Search Results (29,519)

Metal anodes promise improvements in energy density and cost; however, their performance is determined within the first several nanometers at the interface. This review reports on how polymer-based artificial solid electrolyte interphases (SEIs) are engineered to stabilize Li and aqueous-Zn anodes, and how these designs are now evaluated against operando readouts rather than post-mortem snapshots. We group the related molecular strategies into three classes: (i) side-chain/ionomer chemistry (salt-philic, fluorinated, zwitterionic) to increase cation selectivity and manage local solvation; (ii) dynamic or covalently cross-linked networks to absorb microcracks and maintain coverage during plating/stripping; and (iii) polymer–ceramic hybrids that balance modulus, wetting, and ionic transport characteristics. We then benchmark these choices against metal-specific constraints—high reductive potential and inactive Li accumulation for Li, and pH, water activity, corrosion, and hydrogen evolution reaction (HER) for Zn—showing why a universal preparation method is unlikely. A central element is a system of design parameters and operando metrics that links material parameters to readouts collected under bias, including the nucleation overpotential (η_nuc), interfacial impedance (charge transfer resistance (R_ct)/SEI resistance (R_SEI)), morphology/roughness statistics from liquid-cell or cryogenic electron microscopy (Cryo-EM), stack swelling, and (for Li) inactive-Li inventory. By contrast, planar plating/stripping and HER suppression are primary success metrics for Zn. Finally, we outline parameters affecting these systems, including the use of lean electrolytes, the N/P ratio, high areal capacity/current density, and pouch-cell pressure uniformity, and discuss closed-loop workflows that couple molecular design with multimodal operando diagnostics. In this view, polymer artificial SEIs evolve from curated “recipes” into predictive, transferable interfaces, paving a path from coin-cell to prototype-level Li- and Zn-metal batteries. Full article

An important aspect of medical rehabilitation using exoskeletons is objective monitoring of the effectiveness of the exercise program. This control is most often manual and relies on the attention of a rehabilitation physician, but advanced rehabilitation systems also use computer vision technology. Topological skeletons generalize large areas of digital images, representing a virtual internal framework of the analyzed object. The patient and the exoskeleton are described either as a set of spatially disparate (but not explicitly related to either the patient or the exoskeleton) topological skeletons, or as branches of a single topological skeleton which does not allow for objective monitoring of joint displacements. A method to solve this problem for medical rehabilitation using an upper-limb exoskeleton is proposed. It includes the following stages: (I) identifying the exoskeleton, as well as upper and lower parts of the patient’s body; (II) independent construction of three topological skeletons (separately for the exoskeleton and for the upper and lower parts of the patient’s body); (III) their integration. This approach allows for accurate, real-time analysis of movements in the upper-limb joints and prompt notification to the rehabilitation physician of any significant deviations in the technique of performing prescribed exercises. Full article

In this paper, an integrated geometric and thermal-induced errors prediction approach for active error compensation in machine tools is proposed and evaluated. The proposed approach is based on a hybrid of physical and neural network predictive modeling to drive an adaptive position controller for real-time error compensation including geometric and thermal-induced errors. Error components are formulated as a three-dimensional error field in the time-space domain. This approach involves four key steps for its development and implementation: (i) simplified experimental procedure combining a multicomponent laser interferometer measurement system and sixteen thermal sensors for error components measurement, (ii) artificial neural network-based predictive modeling of both position-dependent and position-independent error components, (iii) tridimensional volumetric error mapping using rigid body kinematics, and finally (iv) implementation of the real-time error compensation. Assessed on a turning center, the proposed approach conducts a significant improvement of the machine accuracy. The maximum error is reduced from 30 µm to less than 3 µm under thermally varying conditions. Full article

