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753 Results Found

  • Article
  • Open Access
120 Citations
10,632 Views
16 Pages

Function of SREBP1 in the Milk Fat Synthesis of Dairy Cow Mammary Epithelial Cells

  • Nan Li,
  • Feng Zhao,
  • Chenjie Wei,
  • Mengyao Liang,
  • Na Zhang,
  • Chunmei Wang,
  • Qing-Zhang Li and
  • Xue-Jun Gao

23 September 2014

Sterol regulatory element-binding proteins (SREBPs) belong to a family of nuclear transcription factors. The question of which is the most important positive regulator in milk fat synthesis in dairy cow mammary epithelial cells (DCMECs) between SREBP...

  • Article
  • Open Access
29 Citations
4,851 Views
15 Pages

Disruption of Cancer Metabolic SREBP1/miR-142-5p Suppresses Epithelial–Mesenchymal Transition and Stemness in Esophageal Carcinoma

  • Chih-Ming Huang,
  • Chin-Sheng Huang,
  • Tung-Nien Hsu,
  • Mao-Suan Huang,
  • Iat-Hang Fong,
  • Wei-Hwa Lee and
  • Shao-Cheng Liu

18 December 2019

Elevated activity of sterol regulatory element-binding protein 1 (SREBP1) has been implicated in the tumorigenesis of different cancer types. However, the functional roles of SREBP1 in esophageal cancer are not well appreciated. Here, we aimed to inv...

  • Article
  • Open Access
11 Citations
5,301 Views
14 Pages

Histone Deacetylase 1 Reduces Lipogenesis by Suppressing SREBP1 Transcription in Human Sebocyte Cell Line SZ95

  • Hye Sun Shin,
  • Yuri Lee,
  • Mi Hee Shin,
  • Soo Ick Cho,
  • Christos C. Zouboulis,
  • Min Kyoung Kim,
  • Dong Hun Lee and
  • Jin Ho Chung

Proper regulation of sebum production is important for maintaining skin homeostasis in humans. However, little is known about the role of epigenetic regulation in sebocyte lipogenesis. We investigated histone acetylation changes and their role in key...

  • Article
  • Open Access
6 Citations
2,535 Views
17 Pages

The Aurora Kinase Inhibitor TAK901 Inhibits Glioblastoma Growth by Blocking SREBP1-Mediated Lipid Metabolism

  • Xiudan Zhan,
  • Ru Qiu,
  • Yi He,
  • Zijin Zhao,
  • Meng Huang,
  • Qing Liu,
  • Feng Zhi and
  • Wenyong Long

25 November 2022

Glioblastoma (GBM) is the most common and lethal malignant primary brain tumor. The standard treatment for GBM including surgical resection followed by radiation therapy and adjuvant chemotherapy with temozolomide remains unsatisfactory. In this stud...

  • Article
  • Open Access
27 Citations
4,556 Views
15 Pages

Nonalcoholic fatty liver disease is a frequent liver malady, which can progress to cirrhosis, the end-stage liver disease if proper treatment is not applied. Omega-3 fatty acids, such as docosahexaenoic acid (DHA) and eicosapentaenoic acid, have been...

  • Article
  • Open Access
4 Citations
3,675 Views
13 Pages

Fermented Rhus Verniciflua Stokes Extract Alleviates Nonalcoholic Fatty Liver through the AMPK/SREBP1/PCSK9 Pathway in HFD-Induced Nonalcoholic Fatty Liver Animal Model

  • Seon-Ok Lee,
  • Yinzhu Xu,
  • Hengmin Han,
  • Seok-Tae Jeong,
  • You-Kyung Lee,
  • Jean Kyung Paik,
  • Jin-Sol Cha and
  • Hyo-Jeong Lee

29 September 2020

Background: We have previously reported the anti-hepatic lipogenic effect of fermented Rhus verniciflua stokes extract (FRVE) in an oleic-acid-treated HepG2 cell model. Methods: Herein, we advanced our understanding and evaluated the impact of FRVE i...

