Search Results (311)

Accurate methane emission estimates are essential for climate policy, yet current field methods often struggle with spatial constraints and source complexity. Ground-based mobile approaches frequently miss key plume features, introducing bias and uncertainty in emission rate estimates. This study addresses these limitations by using small unmanned aerial systems equipped with precision gas sensors to measure methane alongside co-released tracers. We tested whether arc-shaped flight paths and alternative ratio estimation methods could improve the accuracy of tracer-based emission quantification under real-world constraints. Controlled releases using ethane and nitrous oxide tracers showed that (1) arc flights provided stronger plume capture and higher correlation between methane and tracer concentrations than traditional flight paths; (2) the cumulative sum method yielded the lowest relative error (as low as 3.3%) under ideal mixing conditions; and (3) the arc flight pattern yielded the lowest relative error and uncertainty across all experimental configurations, demonstrating its robustness for quantifying methane emissions from downwind plume measurements. These findings demonstrate a practical and scalable approach to reducing uncertainty in methane quantification. The method is well-suited for challenging environments and lays the groundwork for future applications at the facility scale. Full article

Hyperuricemia, defined as elevated serum uric acid (SUA) levels (>6.8 mg/dL), is traditionally linked to gout and nephrolithiasis but is increasingly implicated in insulin resistance (IR) and type 2 diabetes mellitus (T2DM). Epidemiological studies, such as NHANES, suggest hyperuricemia increases the risk of T2DM by 1.6 to 2.5 times. Mechanistically, uric acid promotes IR via oxidative stress, chronic inflammation, endothelial dysfunction, and adipocyte dysregulation. Despite growing evidence, significant gaps remain in understanding these pathways, with existing studies often limited by observational designs and short intervention durations. A bibliographic analysis of studies from 2004–2024 using Web of Science and VOSviewer highlights a growing focus on hyperuricemia’s interplay with inflammation, oxidative stress, and metabolic disorders. However, inconsistencies in therapeutic outcomes and limited exploration of causality underscore the need for further research. We also explored the importance of gender stratification and the limitations of the binary model for the relationship between hyperuricemia and insulin resistance. This review emphasizes the importance of addressing these gaps to optimize hyperuricemia management as a potential strategy for diabetes prevention and metabolic health improvement. Full article

Coastal wetlands are critical ecosystems that require effective monitoring to support conservation and restoration efforts. This study evaluates the use of small unmanned aerial systems (sUAS) and multispectral imagery to estimate aboveground biomass (AGB) in tidal marshes, comparing models calibrated with destructive versus non-destructive in situ sampling methods. Imagery was collected over South Carolina’s North Inlet-Winyah Bay National Estuarine Research Reserve, and vegetation indices (VIs) were derived from sUAS imagery to model biomass. Stepwise linear regression was used to develop and validate models based on both sampling approaches. Destructive sampling models, particularly those using the Normalized Difference Vegetation Index (NDVI) and Difference Vegetation Index (DVI), achieved the lowest root mean square error (RMSE) values (as low as 70.91 g/m²), indicating higher predictive accuracy. Non-destructive models, while less accurate (minimum RMSE of 214.86 g/m²), demonstrated higher R² values (0.44 and 0.61), suggesting the potential for broader application with further refinement. These findings highlight the trade-offs between ecological impact and model performance, and support the viability of non-destructive methods for biomass estimation in sensitive wetland environments. Future work should explore machine learning approaches and improved temporal alignment of data collection to enhance model robustness. Full article

