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Article

7 Citations

2,756 Views

22 Pages

DisA Restrains the Processing and Cleavage of Reversed Replication Forks by the RuvAB-RecU Resolvasome

Carolina Gándara,
Rubén Torres,
Begoña Carrasco,
Silvia Ayora and
Juan C. Alonso

Int. J. Mol. Sci.2021, 22(21), 11323;https://doi.org/10.3390/ijms222111323

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20 October 2021

DNA lesions that impede fork progression cause replisome stalling and threaten genome stability. Bacillus subtilis RecA, at a lesion-containing gap, interacts with and facilitates DisA pausing at these branched intermediates. Paused DisA suppresses i...

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Article

13 Citations

4,436 Views

17 Pages

CRISPR/nCas9-Based Genome Editing on GM2 Gangliosidoses Fibroblasts via Non-Viral Vectors

Andrés Felipe Leal,
Javier Cifuentes,
Valentina Quezada,
Eliana Benincore-Flórez,
Juan Carlos Cruz,
Luis Humberto Reyes,
Angela Johana Espejo-Mojica and
Carlos Javier Alméciga-Díaz

Int. J. Mol. Sci.2022, 23(18), 10672;https://doi.org/10.3390/ijms231810672

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14 September 2022

The gangliosidoses GM2 are a group of pathologies mainly affecting the central nervous system due to the impaired GM2 ganglioside degradation inside the lysosome. Under physiological conditions, GM2 ganglioside is catabolized by the β-hexosamini...

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