  • Article
  • Open Access
6 Citations
2,567 Views
23 Pages

α-Tocopherol-13′-Carboxychromanol Induces Cell Cycle Arrest and Cell Death by Inhibiting the SREBP1-SCD1 Axis and Causing Imbalance in Lipid Desaturation

  • Sijia Liao,
  • André Gollowitzer,
  • Lisa Börmel,
  • Charlotte Maier,
  • Luisa Gottschalk,
  • Oliver Werz,
  • Maria Wallert,
  • Andreas Koeberle and
  • Stefan Lorkowski

α-Tocopherol-13′-carboxychromanol (α-T-13′-COOH) is an endogenously formed bioactive α-tocopherol metabolite that limits inflammation and has been proposed to exert lipid metabolism-regulatory, pro-apoptotic, and anti-tu...

  • Article
  • Open Access
1,281 Views
18 Pages

Bufalin Suppresses Colorectal Cancer Liver Metastasis by Inhibiting De Novo Fatty Acid Synthesis via the PI3K/AKT-Mediated SREBP1/FASN Pathway

  • Wenwen Pang,
  • Xiang Li,
  • Suying Yan,
  • Junshi Zhang,
  • Ping Wu,
  • Haiyang Yu,
  • Bowei Zhang and
  • Chunze Zhang

5 September 2025

Background: Colorectal cancer (CRC) is the third most common cancer worldwide, with liver metastasis being the leading cause of mortality. De novo fatty acid synthesis plays a critical role in CRC progression and metastasis. Bufalin, a cardiotonic st...

  • Article
  • Open Access
24 Citations
4,557 Views
20 Pages

1 June 2022

Metabolic syndrome is a chronic metabolic disorder that has turned into a severe health problem worldwide. A previous study reported that large yellow tea exhibited better anti-diabetic and lipid-lowering effects than green tea. Nevertheless, the pot...

  • Article
  • Open Access
24 Citations
4,525 Views
13 Pages

Beneficial Effects of SREBP Decoy Oligodeoxynucleotide in an Animal Model of Hyperlipidemia

  • Hyun-Jin An,
  • Jung-Yeon Kim,
  • Mi-Gyeong Gwon,
  • Hyemin Gu,
  • Hyun-Ju Kim,
  • Jaechan Leem,
  • Sung Won Youn and
  • Kwan-Kyu Park

Hyperlipidemia is a chronic disorder that plays an important role in the development of cardiovascular diseases, type II diabetes, atherosclerosis, hypertension, and non-alcoholic fatty liver disease. Hyperlipidemias have created a worldwide health c...

  • Article
  • Open Access
493 Views
27 Pages

The Functional Interaction Between PRDM16 and the SREBP Pathway Controls Lipid Metabolism

  • Hafiz Majid Mahmood,
  • Maria Teresa Bengoechea-Alonso,
  • Dana E. Al-Ansari,
  • Khaled Machaca and
  • Johan Ericsson

22 October 2025

Dysregulated lipid metabolism is associated with cardiovascular disease, obesity and type 2 diabetes. In the current report, we explore the functional interactions between two important regulators of lipid metabolism, sterol regulatory element-bindin...

  • Review
  • Open Access
43 Citations
10,018 Views
18 Pages

16 January 2024

The prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) is rapidly increasing worldwide at an alarming pace, due to an increase in obesity, sedentary and unhealthy lifestyles, and unbalanced dietary habits. MASLD is a uniqu...

  • Review
  • Open Access
65 Citations
13,568 Views
17 Pages

SREBP Regulation of Lipid Metabolism in Liver Disease, and Therapeutic Strategies

  • Na Li,
  • Xiaodan Li,
  • Yifu Ding,
  • Xiao Liu,
  • Karin Diggle,
  • Tatiana Kisseleva and
  • David A. Brenner

12 December 2023

Sterol regulatory element-binding proteins (SREBPs) are master transcription factors that play a crucial role in regulating genes involved in the biogenesis of cholesterol, fatty acids, and triglycerides. As such, they are implicated in several serio...

  • Article
  • Open Access
124 Citations
10,363 Views
15 Pages

SREBP-1 Has a Prognostic Role and Contributes to Invasion and Metastasis in Human Hepatocellular Carcinoma

  • Chao Li,
  • Wei Yang,
  • Junli Zhang,
  • Xin Zheng,
  • Yingmin Yao,
  • Kangsheng Tu and
  • Qingguang Liu

25 April 2014

Sterol regulatory element-binding protein 1 (SREBP-1) is a well-known nuclear transcription factor involved in lipid synthesis. Recent studies have focused on its functions in tumor cell proliferation and apoptosis, but its role in cell migration and...