Hyperuricemia (HUA) is a metabolic disorder characterized by abnormal purine metabolism and/or reduced uric acid (UA) excretion. Chicory (Cichorium intybus L.), recognized in Traditional Chinese Medicine, is noted for its anti-HUA effects, particularly in enhancing intestinal UA excretion, though the underlying mechanisms remain unclear. Studies indicate that disruptions in gut microbiota and its metabolites are associated with HUA, and chicory has been demonstrated to ameliorate gut microbiota dysbiosis. Among gut microbiota-derived metabolites, butyrate, a short-chain fatty acid, plays a crucial role in gut functions and is linked to HUA. Therefore, butyrate may be pivotal in elucidating the mechanism by which chicory promotes intestinal UA excretion. This study aims to investigate whether chicory facilitates intestinal UA excretion through gut microbiota-derived butyrate and to elucidate the underlying mechanism. We employed an integrated methodology combining network biology with the NHANES database analysis to explore the pathological relationship between butyrate and HUA. Our findings were subsequently validated through animal experiments. We administered chicory to rats with HUA to ascertain whether butyrate serves as the key gut microbiota metabolite through which chicory promotes intestinal UA excretion. Furthermore, we utilized western blotting to assess the expression of core targets within the PPARγ-ABCG2 pathway associated with butyrate under conditions where animals received butyrate supplements and PPARγ agonists separately. The network biology indicates that butyrate is a crucial short-chain fatty acid influencing HUA. Analyses of NHANES data and animal experiments further confirm a significant negative correlation between butyrate and serum uric acid (SUA) levels. HUA rats exhibited intestinal barrier damage, impaired intestinal UA excretion, reduced butyrate levels, and decreased expression of PPARγ and ABCG2 proteins. Intervention with chicory in HUA rats repaired intestinal barrier damage, enhanced intestinal UA excretion, and increased both butyrate levels and the expression of PPARγ and ABCG2 proteins. Similarly, interventions with butyrate supplements or PPARγ agonists in HUA rats effectively promoted intestinal UA excretion and increased the expression of PPARγ and ABCG2 proteins. This study demonstrates that butyrate is a key metabolite produced by gut microbiota, through which chicory regulates gut microbiota to enhance intestinal UA excretion. The underlying mechanism involves the activation of the PPARγ-ABCG2 pathway, which is facilitated by elevated butyrate levels in the intestine. Full article

Background: Elevated serum uric acid (SUA) levels in young people have become a significant public health concern. Dietary habits are a key factor influencing SUA levels. This study aimed to investigate dietary patterns (DPs) of children and adolescents and their associations with SUA. Methods: This cross-sectional study included children and adolescents in Guangzhou, China. We used structured questionnaires to collect data on demographics, lifestyle, and dietary intake, and we collected blood samples for biochemical analysis. DPs were identified by factor analysis. We used robust linear regression to examine the association between these patterns and SUA levels. Parallel mediation analysis was utilized to assess the mediating role of body mass index (BMI) Z-score and waist circumference (WC). Results: The study encompassed 4100 children and adolescents between ages 9–17. The median SUA level was 374 (IQR: 319, 438) μmol/L and the prevalence of hyperuricemia was 41.7%. We identified four DPs, including plant-based, snack–beverage, highprotein, and meat–carbohydrate patterns. There was a positive correlation between the meat–carbohydrate pattern and SUA (β = 3.67 μmol/L, 95% CI: 1.22–6.12). The Q4 group of the highprotein pattern was associated with higher SUA levels (9.17 μmol/L, 95% CI: 2.41–15.93) compared to the Q1 group. BMI Z-score and WC mediated the association between the meat–carbohydrate pattern and SUA. Conclusions: Our findings suggest that BMI Z-score and WC mediated the association between the meat–carbohydrate pattern and SUA. This study emphasizes the significance of targeted dietary interventions for weight control in addressing the increasing SUA levels in children and adolescents. Future research could focus on exploring the molecular mechanisms, developing personalized dietary intervention programs, and conducting multicenter prospective cohort studies. Full article

This study investigates the enhancement of axial and shear strength in brick masonry walls reinforced with steel and fiberglass meshes. The novelty of this study lies in its thorough evaluation of various reinforcement types and their influence on both axial and shear strength, offering valuable insights to enhance the performance of brick masonry structures. By using steel and fiberglass meshes for reinforcement, the study promotes the use of durable materials that can extend the lifespan of brick masonry structures, reducing the need for frequent repairs and replacements. The findings reveal that double-layer steel mesh delivers the highest strength, effectively reducing brittleness and improving deformation capacity in both single- and double-brick walls. Specifically, single-brick walls exhibited increases in compressive strength of 38.8% with single-layer steel mesh, 31.2% with fiberglass mesh, and 19.7% with plaster. In contrast, double-brick walls showed enhancements of 73.6% with double-layer steel mesh and 43.5% with fiberglass mesh. For shear strength, single-brick walls improved by 115.1% with single-layer steel mesh, 91.3% with fiberglass mesh, and 42.1% with plaster, while double-brick walls experienced increases of 162.7% with double-layer steel mesh and 132.5% with fiberglass mesh. Additionally, Abaqus modeling under axial and diagonal compression closely matched experimental results, revealing less than a 10% discrepancy across all reinforcement types. Full article

