Search Results (64)

The spatial separation of port yards and railway hubs, which relies on external truck drayage as a necessary link, hampers the seamless transshipment of sea–rail intermodal containers between ports and railway hubs. This creates challenges in synchronizing yard cranes (YCs) at the port terminal, external trucks (ETs) on the road, and rail-mounted gantry cranes (RMGs) at the railway hub. However, most existing studies focus on equipment scheduling or container transshipment organization under the port–railway integration mode, often overlooking critical time window constraints, such as train schedules and export container delivery deadlines. Therefore, this study investigates the collaborative scheduling of YCs, ETs, and RMGs for synchronized loading and unloading under the port–railway separation mode. A mixed-integer programming (MIP) model is developed to minimize the maximum makespan of all tasks and the empty-load time of ETs, considering practical time window constraints. Given the NP-hard complexity of this problem, an improved genetic algorithm (GA) integrated with a “First Accessible Machinery” rule is designed. Extensive numerical experiments are conducted to validate the correctness of the proposed model and the performance of the solution algorithm. The improved GA demonstrates a 6.08% better solution quality and a 97.94% reduction in computation time compared to Gurobi for small-scale instances. For medium to large-scale instances, it outperforms the adaptive large neighborhood search (ALNS) algorithm by 1.51% in solution quality and reduces computation time by 45.71%. Furthermore, the impacts of objective weights, equipment configuration schemes, port–railway distance, and time window width are analyzed to provide valuable managerial insights for decision-making to improve the overall efficiency of sea–rail intermodal systems. Full article

Expanding soybean planting is vital for food security both in China and globally. The 50° N latitude serves as the northern boundary of major soybean regions. However, enhancing the adaptability of soybean to photothermal conditions enables the potential to extend cultivation to higher latitudes and altitudes. Understanding the genetic basis of super-early maturity of soybean is crucial to achieving this goal. In this study, 438 soybean germplasms collected from high-latitude regions were evaluated in Heihe (HH) (50°15′ N, 127°28′ E, 154 m), Beijicun (BJC) (53°28′ N, 122°21′ E, 295 m) and Labudalin (LBDL) (50°15′ N, 120°19′ E, 577 m). Using resequencing data, we analyzed natural variation and haplotypes in 35 key genes associated with flowering time and maturity. The results showed that the relative maturity groups (RMGs) for BJC, HH, and LBDL were −1.0, 0.0, and −1.2, respectively. Among the 35 genes analyzed, 23 had identical allelic variations, while 12 genes exhibited 19 SNPs and four InDels. Functional mutations were identified in E1, E2, E3, and E4. Notably, all cultivars carried the e1-as allele of E1, which is likely critical for high-latitude adaptation. Additional mutations included a single-base substitution in E2 (16142 A > T) and E3 (5203 C > T), causing premature codon termination, along with frameshift mutations in E4 (3726 and 4099) and E3 (2649). Haplotype analysis revealed significant differences in growth stages among nine gene haplotypes. The higher frequency of early-maturing haplotypes in BJC and LBDL highlights the role of gene accumulation in soybean adaptation. These findings offer valuable insights for improving soybean maturity and expanding its cultivation in high-latitude regions of China. Full article

This paper aims to consider the issue of increasing the environmental friendliness of shipping by using alternative fuels in marine diesel engines. It has been determined that marine diesel engines are not only the main heat engines used on ships of sea and inland waterway transport, but are also sources of emissions of toxic components with exhaust gases. The main compounds whose emissions are controlled and regulated by international organizations are sulfur oxides (SO_X) and nitrogen oxides (NO_X), as well as carbon dioxide (CO₂). Reducing NO_X and CO₂ emissions while simultaneously increasing the environmental friendliness of shipping is possible by using fuel mixtures in marine diesel engines that include biodiesel fuel. During the research carried out on Wartsila 6L32 marine diesel engines (Shanghai Wartsila Qiyao Diesel Co. Ltd., Shanghai, China), RMG500 and DMA10 petroleum fuels were used, as well as their mixtures with biodiesel fuel FAME. It was found that when using mixtures containing 10–30% of FAME biodiesel, NO_X emissions are reduced by 11.20–27.10%; under the same conditions, CO₂ emissions are reduced by 5.31–19.47%. The use of alternative fuels in marine diesel engines (one of which is biodiesel and fuel mixtures containing it) is one of the ways to increase the level of environmental sustainability of seagoing vessels and promote ecological shipping. This is of particular relevance when operating vessels in special ecological areas of the World Ocean. The relatively low energy intensity of the method of creating and using such fuel mixtures contributes to the spread of its use on many means of maritime transport. Full article