  • Article
  • Open Access
6 Citations
3,474 Views
15 Pages

Concomitant Inhibition of FASN and SREBP Provides a Promising Therapy for CTCL

  • Cheng Chi,
  • Lisa Harth,
  • Marina Ramírez Galera,
  • Marina Passos Torrealba,
  • Chella Krishna Vadivel,
  • Carsten Geisler,
  • Charlotte Menné Bonefeld,
  • Pia Rude Nielsen,
  • Michael Bzorek and
  • Jürgen C. Becker
  • + 3 authors

16 September 2022

Cutaneous T cell lymphoma (CTCL) is a group of non-Hodgkin’s primary cutaneous T cell lymphomas, with Mycosis Fungoides and Sézary syndrome (SS) being the two most common subtypes. Fatty acid synthase (FASN) is a crucial enzyme that cata...

  • Article
  • Open Access
1 Citations
2,295 Views
29 Pages

Mechanisms of Regulation of the CHRDL1 Gene by the TWIST2 and ADD1/SREBP1c Transcription Factors

  • José J. Casasnovas-Nieves,
  • Yacidzohara Rodríguez,
  • Hector L. Franco and
  • Carmen L. Cadilla

30 August 2023

Setleis syndrome (SS) is a rare focal facial dermal dysplasia caused by recessive mutations in the basic helix-loop-helix (bHLH) transcription factor, TWIST2. Expression microarray analysis showed that the chordin-like 1 (CHRDL1) gene is up-regulated...

  • Article
  • Open Access
10 Citations
4,576 Views
19 Pages

SREBP-1c Deficiency Affects Hippocampal Micromorphometry and Hippocampus-Dependent Memory Ability in Mice

  • Mary Jasmin Ang,
  • Sueun Lee,
  • Mai Wada,
  • Poornima D. E. Weerasinghe-Mudiyanselage,
  • Sung-Ho Kim,
  • Taekyun Shin,
  • Tae-Il Jeon,
  • Seung-Soon Im and
  • Changjong Moon

Changes in structural and functional neuroplasticity have been implicated in various neurological disorders. Sterol regulatory element-binding protein (SREBP)-1c is a critical regulatory molecule of lipid homeostasis in the brain. Recently, our findi...

  • Article
  • Open Access
2,238 Views
24 Pages

Identification of Potential New Genes Related to the SREBP Pathway in Xanthophyllomyces dendrorhous

  • Maximiliano Venegas,
  • Alejandro Durán,
  • Sebastián Campusano,
  • Salvador Barahona,
  • Dionisia Sepúlveda,
  • Marcelo Baeza,
  • Víctor Cifuentes and
  • Jennifer Alcaíno

29 June 2024

The sterol regulatory element-binding protein (SREBP) pathway is an integral cellular mechanism that regulates lipid homeostasis, in which transcriptional activator SREBPs regulate the expression of various genes. In the carotenogenic yeast Xanthophy...

  • Article
  • Open Access
15 Citations
3,658 Views
22 Pages

Timosaponin A3 Inhibits Palmitate and Stearate through Suppression of SREBP-1 in Pancreatic Cancer

  • Yumi Kim,
  • Wona Jee,
  • Eun-Jin An,
  • Hyun Min Ko,
  • Ji Hoon Jung,
  • Yun-Cheol Na and
  • Hyeung-Jin Jang

Timosaponin A3 (TA3) was demonstrated as a potent anticancer chemical by several studies. Although the effects of inhibiting growth, metastasis, and angiogenesis in various cancer cells were demonstrated through multiple mechanisms, the pharmacologic...

  • Article
  • Open Access
12 Citations
4,491 Views
17 Pages

Transcriptome Profiling Reveals Novel Candidate Genes Related to Hippocampal Dysfunction in SREBP-1c Knockout Mice

  • Mary Jasmin Ang,
  • Juhwan Kim,
  • Sueun Lee,
  • Sung-Ho Kim,
  • Jong-Choon Kim,
  • Tae-Il Jeon,
  • Seung-Soon Im and
  • Changjong Moon

Lipid homeostasis is an important component of brain function, and its disturbance causes several neurological disorders, such as Huntington’s, Alzheimer’s, and Parkinson’s diseases as well as mood disorders. Sterol regulatory eleme...

