Search Results (34)

Background. The Multidimensional Scale of Perceived Social Support (MSPSS) is widely used, although it has not been validated among early adolescents in Darjeeling, India. The aims of the study were to validate the psychometric properties of the MSPSS, and to test for measurement invariance by gender. Methods. Survey data was collected from 274 early adolescents ages 10–14 living in Darjeeling, India. Confirmatory factor analysis (CFA) evaluated 1-, 2-, and 3-factor models. Reliability (Cronbach’s α, McDonald’s ω), convergent (peer problems), and concurrent validity (prosocial behavior) were assessed. Measurement invariance by gender was tested using multi-group CFA. Results. The three-factor model of the MSPSS (Family, Friends, Significant Other) fit these data well (X²[49] = 69.3, p = 0.030; CFI = 0.98; RMSEA = 0.039; SRMR = 0.036). Measures of reliability, concurrent, and convergent validity were good with MSPSS scores correlated positively with prosocial behavior and negatively with peer problems (|r| = 0.30–0.45, p ≤ 0.001). Configural invariance by gender was not supported, indicating differences in item-level loadings. Limitations. The MSPSS is a self-report measure, and social desirability bias is a potential limitation. Conclusion. The MSPSS demonstrates good reliability and validity among early adolescents in Darjeeling, India. Given non-invariance by gender, subscale comparisons across boys and girls should be interpreted with caution. Full article

Background: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, increasingly prevalent worldwide. Type 2 diabetes mellitus (T2DM) is a major chronic disorder and a significant risk factor for AF, contributing to high morbidity and mortality. Metformin monotherapy can contribute to the reduced occurrence of adverse cardiovascular outcomes in patients with T2DM, but its effects on AF are understudied. This meta-analysis evaluates the association of metformin with the risk of incident AF among patients with T2DM on metformin. Methods: Databases, including PubMed, Google Scholar, and EMBASE, were screened through November 2024 for studies evaluating the association between metformin and new-onset AF in patients with T2DM. Comprehensive Meta-Analysis (CMA) version 4, by Biostat, Inc., utilizing a random effects model, was used to pool hazard ratios (HR) and 95% confidence intervals (CI). A meta-regression analysis was also performed to identify factors that may have influenced the results. A p-value < 0.05 was considered statistically significant. Results: A total of seven studies, comprising 4,017,929 patients with T2DM, having a mean age of 62.82 years and 52.5% males, were included. Metformin was associated with a statistically significantly lower risk of new-onset AF among patients with T2DM compared to other hypoglycemic agents (aHR: 0.85; 95% CI 0.76–0.94; p = 0.002). Meta-regression analysis identified age as a significant moderator of the treatment effect (β = −3.15, p = 0.001). Conclusions: Metformin is associated with a lower risk of new-onset AF among patients with T2DM compared to other hypoglycemic agents. Furthermore, age-related attenuation of this association was observed, with older patients with T2DM showing a weaker association. Full article

Background/Objectives: Acne vulgaris is a prevalent dermatological condition, yet clear, region-specific management guidelines, particularly for India’s diverse population, remain limited. Effective acne management extends beyond pharmacologic therapy, emphasizing proper skincare, patient education, and adherence strategies. This consensus aims to provide tailored, evidence-based recommendations for optimizing acne treatment in the Indian context. Methods: A panel of 14 dermatology experts with ≥15 years of experience reviewed literature, real-world clinical practices, and patient-centric factors relevant to acne management in India. Using a modified Delphi process with two virtual voting rounds, 61 statements across seven clinical domains were evaluated. Consensus was defined as ≥75% agreement. Results: Topical retinoids remain the first-line therapy, with combination regimens (benzoyl peroxide or topical antibiotics) preferred to enhance efficacy and minimize antibiotic resistance. Hormonal therapies, including combined oral contraceptives and spironolactone, are recommended for females with resistant acne. Guidance includes individualized treatment plans, baseline investigations, and selection of appropriate topical and systemic agents. Special considerations for pregnancy and lactation prioritize maternal and fetal safety. Conclusions: This expert consensus provides practical, evidence-based recommendations for acne management in India, integrating pharmacological and non-pharmacological approaches. The tailored guidance supports individualized care, antibiotic stewardship, and improved treatment adherence, aiming to enhance patient outcomes nationwide. Full article