Narrow-diameter implants (≤3.5 mm) have garnered significant attention due to their widespread application in areas with insufficient bone volume. However, their mechanical performance is limited. The cervical region, serving as a pivotal stress concentration zone, exhibits a thread form that directly modulates stress distribution and determines the long-term stability of the implant–bone interface. This study was designed to investigate the influence of varying thread forms and face angles on microstrain and stress distribution patterns in narrow-diameter implants (NDIs) and their adjacent cortical bone structures. Through systematic modification of implant thread forms and face angle parameters, finite element analysis (FEA) was employed to develop nine distinct implant models featuring varied geometric characteristics. Each model was implanted into Type III bone tissue, followed by the application of a 100 N occlusal force, including a vertical load and an oblique load deviated 30 degrees lingually from the long axis of the implants. Subsequent biomechanical evaluation quantified peak von Mises stress concentrations at the bone–implant interface, maximum equivalent elastic strain distributions in peri-implant bone tissue, and abutment stress profile characteristics. The results indicated that in the RB thread group, the optimal thread face angle parameter was 60 degrees; in the B thread group, this optimal thread face angle parameter was 45 degrees, whereas in the V thread group, the optimal thread face angle parameter was 30 degrees. Full article

Background: Human adipose-derived mesenchymal stem cells (hADMSCs) are widely used in regenerative medicine due to their ability to proliferate and differentiate. Bone tissue engineering represents an innovative alternative to traditional grafts by combining biomimetic materials, stem cells, and bioactive factors to promote bone regeneration. Gellan gum (GG) is a promising scaffold material owing to its excellent biocompatibility and favorable physicochemical characteristics; however, chemical modifications such as methacrylation are necessary to enhance its mechanical strength and long-term stability. In this in vitro study, osteoprogenitor cells are cultured for 21 days on three 3D-printed GGMA-based scaffolds to evaluate their biological response: (i) neat GGMA, (ii) GGMA functionalized with hydroxyapatite (HAp), and (iii) GGMA functionalized with eumelanin derived from black soldier fly (BSF-Eumelanin). Methods: Cell adhesion, viability, proliferation and osteogenic differentiation are evaluated using MTT assays, histological staining (H&E and Alizarin Red S), alkaline phosphatase (ALP) activity, and gene expression analysis of key osteogenic markers. Results: Our results show that all GGMA-based scaffolds support cell adhesion, growth, and proliferation, while BSF-Eumelanin and HAp notably enhance osteogenic differentiation compared to neat GGMA. Conclusions: These findings highlight the potential of embedding bioactive factors into GGMA scaffolds to improve osteoconductive and osteoinductive performance, offering a promising strategy for bone repair. Full article

In organic solids, the heterogeneous distribution of organic molecules in the solid state gives rise to novel structure–property relationships. Here, we use transmission electron microscopy to investigate the aggregated structure of organic solid of a typical phosphorescent molecule Ir(ppy)₃ at the atomic scale. Through the identification of heavy Ir atoms in the molecular structure, we reveal the existence of organic crystals, clusters and single molecules in the solids. Through electron energy loss spectroscopy, we explore the vibration modes of molecules and lattices in the solids and possible perturbations by excitons induced by electron beam, which could affect the electroluminescent property of the molecules. Full article

The aviation industry requires a series of actions that will transform its current status, aiming for sustainable operations. Aviation’s end-of-life stream is a pivotal lever for circularity, yet current dismantling and recycling practices leave significant value unrealized. Circular Economy could be considered as a transformational approach to the aviation industry and address its environmental and economic challenges, meeting sustainability principles. This study conducts a PRISMA-guided qualitative systematic review across academic and industry sources to synthesize regulations, technologies, and economics of aircraft decommissioning. It aims to quantify material recovery potential and environmental gains at the aircraft level and assess technology readiness and cost drivers for metals, polymers, and composites. Findings indicate that optimized decommissioning enables high-value part reuse and substantial material recovery (notably aluminum), with associated lifecycle greenhouse-gas avoidance at the aircraft scale. However, high costs, weak regulations, and limited recycling technologies hinder adoption. Results show that optimized dismantling and certified part-reuse pathways can recover up to 85–90% of total aircraft mass, with potential CO₂-emission avoidance of 25–35 t per narrow-body aircraft compared with landfill disposal. Metal recycling technologies (TRL 8–9) already achieve high yields, whereas polymer and composite recycling remain limited (TRL 5–6) by purity and certification barriers. A comparative assessment of EU, US, and Asia–Pacific regulations identifies enforcement and infrastructure gaps hindering implementation. The study introduces an integrated CE roadmap for aviation comprising (i) standards-aligned design-for-disassembly and digital traceability, (ii) accredited MRO-to-reuse networks, and (iii) performance-based policy incentives. Full article

