Search Results (185)

Background/Objectives: Severe brain injury (SBI) in very preterm infants includes heterogeneous lesions with distinct timing, burden and outcomes. We used cranial ultrasound (CUS) to describe SBI entity, documented timing, three-domain burden, deaths following documented withdrawal, withholding or non-escalation of life-sustaining treatment for poor neurological prognosis (neuro-WWLST), and survivor outcomes. Methods: Retrospective single-center cohort (1991–2020) of 2841 very preterm infants (<32 weeks’ gestation and/or birth weight ≤ 1500 g) with complete CUS within 48 h after birth. CUS was summarized by four windows, three domains—parenchymal lesion, intraventricular hemorrhage (IVH) and ventriculomegaly—and three mutually exclusive entities: periventricular hemorrhagic infarction (PVHI), cystic periventricular leukomalacia (cPVL and grade 3 IVH without PVHI/cPVL (IVH3 entity). Cross-outcome analyses used common maximal-burden CUS. Results: SBI occurred in 286/2841 infants (10.1%) and neuro-WWLST death in 45/2841 infants (1.6%); 43/45 occurred within SBI, and 43/89 SBI deaths (48.3%) followed documented neuro-WWLST. Using common maximal-burden CUS, severe three-domain involvement was more frequent among neuro-WWLST deaths than survivors (37.2% vs. 8.6%). Among SBI survivors with follow-up, cerebral palsy (CP) occurred in 87/176 (49.4%) and clinically classified school-age cognitive sequelae in 50/155 (32.3%). Outcomes varied by entity, with mainly ambulatory unilateral CP after PVHI, more frequent non-ambulatory bilateral CP after cPVL, and a heterogeneous IVH3 profile. Severe three-domain involvement identified a small subgroup with higher outcome burden, but outcomes were not deterministic. Conclusions: A structured, descriptive CUS approach separating lesion entity, documented timing and multidomain burden may support transparent cohort-level description of SBI trajectories, documented neuro-WWLST deaths and survivor outcomes. Full article

Cadmium (Cd) contamination in paddy soils poses a severe threat to food safety. Although straw incorporation is a key approach to sustainable agriculture, the mechanisms underlying its regulatory effects on safe rice production in Cd-contaminated fields remain unclear. This field study, conducted at two Cd-contaminated sites with two rice cultivars differing in Cd accumulation (low-Cd ZLY8612 and high-Cd YXY2115), evaluated five wheat straw management practices: straw removal (CK), straw mulching (SM), straw incorporation (SI), straw incorporation with organic fertilizer (SOI), and straw-derived biochar incorporation (SBI). The primary findings revealed that SOI and SBI could effectively reduce Cd availability and promoted Cd transformation to residual fractions, with SBI showing superior immobilization effects. SBI also enriched beneficial taxa (Bacillus, Sphingomonas, and Flavisolibacter), increased Proteobacteria, and reduced Chloroflexi and Acidobacteriota. All treatments enhanced rice yield; however, only SBI reduced grain Cd in the high-Cd cultivar to <0.2 mg/kg with high-Cd soil. Collectively, the combined application of straw-derived biochar incorporation and low-Cd-accumulating rice cultivar is a reliable and recommendable agronomic strategy for safe grain production and sustainable straw recycling in Cd-contaminated rice–wheat rotation fields. Full article