SmallUnmanned Aerial Systems (sUAS) have seen rapid adoption thanks to advances in endurance, communications, autonomy, and manufacturing costs, yet most testing remains focused on GPS-supported, above-ground operations. This study introduces new test methodologies and presents comprehensive experimental evaluations of collision tolerance, navigation, and trajectory following for commercial sUAS platforms in GPS-denied indoor environments. We also propose numerical and categorical metrics—based on established vehicle collision protocols such as the Modified Acceleration Severity Index (MASI) and Maximum Delta V (MDV)—to quantify collision resilience; for example, the tested platforms achieved an average MASI of 0.1 g, while demonstrating clear separation between the highest- and lowest-performing systems. The experimental results revealed that performance varied significantly with mission complexity, obstacle proximity, and trajectory requirements, identifying platforms best suited for subterranean or crowded indoor applications. By aggregating these metrics, users can select the optimal drone for their specific mission requirements in challenging enclosed spaces. Full article

Background: Noonan syndrome (NS) is a relatively common RASopathy that can be associated with a variety of phenotypic and genotypic variations and potential long-term health consequences. Its most described prenatal ultrasound features in the first trimester are thickened nuchal translucency (NT) and dilated jugular sacs; while heart defects, polyhydramnios and facial dysmorphisms are its known manifestations in the second and third trimesters. Methods: We present two cases of NS with the prenatal ultrasound diagnosis of external hydrocephalus (EH) in the second trimester. Results: Case 1 had a normal first trimester scan and showed mild polyhydramnios, an echogenic intracardiac focus (EIF) in the left ventricle and pyelectasis in the second trimester in association with the EH. The whole exome sequencing (WES) confirmed a pathogenic variant in the SOS1 gene. Case 2 showed increased NT, agenesis of the ductus venosus (DV), single umbilical artery (SUA), an EIF in the right ventricle and an abnormal prefrontal space ratio (PSFR). By the 19th gestational week, EH appeared. The ambient and quadrigeminal cisterns were also slightly widened. The WES revealed a PTPN11 gene variant. Conclusions: The most reported sonographic features of NS are either non-specific or difficult to integrate into routine screening, requiring substantial experience. In our two cases, we detected EH in the second trimester, which is rarely described as a prenatal ultrasound diagnosis. To our current knowledge, this is the first case reported of EH in NS caused by an SOS1 gene variant and these are the first cases reported with the prenatal sonographic diagnosis of EH in NS. Full article

Background: Hyperuricemia (HUA) is a widespread metabolic disorder that arises from disruptions in purine metabolism, impaired kidney function, or both conditions. FPAW (Phe-Pro-Ala-Trp) is a novel peptide identified from Trachinotus ovatus with great XOD (xanthine oxidase) inhibitory activity (IC₅₀ = 3.81 mM), which can be developed as a potential active ingredient to relieve hyperuricemia. However, it remains unclear whether FPAW alleviates HUA in vivo or not. Methods: In this study, potassium-oxonate-induced hyperuricemic mice were used to evaluate the in vivo anti-hyperuricemic activity of FPAW. Some physiological parameters, such as serum uric acid (SUA), serum creatinine (SCR), blood urea nitrogen (BUN), and the activity of XOD and ADA (adenosine deaminase) in the liver were determined to evaluate the effect of reduced uric acid. The modulations in the gut microbiota and its metabolites (SCFAs) were analyzed by sequencing the V3-V4 region of the 16S rRNA gene and GC-MS in different fecal samples. Molecular docking was used to predict the interactions between the enzymes and FPAW. Results: The results showed that FPAW reduced the levels of serum uric acid, serum creatinine, and blood urea nitrogen, while also suppressing the activity of XOD in the livers of HUA mice. Moreover, the FPAW treatment alleviated gut microbiota dysfunction and increased the production of short-chain fatty acids to protect normal intestinal function and health of the host. Molecular docking simulations revealed that FPAW inhibited XOD activity by entering the hydrophobic channel and interacting with amino acid residues on the surface via hydrogen bonding and hydrophobic interactions. Conclusions: This study provides new candidates for the development of hypouricemic drugs. FPAW exhibited great potential to relieve hyperuricemia of mice induced by diet in the animal experiment. Full article