This study investigates the evolution of customer-centric innovations within modern business ecosystems through the lens of servitization, a concept gaining momentum in contemporary service delivery frameworks. Recognizing the limited exploration of servitization beyond manufacturing, particularly in the context of value-added services, this research employs a multiple case study methodology focused on the tea sector in India and Nepal. Drawing on seven diverse entrepreneurial cases and supported by a thematic analysis, the study identifies nine critical factors influencing successful servitization, including knowledge gaps, procurement strategies, market segmentation, and customer engagement. Central to this investigation is the transformative role of structured training interventions, exemplified by the Chaya School of Tea, which catalyzed innovation and performance improvements among participating businesses. The findings highlight how digital tools, customer education, and strategic planning contribute to product–service integration, yielding enhanced quality, operational efficiency, and sustainable growth. This research contributes to theory by refining the concept of “servitization of services” as a strategic approach for empowering ecosystems through complementary offerings that transcend traditional service delivery. This work provides both conceptual and empirical insights into how service firms, particularly in under-researched sectors, can leverage servitization to drive long-term competitiveness and ecosystem-wide value creation. Full article

Objective: With rapid urbanization in countries like India, understanding the nutritional status and needs of urban populations, particularly among underprivileged groups such as people living in slums, is crucial. This study investigates the prevalence, characteristics, and determinants of child malnutrition in the urban slums of the Kolkata Municipal Corporation (KMC) and Siliguri Municipal Corporation (SMC) in West Bengal, India. Methods: A cross-sectional study was conducted among 736 children aged 6–59 months. Data were collected using structured interviews to gather socioeconomic, demographic, and dietary information, alongside anthropometric measurements. The analysis employed the Composite Index of Anthropometric Failure (CIAF), and multiple linear regression (MLR) models to identify key factors influencing malnutrition. Results: The findings revealed a high prevalence of stunting (24.1%), underweight (22.3%), and wasting (15.4%) among children aged 6–59 months, with significant variations observed between the two study sites. Key predictors of anthropometric malnutrition include low household income, incidence of recent illness, low maternal nutrition, and delayed initiation of breastfeeding. Conclusions: Addressing child malnutrition in urban slums requires integrated strategies encompassing income-generation opportunities, health-sensitive urban planning, and focused maternal and child health interventions. Full article

The dengue virus is globally widespread and has a high infection and fatality rate. Currently, no medication is available. So, this study aims to screen for promising inhibitors from Dodonaea viscosa by targeting NS5 methyltransferase (crucial in RNA capping) of the dengue virus. The compounds were screened from Dodonaea viscosa, and docking analysis was performed with the NS5 methyltransferase (PDB ID: 6KR2). Based on the docking investigation, the top five compounds were selected, having a score range of −7.164 to −5.837 Kcal/Mol, comparably higher than the control (Qunine; −3.050 Kcal/Mol), and examined. Among these selected compounds, Quercetin (PubChem ID; 5280343) revealed highly promising activity and was further analyzed for stability over 100 ns simulation. The ADME of the selected compound was examined and found to have favourable activity. Moreover, the compound can be used for therapeutic development to combat dengue infection. Full article

Coumarin and its annulated heterocycles are mainly found in natural products, many of which show significant biological activities and are used extensively for the preparation of pharmaceutical products. Investigation revealed that many heterocyclic compounds fused with coumarin moiety exhibited antihelmentic, hypnotic, insecticidal, antifungal, and anti-coagulant properties. In industry, coumarin scaffolds are widely used for the preparation of drugs, agrochemicals, pesticides, and dyes. In recent studies, several coumarin derivatives have been used in materials science for the preparation of organic cell imaging materials, fluorescent biological probes, etc. Due to their immense application potential in biological science and material chemistry, much attention has been paid by researchers towards the synthesis of a new class of coumarin annulated heterocycles. In this paper, the synthesis of coumarin-annulated polycyclic heterocycles via sequential Claisen rearrangement and tin-hydride mediated radical cyclization is reported. The requisite starting materials 3-((4-chlorobut-2-yn-1-yl)oxy)-2H-chromen-2-one (1) was prepared from 3-hydroxycoumarin and 1,4-dichlorobut-2-yne. The Claisen rearrangement of 1 in refluxing chlorobenzene afforded 1-(chloromethyl)pyrano[2,3-c]chromen-5(3H)-one (2). Finally, radical cyclization reactions were carried out smoothly using ⁿBu₃SnH and AIBN in toluene at 110 °C, leading to the coumarin-annulated polycyclic heterocycles in high yields. The process is operationally simple and easy to work-up, making it convenient for the preparation of coumarin annulated heterocycles. Full article