Supply chain disruptions have become a major source of macro-financial stress, yet their implications for green finance remain underexplored. This paper investigates the state-dependent connectedness between supply-side bottlenecks and the green finance market, represented by clean energy equities, green bonds, and carbon prices. Using daily data on regional Supply Bottleneck Indices (SBIs) for China, the United States, and the euro area, we first construct a global Supply Bottleneck Index (GSBI) by principal component analysis and then estimate pairwise quantile-on-quantile connectedness (QQC) between supply bottleneck indicators and each green finance submarket. The results show that connectedness is strongly nonlinear, asymmetric, and time-varying. For the global indicator, connectedness intensifies at both joint and cross-tail quantile combinations, while mid-quantile states exhibit weak coupling. Regional results reveal clear heterogeneity: China and the United States display the strongest connectedness with clean energy equities in extreme upper-tail states, whereas the euro-area indicator is most tightly linked with the carbon market. Across many extreme states, supply bottleneck indicators show positive net connectedness with green finance markets, but green finance markets, especially carbon prices, can dominate the bilateral connectedness relation under calmer or intermediate regimes. Robustness checks based on average and quantile-rank GSBI constructions, a post-2023 subsample, and alternative QQC tuning choices support the tail-dominance pattern. These findings suggest that supply bottlenecks are not uniformly related to all green assets; rather, they are associated with state-dependent changes in the internal connectedness architecture of the green finance system. The paper contributes to the literature on financial connectedness and sustainable finance by showing how a real-economy disturbance is associated with changes in the connectedness and resilience of green financial markets. Full article

This study evaluates frame selection during inference as an independent factor in video deepfake detection while keeping the downstream detectors fixed. We compare twelve frame selection strategies, ranging from simple temporal and quality baselines to landmark aware policies, using four validated pretrained detectors: Self-Blended Images (SBIs), Frequency-Enhanced Self-Blended Images (FSBIs), Generative Convolutional Vision Transformer (GenConViT), and GenD. The primary experiment is a complete factorial benchmark with 300 videos and five frame budgets (2, 4, 8, 16, and 32 selected frames), which provides the reference results at 32 frames. To address sample size limitations, an additional validation experiment uses a deduplicated split of 1180 Celeb-DF++ and FaceForensics++ videos, with complete results for 2, 4, and 8 selected frames and a reported subset for 16 selected frames. In the complete 300-video benchmark, 32 frames achieved the strongest average AUC, while 8 and 16 frames recovered most of the attainable performance with lower runtime. The best single validated configuration was GenD with Shot-aware sampling at 32 frames, yielding an AUC of 0.9607 and a balanced accuracy of 0.9133. The study therefore does not claim that smaller budgets universally outperform 32 frames; instead, it quantifies the tradeoff between accuracy and runtime and shows that frame selection remains a meaningful design variable under constrained inference budgets. Full article

Parental divorce, as an adverse childhood experience, may disrupt family systems and exert enduring effects on psychological development, with impacts becoming particularly salient during emerging adulthood, a stage characterized by identity exploration and increasing autonomy. Within the Thai cultural context, inner strengths grounded in Buddhist values may serve as important resources for resilience. This study examined associations between inner strength dimensions derived from the Ten Perfections (Pāramīs) and resilience among emerging adults who experienced parental divorce in childhood. A cross-sectional design was employed with 160 Thai participants aged 20 to 29 years, who completed the Inner Strength-Based Inventory (I-SBI) and the Resilience Inventory (RI-9). Correlation analysis indicated that equanimity, determination, perseverance, wisdom, meditation, and loving-kindness were positively correlated with resilience. Multiple regression analysis showed that equanimity (β = 0.312, p < 0.001), determination (β = 0.227, p < 0.01) and loving-kindness (β = 0.213, p < 0.01) were significantly associated with resilience. These findings suggest that culturally embedded inner strengths are associated with resilience in a non-Western context. More specifically, among the ten dimensions examined, equanimity, determination, and loving-kindness emerged as being significantly associated with resilience in Thai emerging adults with childhood parental divorce experiences. Full article

Large-scale excavation for pumped-storage hydropower stations (PSPSs) in mountainous areas substantially alters slope soils and accelerates ecological degradation, yet quantitative multi-indicator assessments for such projects remain limited. This study integrates field surveys, laboratory analyses, and multi-temporal remote-sensing data to evaluate the disturbance-induced evolution of soil properties at two representative PSPSs in China. Soil bulk density and porosity measurements revealed significant compaction on disturbed slope surfaces, particularly on soil-dominated slopes. Key nutrient indicators, including organic matter, alkali-hydrolysable nitrogen, available phosphorus, and available potassium, showed consistent declines relative to adjacent undisturbed habitats. A comprehensive ecological degradation indicator (EDI) was constructed using five vegetation and soil spectral indices (RVI, NDVI, SAVI, SBI, and SM) weighted through the analytic hierarchy process. Time-series EDI mapping (2019–2023) demonstrated a progressive increase in moderately to extremely degraded areas during intensive construction stages. The results highlight the strong spatial heterogeneity of disturbance effects and underscore the necessity of soil-focused restoration strategies. This integrated assessment framework provides a scientific basis for guiding near-natural restoration and long-term soil–vegetation management in PSPS infrastructure landscapes. Full article