The growing demand for eco-efficient construction materials has driven the development of low-clinker cement systems incorporating recycled mineral additives. Finely ground brick powder represents one of such materials with high pozzolanic potential. This article presents an experimental study on the effect of partially replacing slag cement CEM III and ordinary rapid-hardening cement CEM I with brick powder waste of different chemical compositions and fineness levels (63, 32, and 15 µm) on the physical and mechanical properties of blended cement mortars. Compressive and flexural strengths were determined at 2, 7, and 28 days, along with the strength activity index (SAI). Additionally, the setting times and standard consistency were investigated, with the latter showing a correlation with the workability of fresh mortars. Comprehensive microstructural analysis (TGA, SEM, EDX) confirmed the pozzolanic activity of the brick powder, which was manifested by the formation of C-S-H and C-A-S-H phases. The highest strength characteristics were achieved with a 15% replacement of cement by brick powder with a fineness of 32 μm and an increased SiO₂ content (63.06%). Comparative analysis with fly ash- and silica fume-modified mortars revealed that brick powder exhibits comparable performance, confirming its suitability as an active mineral additive. Full article

The synthesis of high-performance adhesives imposes stringent requirements on the design of stirred reactors: simultaneous achievement of efficient mixing and minimal energy dissipation in highly viscous media remains the principal challenge. In this study, computational fluid dynamics (CFD) was employed to solve the Navier–Stokes equations for the high-viscosity epoxy system and numerically simulating the flow fields of four representative reactor configurations across a prescribed range of rotational speeds. Specifically, the four representative reactor configurations were (i) single-serrated shaft, (ii) eccentric single-serrated shaft, (iii) uniaxial single-blade paddle combined with a single-serrated dual-axis assembly, and (iv) biaxial single-blade paddle coupled with a single-serrated triaxial assembly. The mixing performance was quantitatively assessed by systematically comparing the evolution of mixing speed, vorticity fields, restricted power consumption, and mixing time across a range of rotational speeds. The results demonstrated that the synergistic deployment of an eccentric impeller and a differential-speed single-propeller shaft effectively disrupted the axisymmetric flow pattern, compressed the chaotic isolation zones, and intensified both axial exchange and global chaotic mixing. Among the configurations examined, the uniaxial single-propeller–single-serrated biaxial arrangement reduced the mixing time by 13.43% and cut the specific energy consumption by approximately 58.32%, thereby attaining markedly higher energy efficiency. This research will provide guidance for the study of efficient mixing of adhesives. Full article

Background/Objectives: Cervical cancer is one of the most frequent malignancies among women in Kazakhstan, where human papillomavirus (HPV) vaccination was initiated in 2024. Despite the implementation of vaccination and cytology-based screening programs, diagnostic limitations remain, and local evidence linking HPV infection to clinical outcomes is scarce. This study aimed to evaluate the correlation between HPV status, cervical cytology results, colposcopic impression, and biopsy results in a non-vaccinated female population. Methods: A cross-sectional study was conducted at the University Medical Center, Astana, between November 2024 and March 2025. A total of 396 women of reproductive age were enrolled. Cervical samples underwent liquid-based cytology and high-risk HPV testing with the RealBest assay. Colposcopy was performed following abnormal cervical cytology results, and colposcopy-guided biopsies were obtained where indicated. Sociodemographic characteristics were assessed, and associations between HPV genotype and clinical outcomes were analyzed using descriptive and inferential statistics. Results: HPV infection was detected in 140 women (35.4%). HPV-16 was the most common genotype (11.4%), followed by HPV-52 (6.6%) and HPV-33 (5.3%). Among 198 women evaluated by colposcopy, abnormal findings were observed in 72.2%, with HPV-16 showing a significant association with higher-grade abnormalities (p < 0.001). Biopsies were available for 40 participants: 12 had CIN I, 12 had CIN II, 10 had CIN III, and 4 had carcinoma in situ. HPV-16 was the only genotype significantly linked to CIN II/III lesions. Conclusions: HPV-16 was strongly associated with abnormal colposcopic findings and high-grade histology, underscoring its oncogenic importance. The prevalence of HPV-52 and HPV-33 further supports the need for HPV nonavalent vaccination. These findings highlight the importance of HPV-based screening, genotype-specific triage, and expanded vaccination to reduce cervical cancer incidence in Kazakhstan. Full article