  • Article
  • Open Access
6 Citations
2,394 Views
12 Pages

15 November 2022

The resistance of renal cell carcinoma (RCC) to sunitinib impedes the success of chemotherapy in cancer treatment. Although several sunitinib resistance mechanisms have been proposed, little is known concerning the impact of obesity and adipokines in...

  • Article
  • Open Access
24 Citations
5,898 Views
13 Pages

10 September 2021

Glutamine and lipids are two important components of proliferating cancer cells. Studies have demonstrated that glutamine synthetase (GS) boosts glutamine-dependent anabolic processes for nucleotide and protein synthesis, but the role of GS in regula...

  • Review
  • Open Access
34 Citations
9,502 Views
11 Pages

SREBP-1c-Dependent Metabolic Remodeling of White Adipose Tissue by Caloric Restriction

  • Masaki Kobayashi,
  • Namiki Fujii,
  • Takumi Narita and
  • Yoshikazu Higami

26 October 2018

Caloric restriction (CR) delays the onset of many age-related pathophysiological changes and extends lifespan. White adipose tissue (WAT) is not only a major tissue for energy storage, but also an endocrine tissue that secretes various adipokines. Re...

  • Article
  • Open Access
53 Citations
10,972 Views
12 Pages

Berberine Alleviates Olanzapine-Induced Adipogenesis via the AMPKα–SREBP Pathway in 3T3-L1 Cells

  • Yanjie Li,
  • Xiaomin Zhao,
  • Xiyu Feng,
  • Xuemei Liu,
  • Chao Deng and
  • Chang-Hua Hu

9 November 2016

The aim of this study was to investigate the mechanisms underlying the inhibitory effects of berberine (BBR) on olanzapine (OLZ)-induced adipogenesis in a well-replicated 3T3-L1 cell model. Oil-Red-O (ORO) staining showed that BBR significantly decre...

  • Article
  • Open Access
18 Citations
4,424 Views
16 Pages

Butyrate Lowers Cellular Cholesterol through HDAC Inhibition and Impaired SREBP-2 Signalling

  • Stephanie Bridgeman,
  • Hon Chiu Woo,
  • Philip Newsholme and
  • Cyril Mamotte

7 December 2022

In animal studies, HDAC inhibitors such as butyrate have been reported to reduce plasma cholesterol, while conferring protection from diabetes, but studies on the underlying mechanisms are lacking. This study compares the influence of butyrate and ot...

  • Article
  • Open Access
10 Citations
4,468 Views
18 Pages

The Administration of Chitosan-Tripolyphosphate-DNA Nanoparticles to Express Exogenous SREBP1a Enhances Conversion of Dietary Carbohydrates into Lipids in the Liver of Sparus aurata

  • Jonás I. Silva-Marrero,
  • Juliana Villasante,
  • Ania Rashidpour,
  • Mariana Palma,
  • Anna Fàbregas,
  • María Pilar Almajano,
  • Ivan Viegas,
  • John G. Jones,
  • Montserrat Miñarro and
  • Josep R. Ticó
  • + 2 authors

In addition to being essential for the transcription of genes involved in cellular lipogenesis, increasing evidence associates sterol regulatory element binding proteins (SREBPs) with the transcriptional control of carbohydrate metabolism. The aim of...

  • Article
  • Open Access
16 Citations
4,455 Views
14 Pages

Lipogenesis plays a critical role in the growth and metastasis of tumors, which is becoming an attractive target for anti-tumor drugs. RA-XII, one of the cyclopeptide glycosides isolated from Rubia yunnanensis, exerts anti-tumor effects on liver canc...

  • Article
  • Open Access
22 Citations
7,183 Views
26 Pages

Inactivation of SREBP-1a Phosphorylation Prevents Fatty Liver Disease in Mice: Identification of Related Signaling Pathways by Gene Expression Profiles in Liver and Proteomes of Peroxisomes

  • Birgit Knebel,
  • Sonja Hartwig,
  • Sylvia Jacob,
  • Ulrike Kettel,
  • Martina Schiller,
  • Waltraud Passlack,
  • Cornelia Koellmer,
  • Stefan Lehr,
  • Dirk Müller-Wieland and
  • Jorg Kotzka

The key lipid metabolism transcription factor sterol regulatory element-binding protein (SREBP)-1a integrates gene regulatory effects of hormones, cytokines, nutrition and metabolites as lipids, glucose, or cholesterol via phosphorylation by differen...