Cisplatin, a powerful chemotherapy medication, has long been a cornerstone in the fight against cancer due to chemotherapeutic failure. The mechanism of cisplatin resistance/failure is a multifaceted and complex issue that consists mainly of apoptosis inhibition through autophagy sensitization. Currently, researchers are exploring ways to regulate autophagy in order to tip the balance in favor of effective chemotherapy. Based on this notion, the current study primarily identifies the differentially expressed genes (DEGs) in cisplatin-treated autophagic ACHN cells through the Illumina Hi-seq platform. A protein–protein interaction network was constructed using the STRING database and KEGG. GO classifiers were implicated to identify genes and their participating biological pathways. ClueGO, David, and MCODE detected ontological enrichment and sub-networking. The network topology was further examined using 12 different algorithms to identify top-ranked hub genes through the Cytoscape plugin Cytohubba to identify potential targets, which established profound drug efficacy under an autophagic environment. Considerable upregulation of genes related to autophagy and apoptosis suggests that autophagy boosts cisplatin efficacy in malignant ACHN cells with minimal harm to normal HEK-293 growth. Furthermore, the determination of cellular viability and apoptosis by AnnexinV/FITC-PI assay corroborates with in silico data, indicating the reliability of the bioinformatics method followed by qRT-PCR. Altogether, our data provide a clear molecular insight into drug efficacy under starved conditions to improve chemotherapy and will likely prompt more clinical trials on this aspect. Full article

Psychotropic medications, commonly prescribed for psychiatric disorders, can have underappreciated dermatological side effects. This in-depth review explores the intricate relationship between psychotropic drugs and the skin, emphasizing the significance of recognizing and managing these side effects in clinical practice. It categorizes the dermatological side effects associated with different classes of psychotropic medications. These include antidepressants, antipsychotics, mood stabilizers, and anxiolytics. We delve into the spectrum of dermatological conditions, from mild issues like dry skin and acne to severe complications such as Stevens–Johnson syndrome and drug-induced lupus erythematosus. In conclusion, a comprehensive understanding of the dermatological side effects of psychotropic medications is essential for healthcare providers, enabling a holistic approach to patient care. This review is a valuable resource for clinicians, researchers, and educators, facilitating better-informed decision-making in the treatment of mental health disorders while prioritizing skin health and overall well-being. Full article

Japan has a longstanding tradition of horror narratives that feature a variety of macabre embodiments. They draw upon ancient folklore, thereby providing a unique perspective on spirits specific to Japanese culture. The influence of these countless supernatural beings from Japanese mythology and folklore has molded many incarnations seen in popular culture, which have been commonly deemed “strange” and “weird”. This study seeks to demystify the ambiguity and “strangeness” surrounding three Japanese anime series, Another, Yamishibai, and Mononoke. It attempts to analyze how each of these anime employs folklore and traditional art-styles to portray a modern society plagued with sociocultural complications. Full article

Polymer electrolytes, a type of electrolyte used in lithium-ion batteries, combine polymers and ionic salts. Their integration into lithium-ion batteries has resulted in significant advancements in battery technology, including improved safety, increased capacity, and longer cycle life. This review summarizes the mechanisms governing ion transport mechanism, fundamental characteristics, and preparation methods of different types of polymer electrolytes, including solid polymer electrolytes and gel polymer electrolytes. Furthermore, this work explores recent advancements in non-aqueous Li-based battery systems, where polymer electrolytes lead to inherent performance improvements. These battery systems encompass Li-ion polymer batteries, Li-ion solid-state batteries, Li-air batteries, Li-metal batteries, and Li-sulfur batteries. Notably, the advantages of polymer electrolytes extend beyond enhancing safety. This review also highlights the remaining challenges and provides future perspectives, aiming to propose strategies for developing novel polymer electrolytes for high-performance Li-based batteries. Full article