Background/Objective: Ovarian clear cell carcinomas (OCCCs) are a rare histological subtype of epithelial ovarian cancer characterized by resistance to platinum-based therapy. CDK8/19, a component of the regulatory CDK module associated with Mediator complex, has been implicated in transcriptional reprogramming and drug resistance in various solid tumors. Our study aimed to investigate the therapeutic potential of CDK8/19 kinase inhibition using selective inhibitors SNX631 and SNX631-6 in OCCC treatment, both as monotherapy and in combination with standard chemotherapeutics. Methods: CDK8 and Ki67 levels were evaluated via immunohistochemistry in benign, primary, and metastatic ovarian cancer tissues. The efficacy of SNX631 alone and in combination with cisplatin or paclitaxel was assessed in OCCC cell lines (ES-2, TOV-21-G, RMG-1). In vivo evaluation utilized xenograft models with subcutaneous and intraperitoneal delivery of the OCCC ES2 cells and oral delivery of SNX631-6, with the monitoring of tumor growth, metastatic spread, and survival. Results: CDK8 protein levels were elevated in OC tissues, particularly in OCCC primary and metastatic lesions compared to benign tissue. While CDK8/19 inhibition showed limited effects on in vitro cell proliferation, SNX631-6 demonstrated significant antitumor and anti-metastatic activity in vivo. Notably, SNX631-6 enhanced the efficacy of cisplatin, substantially inhibiting tumor growth and extending overall survival. Conclusions: Therapeutically achievable doses of CDK8/19 inhibitors may provide clinical benefit for OCCC patients by inhibiting tumor growth and reversing platinum resistance, potentially addressing a critical treatment challenge in this rare ovarian cancer subtype. Full article

Retinal Müller glial cells (RMG) play a crucial role in retinal neuroinflammation, including autoimmune uveitis. Increasing evidence supports their function as active modulators of immune responses and potential atypical antigen-presenting cells (APCs). To further investigate this hypothesis, we conducted a differential proteome analysis of primary equine RMG from healthy controls and horses with equine recurrent uveitis (ERU), a spontaneous model of autoimmune uveitis. This analysis identified 310 proteins with differential abundance. Among these, the Major Histocompatibility Complex (MHC) class II and the enzyme Arginase 1 (ARG1) were significantly enriched in RMG from uveitis-affected horses, whereas Mannose Receptor C-type 2 (MRC2) and its interactor Thrombospondin 1 (THBS1) were more abundant in healthy RMG. The detection of MHC class II in equine RMG, consistent with previous studies, validates the robustness of our approach. Furthermore, the identification of ARG1 and MRC2, together with THBS1, provides new insights into the immunomodulatory and antigen-presenting properties of RMG. Immunohistochemical analyses confirmed the proteomic findings and revealed the spatial distribution of ARG1 and MRC2. ARG1 and MRC2 are thus markers for RMG in the neuroinflammatory or physiological milieu and highlight potential differences in the immune function of RMG, particularly in antigen presentation. Full article