  • Article
  • Open Access
22 Citations
4,410 Views
18 Pages

Targeting the SREBP-1/Hsa-Mir-497/SCAP/FASN Oncometabolic Axis Inhibits the Cancer Stem-like and Chemoresistant Phenotype of Non-Small Cell Lung Carcinoma Cells

  • Tung-Yu Tiong,
  • Pei-Wei Weng,
  • Chun-Hua Wang,
  • Syahru Agung Setiawan,
  • Vijesh Kumar Yadav,
  • Narpati Wesa Pikatan,
  • Iat-Hang Fong,
  • Chi-Tai Yeh,
  • Chia-Hung Hsu and
  • Kuang-Tai Kuo

Background: Lung cancer remains a leading cause of cancer-related death, with an annual global mortality rate of 18.4%. Despite advances in diagnostic and therapeutic technologies, non–small cell lung carcinoma (NSCLC) continues to be character...

  • Article
  • Open Access
6 Citations
3,052 Views
21 Pages

Modulation of SREBP Expression and Fatty Acid Levels by Bacteria-Induced ER Stress Is Mediated by Hemocyanin in Penaeid Shrimp

  • Zishu Huang,
  • Xiaoyu Zheng,
  • Zeyan Chen,
  • Zhihong Zheng,
  • Defu Yao,
  • Shen Yang,
  • Yueling Zhang and
  • Jude Juventus Aweya

28 February 2023

Many environmental and pathogenic insults induce endoplasmic reticulum (ER) stress in animals, especially in aquatic ecosystems, where these factors are crucial for life. In penaeid shrimp, pathogens and environmental stressors induce hemocyanin expr...

  • Article
  • Open Access
5 Citations
3,927 Views
12 Pages

Lecithin Inclusion by α-Cyclodextrin Activates SREBP2 Signaling in the Gut and Ameliorates Postprandial Hyperglycemia

  • Eunyoung Lee,
  • Xilin Zhang,
  • Tomoe Noda,
  • Junki Miyamoto,
  • Ikuo Kimura,
  • Tomoaki Tanaka,
  • Kenichi Sakurai,
  • Ryo Hatano and
  • Takashi Miki

6 October 2021

Background: α-cyclodextrin (α-CD) is one of the dietary fibers that may have a beneficial effect on cholesterol and/or glucose metabolism, but its efficacy and mode of action remain unclear. Methods: In the present study, we examined the anti-hypergl...

  • Article
  • Open Access
26 Citations
5,814 Views
12 Pages

5 October 2018

Recent research suggests that the activation of lipid biosynthesis (lipogenesis) is linked with prostate cancer (PCa) malignancy. Sterol regulatory element-binding protein-1 (SREBP-1) is a key transcriptional regulator controlling lipogenesis. Moreov...

  • Article
  • Open Access
1 Citations
828 Views
27 Pages

Cholesterol and SREBP2 Dynamics During Spermatogenesis Stages in Rabbits: Effects of High-Fat Diet and Protective Role of Extra Virgin Olive Oil

  • María Virginia Avena,
  • Abi Karenina Funes,
  • María Ángeles Monclus,
  • Paola Vanina Boarelli,
  • Luis Fernando Barbisan,
  • M. Rosa Bernal-López,
  • Ricardo Gómez-Huelgas,
  • Tania Estefania Saez Lancellotti and
  • Miguel Walter Fornés

High-fat diets (HFDs) have been found to compromise male fertility, with cholesterol dysregulation being a key factor. Sterol regulatory element-binding protein 2 (SREBP2) is a crucial transcription factor that regulates cholesterol biosynthesis and...

  • Article
  • Open Access
45 Citations
6,325 Views
14 Pages

Xyloketal B Attenuates Fatty Acid-Induced Lipid Accumulation via the SREBP-1c Pathway in NAFLD Models

  • Youying Zhang,
  • Tian Meng,
  • Ling Zuo,
  • Yu Bei,
  • Qihao Zhang,
  • Zhijian Su,
  • Yadong Huang,
  • Jiyan Pang,
  • Qi Xiang and
  • Hongtu Yang

3 June 2017

The goal of this study was to examine the effects of xyloketal B on nonalcoholic fatty liver disease (NAFLD) and to explore the molecular mechanisms underlying its effects in both in vivo and in vitro models. We discovered an association between xylo...