Adult neurogenesis is well established in canonical niches—the dentate gyrus and the subventricular zone, where aerobic exercise reliably enhances progenitor proliferation, survival, and synaptic integration via increased cerebral blood flow, neurotrophins (e.g., BDNF, IGF-1), neurotransmitter regulation, and reduced neuroinflammation. Nutraceuticals (e.g., polyphenols, omega-3, creatine, vitamins) further support neuroplasticity and neuronal survival through convergent trophic, anti-inflammatory, and metabolic pathways. By contrast, the hypothalamus, a metabolically pivotal, non-canonical niche, remains comparatively understudied. Here, we synthesize anatomical and functional features of hypothalamic neural stem cells, primarily tanycytes (α1, α2, β1, β2), which line the third ventricle and differentially contribute to neuronal activity regulation, metabolic signaling, and cerebrospinal fluid–portal vasculature coupling, thereby linking neurogenesis to endocrine control. Notably, tanycytes can form neurospheres in vitro, enabling mechanistic interrogation. Although evidence for adult hypothalamic neurogenesis in humans is debated due to methodological constraints, animal data suggest potential relevance to disorders characterized by neuronal loss, metabolic dysregulation, and impaired neuroendocrine function. We propose that an integrative framework is timely: exercise and diet likely interact in the hypothalamic niche through shared mediators (BDNF, IGF-1, CNTF, GPR40) and exercise-derived signals (e.g., lactate, IL-6) that may be complemented by defined nutraceuticals. Yet critical uncertainties persist, including the extent of bona fide hypothalamic neurogenesis, nucleus-specific responses (arcuate nucleus, paraventricular nucleus, ventromedial hypothalamic nucleus), and the mechanistic integration of lifestyle signals in this region. To address these gaps, we outline actionable priorities: (i) single-cell and lineage-tracing studies of tanycyte subtypes under distinct training modalities (aerobic, high-intensity interval training, resistance); (ii) combinatorial interventions pairing structured exercise with nutraceuticals to test synergy on progenitor dynamics and inflammation; and (iii) multi-omics and translational studies to identify biomarkers and establish clinical relevance. Clarifying these interactions will determine whether lifestyle and supplementation strategies can synergistically modulate hypothalamic neurogenesis and inform therapies for neurological, neuropsychiatric, and metabolic disorders. Full article

Conflicts between farmers and herders are a persistent challenge in Sudanian and Sudano-Guinean zones of Benin, largely driven by competition over access to pastoral resources. This study aimed to characterize the prevalence, causes, and typology of such conflicts and to assess their implications for the sedentarization of cattle farming systems. Data were collected from 480 livestock farms across four municipalities (Materi and Gogounou in the Sudanian zone; Tchaourou and Djougou in the Sudano-Guinean zone) through surveys, mapping, and herd productivity assessments. Multiple Correspondence Factorial Analysis was used to classify the conflict types. The results revealed that 52.29% of herders had experienced conflicts, with a higher incidence in the Sudano-Guinean zone (36.88%). Four main categories of conflict were identified: (i) blows and injuries to people and animals (38.64%), (ii) displacement of herders and their farms (34.26%), (iii) property damage and animal slaughter (15.13%), and (iv) violent verbal altercations and animal poisoning (11.97%). These findings indicate that recurrent conflicts are accelerating the shift from transhumance towards sedentarization, underscoring the need for tailored conflict management strategies and sustainable livestock policies. Full article