The emergence of vancomycin-intermediate Staphylococcus aureus (VISA) threatens the efficacy of this last-line antibiotic. The GraSR two-component system is frequently mutated in VISA strains. Here, we demonstrate that the GraS(T136I) point mutation, identified in the clinical VISA isolate XN108, is a key determinant of reduced vancomycin susceptibility. Introducing this mutation into the susceptible strain Newman increased the vancomycin MIC from 1.5 to 4 mg/L, while its reversion in XN108 decreased the MIC from 12 to 8 mg/L. The mutation conferred common phenotypes, including thickened cell wall, decreased autolysis, and reduced cell surface negative charge via upregulation of the dltABCD operon and mprF. Notably, the GraS(T136I) mutation also upregulated virulence genes (efb, hlb, sbi, hld) and enhanced hemolytic activity. Interestingly, despite this hypervirulent profile, the mutant showed impaired long-term survival within macrophages. Our study reveals that a single GraSR mutation can co-regulate vancomycin resistance and virulence, offering new insights into the adaptation of S. aureus to antibiotic pressure. Full article

Silicon carbide particle-reinforced aluminum matrix (SiCp/Al) composites are prone to surface defects during grinding owing to the heterogeneous deformation of the aluminum matrix and SiC particles, rendering conventional two-dimensional roughness parameters inadequate for precise surface characterization. In this study, three-dimensional surface roughness parameters were adopted to assess the ground surface quality of SiCp/Al composites. Orthogonal grinding experiments were carried out with four key process parameters (grinding wheel grit size, spindle speed, feed speed, and grinding depth), and the quantitative relationships between processing parameters and 3D roughness parameters, including arithmetical mean height (Sa), root mean square height (Sq), skewness (Ssk), kurtosis (Sku), surface bearing index (Sbi), core fluid retention index (Sci), and valley fluid retention index (Svi), were analyzed. The results reveal that the machined surface presents typical features including grooves from abrasive–matrix interaction, pits induced by SiC particle pull-out, scratches caused by dragged SiC particles, and tailing phenomena due to aluminum matrix melting under grinding heat. Grinding parameters exert distinct effects on surface topography: grinding wheel grit size shows the most significant influence on the Sa index, with its weight decreasing from 34% to 13% as grit becomes finer, while the combined influence weight of spindle speed, feed speed and grinding depth increases from 22% to 29%. Based on the comprehensive 3D roughness evaluation index, the optimal grinding parameter combination is determined as 320# grinding wheel, 4000 r/min spindle speed, 20 mm/min feed speed and 20 μm grinding depth. Additionally, the PSO-BP neural network achieves higher accuracy and better stability in predicting Sa and Sci than the conventional BP neural network. Full article

The ambient stability of ambient-processed lead-free perovskite absorbers remains a critical challenge toward scalable, eco-friendly photovoltaics. Herein, we systematically investigate the time-dependent structural and morphological evolution of drop-cast ambient-processed Cs₃Sb₂I₉ thin films, being a potential non-toxic and stable solar absorber candidate (energy bandgap ~2 eV) for solar cells, stored under uncontrolled ambient condition (~60% Relative humidity) for 28 days. Sequential X-ray diffraction (XRD) and surface morphology analyses using scanning electron microscope (SEM) reveal that the films preserve their trigonal P$\overline{3}$m1 phase throughout aging, confirming phase stability. Moderate moisture exposure may induce partial recrystallization and subtle structural reorganization, possibly including minor c-axis realignment, leading to reduced lattice strain and improved crystallite coherence. Even after prolonged aging, no secondary phases or micro-cracks are detected, underscoring the slow degradation kinetics and robust Sb–I bonding that stabilize the layered [Sb₂I₉]³⁻ dimers. The late-stage increase in diffraction intensity and partial recovery of crystallographic parameters could indicate transient structural reorganization, potentially associated with moisture-mediated reordering within an overall degradation pathway. These observations suggest some degree of morphological persistence and structural tolerance of Cs₃Sb₂I₉ under ambient conditions, rather than complete stability. This behavior offers useful insights into ambient processing and the long-term reliability of lead-free perovskite photovoltaics. Full article