  • Article
  • Open Access
557 Views
22 Pages

Hepatocellular EVs Regulate Lipid Metabolism via SIRT1/SREBP−1c/PGC−1α Signaling in Primary Calf Hepatocytes

  • Daoliang Zhang,
  • Jishun Tang,
  • Leihong Liu,
  • Chang Zhao,
  • Shibin Feng,
  • Xichun Wang,
  • Hongyan Ding and
  • Yu Li

25 September 2025

SIRT1-SREBP−1c/PGC−1α signaling is involved in the production of non-esterified fatty acids (NEFAs) and liver lipid metabolism disorders in ketotic calf. The molecules contained in extracellular vesicles (EVs) regulate intercellular...

  • Article
  • Open Access
15 Citations
3,277 Views
16 Pages

4 November 2022

Fatty acid binding protein-4 (FABP4) is not normally expressed in the liver but is induced in alcohol-dependent liver disease (ALD)). This study sought to identify mechanisms whereby ethanol (EtOH) metabolism alters triglyceride accumulation and FABP...

  • Article
  • Open Access
3 Citations
2,699 Views
20 Pages

7 November 2022

Sterol regulatory element-binding proteins (SREBPs) play vital roles in fatty acid metabolism and other metabolic processes in mammals. However, in penaeid shrimp, the repertoire of genes modulated by SREBP is unknown. Here, RNA interference-mediated...

  • Article
  • Open Access
8 Citations
3,909 Views
19 Pages

Targeting Protein Translation in Melanoma by Inhibiting EEF-2 Kinase Regulates Cholesterol Metabolism though SREBP2 to Inhibit Tumour Development

  • Saketh S. Dinavahi,
  • Yu-Chi Chen,
  • Raghavendra Gowda,
  • Pavan Kumar Dhanyamraju,
  • Kishore Punnath,
  • Dhimant Desai,
  • Arthur Berg,
  • Scot R. Kimball,
  • Shantu Amin and
  • Jin-Ming Yang
  • + 1 author

Decreasing the levels of certain proteins has been shown to be important for controlling cancer but it is currently unknown whether proteins could potentially be targeted by the inhibiting of protein synthesis. Under this circumstance, targeting prot...

  • Article
  • Open Access
13 Citations
4,526 Views
17 Pages

Nifedipine Exacerbates Lipogenesis in the Kidney via KIM-1, CD36, and SREBP Upregulation: Implications from an Animal Model for Human Study

  • Yen-Chung Lin,
  • Jhih-Cheng Wang,
  • Mai-Szu Wu,
  • Yuh-Feng Lin,
  • Chang-Rong Chen,
  • Chang-Yu Chen,
  • Kuan-Chou Chen and
  • Chiung-Chi Peng

Dysregulation of fatty acid oxidation and accumulation of fatty acids can cause kidney injury. Nifedipine modulates lipogenesis-related transcriptional factor SREBP-1/2 in proximal tubular cells by inhibiting the Adenosine 5‘-monophosphate (AMP...

  • Article
  • Open Access
4 Citations
3,093 Views
15 Pages

Hepatic G Protein-Coupled Receptor 180 Deficiency Ameliorates High Fat Diet-Induced Lipid Accumulation via the Gi-PKA-SREBP Pathway

  • Yunhua Zhang,
  • Ziming Zhu,
  • Lijun Sun,
  • Wenzhen Yin,
  • Yuan Liang,
  • Hong Chen,
  • Yanghui Bi,
  • Wenbo Zhai,
  • Yue Yin and
  • Weizhen Zhang

11 April 2023

Single-nucleotide polymorphisms in G protein-coupled receptor 180 (GPR180) are associated with hypertriglyceridemia. The aim of this study was to determine whether hepatic GPR180 impacts lipid metabolism. Hepatic GPR180 was knocked down using two app...

  • Article
  • Open Access
883 Views
20 Pages

CES1 Increases Hepatic Triacylglycerol Synthesis Through Activation of PPARγ, LXR and SREBP1c

  • Rajakumar Selvaraj,
  • Jihong Lian,
  • Russell Watts,
  • Randal Nelson,
  • Michael F. Saikali,
  • Carolyn L. Cummins and
  • Richard Lehner

3 October 2025

Increased hepatic triacylglycerol (TG) storage in lipid droplets (LDs) is a hallmark of metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH). Human carboxylesterase 1 (CES1) regu...