Background: Serum uric acid and serum creatinine ratio (SUA/sCr) is strongly linked to increased cardiovascular risk. Atherosclerotic renal artery stenosis (ARAS) is a secondary cause of hypertension and is associated with ischemic nephropathy, congestive heart failure, accelerated cardiovascular disease, and autonomic dysfunction. The aim of this study was to investigate whether SUA levels and SUA/sCr could represent markers of autonomic dysfunction and increased left ventricular mass index (LVMI) in patients with ARAS. Methods: Patients diagnosed with ARAS were enrolled in the study. All patients underwent clinical evaluation, biochemical analysis, 24 h electrocardiogram (ECG), and Renal Doppler Ultrasound with renal resistive index parameters. Heart rate variability for global autonomic dysfunction was assessed through the analysis of a 24 h ECG to detect the standard deviation of normal-to-normal RR intervals (SDNN). Echocardiographic measurement of LVMI was performed. Results: A total of 27 patients (F = 16 (59%), median age 67 years (IQR 60–77)) diagnosed with ARAS were enrolled in the study. We found a statistically significant negative linear correlation between SUA/sCr and SDNN (r = −0.519, p < 0.01). We found a statistically significant positive linear correlation between SUA/sCr and LVMI (r = 0.413, p < 0.05). Median SDNN was significantly lower in patients with SUA ≥ 5.6 mg/dL than in patients with SUA < 5.6 mg/dL (94.2 (IQR 86.8–108.1) vs. 112.8 (IQR 108.9–114.7), p < 0.01). Median LVMI was significantly higher in patients with SUA ≥ 5.6 mg/dL compared to patients with SUA < 5.6 mg/dL (133 g/m² (IQR 120–149) vs. 111 g/m² (IQR 99–129), p < 0.05). Conclusion: In patients with ARAS, SUA/sCr is associated with autonomic dysfunction and LVMI in ARAS patients. The ratio and related cut-off value of SUA/sCr could represent a useful biomarker to evaluate cardiovascular risk in ARAS patients. Full article

Strongyloidiasis represents a public health problem in tropical and subtropical regions. The medicinal plants demonstrate the potential of plants as a source of molecules with helminthic activity. In this research, we assessed the potential of five extracts medicinally used in Mexico against Strongyloides venezuelensis third-stage infective larvae (L3). Plant methanol (MeOH) extracts of Argemone mexicana (chicalote), Jatropha dioica (Sangre de Drago), Lippia graveolens (oregano), Thymus vulgaris (tomillo), and Kalanchoe daigremontiana (aranto) were prepared by the maceration technique. The toxicity of the extracts was evaluated in human red blood cells by the hemolysis test and in monkey kidney epithelial cells (Vero cells) using the reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. In addition, we showed their antioxidant potential by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. The methanolic extracts of A. mexicana, J. dioica, L. graveolens, and T. vulgaris exhibited significant activity against L3 cultures at 72 and 96 h post-incubation. None of the extracts showed hemolytic effects on red cells or Vero cells. L. graveolens demonstrated the strongest antioxidant activity, with an EC₅₀ of 19.80 µg/mL. Plant MeOH extracts used in this study showed a promising anthelmintic effect in vitro, making it a suitable candidate for future research in nematocidal therapies. Full article

Background and Objectives: Behçet’s syndrome (BS) is a systemic inflammatory disorder characterized by recurrent oral and genital ulcers, uveitis, and vascular involvement. Serum uric acid (SUA) has been implicated in various inflammatory conditions, due to its antioxidant properties and role in oxidative stress. Abnormal SUA levels, particularly hypouricemia, may influence inflammatory processes, but their significance in BS pathophysiology remains unexplored. This study aimed to determine the prevalence of abnormal SUA levels among BS patients and investigate their associations with its clinical manifestations and laboratory parameters. Materials and Methods: A retrospective analysis was conducted on 436 patients with complete data who met the international criteria for Behçet’s syndrome, including 420 patients classified as hypouricemic or normouricemic, for detailed evaluation. Patients were classified as hypouricemic (<3 mg/dL), hyperuricemic (>7 mg/dL), or normouricemic (3–7 mg/dL). Data on sociodemographics, laboratory findings, and clinical characteristics were collected. Mortality and malignancy associations were analyzed using logistic regression. Inverse probability weighting (IPW) was employed to adjust for confounding factors. Results: Initial unadjusted analysis showed that hypouricemic BS patients had significantly lower rates of acneiform lesions (7.3% vs. 14.4%, p = 0.020) and vascular involvement (3.8% vs. 11.6%, p = 0.038) compared to normouricemic patients. However, after adjustment for confounding variables using the IPW methodology, these associations lost statistical significance (p = 0.592 and p = 0.519, respectively). Both before and after adjustment, no significant differences were observed between groups regarding major organ involvement, disease severity, or activity markers. Conclusions: After controlling for confounding factors, hypouricemia in BS patients did not demonstrate significant associations with specific clinical manifestations or disease outcomes. While the unadjusted data initially suggested potential relationships with acneiform lesions and vascular involvement, these associations were not supported by comprehensive statistical analysis. Further prospective studies are warranted to elucidate the complex relationship between uric acid metabolism and BS pathophysiology. Full article

