detected in the applanation tonometry parameters within the groups. The differences between the PE and healthy pregnant women continued to exist in the left-lateral and supine positions during the roll-over test. Conclusions: This is the first study combining a roll-over test and arterial stiffness measurements in healthy pregnant females and in those with PE. Although we can confirm that arterial stiffness measurements can be used to detect hemodynamic changes in pregnant women with PE, combining it with a roll-over test is unsuitable for improving the method’s sensitivity. Full article