  • Article
  • Open Access
17 Citations
6,836 Views
17 Pages

12 August 2021

Proprotein convertase subtilisin/kexin type 9 (PCSK9) can promote the degradation of low-density lipoprotein (LDL) receptor (LDLR), leading to hypercholesterolemia and myocardial dysfunction. The intracellular regulatory mechanism by which the natura...

  • Article
  • Open Access
16 Citations
2,671 Views
11 Pages

10 October 2021

The resistance of colorectal cancer (CRC) to chemotherapy, e.g., 5-fluorouracil (5-FU), is an impediment to successful cancer treatment. Although many mechanisms have been proposed to explain the occurrence of resistance, little is known concerning t...

  • Article
  • Open Access
38 Citations
3,102 Views
20 Pages

Resveratrol Inhibits Proliferation and Induces Autophagy by Blocking SREBP1 Expression in Oral Cancer Cells

  • Masakatsu Fukuda,
  • Yudai Ogasawara,
  • Hiroyasu Hayashi,
  • Katsuyuki Inoue and
  • Hideaki Sakashita

26 November 2022

Resveratrol is a polyphenolic antioxidant found in grapes, red wine, and peanuts and has been reported to have anti-neoplastic effects on various cancer types. However, the exact mechanism of its anti-cancer effects in oral cancer is not fully unders...

  • Article
  • Open Access
30 Citations
7,142 Views
13 Pages

Salicortin-Derivatives from Salix pseudo-lasiogyne Twigs Inhibit Adipogenesis in 3T3-L1 Cells via Modulation of C/EBPα and SREBP1c Dependent Pathway

  • Mina Lee,
  • Sang Hoon Lee,
  • Jimmy Kang,
  • Heejung Yang,
  • Eun Ju Jeong,
  • Hong Pyo Kim,
  • Young Choong Kim and
  • Sang Hyun Sung

30 August 2013

Obesity is reported to be associated with excessive growth of adipocyte mass tissue as a result of increases in the number and size of adipocytes differentiated from preadipocytes. To search for anti-adipogenic phytochemicals, we screened for inhibit...

  • Article
  • Open Access
29 Citations
5,929 Views
15 Pages

Nifedipine Modulates Renal Lipogenesis via the AMPK-SREBP Transcriptional Pathway

  • Yen-Chung Lin,
  • Mai-Szu Wu,
  • Yuh-Feng Lin,
  • Chang-Rong Chen,
  • Chang-Yu Chen,
  • Chang-Jui Chen,
  • Che-Chou Shen,
  • Kuan-Chou Chen and
  • Chiung-Chi Peng

Lipid accumulation in renal cells has been implicated in the pathogenesis of obesity-related kidney disease, and lipotoxicity in the kidney can be a surrogate marker for renal failure or renal fibrosis. Fatty acid oxidation provides energy to renal t...

  • Article
  • Open Access
3 Citations
2,412 Views
10 Pages

13 November 2024

Objectives: Isostrictiniin (ITN), a natural polyphenol extracted from Nymphaea candida (snow-white waterlily), has antioxidant and hepatoprotective activities that may be beneficial in treating metabolic dysfunction-associated steatotic liver disease...

  • Article
  • Open Access
7 Citations
3,713 Views
23 Pages

SKI-1/S1P Facilitates SARS-CoV-2 Spike Induced Cell-to-Cell Fusion via Activation of SREBP-2 and Metalloproteases, Whereas PCSK9 Enhances the Degradation of ACE2

  • Rachid Essalmani,
  • Ursula Andréo,
  • Alexandra Evagelidis,
  • Maïlys Le Dévéhat,
  • Oscar Henrique Pereira Ramos,
  • Carole Fruchart Gaillard,
  • Delia Susan-Resiga,
  • Éric A. Cohen and
  • Nabil G. Seidah

27 January 2023

Proprotein convertases activate various envelope glycoproteins and participate in cellular entry of many viruses. We recently showed that the convertase furin is critical for the infectivity of SARS-CoV-2, which requires cleavage of its spike protein...

  • Article
  • Open Access
3 Citations
2,039 Views
10 Pages

26 November 2022

The epididymis is an organ that transports, matures and stores sperm, and has functions such as secretion and absorption. Polyunsaturated fatty acid (PUFA) compositions in sperm membrane were changed during the process of epididymis maturation and in...

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