The current paradigm of low-T combustion and autoignition of hydrocarbons is based on the sequential two-step oxygenation of fuel radicals. The key chain-branching occurs when the second oxygenation adduct (OOQOOH) is isomerized releasing an OH radical and a key ketohydroperoxide (KHP) intermediate. The subsequent homolytic dissociation of relatively weak O–O bonds in KHP generates two more radicals in the oxidation chain leading to ignition. Based on the recently introduced intramolecular “catalytic hydrogen atom transfer” mechanism (J. Phys. Chem. 2024, 128, 2169), abbreviated here as I-CHAT, we have identified a novel unimolecular decomposition channel for KHPs to form their classical isomers—enol hydroperoxides (EHP). The uncertainty in the contribution of enols is typically due to the high computed barriers for conventional (“direct”) keto–enol tautomerization. Remarkably, the I-CHAT dramatically reduces such barriers. The novel mechanism can be regarded as an intramolecular version of the intermolecular relay transfer of H-atoms mediated by an external molecule following the general classification of such processes (Catal. Rev.-Sci. Eng. 2014, 56, 403). Here, we present a detailed mechanistic and kinetic analysis of the I-CHAT-facilitated pathways applied to n-hexane, n-heptane, and n-pentane models as prototype molecules for gasoline, diesel, and hybrid rocket fuels. We particularly examined the formation kinetics and subsequent dissociation of the γ-enol-hydroperoxide isomer of the most abundant pentane-derived isomer γ-C5-KHP observed experimentally. To gain molecular-level insight into the I-CHAT catalysis, we have also explored the role of the internal catalyst moieties using truncated models. All applied models demonstrated a significant reduction in the isomerization barriers, primarily due to the decreased ring strain in transition states. In addition, the longer-range and sequential H-migration processes were also identified and illustrated via a combined double keto–enol conversion of heptane-2,6-diketo-4-hydroperoxide as a potential chain-branching model. To assess the possible impact of the I-CHAT channels on global fuel combustion characteristics, we performed a detailed kinetic analysis of the isomerization and decomposition of γ-C5-KHP comparing I-CHAT with key alternative reactions—direct dissociation and Korcek channels. Calculated rate parameters were implemented into a modified version of the n-pentane kinetic model developed earlier using RMG automated model generation tools (ACS Omega, 2023, 8, 4908). Simulations of ignition delay times revealed the significant effect of the new pathways, suggesting an important role of the I-CHAT pathways in the low-T combustion of large alkanes. Full article

In recent years, the growth of utilizing rural microgrids (RMGs) has been accompanied by various challenges. These necessitate the development of appropriate models for optimal generation in RMGs and RMGs’ coordination. In this paper, two distinct models for RMGs are presented. The first model includes an islanded rural microgrid (IRMG) and the second model consists of three RMGs that are interconnected with one another and linked to the distribution network. The proposed models take into account the uncertainty in load, photovoltaics (PVs), and wind turbines (WTs) with consideration of their correlation by using a scenario-based technique. Three objective functions are defined for optimization: minimizing operational costs including maintenance and fuel expenses, reducing voltage deviation to maintain power quality, and decreasing pollution emissions from fuel cells and microturbines. A new optimization method, namely the Improved Multi-Objective Crow Search Algorithm (IMOCSA), is proposed to solve the problem models. IMOCSA enhances the standard Crow Search Algorithm through three key improvements: an adaptive chaotic awareness probability to better balance exploration and exploitation, a mutation mechanism applied to the solution repository to prevent premature convergence, and a K-means clustering method to control repository size and increase algorithmic efficiency. Since the proposed problem is a multi-objective non-linear optimization problem with conflicting objectives, the idea of the Pareto front is used to find a group of optimal solutions. To assess the effectiveness and efficiency of the proposed models, they are implemented in two different case studies and the analysis and results are illustrated. Full article

Forest operations consume a large amount of fossil fuels. Storing wood in the field reduces the weight of the wood, optimizing transportation and reducing fuel consumption. However, there are few studies linking these variables. The objective was to evaluate the drying of logs with different diameters and assess the fossil fuel consumption considering the mass of dry wood transported. Eucalyptus logs were divided into two diameter classes: 6 ≤ D1 ≤ 11 cm and 11.1 ≤ D2 ≤ 14 cm. These logs were arranged in a stack, divided into base, intermediate, and top positions, and subjected to drying. The wood moisture values were correlated with the amount of transported dry wood, fuel consumption, and costs. These calculations were based on a vehicle with a load capacity of 41.6 Mg, a fuel consumption rate of 1.82 L/km, and a road cost of 0.51 R$·Mg⁻¹·km⁻¹. The moisture content was lower in smaller-diameter logs located at the top of the storage stack and higher in larger-diameter logs in the intermediate position and in both diameter classes at the bottom position after 365 days of drying. Storage for 365 days, on average, increased the dry wood transport capacity by 90%, resulting in similar gains in fuel economy and the final cost of transportation. Storing wood outdoors has proven effective in reducing its moisture content, resulting in lower fossil fuel consumption during forestry operations, reducing environmental impact, and generating economic gains. Full article