Vacancy-ordered double-perovskite Cs₂SnI₆ is known to be a good candidate for perovskite photovoltaics, as it is a light harvesting material which has potential both as an individual compound and as a component of a composite material. The compound is interesting due to being free of atom sites in B cationic positions, making the lattice “breathable” and giving it optoelectronic characteristics that vary with dopants. Here, antimony was examined as a possible heterovalent dopant with an ionic radius larger than that of Sn⁴⁺. In practice, it has been found that most of the materials are composites of Cs₂SnI₆ and Cs₃Sb₂I₉ phases. In the CsI–SnI₄–SbI₃ phase triangle, the melt crystallization process produced a layered (111)-oriented microstructure of crystallites with an increasing percentage of antimony. Two-dimensional perovskite materials look more promising in the decomposition of a solid solution to Cs₂SnI₆ and Cs₃Sb₂I₉ phases than in heterophase nucleation. The observed effect of (111)-oriented growth could be translated to other inorganic halides to form new oriented films or single crystals of perovskite materials. Diffuse reflectance spectroscopy showed an additional absorption shoulder in the NIR region for all groups of compounds, most likely induced by point defects in I sublattices of Cs₂SnI₆. Expanding the Cs₂SnI₆ absorption range to the NIR region could lead to new perspectives for its application. Full article

Background/Objectives: The itch–scratch cycle is a key driver of exacerbation in atopic dermatitis (AD) and requires objective monitoring, yet patient-reported itch scores are often unreliable in children. This study aimed to evaluate smartwatch-derived nocturnal scratching metrics as digital biomarkers of disease activity and treatment response in pediatric AD. Methods: In this prospective observational study, 50 children (median age 9 years) with physician-diagnosed AD wore an Apple Watch with the Itch Tracker application for 5–14 nights during initiation of topical therapy. Three scratch metrics—scratch count rate (SCR), scratch duration ratio (SDR), and scratch burden index (SBI, duration × intensity)—were analyzed. Associations with clinical outcomes [Eczema Area and Severity Index (EASI), Patient-Oriented Eczema Measure (POEM)], serum thymus and activation-regulated chemokine (TARC), and itch numerical rating scale (NRS) were examined. Logistic regression models were evaluated to examine whether these metrics could identify children who achieved clinically meaningful improvement, defined as EASI-50 plus ≥ 4-point POEM reduction. Results: All scratch metrics correlated with baseline EASI (r = 0.60–0.64, p < 0.001) and serum TARC (r = 0.58–0.60, p < 0.001). Reductions in scratching paralleled clinical improvement (r = 0.67–0.71, p < 0.0001). Among models, the SBI-based logistic regression demonstrated the best discriminative performance (AUC = 0.78, 95% CI: 0.64–0.92). Conclusions: Wearable-derived nocturnal scratching metrics showed moderate but consistent associations with disease severity and short-term improvement. Although predictive capability remains to be established, these metrics may serve as treatment-responsive digital measures. Given the cross-sectional nature of biomarker analyses and other study limitations, further prospective validation is required before clinical application in real-world pediatric AD monitoring. Full article