Background/Objectives: Gender disparity is prevalent in urology and other surgical specialties, with under-representation of females in both academic and professional settings, including in the Persian Gulf region. To investigate female participation in Persian Gulf urological conferences over the past three years, focusing on abstract presenters, faculty, speakers, and moderators. Methods: Data were collected from three major conferences: the 34th Saudi Urological Conference (SUA), the Urological Asian Association and Emirates Urological Conference (UAA-EUSC), and the 11th Emirates Urological Conference and 18th Pan Arab Continence Society Conference (EUSC-PACSC). The gender of the presenters and faculty was identified using genderize.io, faculty images, and Google searches. Statistical analyses, including chi-square and Fisher’s exact tests, were conducted to assess gender disparities. Results: Out of 536 abstracts, 13.25% were presented by females, with significant variation across conferences (p = 0.018). Female representation was lowest in the basic sciences category (3.13%) and highest in the other category (35.29%) (p = 0.01). Abstract to publication rates did not differ significantly between genders. Male dominance was noted among faculty members (94.21% male), speakers (96.44% male), and moderators (98.98% male), with no significant gender distribution differences across roles (p = 0.1762). Conclusions: This study highlights significant gender disparities at Persian Gulf urological conferences, particularly in leadership roles and research presentations. Recommendations include promoting female leadership, supporting mentorship programs, and ensuring gender diversity in conference management and speaker line-ups to foster a more inclusive environment. Full article

Background: Glucose metabolism disorders are major contributors to morbidity and mortality. Elevated serum uric acid (SUA) is closely linked to the cardiometabolic consequences of glucose metabolism disorders, various other comorbidities, and mortality. In this study, we explore the relationship between SUA and fasting plasma glucose (FPG), insulin levels, and insulin resistance in an older Finnish adult cohort. Methods: We used data from the GOAL (GOod Ageing in Lahti region) study—a prospective, population-based study of Finnish individuals aged 52–76 years. A total of 2322 non-diabetic subjects were included in the study. Data of SUA, FPG, and other laboratory parameters, comorbidities, lifestyle habits, and socioeconomic factors were collected. Subjects with SUA values of >410 μmol/L (≈6.9 mg/dL; 75th percentile) were regarded as hyperuricemic. We investigated the relationship between SUA and FPG, insulin levels, and insulin resistance [homeostatic model assessment of insulin resistance (HOMA-IR) ≥2.65]. Results: We found statistically significant sex-, age- and BMI-adjusted small to moderate relationships (Cohen’s standard for β values above 0.10 and 0.30, respectively) between SUA and FPG, insulin levels, and insulin resistance in the whole study population as well as in the female and male subgroups. The higher the SUA level, the higher the HOMA-IR [(adjusted β = 0.21 (95% CI: 0.17 to 0.25)], and it rises drastically if SUA is above 400 μmol/L (≈6.7 mg/dL). The probability of a subject having insulin resistance is related to SUA level. Conclusions: Hyperuricemia is associated with elevated FPG and insulin resistance, emphasizing the importance of addressing both conditions. Further research may explore hyperuricemia treatment’s role in preventing glucose metabolism disorders and their cardiometabolic consequences. Full article

This paper describes flight planning supported by modeling, guidance, and feedback control for an electric Vertical Take-Off and Landing (eVTOL) QuadPlane small Uncrewed Aircraft System (sUAS). Five Lift+Cruise sUAS waypoint types are defined and used to construct smooth flight path geometries and acceleration profiles. Novel accelerated coverage flight plan segments for hover (Lift) and coverage (Cruise) waypoint types are defined as a complement to traditional fly-over, fly-by, and Dubins path waypoint transit solutions. Carrot-chasing guidance shows a tradeoff between tracking accuracy and control stability as a function of the carrot time step. Experimentally validated aerodynamic and thrust models for vertical, forward, and hybrid flight modes are developed as a function of airspeed and angle of attack from wind tunnel data. A QuadPlane feedback controller augments classical multicopter and fixed-wing controllers with a hybrid control mode that combines multicopter and aircraft control actuators to add a controllable pitch degree of freedom at the cost of increased energy use. Multi-mode flight simulations show Cruise mode to be the most energy efficient with a relatively large turning radius constraint, while quadrotor mode enables hover and smaller radius turns. Energy efficiency analysis over QuadPlane plans with modest inter-waypoint distances indicates cruise or aircraft mode is $30\%$ more energy efficient overall than quadrotor mode. Energy-aware coverage planner simulation results show fly-coverage (cruise) waypoints are always the most efficient given long distances between waypoints. A Pareto analysis of energy use versus area coverage is presented to analyze waypoint-type tradeoffs in case studies with closely spaced waypoints. Coverage planning and guidance methods from this paper can be applied to any Lift+Cruise aircraft configuration requiring waypoint flight mode optimization over energy and coverage metrics. Full article