The article presents an analysis of the results obtained during the three-point bending test for seven variants of epoxy rubber–glass composites manufactured according to innovative technology. Different contents of rubber recyclate (3, 5, and 7%) and different methods of distribution of the recyclate in the composite structure (1, 2, and 3 layers with a constant share of 5% of the recyclate) were used in the tested materials. To determine the stress values at which critical failures of the tested materials are initiated in the bending test, an analysis was carried out using the Kolmogorov–Sinai (E_K-S) metric entropy calculations. The analysis results showed that for each of the above-mentioned variants of the tested epoxy–glass composites, the onset of critical changes occurring in the material structure occurs below the recorded values of the flexural strength Rmg. The decrease in the Rmg_K-S value in relation to Rmg is different for different material variants and depends mainly on the % content of rubber recyclate and the amount and method of decomposition of rubber recyclate in the layers of the analyzed materials. The research showed that the introduction of rubber recyclate into the composition of composites has a positive effect on their strength properties. This process allows for the efficient use of hard to degrade waste and opens up the possibility of using the newly developed materials in many industrial sectors. Full article

The insular cortex is an important hub for sensory and emotional integration. It is one of the areas consistently found activated during pain. While the insular’s connections to the limbic system might play a role in the aversive and emotional component of pain, its connections to the descending pain system might be involved in pain intensity coding. Here, we used anterograde tracing with viral expression of mCherry fluorescent protein, to examine the connectivity of insular axons to different brainstem nuclei involved in the descending modulation of pain in detail. We found extensive connections to the main areas of descending pain control, namely, the periaqueductal gray (PAG) and the raphe magnus (RMg). In addition, we also identified an extensive insular connection to the parabrachial nucleus (PBN). Although not as extensive, we found a consistent axonal input from the insula to different noradrenergic nuclei, the locus coeruleus (LC), the subcoereuleus (SubCD) and the A5 nucleus. These connections emphasize a prominent relation of the insula with the descending pain modulatory system, which reveals an important role of the insula in pain processing through descending pathways. Full article

This article considers the issues of ensuring operational performance and environmental sustainability of marine diesel engines by using biodiesel fuel. This research was conducted on 5S60ME-C8 MAN-B&W Diesel Group and 6DL-16 Daihatsu Diesel marine diesel engines, which are operated using RMG380 petroleum fuel and B10 and B30 biodiesel fuels. The efficiency of biofuel usage was assessed based on environmental (reduced nitrogen oxide concentration in exhaust gases) and economic (increased specific effective fuel consumption) criteria. It was found that the use of B10 and B30 biofuels provides a reduction in nitrogen oxide concentration in exhaust gases by 14.71–25.13% but at the same time increases specific effective fuel consumption by 1.55–6.01%. Optimum fuel injection advance angles were determined that ensure the best thermal energy, economic and environmental performance of diesel engines. The optimum angle of biofuel supply advance is determined experimentally and should correspond to the limits recommended by the diesel engine operating instructions. It has been proven experimentally that the use of biofuel increases the environmental sustainability of marine diesel engines by 13.75–29.42%. It increases the diesel engines environmental safety in case of emergency situations as well as accidental and short-term emissions of exhaust gases with an increased content of nitrogen oxides into the atmosphere phenomena that are possible in starting modes of diesel engine operation as well as in modes of sudden load changes. It is the increase in the environmental friendliness of marine diesel engines in the case of using biofuel that is the most positive criterion and contributes to the intensity of biofuel use in power plants of sea vessels. Full article

Background/Objective: Wound infiltration with local anesthetics emerges as a promising modality for postoperative pain alleviation. However, such strategies in neck surgery have not been a well-established practice. To assess wound infiltration with ropivacaine plus magnesium sulfate for pain relief following thyroid surgery. Methods: This prospective, double-blind, randomized study enrolled 68 patients who underwent thyroid surgery. Concerning the solution used for surgical wound infiltration, the study participants were randomly allocated into three groups: (1) 100 mg of ropivacaine (Group R); (2) 100 mg of ropivacaine plus magnesium sulfate 10 mg/kg (Group RMg); and (3) normal saline which served as a placebo (Group P). Pain perception both at rest and at movement, was measured using the Visual Analogue Scale (VAS) at 30 min, as well as at 1, 2, 4, 6, 12, and 24 h postoperatively. The total consumption of analgesics in morphine equivalents was also recorded. Moreover, adverse effects and patient satisfaction were recorded. Cortisol, TNF-α, and IL-6 levels were measured 30 min before infiltration and 6 h and 24 h postoperatively. Results: Demographics and clinical characteristics were similar between the groups. The VAS scores at rest and during movement were significantly lower in the RMg group compared to the saline or ropivacaine groups. Total analgesic consumption was also significantly lower in the RMg group. No operation-, wound-, or infiltration-related adverse effects were recorded in the study groups. Better overall satisfaction was obtained for the RMg group. Conclusions: Ropivacaine plus magnesium sulfate wound infiltration provided better pain control and the analgesic effect was more significant, contributing to effective postoperative analgesia in patients undergoing thyroid surgery. Full article