Background/Objectives: Work stress (WS), occupational fatigue (OF), and Burnout syndrome (BS) among administrative workers are associated with negative psychosocial and metabolic effects. Although antioxidant-rich nutritional strategies have been proposed to help manage stress, evidence from real-world occupational settings is still limited. This study evaluated the total antioxidant capacity (TAC) of a multi-antioxidant dietary supplement 2.0 (DS2.0; apple polyphenols, [APP], astaxanthin [AXT], and fucoxanthin [FXT]; 387:12:1 ratio) and explored its association with metabolic parameters, OF, psychosocial outcomes, and hair cortisol concentration (HCC) in administrative workers with and without obesity. Methods: A quasi-experimental pilot study was conducted among 22 workers, who received DS2.0 (52.13 mg/day, n = 17) or a placebo (n = 5) for 30 days. TAC was analytically assessed using standardized assays. Metabolic outcomes (lipid profile, fasting plasma glucose), psychosocial variables (SOFI-SM, CESQT/SBI, and IMSS tests), and HCC (competitive immunoassay) were evaluated before and after supplementation. Statistical analyses included within-group pre–post comparisons, independent-sample tests, and effect size estimation. Results: DS2.0 demonstrated high TAC. Supplementation was associated with reductions in total lipids, total cholesterol, and non-HDL cholesterol, as well as decreases in OF, BS, and WS scores. HCC decreased in the overall sample (217.19 vs. 31.64 pg/mg; p = 0.000) and among workers with obesity (276.80 vs. 34.13 pg/mg; p = 0.002). Stress-related symptoms, including sleep deprivation, exhaustion, appetite changes, difficulty waking, and palpitations, also improved (p ≤ 0.05). Conclusions: An antioxidant-rich DS2.0 supplement may be associated with psychosocial and stress-related biomarkers; however, these exploratory findings require confirmation in larger randomized controlled trials. Trial registration: ISRCTN 12762846. Full article

Background/Objectives: Abnormalities in the partial pressure of carbon dioxide (PCO₂) can occur during respiratory support and may contribute to adverse neonatal outcomes. This study aimed to assess the incidence of early hypocapnia and hypercapnia in mechanically ventilated preterm infants and their major associated outcomes. Methods: A single-center retrospective cohort study (2017–2024) was conducted in preterm infants < 32 weeks’ gestation who required > 24 h of invasive ventilation within the first 3 days of life. Perinatal–neonatal data were retrieved from the medical database. Admission blood gas values (arterial and capillary–venous) and the maximum and minimum PCO₂ in the first 72 h were evaluated. Normocapnia was defined as PCO₂ 35–45 mmHg, hypocapnia as < 35 mmHg, and hypercapnia as > 45 mmHg. Primary outcomes were the incidence of PCO₂ abnormalities; secondary outcomes included death or severe brain injury (SBI), SBI alone, and bronchopulmonary dysplasia (BPD) among survivors. Logistic regression identified independent predictors of the secondary outcomes. Results: Among the 134 infants evaluated, most experienced both hypercapnia and hypocapnia. Hypercapnia occurred in 81.3% of infants, and hypocapnia in 93.2%. Death or SBI was observed in 51.5%, and SBI alone in 42.5%. Gestational age < 28 weeks, air-leak syndromes, and pulmonary hemorrhage were independent predictors of death or SBI. Among survivors, hypercapnia and gestational age < 28 weeks independently predicted BPD. Infants with adverse outcomes had higher maximum PCO₂ values and greater PCO₂ variability, although these were not independent predictors of SBI or death. Conclusions: PCO₂ instability is highly prevalent in ventilated preterm infants, underscoring the need for individualized ventilation strategies. Extreme prematurity emerged as the primary risk factor for adverse outcomes, while hypercapnia was independently associated with BPD. Full article