Background: Minimally invasive hyperthermia and regenerative therapies require materials that deliver precise, localized heat without compromising biocompatibility. Most conventional polymers are thermally insulating and challenging to control in vivo, motivating this review. Objectives: We aimed to (i) examine the use of thermally enhanced biopolymers in hyperthermia-based therapies, (ii) appraise evidence from clinical and preclinical studies, (iii) identify and classify principal applications in regenerative medicine. Methods: A PRISMA-guided systematic review (2020–2025) with predefined inclusion/exclusion criteria was conducted and complemented by a bibliometric analysis using VOSviewer for mapping and visualization. Results: Modifying biopolymers—via functionalization with photothermal or magnetic nanoagents (Au; Fe₂O₃/Fe₃O₄/CoFe₂O₄; CuS; Ag; MXenes, e.g., Nb₂C), crosslinking strategies, and hybrid formulations—significantly increased thermal conductivity, enabling localized hyperthermia and controlled drug release. In vitro and in vivo studies showed that europium-doped iron oxide nanoparticles embedded in chitosan generated heat efficiently while sparing healthy tissues, underscoring the need to balance biocompatibility and thermal performance. Hydrogel systems enriched with carbon nanomaterials (graphene, carbon nanotubes) and matrices such as GelMA, PNIPAM, hyaluronic acid, and PLA/PLGA demonstrated tissue compatibility and effective thermal behavior; graphene was compatible with neural tissue without inducing inflammation. Conclusions: Thermally conductive biopolymers show growing potential for oncology and regenerative medicine. The evidence supports further academic and interdisciplinary research to optimize safety, performance, and translational pathways. Full article

Background: Smoking cessation has been associated with reduced lung cancer mortality. This study aimed to synthesize current evidence on the impact of quitting smoking at or around the time of diagnosis of lung cancer on survival, considering factors such as histological subtype, cancer stage, and cessation intervention. Methods: A systematic search was conducted in the Ovid-MEDLINE, Ovid-EMBASE, Cochrane Central Register of Controlled Trials, and KoreaMed databases up to September 2024. Randomized controlled trials and cohort studies enrolling adult current smokers with pathologically confirmed lung cancer and comparing smoking cessation at or around diagnosis with continued smoking, were included. The primary outcome was overall survival (minimum follow-up of 3 months). The included studies were critically appraised using the revised Risk of Bias for Nonrandomized Studies (RoBANS 2) tool and meta-analyzed. Results: A total of 25 cohort studies comprising 17,584 patients were reviewed. Quitting smoking at diagnosis was associated with a 26% reduction in mortality risk (adjusted HR [aHR] 0.74, 95% CI 0.68–0.81). In subgroup analyses, quitting smoking was associated with improved survival in both non-small cell lung cancer (aHR 0.73, 95% CI 0.64–0.83) and small cell lung cancer (aHR 0.61, 95% CI 0.51–0.72), with a more pronounced benefit among patients with early-stage disease (stage I–III or limited stage; aHR 0.64, 95% CI 0.56–0.74). Furthermore, active smoking cessation interventions were significantly associated with improved survival (aHR 0.55, 95% CI 0.35–0.88). Conclusions: The findings underscore the importance of encouraging smoking cessation at the time of lung cancer diagnosis as an integral part of patient management to improve survival outcomes. Full article

Background and Clinical Significance: Mesonephric adenocarcinoma (MA) of the uterine cervix is an exceptionally uncommon and aggressive cancer that arises from remnants of the mesonephric duct. It was first classified by the World Health Organization (WHO) in the 2020 WHO Classification of Female Genital Tumors as a type of cervical adenocarcinoma, also referred to as Gartner’s duct carcinoma. Due to its rarity, both detection and treatment pose significant challenges, and there is little information on its clinical manifestations and prognosis. Mesonephric hyperplasia (MH) in the uterine cervix is an uncommon condition that is often misdiagnosed as adenocarcinoma. Case Presentation: We present the case of a 49-year-old, asymptomatic, perimenopausal woman diagnosed with cervical mesonephric adenocarcinoma following a routine Pap smear, performed by Papanicolaou test, with a III A-B result; however, a cone biopsy revealed stage IB1 mesonephric adenocarcinoma. The patient underwent a radical hysterectomy type C (Querleu–Morrow 2017 classification). The final pathology confirmed stage IB2 of the cancer (2018 classification) according to The International Federation of Gynecology and Obstetrics (FIGO), with previous evidence of mesonephric hyperplasia from a trial abrasion performed three years earlier. Conclusions: This case highlights the challenges in recognizing and managing mesonephric hyperplasia and adenocarcinoma of the cervix. Given the uncommon nature of this cancer, clinicians should consider it when treating patients with ambiguous cervical pathology and mesonephric hyperplasia. Optimizing patient outcomes relies on early detection, accurate staging, and radical surgical treatment. Full article