With the unexpected onset of COVID-19, governments across the world responded with a range of preventive measures, including the imposition of lockdowns. To mitigate the adverse effects of lockdowns arising from supply chain shocks and employment loss, governments worldwide chose to implement policies to stimulate their economies and keep them working. This study assesses the impact and effectiveness of four of these packages in Bangladesh, employing a mixed-method approach. These packages include “salary support for workers in export-oriented RMG industries”, “working capital loans for affected industries and service sectors”, “working capital loans for cottage, micro, small, and medium enterprises”, and initiatives for “revitalizing the rural economy and job creation”. Each package was examined individually because of their differences in beneficiary groups, implementation methods, and individual objectives. Quantitative analysis involved propensity score matching (PSM), the difference in difference model (DID), and structural equation modelling (SEM). Stakeholders, including policy implementers, Bangladesh Bank officials, policy analysts, academics, workers, and beneficiaries, contributed to the qualitative analysis through extensive key-informant interviews, providing a comprehensive assessment of intervention outcomes. Ultimately, the results show that the packages achieved their socio-economic relief objectives for beneficiaries. The research examined both positive impacts and challenges in their implementation. It suggests that all four packages successfully achieved their goals, such as providing social and economic support, sustaining livelihoods, addressing marginalized groups’ needs, ensuring survival for large industries and small businesses, and promoting employment. In order to better address future shocks, establishing a beneficiary database integrated with the national system is recommended for smoother policy rollout. Despite acknowledged limitations, including challenges in beneficiary identification, data availability, and time constraints, the study’s unbiased estimations provide valuable insights to guide future policy directions in similar situations. Full article

In this paper, a new axial-type magnetic gear with an auxiliary flux-enhancing structure (AFS-AMG) is proposed. Compared to conventional AMGs, it has a higher torque density and higher permanent magnet (PM) utilization factor. Firstly, the design rules and operating principles of the proposed AFS-AMG are elaborated. Then, the mapping relation between the radial-type magnetic gears (RMGs) and AMGs are elucidated. Compared to its counterparts in RMGs, the AFS-AMG achieves a small size. Then, the geometrical parameters of the AFS-AMG are optimized to obtain better electromagnetic performance, where the torque density per volume and per PM volume is adopted as the evaluation standard. Finally, three different AMG topologies are constructed in finite element analysis (FEA) software for comparison. It is proven that the AFS-AMG has the largest torque density per volume and per PM volume. Full article

This mini-review offers a comprehensive overview of the advancements made over the last three years in utilizing highly polar s-block organometallic reagents (specifically, RLi, RNa and RMgX compounds) in organic synthesis run under bench-type reaction conditions. These conditions involve exposure to air/moisture and are carried out at room temperature, with the use of sustainable solvents as reaction media. In the examples provided, the adoption of Deep Eutectic Solvents (DESs) or even water as non-conventional and protic reaction media has not only replicated the traditional chemistry of these organometallic reagents in conventional and toxic volatile organic compounds under Schlenk-type reaction conditions (typically involving low temperatures of −78 °C to 0 °C and a protective atmosphere of N₂ or Ar), but has also resulted in higher conversions and selectivities within remarkably short reaction times (measured in s/min). Furthermore, the application of the aforementioned polar organometallics under bench-type reaction conditions (at room temperature/under air) has been extended to other environmentally responsible reaction media, such as more sustainable ethereal solvents (e.g., CPME or 2-MeTHF). Notably, this innovative approach contributes to enhancing the overall sustainability of s-block-metal-mediated organic processes, thereby aligning with several key principles of Green Chemistry. Full article