In recent years, there has been a surge in research pertaining to sustainable urban development. Importance–performance analysis (IPA) has emerged as one of the most widely used methods. However, few studies have combined IPA with structural equation modelling (SEM). This study introduces and evaluates an integrated IPA–SEM approach to assess the impact of perceived importance and performance of sustainable city dimensions on residents’ satisfaction and loyalty. The data for this study were collected from 425 survey respondents residing in Siliguri City of West Bengal, India. The results indicate that the ‘Keep Up the Good Work’ quadrant, consisting of social quality, connectivity conditions, and environmental quality, significantly and positively affected satisfaction. On the other hand, the ‘Concentrate Here’ quadrant concerning environmental pollution presented a negative yet insignificant relationship with satisfaction while both the ‘Low Priority’ and ‘Potential Overkill’ quadrants demonstrated no notable influence. Furthermore, a robust positive correlation between satisfaction and loyalty is confirmed. Overall, the findings offer valuable implications for urban planning, policy-making, and strategies aimed at enhancing Siliguri residents’ quality of life. Full article

Stress has an impact, not only on a person’s physical health, but also on the ability to perform at the workplace in daily life. The well-established relation between psychological stress and its pathogeneses highlights the need for detecting psychological stress early, in order to prevent disease advancement and to save human lives. Electroencephalography (EEG) signal recording tools are widely used to collect these psychological signals/brain rhythms in the form of electric waves. The aim of the current research was to apply automatic feature extraction to decomposed multichannel EEG recordings, in order to efficiently detect psychological stress. The traditional deep learning techniques, namely the convolution neural network (CNN), long short-term memory (LSTM), bidirectional long short-term memory (BiLSTM), gated recurrent unit (GRU) and recurrent neural network (RNN) models, have been frequently used for stress detection. A hybrid combination of these techniques may provide improved performance, and can handle long-term dependencies in non-linear brain signals. Therefore, this study proposed an integration of deep learning models, called DWT-based CNN, BiLSTM, and two layers of a GRU network, to extract features and classify stress levels. Discrete wavelet transform (DWT) analysis was used to remove the non-linearity and non-stationarity from multi-channel (14 channel) EEG recordings, and to decompose them into different frequency bands. The decomposed signals were utilized for automatic feature extraction using the CNN, and the stress levels were classified using BiLSTM and two layers of GRU. This study compared five combinations of the CNN, LSTM, BiLSTM, GRU and RNN models with the proposed model. The proposed hybrid model performed better in classification accuracy compared to the other models. Therefore, hybrid combinations are appropriate for the clinical intervention and prevention of mental and physical problems. Full article

The possibility of observing negative Shapiro-like gravitational time delay (or time advancement) due to the Earth’s gravity employing interferometric experiments on the Earth’s surface is discussed. It is suggested that such a measurement may be realized in the near future with the help of modern versions of Michelson–Morley-type experiments. Full article

Changes in extreme human bioclimate conditions are accepted evidence for and serve as a broad measure of anthropogenic climate change. The essential objective of the current study was to investigate past and future thermal bioclimate conditions across West Bengal (WB), India. The daily physiologically equivalent temperature (PET) was calculated by considering definite climate variables as inputs. These meteorological variables were captured from the Coordinated Regional Downscaling Experiment (CORDEX)-South Asia. The initial results from this research work present the mean monthly distribution of each PET class over the considered stations of WB during the period (1986–2005) and three future time periods: (i) near future (2016–2035), (ii) mid-future (2046–2065), and (iii) far future (2080–2099). It was observed that the months from April to June comprise heat stress months in terms of human thermal perception, whereas thermally acceptable conditions begin in November and continue until March for most stations. Results from future PET changes over WB in the context of the reference period (1986–2005) reveal a prominent increase in warm and hot PETs for all future time periods in two different greenhouse gas emission scenarios. During the far-future time period, stations within a kilometer of the Bay of Bengal such as Digha, Diamond Harbour, Canning, and Baruipur account for the highest percentage in the warm PET class (35.7–43.8 °C) in high-end emission scenarios. Simultaneously, during the period from 2080 to 2099, Kolkata, Dum Dum, Kharagpur, and Siliguri will experience a PET greater than 43.8 °C for close to 10% of the days in the year and more than 10% in Sriniketan, Malda, Asansol, and Birbhum. During the far-future period, a negative change in the very cool PET class (<3.3 °C) indicating a decrease in cold days was the largest for Darjeeling. Full article