Background and Objectives: Overt perioperative stroke remains a feared complication of adult cardiac surgery. Diffusion-weighted magnetic resonance imaging (DWI-MRI) has revealed a more prevalent form of cerebral injury, termed silent stroke or silent brain injury (SBI). Covert ischemic lesions occur without focal neurological deficits but are increasingly associated with postoperative delirium, cognitive decline, and elevated long-term cerebrovascular risk. Despite growing recognition, the true burden, mechanisms, and clinical relevance of SBI remain incompletely integrated into perioperative practice. Materials and Methods: We performed a narrative review of the literature published between January 2000 and December 2025, identified through PubMed/MEDLINE and Scopus. Eligible studies included prospective and retrospective cohorts, randomized trials, systematic reviews, and meta-analyses involving adult patients undergoing coronary artery bypass grafting, valve surgery, or minimally invasive cardiac procedures, with or without cardiopulmonary bypass, and reporting MRI-detected ischemic lesions or validated surrogate markers of cerebral injury. Pediatric studies, transcatheter interventions, case reports, and non-English publications were excluded. Sixty studies met the inclusion criteria. Results: Silent stroke occurred more frequently than clinically apparent stroke, with new DWI-MRI lesions detected in approximately 20–60% of patients following cardiac surgery. Lesions were typically small, multifocal, and embolic in distribution, predominantly affecting cortical and watershed regions. Cardiopulmonary bypass-related factors, including aortic manipulation, cerebral microembolization, hemodilution, hypoperfusion, and impaired oxygen delivery, emerged as key contributors. Several studies demonstrated associations between SBI burden and postoperative delirium, early cognitive dysfunction, and functional decline. Perfusion-based neuroprotective strategies showed mechanistic benefit, although no single intervention conclusively prevented SBI. Conclusions: Silent stroke represents the most frequent form of neurological injury in adult cardiac surgery. Evidence suggests that these covert lesions reflect clinically meaningful cerebral injury, with potential short- and long-term consequences. Recognition of silent stroke as a relevant neurological endpoint supports a shift toward multimodal, perfusion-driven neuroprotective strategies and the routine incorporation of MRI-based outcomes in future cardiac surgical research. Full article

To investigate the rationality of water-use efficiency in agroforestry systems within this region, this study utilised the medicinal and edible plant Sophora japonica cv.jinhuai as a foundation. Five mixed planting models were established, incorporating Ardisia gigantifolia, Melicope pteleifolia, Camellia limonia, Belamcanda chinensis, Isatidis radix, and Pilea basicordata. Water-use efficiency (WUE) was analysed by measuring the carbon-stable isotope composition (δ¹³C) of plant leaves. Compared to previous studies that primarily focused on δ¹³C in single species or simple composite systems, this research innovatively evaluates the water-use efficiency (WUE) performance of different composite patterns and their impact on system stability at both the species and system levels, integrating the theory of fitness differentiation. Results indicate that the ranges of δ¹³C and WUE for the five mixed cropping systems were −27.0633‰ to 31.2188‰ and 27.7191 to 50.0365 μmol/mol, respectively. WUE ranking was: Sophora japonica cv.jinhuai—Camellia limonia—Pilea basicordata (SCP) > Sophora japonica cv.jinhuai—Camellia limonia (SC) > Sophora japonica cv.jinhuai—Belamcanda chinensis + Isatidis radix (SBI) > Sophora japonica cv.jinhuai—Melicope pteleifolia (SM) > Sophora japonica cv.jinhuai—Ardisia gigantifolia (SA). At the species level, the Sophora japonica cv.jinhuai—Camellia limonia—Pilea basicordata (SCP) composite planting model is better suited to karst arid environments, while the Sophora japonica cv.jinhuai—Ardisia gigantifolia (SA) composite planting model exhibits lower overall plant water-use efficiency (WUE) and weaker drought resistance. At the system level, Sophora japonica cv. jinhuai exhibited significantly higher water-use efficiency (WUE) than understory medicinal plants in most composite patterns, with pronounced differences in species fitness and poor system stability. The Sophora japonica cv.jinhuai—Camellia limonia—Pilea basicordata (SCP) model exhibited the highest WUE. Furthermore, no significant difference in WUE was observed between Sophora japonica cv.jinhuai and Pilea basicordata, indicating relatively high fitness matching and good coordination in water use. These species can coexist stably, suggesting promising application potential in karst arid environments. Therefore, this study not only evaluated the water-use performance of each species within the composite model but also identified SCP as the most suitable agroforestry configuration for karst regions from a system stability perspective. This provides a scientifically grounded basis for optimising agroforestry practices in these areas, integrating both species-level and system-level perspectives. It should be clarified that the WUE calculated based on δ¹³C in this study is a relative indicator rather than an absolute physiological measurement. Its reliability depends on the core assumptions and parameter settings of the isotope model. Full article